ES2064641T3 - Productos farmaceuticos. - Google Patents

Productos farmaceuticos.

Info

Publication number
ES2064641T3
ES2064641T3 ES90307633T ES90307633T ES2064641T3 ES 2064641 T3 ES2064641 T3 ES 2064641T3 ES 90307633 T ES90307633 T ES 90307633T ES 90307633 T ES90307633 T ES 90307633T ES 2064641 T3 ES2064641 T3 ES 2064641T3
Authority
ES
Spain
Prior art keywords
alkyl
hydrogen
group
together form
linear polymethylene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90307633T
Other languages
English (en)
Inventor
Vittorio Vecchietti
Giuseppe Giardina
Roberto Colle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline SpA
Original Assignee
Smithkline Beecham Farmaceutici SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Farmaceutici SpA filed Critical Smithkline Beecham Farmaceutici SpA
Application granted granted Critical
Publication of ES2064641T3 publication Critical patent/ES2064641T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

COMPUESTO, O SOLUTO O SAL DERIVADA, DE FORMULA (I): FIG EN LA QUE: RCO ES UN GRUPO ACIL EN EL QUE EL GRUPO R CONTIENE UN ANILLO CARBOCICLICO AROMATICO HETEROCICLICO SUSTITUIDO O NO SUSTITUIDO Y R1 Y R2 SON INDEPENDIENTEMENTE H, GRUPOS C1-6 ALQUIL, C2-6 ALQUENIL, C3-6 CICLOALQUIL O C4-12 CICLOALQUILALQUIL SUSTITUIDOS OPCIONALMENTE CON UN HETEROATOMO; R3 ES H, C1-6 ALQUIL, PREFRIBLEMENTE METIL O ETIL, O FENIL, O R3 JUNTO CON R1 FORMA UN GRUPO -(CH2)3 H O ALQUIL C1-6, O JUNTOS FORMAN UN GRUPO POLIMETILENO LINEAL C2-5; R6 Y R7 SON IDENTICOS Y SON H O C1-6 ALQUIL, O JUNTOS FORMAN UN GRUPO POLIMETILENO LINEAL C2-5; O R5 Y R6 SON JUNTOS -CH2 R6 Y R7 NO SEAN SIMULTANEAMENTE H; R8 Y R9, QUE PUDEN SER IGUALES O DIFERENTES, SEAN H, C1-6 ALQUIL, -CH2OR10, HALOGENO, HIDROXI, C1-6 ALCOXI, C1-6 ALCOXICARBONIL, TIOL, C1-6 ALQUILTIO, FIGEN LOS QUE CADA R10 A R15 ES INDEPENDIENTEMENTE H, C1-6 ALQUIL, ARIL O ARALQUIL, ES UTIL PARA EL TRATAMIENTO DEL DOLOR, Y PARA LOS TRASTORNOS HIPONATREMICOS Y/O LA ISQUEMIACEREBRAL.
ES90307633T 1989-07-18 1990-07-12 Productos farmaceuticos. Expired - Lifetime ES2064641T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898916395A GB8916395D0 (en) 1989-07-18 1989-07-18 Pharmaceuticals

Publications (1)

Publication Number Publication Date
ES2064641T3 true ES2064641T3 (es) 1995-02-01

Family

ID=10660199

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90307633T Expired - Lifetime ES2064641T3 (es) 1989-07-18 1990-07-12 Productos farmaceuticos.

Country Status (15)

Country Link
US (1) US5254564A (es)
EP (1) EP0409489B1 (es)
JP (1) JPH0352864A (es)
KR (1) KR910002801A (es)
AT (1) ATE113275T1 (es)
AU (1) AU632832B2 (es)
CA (1) CA2021213A1 (es)
DE (1) DE69013602T2 (es)
DK (1) DK0409489T3 (es)
ES (1) ES2064641T3 (es)
GB (1) GB8916395D0 (es)
IE (1) IE64923B1 (es)
NZ (1) NZ234533A (es)
PT (1) PT94711B (es)
ZA (1) ZA905556B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8916395D0 (en) * 1989-07-18 1989-09-06 Zambeletti Spa L Pharmaceuticals
GB8926560D0 (en) * 1989-11-24 1990-01-17 Zambeletti Spa L Pharmaceuticals
AU7681491A (en) * 1990-04-28 1991-11-27 Dr. Lo Zambeletti S.P.A. Novel 1-(2h-1-oxo-3,4-dihydronaphtyl-6)-acetyl-piperidines, process for their preparation and therapeutic use
DE4217846C1 (de) * 1992-05-29 1993-12-23 Basf Ag Verfahren zur Herstellung von 5-Dichloracetyl-3,3,6-trimethyl-9-oxo-1,5-diazabicyclo[4,3,0]nonan
US5389638A (en) * 1993-09-10 1995-02-14 Abbott Laboratories Tetrahydroisoquinolines as alpha-2 antagonists and biogenic amine uptake inhibitors
US6239154B1 (en) 1996-03-08 2001-05-29 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
US5763445A (en) 1996-03-08 1998-06-09 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
BR9810706A (pt) * 1997-07-14 2000-08-08 Adolor Corp Processo para a prevenção ou tratamento do prurido em um mamìfero em necessidade de tal prevenção ou tratamento
US5760023A (en) * 1997-07-14 1998-06-02 Adolor Corporation Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith
CN100503571C (zh) * 2006-07-12 2009-06-24 中国药科大学 四氢异喹啉类衍生物、其制备方法及其医药用途
US8367700B2 (en) * 2008-12-17 2013-02-05 Gruenenthal Gmbh Substituted 4-(1.2,3,4-tetrahydroisoquinolin-2-yl)-4-oxobutyric acid amide as KCNQ2/3 modulators
CN103435545B (zh) * 2013-08-14 2015-10-07 中国药科大学 四氢异喹啉季铵盐类衍生物、其制备方法及其镇痛用途
RU2648445C1 (ru) * 2016-11-03 2018-03-26 Светлана Асылхановна Астафьева 6-(3,3- диметил-3,4-дигидроизохинолин-1-ил) аминогексановая кислота и фармацевтическая композиция на ёе основе, обладающие анальгетической активностью

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2361390A1 (de) * 1973-12-10 1975-06-19 Merck Patent Gmbh Isochinolinderivate und verfahren zu ihrer herstellung
GB8601796D0 (en) * 1986-01-24 1986-02-26 Zambeletti Spa L Compounds
ES2004259A6 (es) * 1986-03-12 1988-12-16 Cons Environmental Tech Un metodo de construir un pozo de sondeo submarino de gran diametro
DE68910999T2 (de) * 1988-02-19 1994-03-24 Smithkline Beecham Farma 1,2,3,4-Tetrahydroisoquinoline, Verfharen zu ihrer Herstellung und ihre Verwendung als Kappa-Rezeptor Agonisten.
PT89780A (pt) * 1988-02-23 1989-10-04 Glaxo Group Ltd Processo para a preparacao de derivados da tetrahidroisoquinolina
GB8916395D0 (en) * 1989-07-18 1989-09-06 Zambeletti Spa L Pharmaceuticals

Also Published As

Publication number Publication date
CA2021213A1 (en) 1991-01-19
DE69013602T2 (de) 1995-03-23
IE902586A1 (en) 1991-02-27
KR910002801A (ko) 1991-02-26
IE64923B1 (en) 1995-09-20
ZA905556B (en) 1991-06-26
PT94711A (pt) 1991-03-20
AU5905790A (en) 1991-01-24
JPH0352864A (ja) 1991-03-07
ATE113275T1 (de) 1994-11-15
NZ234533A (en) 1992-12-23
EP0409489A3 (en) 1991-05-15
EP0409489A2 (en) 1991-01-23
PT94711B (pt) 1997-04-30
GB8916395D0 (en) 1989-09-06
DK0409489T3 (da) 1994-12-12
AU632832B2 (en) 1993-01-14
DE69013602D1 (de) 1994-12-01
US5254564A (en) 1993-10-19
EP0409489B1 (en) 1994-10-26

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