DE60205635D1 - Einfaches enzymatisches Verfahren zur Herstellung von Cefazolin - Google Patents

Einfaches enzymatisches Verfahren zur Herstellung von Cefazolin

Info

Publication number
DE60205635D1
DE60205635D1 DE60205635T DE60205635T DE60205635D1 DE 60205635 D1 DE60205635 D1 DE 60205635D1 DE 60205635 T DE60205635 T DE 60205635T DE 60205635 T DE60205635 T DE 60205635T DE 60205635 D1 DE60205635 D1 DE 60205635D1
Authority
DE
Germany
Prior art keywords
acid
cefazolin
production
cephem
thiomethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60205635T
Other languages
English (en)
Inventor
Ferrer Alvaro Sanchez
Carmona Francisco Garcia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bioferma Murcia SA
Original Assignee
Bioferma Murcia SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioferma Murcia SA filed Critical Bioferma Murcia SA
Application granted granted Critical
Publication of DE60205635D1 publication Critical patent/DE60205635D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
    • C12Y305/01011—Penicillin amidase (3.5.1.11), i.e. penicillin-amidohydrolase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/04—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by acylation of the substituent in the 7 position

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Cephalosporin Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE60205635T 2002-10-31 2002-10-31 Einfaches enzymatisches Verfahren zur Herstellung von Cefazolin Expired - Lifetime DE60205635D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02380224A EP1416054B1 (de) 2002-10-31 2002-10-31 Einfaches enzymatisches Verfahren zur Herstellung von Cefazolin

Publications (1)

Publication Number Publication Date
DE60205635D1 true DE60205635D1 (de) 2005-09-22

Family

ID=32088098

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60205635T Expired - Lifetime DE60205635D1 (de) 2002-10-31 2002-10-31 Einfaches enzymatisches Verfahren zur Herstellung von Cefazolin

Country Status (5)

Country Link
EP (2) EP1416054B1 (de)
AT (1) ATE302283T1 (de)
AU (1) AU2003282071A1 (de)
DE (1) DE60205635D1 (de)
WO (1) WO2004039997A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100432214C (zh) * 2005-04-08 2008-11-12 中国船舶重工集团公司第七二五研究所 一种产氨菌
CN100368554C (zh) * 2005-04-26 2008-02-13 华南理工大学 酶催化“一锅法”制备β-内酰胺抗生素的方法
CN102605033B (zh) * 2012-01-17 2013-11-27 湖南福来格生物技术有限公司 头孢唑啉中间体tda的制备方法
CN102617607B (zh) * 2012-03-31 2014-04-16 哈药集团制药总厂 一种制备头孢唑啉化合物的方法
CN103937692B (zh) * 2014-04-30 2016-03-23 江南大学 一株丝枝霉菌株及其生产β-葡萄糖苷酶的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0171897B1 (ko) * 1989-12-27 1999-02-01 후지사와 도모끼찌로 7-아미노세펨 화합물 또는 그 염류의 제조 방법
EP1352968A1 (de) * 1997-09-09 2003-10-15 BIOCHEMIE Gesellschaft m.b.H. Esterasefreie Enzymen
AU2002316862A1 (en) * 2001-04-19 2002-11-05 Bioferma Murcia, S.A. Enzymatic process for preparing cephalosporin derivatives

Also Published As

Publication number Publication date
WO2004039997A1 (en) 2004-05-13
ATE302283T1 (de) 2005-09-15
EP1416054B1 (de) 2005-08-17
AU2003282071A1 (en) 2004-05-25
EP1556500A1 (de) 2005-07-27
EP1416054A1 (de) 2004-05-06

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