ATE113275T1 - Arzneimittel. - Google Patents

Arzneimittel.

Info

Publication number
ATE113275T1
ATE113275T1 AT90307633T AT90307633T ATE113275T1 AT E113275 T1 ATE113275 T1 AT E113275T1 AT 90307633 T AT90307633 T AT 90307633T AT 90307633 T AT90307633 T AT 90307633T AT E113275 T1 ATE113275 T1 AT E113275T1
Authority
AT
Austria
Prior art keywords
alkyl
hydrogen
group
together form
linear polymethylene
Prior art date
Application number
AT90307633T
Other languages
English (en)
Inventor
Vittorio Vecchietti
Giuseppe Giardina
Roberto Colle
Original Assignee
Smithkline Beecham Farma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Farma filed Critical Smithkline Beecham Farma
Application granted granted Critical
Publication of ATE113275T1 publication Critical patent/ATE113275T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
AT90307633T 1989-07-18 1990-07-12 Arzneimittel. ATE113275T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898916395A GB8916395D0 (en) 1989-07-18 1989-07-18 Pharmaceuticals

Publications (1)

Publication Number Publication Date
ATE113275T1 true ATE113275T1 (de) 1994-11-15

Family

ID=10660199

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90307633T ATE113275T1 (de) 1989-07-18 1990-07-12 Arzneimittel.

Country Status (15)

Country Link
US (1) US5254564A (de)
EP (1) EP0409489B1 (de)
JP (1) JPH0352864A (de)
KR (1) KR910002801A (de)
AT (1) ATE113275T1 (de)
AU (1) AU632832B2 (de)
CA (1) CA2021213A1 (de)
DE (1) DE69013602T2 (de)
DK (1) DK0409489T3 (de)
ES (1) ES2064641T3 (de)
GB (1) GB8916395D0 (de)
IE (1) IE64923B1 (de)
NZ (1) NZ234533A (de)
PT (1) PT94711B (de)
ZA (1) ZA905556B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8916395D0 (en) * 1989-07-18 1989-09-06 Zambeletti Spa L Pharmaceuticals
GB8926560D0 (en) * 1989-11-24 1990-01-17 Zambeletti Spa L Pharmaceuticals
EP0594611A1 (de) * 1990-04-28 1994-05-04 Dr. Lo. Zambeletti S.p.A. Neue 1-[2h-1-oxo-3,4-dihydronaphthyl-g]-acetyl-piperdine, herstellungsverfahren und therapeutische anwendung
DE4217846C1 (de) * 1992-05-29 1993-12-23 Basf Ag Verfahren zur Herstellung von 5-Dichloracetyl-3,3,6-trimethyl-9-oxo-1,5-diazabicyclo[4,3,0]nonan
US5389638A (en) * 1993-09-10 1995-02-14 Abbott Laboratories Tetrahydroisoquinolines as alpha-2 antagonists and biogenic amine uptake inhibitors
US6239154B1 (en) 1996-03-08 2001-05-29 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
US5763445A (en) 1996-03-08 1998-06-09 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
JP2003526594A (ja) * 1997-07-14 2003-09-09 アドラー コーポレーション カッパ・アゴニスト抗掻痒薬学的製剤およびそれにより掻痒を治療する方法
US5760023A (en) * 1997-07-14 1998-06-02 Adolor Corporation Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith
CN100503571C (zh) * 2006-07-12 2009-06-24 中国药科大学 四氢异喹啉类衍生物、其制备方法及其医药用途
US8367700B2 (en) * 2008-12-17 2013-02-05 Gruenenthal Gmbh Substituted 4-(1.2,3,4-tetrahydroisoquinolin-2-yl)-4-oxobutyric acid amide as KCNQ2/3 modulators
CN103435545B (zh) * 2013-08-14 2015-10-07 中国药科大学 四氢异喹啉季铵盐类衍生物、其制备方法及其镇痛用途
RU2648445C1 (ru) * 2016-11-03 2018-03-26 Светлана Асылхановна Астафьева 6-(3,3- диметил-3,4-дигидроизохинолин-1-ил) аминогексановая кислота и фармацевтическая композиция на ёе основе, обладающие анальгетической активностью

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2361390A1 (de) * 1973-12-10 1975-06-19 Merck Patent Gmbh Isochinolinderivate und verfahren zu ihrer herstellung
GB8601796D0 (en) * 1986-01-24 1986-02-26 Zambeletti Spa L Compounds
ES2004259A6 (es) * 1986-03-12 1988-12-16 Cons Environmental Tech Un metodo de construir un pozo de sondeo submarino de gran diametro
DE68910999T2 (de) * 1988-02-19 1994-03-24 Smithkline Beecham Farma 1,2,3,4-Tetrahydroisoquinoline, Verfharen zu ihrer Herstellung und ihre Verwendung als Kappa-Rezeptor Agonisten.
PT89780A (pt) * 1988-02-23 1989-10-04 Glaxo Group Ltd Processo para a preparacao de derivados da tetrahidroisoquinolina
GB8916395D0 (en) * 1989-07-18 1989-09-06 Zambeletti Spa L Pharmaceuticals

Also Published As

Publication number Publication date
EP0409489A2 (de) 1991-01-23
EP0409489A3 (en) 1991-05-15
PT94711B (pt) 1997-04-30
ES2064641T3 (es) 1995-02-01
US5254564A (en) 1993-10-19
AU632832B2 (en) 1993-01-14
AU5905790A (en) 1991-01-24
PT94711A (pt) 1991-03-20
DE69013602D1 (de) 1994-12-01
GB8916395D0 (en) 1989-09-06
KR910002801A (ko) 1991-02-26
ZA905556B (en) 1991-06-26
DE69013602T2 (de) 1995-03-23
IE902586A1 (en) 1991-02-27
NZ234533A (en) 1992-12-23
JPH0352864A (ja) 1991-03-07
EP0409489B1 (de) 1994-10-26
IE64923B1 (en) 1995-09-20
CA2021213A1 (en) 1991-01-19
DK0409489T3 (da) 1994-12-12

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee