ATE126802T1 - Heterocyclische derivate. - Google Patents
Heterocyclische derivate.Info
- Publication number
- ATE126802T1 ATE126802T1 AT89302486T AT89302486T ATE126802T1 AT E126802 T1 ATE126802 T1 AT E126802T1 AT 89302486 T AT89302486 T AT 89302486T AT 89302486 T AT89302486 T AT 89302486T AT E126802 T1 ATE126802 T1 AT E126802T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- hydrogen
- alkyl
- het
- hetero
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/42—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having etherified hydroxy groups and at least two amino groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB888806210A GB8806210D0 (en) | 1988-03-16 | 1988-03-16 | Novel compounds |
GB888823562A GB8823562D0 (en) | 1988-10-07 | 1988-10-07 | Novel compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE126802T1 true ATE126802T1 (de) | 1995-09-15 |
Family
ID=26293641
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT89302486T ATE126802T1 (de) | 1988-03-16 | 1989-03-14 | Heterocyclische derivate. |
Country Status (14)
Country | Link |
---|---|
US (1) | US4999359A (de) |
EP (1) | EP0333427B1 (de) |
JP (1) | JPH02101062A (de) |
KR (1) | KR890014478A (de) |
AT (1) | ATE126802T1 (de) |
AU (1) | AU616488B2 (de) |
CA (1) | CA1336909C (de) |
DE (1) | DE68923891T2 (de) |
DK (1) | DK124089A (de) |
ES (1) | ES2075849T3 (de) |
GR (1) | GR3017213T3 (de) |
IE (1) | IE67334B1 (de) |
NZ (1) | NZ228331A (de) |
PT (1) | PT90001B (de) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8824400D0 (en) * | 1988-10-18 | 1988-11-23 | Glaxo Group Ltd | Chemical compounds |
GB8827479D0 (en) * | 1988-11-24 | 1988-12-29 | Zambeletti Spa L | Novel compounds |
DE3935371A1 (de) * | 1988-12-23 | 1990-07-05 | Merck Patent Gmbh | Stickstoffhaltige ringverbindungen |
US5322848A (en) * | 1989-11-24 | 1994-06-21 | Dr. Lo Zembeletti S.P.A. | N-acyl-substituted azacyclic compounds, processes for their preparation, and their use as pharmaceuticals |
GB8926560D0 (en) * | 1989-11-24 | 1990-01-17 | Zambeletti Spa L | Pharmaceuticals |
US5428042A (en) * | 1990-04-28 | 1995-06-27 | Dr Lo Zambeletti S.P.A. | 1-(2H-1-oxo-3,4-dihydronaphtyl-6-yl)-acetyl-piperidines as kappa agonists |
GB9104839D0 (en) * | 1991-03-07 | 1991-04-17 | Zambeletti Spa L | Novel compounds |
AU1532492A (en) * | 1991-04-18 | 1992-11-17 | Dr. Lo Zambeletti S.P.A. | Use of heterocyclic compounds for the treatment of inflammatory pain |
US6239154B1 (en) | 1996-03-08 | 2001-05-29 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
US5763445A (en) | 1996-03-08 | 1998-06-09 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
US5760023A (en) * | 1997-07-14 | 1998-06-02 | Adolor Corporation | Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith |
IL132363A (en) * | 1997-07-14 | 2004-02-19 | Adolor Corp | Capa agonist compounds for use in the prevention or treatment of itching and antipruritic pharmaceutical preparations containing them |
US7361666B2 (en) | 1999-05-25 | 2008-04-22 | Sepracor, Inc. | Heterocyclic analgesic compounds and methods of use thereof |
US6677332B1 (en) | 1999-05-25 | 2004-01-13 | Sepracor, Inc. | Heterocyclic analgesic compounds and methods of use thereof |
US6635661B2 (en) | 2000-05-25 | 2003-10-21 | Sepracor Inc. | Heterocyclic analgesic compounds and methods of use thereof |
WO2001092226A1 (en) * | 2000-05-25 | 2001-12-06 | Sepracor, Inc. | Heterocyclic analgesic compounds and method of use thereof |
US6476046B1 (en) * | 2000-12-04 | 2002-11-05 | Sepracor, Inc. | Diazabicyclo[4.3.0]nonanes, and methods of use thereof |
CL2007002097A1 (es) | 2006-07-20 | 2008-01-18 | Smithkline Beecham Corp | Compuestos derivados de pirrolidina o morfolina antagonistas de urotensina ii; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar insuficiencia cardiaca congestiva, insuficiencia cardiaca isquemica, angina, isquemia del miocardio, vejiga hiperactiva, asma y/o copd, entre otras. |
UY30892A1 (es) * | 2007-02-07 | 2008-09-02 | Smithkline Beckman Corp | Inhibidores de la actividad akt |
BRPI1006896B1 (pt) | 2009-01-30 | 2022-05-24 | Novartis Ag | Cloridrato de n-{(1s)-2-amino-1-[(3-fluorfenil)metil]etil}-5-cloro-4-(4-cloro-1-metil-1h- pirazol-5-il)-2-tiofenocarboxamida cristalino, composição farmacêutica compreendendo o mesmo e uso do dito composto para tratar ou diminuir a gravidade de câncer e artrite |
NZ731621A (en) | 2009-12-04 | 2019-01-25 | Sunovion Pharmaceuticals Inc | Multicyclic compounds and methods of use thereof |
MA45795A (fr) | 2016-07-29 | 2019-06-05 | Sunovion Pharmaceuticals Inc | Composés et compositions, et utilisations associées |
JP7187437B2 (ja) | 2016-07-29 | 2022-12-12 | サノビオン ファーマシューティカルズ インク | 化合物および組成物ならびにそれらの使用 |
ES2862405T3 (es) * | 2016-12-02 | 2021-10-07 | Fraunhofer Ges Forschung | Inhibidores de glutaminil ciclasas bacterianas y uso de los mismos en el tratamiento de periodontitis |
JP7146782B2 (ja) | 2017-02-16 | 2022-10-04 | サノビオン ファーマシューティカルズ インク | 統合失調症を処置する方法 |
MX2020000523A (es) | 2017-08-02 | 2020-08-20 | Sunovion Pharmaceuticals Inc | Compuestos de isocromano y usos de los mismos. |
CA3091292A1 (en) | 2018-02-16 | 2019-08-22 | Sunovion Pharmaceuticals Inc. | Salts, crystal forms, and production methods thereof |
KR20210139376A (ko) | 2019-03-14 | 2021-11-22 | 선오비온 파마슈티컬스 인코포레이티드 | 이소크로마닐 화합물의 염, 및 이의 결정성 형태, 제조방법, 치료 용도 및 약제학적 조성물 |
US11738002B2 (en) | 2020-04-14 | 2023-08-29 | Sunovion Pharmaceuticals Inc. | Methods of treating neurological and psychiatric disorders |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8601796D0 (en) * | 1986-01-24 | 1986-02-26 | Zambeletti Spa L | Compounds |
GB8618188D0 (en) * | 1986-07-25 | 1986-09-03 | Ici Plc | Diamine compounds |
DE3766335D1 (de) * | 1986-09-17 | 1991-01-03 | Zambeletti Spa L | N-1-acylierte-(1-(phenyl- oder benzyl-))-1,2-aethylendiamine. |
DE3935371A1 (de) * | 1988-12-23 | 1990-07-05 | Merck Patent Gmbh | Stickstoffhaltige ringverbindungen |
-
1989
- 1989-03-14 DK DK124089A patent/DK124089A/da not_active Application Discontinuation
- 1989-03-14 EP EP89302486A patent/EP0333427B1/de not_active Expired - Lifetime
- 1989-03-14 AU AU31315/89A patent/AU616488B2/en not_active Ceased
- 1989-03-14 NZ NZ228331A patent/NZ228331A/xx unknown
- 1989-03-14 PT PT90001A patent/PT90001B/pt not_active IP Right Cessation
- 1989-03-14 IE IE81689A patent/IE67334B1/en not_active IP Right Cessation
- 1989-03-14 DE DE68923891T patent/DE68923891T2/de not_active Expired - Fee Related
- 1989-03-14 US US07/323,617 patent/US4999359A/en not_active Expired - Fee Related
- 1989-03-14 ES ES89302486T patent/ES2075849T3/es not_active Expired - Lifetime
- 1989-03-14 AT AT89302486T patent/ATE126802T1/de not_active IP Right Cessation
- 1989-03-14 CA CA000593618A patent/CA1336909C/en not_active Expired - Fee Related
- 1989-03-15 KR KR1019890003299A patent/KR890014478A/ko not_active Application Discontinuation
- 1989-03-16 JP JP1062376A patent/JPH02101062A/ja active Pending
-
1995
- 1995-08-24 GR GR950402211T patent/GR3017213T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
JPH02101062A (ja) | 1990-04-12 |
IE890816L (en) | 1989-09-16 |
DE68923891D1 (de) | 1995-09-28 |
DE68923891T2 (de) | 1996-02-22 |
ES2075849T3 (es) | 1995-10-16 |
AU3131589A (en) | 1989-09-21 |
PT90001B (pt) | 1994-06-30 |
EP0333427A1 (de) | 1989-09-20 |
PT90001A (pt) | 1989-11-10 |
DK124089A (da) | 1989-09-17 |
US4999359A (en) | 1991-03-12 |
EP0333427B1 (de) | 1995-08-23 |
NZ228331A (en) | 1991-10-25 |
CA1336909C (en) | 1995-09-05 |
GR3017213T3 (en) | 1995-11-30 |
DK124089D0 (da) | 1989-03-14 |
AU616488B2 (en) | 1991-10-31 |
KR890014478A (ko) | 1989-10-23 |
IE67334B1 (en) | 1996-03-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |