ATE106406T1 - Verfahren zur reinigung von vitamin k-abhängigen proteinen. - Google Patents
Verfahren zur reinigung von vitamin k-abhängigen proteinen.Info
- Publication number
- ATE106406T1 ATE106406T1 AT89310061T AT89310061T ATE106406T1 AT E106406 T1 ATE106406 T1 AT E106406T1 AT 89310061 T AT89310061 T AT 89310061T AT 89310061 T AT89310061 T AT 89310061T AT E106406 T1 ATE106406 T1 AT E106406T1
- Authority
- AT
- Austria
- Prior art keywords
- vitamin
- proteins
- purification
- procedures
- dependent proteins
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/647—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6478—Aspartic endopeptidases (3.4.23)
- C12N9/6481—Pepsins (3.4.23.1; 3.4.23.2; 3.4.23.3)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Enzymes And Modification Thereof (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25327988A | 1988-10-04 | 1988-10-04 | |
US07/393,281 US4981952A (en) | 1988-10-04 | 1989-08-16 | Method for the purification of vitamin K-dependent proteins |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE106406T1 true ATE106406T1 (de) | 1994-06-15 |
Family
ID=26943089
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT89310061T ATE106406T1 (de) | 1988-10-04 | 1989-10-02 | Verfahren zur reinigung von vitamin k-abhängigen proteinen. |
Country Status (13)
Country | Link |
---|---|
US (1) | US4981952A (de) |
EP (1) | EP0363126B2 (de) |
JP (1) | JP2848461B2 (de) |
KR (1) | KR0139209B1 (de) |
AT (1) | ATE106406T1 (de) |
AU (1) | AU635222B2 (de) |
CA (1) | CA1314011C (de) |
DE (1) | DE68915675T3 (de) |
DK (1) | DK176090B1 (de) |
ES (1) | ES2054019T5 (de) |
HU (1) | HU204538B (de) |
IE (1) | IE63765B1 (de) |
IL (1) | IL91822A (de) |
Families Citing this family (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8729822D0 (en) * | 1987-12-22 | 1988-02-03 | Central Blood Lab Authority | Chemical process |
DE3833936C1 (de) * | 1988-10-05 | 1989-09-21 | Henning Berlin Gmbh Chemie- Und Pharmawerk, 1000 Berlin, De | |
DE3911629A1 (de) * | 1989-04-10 | 1990-10-11 | Behringwerke Ag | Verfahren zur abtrennung von toxinen aus proteinloesungen |
IL97312A (en) | 1990-02-23 | 1999-01-26 | Lilly Co Eli | A method of generating a polypeptide in an eukaryotic vector AND recombinant surrogate cell containing an enhanced transcriptional control unit based on the primary late adenovirus coefficient |
DK0573605T3 (da) * | 1991-03-01 | 2001-01-02 | Rhone Poulenc Rorer Int | Fremstilling af faktor IX |
IT1262899B (it) * | 1992-03-27 | 1996-07-22 | Sclavo Spa | Processo per l'isolamento di fattore ix, fattore x e fattore ii altamente purificati dal complesso protrombinico o dal plasma umano |
MY110664A (en) * | 1992-05-21 | 1999-01-30 | Lilly Co Eli | Protein c derivatives |
DK38293D0 (da) * | 1993-03-31 | 1993-03-31 | Novo Nordisk As | Fremstilling af proteiner |
US5618714A (en) * | 1993-12-15 | 1997-04-08 | Eli Lilly And Company | Methods for producing protein C |
DE4406515C1 (de) * | 1994-02-28 | 1995-10-19 | Immuno Ag | Verfahren zur Isolierung und Reinigung Vitamin K-abhängiger Proteine |
DE4435520A1 (de) * | 1994-10-04 | 1996-04-11 | Immuno Ag | Verfahren zur Trennung von rekombinantem pro-Faktor IX von rekombinantem Faktor IX |
US5714583A (en) * | 1995-06-07 | 1998-02-03 | Genetics Institute, Inc. | Factor IX purification methods |
US5869604A (en) * | 1995-11-09 | 1999-02-09 | Georgia Institute Of Technology | Crystallization and purification of polypeptides |
US5843731A (en) * | 1996-09-05 | 1998-12-01 | Asahi Kogaku Kogyo Kabushiki Kaisha | Method for purifying plasmid DNA on calcium phosphate compound |
US5910584A (en) * | 1996-09-05 | 1999-06-08 | Asahi Kogaku Kogyo Kabushiki Kaisha | Method for isolating plasmid DNA |
US6630137B1 (en) * | 1997-04-28 | 2003-10-07 | Eli Lilly And Company | Activated protein C formulations |
EP1557463A1 (de) * | 1997-04-28 | 2005-07-27 | Eli Lilly & Company | Verbesserte Methoden zur Verarbeitung von aktiviertem Protein C |
JP4383546B2 (ja) * | 1997-04-28 | 2009-12-16 | イーライ・リリー・アンド・カンパニー | 活性化プロテインcの改良プロセシング方法 |
CN1265598A (zh) * | 1997-06-05 | 2000-09-06 | 伊莱利利公司 | 治疗血栓形成性疾病的方法 |
HUP0001237A3 (en) | 1997-10-20 | 2002-01-28 | Lilly Co Eli | Methods for treating vascular disorders |
CN1324244A (zh) | 1998-10-22 | 2001-11-28 | 伊莱利利公司 | 治疗脓毒症的方法 |
IL142255A0 (en) | 1998-11-13 | 2002-03-10 | Lilly Co Eli | Method of treating heparin-induced thrombocytopenia |
WO2000030677A1 (en) | 1998-11-20 | 2000-06-02 | Eli Lilly And Company | Method of treating viral hemorrhagic fever |
WO2000030676A1 (en) | 1998-11-23 | 2000-06-02 | Eli Lilly And Company | Method of treating sickle cell disease and thalassemia |
US7204981B2 (en) * | 2000-03-28 | 2007-04-17 | Eli Lilly And Company | Methods of treating diseases with activated protein C |
CA2410567A1 (en) | 2000-05-24 | 2001-11-29 | Eli Lilly And Company | Formulations and use of activated protein c and protein c zymogen for treating hypercoagulable states |
KR100841599B1 (ko) * | 2000-07-21 | 2008-06-26 | 자이단호진 가가쿠오요비겟세이료호겐쿠쇼 | 칼슘 이온-결합 단백질의 정제 방법 |
US20040198652A1 (en) * | 2001-04-24 | 2004-10-07 | Carter J. Paul | Methods and compositions for preventing and treating septic shock and endotoxemia |
US20030055003A1 (en) * | 2001-07-19 | 2003-03-20 | David Bar-Or | Use of copper chelators to inhibit the inactivation of protein C |
JP4628618B2 (ja) * | 2001-09-26 | 2011-02-09 | 富士フイルム株式会社 | 撮像光学系 |
EP1485121A4 (de) * | 2002-03-08 | 2007-11-07 | Lilly Co Eli | Aktivierte protein-c-formulierungen |
WO2004056309A2 (en) | 2002-12-05 | 2004-07-08 | Socratech L.L.C. | Neuroprotective activity of activated protein c is independent of its anticoagulant activity |
US20070142272A1 (en) * | 2003-01-24 | 2007-06-21 | Zlokovic Berislav V | Neuroprotective activity of activated protein c independent of its anticoagulant activity |
WO2005007820A2 (en) | 2003-07-08 | 2005-01-27 | The Scripps Research Institute | Activated protein c variants with normal cytoprotective activity but reduced anticoagulant activity |
US9192657B2 (en) | 2003-07-08 | 2015-11-24 | The Scripps Research Institute | Activated protein C variants with normal cytoprotective activity but reduced anticoagulant activity |
CA2574598A1 (en) * | 2004-07-23 | 2006-02-09 | The University Of Rochester | Activated protein c inhibits undesirable effects of plasminogen activator in the brain |
EP1831242B1 (de) | 2004-12-23 | 2012-09-26 | Novo Nordisk Health Care AG | Reduktion des gehaltes an kontaminierenden proteinen in zusammensetzungen, die vitamin k-abhängige proteine von interesse umfassen |
EP1841863B1 (de) * | 2005-01-14 | 2010-08-04 | Bayer HealthCare LLC | Verfahren zur reinigung von factor vii |
AU2006273696B2 (en) * | 2005-06-24 | 2012-08-30 | Drugrecure Aps | Airway administration of activated protein C in inflammatory conditions affecting the respiratory tract |
WO2007071767A1 (en) * | 2005-12-23 | 2007-06-28 | Novo Nordisk Health Care Ag | Purification of vitamin k-dependent polypeptides using preparative reverse phase chromatography (rpc) |
US7566565B2 (en) | 2006-03-24 | 2009-07-28 | Syntonix Pharmaceuticals, Inc. | PC5 as a factor IX propeptide processing enzyme |
US20100284997A1 (en) * | 2006-10-31 | 2010-11-11 | Griffin John H | Dosing regimen of activated protein c and variants having reduced anticoagulant activity |
WO2008104372A1 (en) * | 2007-02-28 | 2008-09-04 | Baxter International Inc. | Method for the purification of recombinant blood coagulation factor ix enriched in sulfated and/or phosphorylated molecules |
EP2517714A1 (de) | 2007-04-26 | 2012-10-31 | Inspiration Biopharmaceuticals, Inc. | Rekombinante Vitamin-K-abhängige Proteine mit hohem Sialsäuregehalt und Verfahren zu ihrer Herstellung |
DE17196350T1 (de) | 2007-07-09 | 2018-12-27 | Genentech, Inc. | Verhindern der disulfid-bindungsreduktion während der rekombinanten herstellung von polypeptiden |
BRPI0922716A2 (pt) | 2008-12-02 | 2016-11-01 | Novo Nordisk Healthcare Ag | purificação de polipeptídeo |
EP2199387A1 (de) | 2008-12-19 | 2010-06-23 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Serinproteasederivate und deren Verwendung zur Vorbeugung und/oder Behandlung von Blutgerinnungsstörungen |
EP2358874B1 (de) | 2008-12-19 | 2017-03-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Serinproteasederivate und deren verwendung zur vorbeugung und/oder behandlung von blutgerinnungsstörungen |
EP2494040B1 (de) | 2009-10-30 | 2018-08-29 | Aptevo BioTherapeutics LLC | Verfahren zur herstellung rekombinanter vitamin-k-abhängiger proteine |
WO2011086197A1 (en) | 2010-01-18 | 2011-07-21 | Novo Nordisk Health Care Ag | Purification of blood coagulation factors |
NZ603289A (en) | 2010-04-29 | 2014-07-25 | Baxter Int | Purification method for divalent cation binding proteins on anion exchange resin |
SG193545A1 (en) | 2011-03-29 | 2013-11-29 | Glaxosmithkline Llc | Buffer system for protein purification |
JP2014525475A (ja) | 2011-09-06 | 2014-09-29 | メディミューン,エルエルシー | 凝固因子を処理する方法 |
EP2748180B1 (de) * | 2011-10-14 | 2018-08-15 | Baxalta GmbH | Proteinaufreinigung mithilfe der anionenaustauschchromatographie |
US10378004B2 (en) | 2011-10-14 | 2019-08-13 | Baxalta GmbH | Protein purification by anion exchange chromatography |
JP6273272B2 (ja) | 2012-07-04 | 2018-01-31 | ジージー バイオテック エルエルシー | 炎症性皮膚障害の治療 |
SI2970376T1 (sl) * | 2013-03-15 | 2018-09-28 | Baxalta Incorporated | Metoda čiščenja za vitamin k odvisne proteine z anionsko izmenjevalno kromatografijo |
PL3137102T3 (pl) | 2014-04-16 | 2022-02-07 | Zz Biotech Llc | Apc do stosowania w leczeniu nieprawidłowego bliznowacenia skóry |
AU2017205364B2 (en) * | 2016-01-07 | 2021-03-04 | Eio Biomedical Ltd | Methods, compositions and kits for reducing tissue adhesions |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4512992A (en) * | 1980-06-13 | 1985-04-23 | Burroughs Wellcome Co. | Treatment with dialkoxy pyridopyrimidine compounds |
DE3101752A1 (de) * | 1981-01-21 | 1982-08-26 | Behringwerke Ag, 3550 Marburg | "verfahren zur reinigung der blutgerinnungsfaktoren ii, vii, ix und/oder x und danach hergestellte praeparationen" |
US4518526A (en) * | 1982-12-22 | 1985-05-21 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
US4599197A (en) * | 1982-12-22 | 1986-07-08 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
US4766224A (en) * | 1985-08-19 | 1988-08-23 | International Minerals & Chemical Corp. | Purification and activation of proteins from insoluble inclusion bodies |
US4677196A (en) * | 1985-09-06 | 1987-06-30 | International Minerals & Chemical Corp. | Purification and activation of proteins from insoluble inclusion bodies |
US4786726A (en) * | 1986-01-06 | 1988-11-22 | Blood Systems, Inc. | Factor IX therapeutic blood product, means and methods of preparing same |
US4734362A (en) * | 1986-02-03 | 1988-03-29 | Cambridge Bioscience Corporation | Process for purifying recombinant proteins, and products thereof |
DE3615558A1 (de) * | 1986-05-09 | 1987-11-12 | Behringwerke Ag | Verfahren zur herstellung eines faktor v-konzentrats |
-
1989
- 1989-08-16 US US07/393,281 patent/US4981952A/en not_active Expired - Lifetime
- 1989-09-27 CA CA000613553A patent/CA1314011C/en not_active Expired - Lifetime
- 1989-09-28 IL IL9182289A patent/IL91822A/en not_active IP Right Cessation
- 1989-10-02 ES ES89310061T patent/ES2054019T5/es not_active Expired - Lifetime
- 1989-10-02 EP EP89310061A patent/EP0363126B2/de not_active Expired - Lifetime
- 1989-10-02 AT AT89310061T patent/ATE106406T1/de not_active IP Right Cessation
- 1989-10-02 DE DE68915675T patent/DE68915675T3/de not_active Expired - Lifetime
- 1989-10-03 DK DK198904855A patent/DK176090B1/da not_active IP Right Cessation
- 1989-10-03 HU HU895158A patent/HU204538B/hu not_active IP Right Cessation
- 1989-10-03 JP JP1259873A patent/JP2848461B2/ja not_active Expired - Lifetime
- 1989-10-03 IE IE315989A patent/IE63765B1/en not_active IP Right Cessation
- 1989-10-03 AU AU42519/89A patent/AU635222B2/en not_active Ceased
- 1989-10-04 KR KR1019890014186A patent/KR0139209B1/ko not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JP2848461B2 (ja) | 1999-01-20 |
DK485589D0 (da) | 1989-10-03 |
CA1314011C (en) | 1993-03-02 |
ES2054019T5 (es) | 2002-10-16 |
IE63765B1 (en) | 1995-06-14 |
AU635222B2 (en) | 1993-03-18 |
EP0363126A2 (de) | 1990-04-11 |
EP0363126A3 (de) | 1991-09-11 |
IL91822A (en) | 2001-06-14 |
KR0139209B1 (ko) | 1998-04-30 |
JPH02200180A (ja) | 1990-08-08 |
DE68915675T2 (de) | 1994-10-20 |
AU4251989A (en) | 1990-04-12 |
US4981952A (en) | 1991-01-01 |
DE68915675D1 (de) | 1994-07-07 |
HU204538B (en) | 1992-01-28 |
DK176090B1 (da) | 2006-05-22 |
EP0363126B2 (de) | 2002-03-06 |
KR900006511A (ko) | 1990-05-08 |
EP0363126B1 (de) | 1994-06-01 |
ES2054019T3 (es) | 1994-08-01 |
IE893159L (en) | 1990-04-04 |
DE68915675T3 (de) | 2002-08-14 |
DK485589A (da) | 1990-04-05 |
IL91822A0 (en) | 1990-06-10 |
HUT53373A (en) | 1990-10-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |