ATE129697T1 - 9-amino-7-substituierte-6-desmethyl-6- desoxytetracyclin. - Google Patents

9-amino-7-substituierte-6-desmethyl-6- desoxytetracyclin.

Info

Publication number
ATE129697T1
ATE129697T1 AT92114054T AT92114054T ATE129697T1 AT E129697 T1 ATE129697 T1 AT E129697T1 AT 92114054 T AT92114054 T AT 92114054T AT 92114054 T AT92114054 T AT 92114054T AT E129697 T1 ATE129697 T1 AT E129697T1
Authority
AT
Austria
Prior art keywords
amino
substituted
deoxytetracycline
desmethyl
disclosed
Prior art date
Application number
AT92114054T
Other languages
German (de)
English (en)
Inventor
Joseph J Hlavka
Phaik-Eng Sum
Yakov Gluzman
Ving J Lee
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Application granted granted Critical
Publication of ATE129697T1 publication Critical patent/ATE129697T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Seasonings (AREA)
  • Luminescent Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Quinoline Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Moulding By Coating Moulds (AREA)
  • Tires In General (AREA)
  • Spinning Or Twisting Of Yarns (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT92114054T 1991-10-04 1992-08-18 9-amino-7-substituierte-6-desmethyl-6- desoxytetracyclin. ATE129697T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/771,697 US5281628A (en) 1991-10-04 1991-10-04 9-amino-7-(substituted)-6-demethyl-6-deoxytetracyclines

Publications (1)

Publication Number Publication Date
ATE129697T1 true ATE129697T1 (de) 1995-11-15

Family

ID=25092681

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92114054T ATE129697T1 (de) 1991-10-04 1992-08-18 9-amino-7-substituierte-6-desmethyl-6- desoxytetracyclin.

Country Status (25)

Country Link
US (3) US5281628A (cg-RX-API-DMAC10.html)
EP (1) EP0535346B1 (cg-RX-API-DMAC10.html)
JP (1) JP3183729B2 (cg-RX-API-DMAC10.html)
KR (1) KR100261528B1 (cg-RX-API-DMAC10.html)
CN (1) CN1053182C (cg-RX-API-DMAC10.html)
AT (1) ATE129697T1 (cg-RX-API-DMAC10.html)
AU (1) AU651734B2 (cg-RX-API-DMAC10.html)
CA (1) CA2079703C (cg-RX-API-DMAC10.html)
CZ (1) CZ285015B6 (cg-RX-API-DMAC10.html)
DE (1) DE69205792T2 (cg-RX-API-DMAC10.html)
DK (1) DK0535346T3 (cg-RX-API-DMAC10.html)
ES (1) ES2081005T3 (cg-RX-API-DMAC10.html)
FI (1) FI111716B (cg-RX-API-DMAC10.html)
GR (1) GR3017978T3 (cg-RX-API-DMAC10.html)
HK (1) HK1000319A1 (cg-RX-API-DMAC10.html)
HU (2) HU211214B (cg-RX-API-DMAC10.html)
IL (1) IL103319A (cg-RX-API-DMAC10.html)
MX (1) MX9205573A (cg-RX-API-DMAC10.html)
NO (1) NO300129B1 (cg-RX-API-DMAC10.html)
NZ (1) NZ244556A (cg-RX-API-DMAC10.html)
PH (1) PH30343A (cg-RX-API-DMAC10.html)
PL (2) PL170939B1 (cg-RX-API-DMAC10.html)
SK (1) SK281113B6 (cg-RX-API-DMAC10.html)
TW (1) TW222616B (cg-RX-API-DMAC10.html)
ZA (1) ZA927608B (cg-RX-API-DMAC10.html)

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AU666372B2 (en) * 1992-05-28 1996-02-08 Centre For Molecular Biology And Medicine Therapeutic compositions
US5420272A (en) * 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5442059A (en) * 1992-08-13 1995-08-15 American Cyanamid Company 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines
US5328902A (en) * 1992-08-13 1994-07-12 American Cyanamid Co. 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5371076A (en) * 1993-04-02 1994-12-06 American Cyanamid Company 9-[(substituted glycyl)amido]-6-(substituted)-5-hydroxy-6-deoxytetracyclines
CA2183565A1 (en) * 1994-02-17 1995-08-24 Wei-Guo Su 9-(substituted amino)-alpha-6-deoxy-5-oxy tetracycline derivatives, their preparation and their use as antibiotics
AU2466099A (en) * 1998-01-23 1999-08-09 Trustees Of Tufts College Pharmaceutically active compounds and methods of use thereof
ES2260051T3 (es) * 1999-09-14 2006-11-01 Trustees Of Tufts College Metodo para preparar tetraciclinas substituidas con quimicas basadas en metales de transicion.
US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
US6686365B2 (en) * 2000-02-04 2004-02-03 Eli Lilly And Company Pharmaceutical composition
US20020132798A1 (en) * 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
AU2001268475A1 (en) * 2000-06-16 2002-01-02 Trustees Of Tufts College 7-phenyl-substituted tetracycline compounds
AU7164201A (en) * 2000-07-07 2002-01-21 Tufts College 7-substituted tetracycline compounds
US7094806B2 (en) 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
AU8638801A (en) * 2000-07-07 2002-01-21 Tufts College 9-substituted minocycline compounds
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US20060194773A1 (en) * 2001-07-13 2006-08-31 Paratek Pharmaceuticals, Inc. Tetracyline compounds having target therapeutic activities
EP2327409A1 (en) 2001-07-13 2011-06-01 Paratek Pharmaceuticals, Inc. Tetracycline compound having target therapeutic activities
AU2002365120A1 (en) 2001-08-02 2003-07-15 Paratek Pharmaceuticals, Inc. Medicaments
US20030181371A1 (en) * 2001-12-28 2003-09-25 Angiotech Pharmaceuticals, Inc. Compositions and methods of using collajolie
EP2322501B1 (en) 2002-01-08 2015-08-05 Paratek Pharmaceuticals, Inc. 4-dedimethylamino tetracycline compounds
CN101307017A (zh) * 2002-03-08 2008-11-19 帕拉特克药品公司 氨基-甲基取代的四环素类化合物
CA2479877C (en) 2002-03-21 2012-08-21 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
EP2345637A3 (en) 2002-07-12 2012-02-15 Paratek Pharmaceuticals, Inc. 3, 10, and 12a substituted tetracycline compounds
BR0317715A (pt) * 2002-12-27 2005-11-22 Angiotech Int Ag Composições e processos de uso de collajolie
US20050143352A1 (en) 2003-07-09 2005-06-30 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
US20060287283A1 (en) * 2003-07-09 2006-12-21 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
US7786099B2 (en) * 2004-01-15 2010-08-31 Paratek Pharmaceuticals, Inc. Aromatic a-ring derivatives of tetracycline compounds
EP2284153A3 (en) 2004-10-25 2012-03-14 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
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US8088755B2 (en) * 2005-02-04 2012-01-03 Paratek Pharmaceuticals, Inc. 11a, 12-derivatives of tetracycline compounds
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AR057032A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos de preparacion
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EP1965770A2 (en) * 2005-12-22 2008-09-10 Wyeth a Corporation of the State of Delaware Oral formulations comprising tigecycline
EP1962860A1 (en) * 2005-12-22 2008-09-03 Wyeth Methods of treating gastrointestinal tract infections with tigecycline
CA2649221A1 (en) * 2006-04-17 2007-10-25 Evgeny Tsiperman Isolation of tetracycline derivatives
US8198470B2 (en) * 2006-04-24 2012-06-12 Teva Pharmaceutical Industries Ltd. Crystalline form II of tigecycline and processes for preparation thereof
PT2016045E (pt) * 2006-04-24 2015-02-05 Teva Pharma Forma cristalina de tigeciclina e processos para a sua preparação
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EP2029749A2 (en) 2006-05-15 2009-03-04 Paratek Pharmaceuticals, Inc. Methods of regulating expression of genes or of gene products using substituted tetracycline compounds
MX2008009520A (es) 2006-11-29 2009-02-26 Teva Pharma Formas cristalinas de tigeciclina y procesos de preparacion de ellas.
EP2084126A1 (en) * 2006-11-30 2009-08-05 Teva Pharmaceutical Industries Ltd. Processes for preparation of 9-haloacetamidominocyclines
US20080214869A1 (en) * 2007-03-01 2008-09-04 Sergei Fine Processes for purification of tigecycline
SI2225253T1 (sl) 2007-11-29 2012-09-28 Actelion Pharmaceuticals Ltd Derivati fosfonske kisline in njihova uporaba kot antagonisti receptorja P2Y12
WO2010032219A1 (en) * 2008-09-18 2010-03-25 Ranbaxy Laboratories Limited Process for the preparation of tigecycline
CA2751238A1 (en) * 2009-03-12 2010-10-07 Wyeth Llc Nitration of tetracyclines
SI2327676T1 (sl) * 2009-11-26 2014-07-31 Sandoz Ag Reakcije organskih spojin z nizkimi količinami vodika

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US2997471A (en) * 1958-08-18 1961-08-22 Bristol Myers Co Tetracycline derivatives
US3007965A (en) * 1959-02-13 1961-11-07 American Cyanamid Co New tetracyclines produced by streptomyces aureofaciens
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Also Published As

Publication number Publication date
EP0535346A1 (en) 1993-04-07
FI924453L (fi) 1993-04-05
CA2079703C (en) 2004-07-20
CN1053182C (zh) 2000-06-07
IL103319A0 (en) 1993-03-15
PL170939B1 (pl) 1997-02-28
NO923856D0 (no) 1992-10-02
HU211214B (en) 1995-11-28
CZ297292A3 (en) 1993-04-14
NO300129B1 (no) 1997-04-14
MX9205573A (es) 1993-05-01
GR3017978T3 (en) 1996-02-29
US5326759A (en) 1994-07-05
DK0535346T3 (da) 1995-12-04
PL170933B1 (pl) 1997-02-28
HU9203143D0 (en) 1992-12-28
FI111716B (fi) 2003-09-15
EP0535346B1 (en) 1995-11-02
ES2081005T3 (es) 1996-02-16
AU2618292A (en) 1993-04-08
US5401863A (en) 1995-03-28
SK297292A3 (en) 1994-12-07
NZ244556A (en) 1994-06-27
HUT64298A (en) 1993-12-28
JP3183729B2 (ja) 2001-07-09
JPH05239006A (ja) 1993-09-17
DE69205792T2 (de) 1996-06-20
NO923856L (no) 1993-04-05
KR930007895A (ko) 1993-05-20
PL296140A1 (en) 1993-11-02
FI924453A0 (fi) 1992-10-02
AU651734B2 (en) 1994-07-28
CA2079703A1 (en) 1993-04-05
DE69205792D1 (de) 1995-12-07
KR100261528B1 (ko) 2000-07-15
HU211922A9 (en) 1996-01-29
CZ285015B6 (cs) 1999-05-12
TW222616B (cg-RX-API-DMAC10.html) 1994-04-21
ZA927608B (en) 1993-04-13
PH30343A (en) 1997-04-02
IL103319A (en) 1996-07-23
CN1071415A (zh) 1993-04-28
US5281628A (en) 1994-01-25
SK281113B6 (sk) 2000-12-11
HK1000319A1 (en) 1998-02-27

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee