ATE118818T1 - Verfahren zur herstellung synthetischer oligonukleotide, die spezifisch an bestimmungsstellen auf duplex-dna-molekülen binden durch formen eines kolinearen triplex, die synthetischen oligonukleotide und verfahren zu ihrer herstellung. - Google Patents
Verfahren zur herstellung synthetischer oligonukleotide, die spezifisch an bestimmungsstellen auf duplex-dna-molekülen binden durch formen eines kolinearen triplex, die synthetischen oligonukleotide und verfahren zu ihrer herstellung.Info
- Publication number
- ATE118818T1 ATE118818T1 AT89313391T AT89313391T ATE118818T1 AT E118818 T1 ATE118818 T1 AT E118818T1 AT 89313391 T AT89313391 T AT 89313391T AT 89313391 T AT89313391 T AT 89313391T AT E118818 T1 ATE118818 T1 AT E118818T1
- Authority
- AT
- Austria
- Prior art keywords
- synthetic oligonucleotides
- dna
- bind
- duplex
- duplex dna
- Prior art date
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N15/09—Recombinant DNA-technology
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- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
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- C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
- C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
- C12Y205/01018—Glutathione transferase (2.5.1.18)
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- C12Y207/07—Nucleotidyltransferases (2.7.7)
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- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
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- Physics & Mathematics (AREA)
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- Animal Behavior & Ethology (AREA)
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Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28735988A | 1988-12-20 | 1988-12-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE118818T1 true ATE118818T1 (de) | 1995-03-15 |
Family
ID=23102554
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT89313391T ATE118818T1 (de) | 1988-12-20 | 1989-12-20 | Verfahren zur herstellung synthetischer oligonukleotide, die spezifisch an bestimmungsstellen auf duplex-dna-molekülen binden durch formen eines kolinearen triplex, die synthetischen oligonukleotide und verfahren zu ihrer herstellung. |
Country Status (10)
Country | Link |
---|---|
EP (2) | EP0449972A4 (de) |
JP (1) | JPH04502407A (de) |
AT (1) | ATE118818T1 (de) |
AU (1) | AU640910B2 (de) |
CA (1) | CA2006008C (de) |
DE (1) | DE68921315T2 (de) |
DK (1) | DK120091A (de) |
ES (1) | ES2069598T3 (de) |
PT (1) | PT92640B (de) |
WO (1) | WO1990006934A1 (de) |
Families Citing this family (118)
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US5928863A (en) * | 1986-11-26 | 1999-07-27 | Princeton University | Triple-stranded nucleic acids |
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US5849482A (en) * | 1988-09-28 | 1998-12-15 | Epoch Pharmaceuticals, Inc. | Crosslinking oligonucleotides |
US5399676A (en) * | 1989-10-23 | 1995-03-21 | Gilead Sciences | Oligonucleotides with inverted polarity |
US5721218A (en) * | 1989-10-23 | 1998-02-24 | Gilead Sciences, Inc. | Oligonucleotides with inverted polarity |
IE20010427A1 (en) * | 1990-04-10 | 2003-03-05 | Canji Inc | Gene therapy for cell proliferative diseases |
EP0531436A4 (en) * | 1990-05-25 | 1993-06-16 | Gilead Sciences, Inc. | Sequence-specific nonphotoactivated crosslinking agents which bind to the major groove of duplex dna |
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US5734022A (en) * | 1990-08-01 | 1998-03-31 | The Johns Hopkins University | Antibodies to a novel mammalian protein associated with uncontrolled cell division |
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IL103311A0 (en) * | 1991-10-07 | 1993-03-15 | Univ Johns Hopkins | Formation of triple helix complexes of single stranded nucleic acids using nucleoside oligomers |
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US5594121A (en) * | 1991-11-07 | 1997-01-14 | Gilead Sciences, Inc. | Enhanced triple-helix and double-helix formation with oligomers containing modified purines |
US5484908A (en) * | 1991-11-26 | 1996-01-16 | Gilead Sciences, Inc. | Oligonucleotides containing 5-propynyl pyrimidines |
TW393513B (en) * | 1991-11-26 | 2000-06-11 | Isis Pharmaceuticals Inc | Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines |
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JP3739785B2 (ja) * | 1991-11-26 | 2006-01-25 | アイシス ファーマシューティカルズ,インコーポレイティド | 修飾されたピリミジンを含有するオリゴマーを使用する増強された三重らせんおよび二重らせんの成形 |
US5616461A (en) * | 1992-05-14 | 1997-04-01 | Dana-Farber Cancer Institute | Assay for antiviral activity using complex of herpesvirus origin of replication and cellular protein |
US6403302B1 (en) | 1992-09-17 | 2002-06-11 | California Institute Of Technology | Methods and compositions for triple helix formation |
WO1994007367A1 (en) * | 1992-09-29 | 1994-04-14 | Apollon, Inc. | Anti-viral oligomers that bind polypurine tracts of single-stranded rna or rna-dna hybrids |
CA2148687A1 (en) * | 1992-11-09 | 1994-05-26 | Darwin Prockop | Antisense oligonucleotides to inhibit expression of mutated and wild type genes for collagen |
EP0674707A4 (de) * | 1992-12-04 | 1998-01-14 | Apollon Inc | Verbindungen und methoden zur behandlung von leukämien. |
JPH08504103A (ja) * | 1992-12-08 | 1996-05-07 | ジンタ・インコーポレイテッド | 新しいモチーフを用いた3重らせん複合体の形成 |
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WO1995011253A1 (en) * | 1993-10-18 | 1995-04-27 | The Walter And Eliza Hall Institute Of Medical Research | A method for enhancing neurone survival and agents useful for same |
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US5808037A (en) * | 1995-09-15 | 1998-09-15 | Ramareddy Venkata Guntaka | Oligomers which inhibit expression of collagen genes |
US5780611A (en) * | 1995-09-15 | 1998-07-14 | Ramareddy Venkata Guntaka | Oligomers which inhibit expression of collagen genes |
US6156513A (en) * | 1995-09-15 | 2000-12-05 | Ramareddy V. Guntaka | Oligmers which inhibit expression of collagen genes |
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-
1989
- 1989-12-19 CA CA002006008A patent/CA2006008C/en not_active Expired - Fee Related
- 1989-12-20 JP JP2502252A patent/JPH04502407A/ja active Pending
- 1989-12-20 AU AU48384/90A patent/AU640910B2/en not_active Ceased
- 1989-12-20 PT PT92640A patent/PT92640B/pt not_active IP Right Cessation
- 1989-12-20 ES ES89313391T patent/ES2069598T3/es not_active Expired - Lifetime
- 1989-12-20 DE DE68921315T patent/DE68921315T2/de not_active Expired - Fee Related
- 1989-12-20 AT AT89313391T patent/ATE118818T1/de not_active IP Right Cessation
- 1989-12-20 WO PCT/US1989/005769 patent/WO1990006934A1/en not_active Application Discontinuation
- 1989-12-20 EP EP19900901460 patent/EP0449972A4/en active Pending
- 1989-12-20 EP EP89313391A patent/EP0375408B1/de not_active Expired - Lifetime
-
1991
- 1991-06-20 DK DK120091A patent/DK120091A/da not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO1990006934A1 (en) | 1990-06-28 |
AU4838490A (en) | 1990-07-10 |
CA2006008C (en) | 2000-02-15 |
EP0449972A4 (en) | 1992-03-18 |
PT92640A (pt) | 1990-06-29 |
DE68921315D1 (de) | 1995-03-30 |
JPH04502407A (ja) | 1992-05-07 |
EP0375408A1 (de) | 1990-06-27 |
PT92640B (pt) | 1995-09-12 |
ES2069598T3 (es) | 1995-05-16 |
DK120091D0 (da) | 1991-06-20 |
EP0375408B1 (de) | 1995-02-22 |
AU640910B2 (en) | 1993-09-09 |
DE68921315T2 (de) | 1995-08-03 |
CA2006008A1 (en) | 1990-06-20 |
DK120091A (da) | 1991-06-20 |
EP0449972A1 (de) | 1991-10-09 |
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