AT408549B - Virushältiger impfstoff, rekombinantes virus und verfahren zum exprimieren eines genproduktes - Google Patents
Virushältiger impfstoff, rekombinantes virus und verfahren zum exprimieren eines genproduktes Download PDFInfo
- Publication number
- AT408549B AT408549B AT0900788A AT900788A AT408549B AT 408549 B AT408549 B AT 408549B AT 0900788 A AT0900788 A AT 0900788A AT 900788 A AT900788 A AT 900788A AT 408549 B AT408549 B AT 408549B
- Authority
- AT
- Austria
- Prior art keywords
- virus
- recombinant
- antigen
- gene
- promoter
- Prior art date
Links
- 241000700605 Viruses Species 0.000 title claims description 185
- 108090000623 proteins and genes Proteins 0.000 title claims description 130
- 238000000034 method Methods 0.000 title claims description 42
- 108010008038 Synthetic Vaccines Proteins 0.000 title description 2
- 206010037742 Rabies Diseases 0.000 claims description 84
- 238000002255 vaccination Methods 0.000 claims description 77
- 239000000427 antigen Substances 0.000 claims description 64
- 108091007433 antigens Proteins 0.000 claims description 64
- 102000036639 antigens Human genes 0.000 claims description 64
- 206010046865 Vaccinia virus infection Diseases 0.000 claims description 47
- 208000007089 vaccinia Diseases 0.000 claims description 47
- 241000700663 Avipoxvirus Species 0.000 claims description 44
- 238000012360 testing method Methods 0.000 claims description 43
- 230000014509 gene expression Effects 0.000 claims description 40
- 229960005486 vaccine Drugs 0.000 claims description 39
- 241000251539 Vertebrata <Metazoa> Species 0.000 claims description 38
- 230000028993 immune response Effects 0.000 claims description 33
- 241000283973 Oryctolagus cuniculus Species 0.000 claims description 31
- 241000714165 Feline leukemia virus Species 0.000 claims description 29
- 241001465754 Metazoa Species 0.000 claims description 27
- 244000052769 pathogen Species 0.000 claims description 23
- 210000002966 serum Anatomy 0.000 claims description 23
- 108091026890 Coding region Proteins 0.000 claims description 22
- 241000283690 Bos taurus Species 0.000 claims description 18
- 241000124008 Mammalia Species 0.000 claims description 18
- 238000000338 in vitro Methods 0.000 claims description 17
- 230000001717 pathogenic effect Effects 0.000 claims description 17
- 241000714266 Bovine leukemia virus Species 0.000 claims description 16
- 241000700662 Fowlpox virus Species 0.000 claims description 16
- 108091029865 Exogenous DNA Proteins 0.000 claims description 14
- 241000699670 Mus sp. Species 0.000 claims description 14
- 238000010790 dilution Methods 0.000 claims description 12
- 239000012895 dilution Substances 0.000 claims description 12
- 241000700584 Simplexvirus Species 0.000 claims description 11
- 230000010076 replication Effects 0.000 claims description 10
- 230000003612 virological effect Effects 0.000 claims description 10
- 241000178270 Canarypox virus Species 0.000 claims description 8
- 241000282326 Felis catus Species 0.000 claims description 8
- 241001494479 Pecora Species 0.000 claims description 7
- 241000894007 species Species 0.000 claims description 7
- 241000282472 Canis lupus familiaris Species 0.000 claims description 5
- 238000004113 cell culture Methods 0.000 claims description 5
- 101000678879 Homo sapiens Atypical chemokine receptor 1 Proteins 0.000 claims description 4
- 238000001727 in vivo Methods 0.000 claims description 4
- 230000009467 reduction Effects 0.000 claims description 4
- 230000001939 inductive effect Effects 0.000 claims description 3
- 102100022717 Atypical chemokine receptor 1 Human genes 0.000 claims 2
- 230000001737 promoting effect Effects 0.000 claims 2
- 241000282887 Suidae Species 0.000 claims 1
- 238000012606 in vitro cell culture Methods 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 239000013612 plasmid Substances 0.000 description 134
- 239000012634 fragment Substances 0.000 description 103
- 210000004027 cell Anatomy 0.000 description 64
- 208000015181 infectious disease Diseases 0.000 description 55
- 239000013598 vector Substances 0.000 description 44
- 241000287828 Gallus gallus Species 0.000 description 42
- 235000013330 chicken meat Nutrition 0.000 description 42
- 238000003780 insertion Methods 0.000 description 41
- 230000037431 insertion Effects 0.000 description 41
- 241000271566 Aves Species 0.000 description 40
- 238000010276 construction Methods 0.000 description 40
- 108020004414 DNA Proteins 0.000 description 38
- 102000053602 DNA Human genes 0.000 description 38
- 244000144977 poultry Species 0.000 description 36
- 235000013594 poultry meat Nutrition 0.000 description 35
- 108010005774 beta-Galactosidase Proteins 0.000 description 34
- 230000006798 recombination Effects 0.000 description 34
- 108091034117 Oligonucleotide Proteins 0.000 description 32
- 241000700618 Vaccinia virus Species 0.000 description 32
- 208000000666 Fowlpox Diseases 0.000 description 30
- 238000005215 recombination Methods 0.000 description 29
- 201000006082 Chickenpox Diseases 0.000 description 26
- 206010046980 Varicella Diseases 0.000 description 26
- 101710154606 Hemagglutinin Proteins 0.000 description 22
- 101710093908 Outer capsid protein VP4 Proteins 0.000 description 22
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 description 22
- 101710176177 Protein A56 Proteins 0.000 description 22
- 102000004169 proteins and genes Human genes 0.000 description 22
- 108090000288 Glycoproteins Proteins 0.000 description 21
- 102000005936 beta-Galactosidase Human genes 0.000 description 21
- 102000003886 Glycoproteins Human genes 0.000 description 20
- 239000000185 hemagglutinin Substances 0.000 description 19
- 108010061100 Nucleoproteins Proteins 0.000 description 18
- 108700004025 env Genes Proteins 0.000 description 18
- 101150030339 env gene Proteins 0.000 description 18
- 238000002474 experimental method Methods 0.000 description 17
- 102000011931 Nucleoproteins Human genes 0.000 description 16
- 239000011159 matrix material Substances 0.000 description 16
- 108010054576 Deoxyribonuclease EcoRI Proteins 0.000 description 15
- 101150082239 G gene Proteins 0.000 description 15
- 241000711450 Infectious bronchitis virus Species 0.000 description 15
- 239000002773 nucleotide Substances 0.000 description 15
- 125000003729 nucleotide group Chemical group 0.000 description 15
- 102000004594 DNA Polymerase I Human genes 0.000 description 14
- 108010017826 DNA Polymerase I Proteins 0.000 description 14
- 230000003902 lesion Effects 0.000 description 14
- 210000004369 blood Anatomy 0.000 description 13
- 239000008280 blood Substances 0.000 description 13
- 230000036961 partial effect Effects 0.000 description 13
- 238000002965 ELISA Methods 0.000 description 12
- 241000700647 Variola virus Species 0.000 description 12
- 230000029087 digestion Effects 0.000 description 12
- 230000004044 response Effects 0.000 description 12
- 238000013519 translation Methods 0.000 description 12
- 241001135961 Amsacta moorei entomopoxvirus Species 0.000 description 11
- 241000711404 Avian avulavirus 1 Species 0.000 description 10
- 108091028043 Nucleic acid sequence Proteins 0.000 description 10
- 239000002299 complementary DNA Substances 0.000 description 10
- 238000003018 immunoassay Methods 0.000 description 10
- 238000001114 immunoprecipitation Methods 0.000 description 10
- 206010022000 influenza Diseases 0.000 description 10
- 238000011081 inoculation Methods 0.000 description 10
- 108700026244 Open Reading Frames Proteins 0.000 description 9
- 230000000890 antigenic effect Effects 0.000 description 9
- 239000006166 lysate Substances 0.000 description 9
- 238000004519 manufacturing process Methods 0.000 description 9
- 229920002477 rna polymer Polymers 0.000 description 9
- 238000013518 transcription Methods 0.000 description 9
- 230000035897 transcription Effects 0.000 description 9
- 108091081024 Start codon Proteins 0.000 description 8
- 230000015572 biosynthetic process Effects 0.000 description 8
- 238000003776 cleavage reaction Methods 0.000 description 8
- 238000009396 hybridization Methods 0.000 description 8
- 230000002458 infectious effect Effects 0.000 description 8
- 230000007017 scission Effects 0.000 description 8
- 241000712461 unidentified influenza virus Species 0.000 description 8
- 238000010367 cloning Methods 0.000 description 7
- 210000002257 embryonic structure Anatomy 0.000 description 7
- 230000036039 immunity Effects 0.000 description 7
- 238000007918 intramuscular administration Methods 0.000 description 7
- 238000002360 preparation method Methods 0.000 description 7
- 239000002356 single layer Substances 0.000 description 7
- 230000004083 survival effect Effects 0.000 description 7
- 241000711798 Rabies lyssavirus Species 0.000 description 6
- 241000287219 Serinus canaria Species 0.000 description 6
- 230000034994 death Effects 0.000 description 6
- 231100000517 death Toxicity 0.000 description 6
- 230000002068 genetic effect Effects 0.000 description 6
- 210000004962 mammalian cell Anatomy 0.000 description 6
- 238000010186 staining Methods 0.000 description 6
- 238000007920 subcutaneous administration Methods 0.000 description 6
- 230000003442 weekly effect Effects 0.000 description 6
- 241000588724 Escherichia coli Species 0.000 description 5
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 5
- 230000001419 dependent effect Effects 0.000 description 5
- 235000013601 eggs Nutrition 0.000 description 5
- 108020001507 fusion proteins Proteins 0.000 description 5
- 239000000523 sample Substances 0.000 description 5
- 241000238631 Hexapoda Species 0.000 description 4
- 206010062016 Immunosuppression Diseases 0.000 description 4
- 241000286209 Phasianidae Species 0.000 description 4
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 description 4
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 description 4
- 108020004511 Recombinant DNA Proteins 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 230000000740 bleeding effect Effects 0.000 description 4
- 239000013592 cell lysate Substances 0.000 description 4
- 238000004140 cleaning Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 230000003053 immunization Effects 0.000 description 4
- 230000001506 immunosuppresive effect Effects 0.000 description 4
- 239000003550 marker Substances 0.000 description 4
- 239000012528 membrane Substances 0.000 description 4
- 238000006386 neutralization reaction Methods 0.000 description 4
- 229920001184 polypeptide Polymers 0.000 description 4
- 108090000765 processed proteins & peptides Proteins 0.000 description 4
- 102000004196 processed proteins & peptides Human genes 0.000 description 4
- 230000003362 replicative effect Effects 0.000 description 4
- 108091008146 restriction endonucleases Proteins 0.000 description 4
- 230000000405 serological effect Effects 0.000 description 4
- 238000006467 substitution reaction Methods 0.000 description 4
- 101150110188 30 gene Proteins 0.000 description 3
- OPIFSICVWOWJMJ-AEOCFKNESA-N 5-bromo-4-chloro-3-indolyl beta-D-galactoside Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1OC1=CNC2=CC=C(Br)C(Cl)=C12 OPIFSICVWOWJMJ-AEOCFKNESA-N 0.000 description 3
- 108020004705 Codon Proteins 0.000 description 3
- 230000004543 DNA replication Effects 0.000 description 3
- 201000004624 Dermatitis Diseases 0.000 description 3
- 101150039660 HA gene Proteins 0.000 description 3
- 241000700721 Hepatitis B virus Species 0.000 description 3
- 241000699666 Mus <mouse, genus> Species 0.000 description 3
- 241000700159 Rattus Species 0.000 description 3
- 238000012300 Sequence Analysis Methods 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 208000010668 atopic eczema Diseases 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 230000000120 cytopathologic effect Effects 0.000 description 3
- 230000008014 freezing Effects 0.000 description 3
- 238000007710 freezing Methods 0.000 description 3
- 101150036031 gD gene Proteins 0.000 description 3
- 230000012010 growth Effects 0.000 description 3
- 230000012447 hatching Effects 0.000 description 3
- 238000002649 immunization Methods 0.000 description 3
- 238000010166 immunofluorescence Methods 0.000 description 3
- 230000005764 inhibitory process Effects 0.000 description 3
- 230000000977 initiatory effect Effects 0.000 description 3
- 238000013507 mapping Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 238000002703 mutagenesis Methods 0.000 description 3
- 231100000350 mutagenesis Toxicity 0.000 description 3
- 210000002729 polyribosome Anatomy 0.000 description 3
- 239000002243 precursor Substances 0.000 description 3
- 230000035755 proliferation Effects 0.000 description 3
- 230000001681 protective effect Effects 0.000 description 3
- 238000010561 standard procedure Methods 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 238000010257 thawing Methods 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 238000001890 transfection Methods 0.000 description 3
- 241000700570 unidentified entomopoxvirus Species 0.000 description 3
- 238000011144 upstream manufacturing Methods 0.000 description 3
- 208000030507 AIDS Diseases 0.000 description 2
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 2
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 101100333573 Bovine leukemia virus env gene Proteins 0.000 description 2
- 101100148606 Caenorhabditis elegans pst-1 gene Proteins 0.000 description 2
- 241000283707 Capra Species 0.000 description 2
- 241000282693 Cercopithecidae Species 0.000 description 2
- 206010011703 Cyanosis Diseases 0.000 description 2
- 102100030796 E3 ubiquitin-protein ligase rififylin Human genes 0.000 description 2
- 102100027723 Endogenous retrovirus group K member 6 Rec protein Human genes 0.000 description 2
- 101710121417 Envelope glycoprotein Proteins 0.000 description 2
- 101100484387 Fowlpox virus FPV127 gene Proteins 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- 101000703348 Homo sapiens E3 ubiquitin-protein ligase rififylin Proteins 0.000 description 2
- 241000255777 Lepidoptera Species 0.000 description 2
- 101150118742 NP gene Proteins 0.000 description 2
- 206010033799 Paralysis Diseases 0.000 description 2
- 101100271190 Plasmodium falciparum (isolate 3D7) ATAT gene Proteins 0.000 description 2
- 101710182846 Polyhedrin Proteins 0.000 description 2
- 241000713824 Rous-associated virus Species 0.000 description 2
- 238000002105 Southern blotting Methods 0.000 description 2
- 101150003725 TK gene Proteins 0.000 description 2
- 108091023040 Transcription factor Proteins 0.000 description 2
- 102000040945 Transcription factor Human genes 0.000 description 2
- 208000036142 Viral infection Diseases 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- VEZXCJBBBCKRPI-UHFFFAOYSA-N beta-propiolactone Chemical compound O=C1CCO1 VEZXCJBBBCKRPI-UHFFFAOYSA-N 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 210000000805 cytoplasm Anatomy 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 235000021186 dishes Nutrition 0.000 description 2
- 210000002950 fibroblast Anatomy 0.000 description 2
- 230000004927 fusion Effects 0.000 description 2
- 102000037865 fusion proteins Human genes 0.000 description 2
- 230000035931 haemagglutination Effects 0.000 description 2
- 230000002163 immunogen Effects 0.000 description 2
- 230000016784 immunoglobulin production Effects 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 210000003292 kidney cell Anatomy 0.000 description 2
- 210000001161 mammalian embryo Anatomy 0.000 description 2
- 230000003472 neutralizing effect Effects 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 150000007523 nucleic acids Chemical class 0.000 description 2
- 229920002401 polyacrylamide Polymers 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 229960000380 propiolactone Drugs 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 238000004448 titration Methods 0.000 description 2
- 210000003437 trachea Anatomy 0.000 description 2
- 230000009385 viral infection Effects 0.000 description 2
- 239000007762 w/o emulsion Substances 0.000 description 2
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
- 101150017816 40 gene Proteins 0.000 description 1
- 108010039224 Amidophosphoribosyltransferase Proteins 0.000 description 1
- 241000670670 Amsacta Species 0.000 description 1
- IJYZHIOOBGIINM-WDSKDSINSA-N Arg-Ser Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@@H](N)CCCN=C(N)N IJYZHIOOBGIINM-WDSKDSINSA-N 0.000 description 1
- 241001203868 Autographa californica Species 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 102100021935 C-C motif chemokine 26 Human genes 0.000 description 1
- 101100287651 Caenorhabditis elegans kbp-3 gene Proteins 0.000 description 1
- 241000173351 Camvirus Species 0.000 description 1
- 108020004638 Circular DNA Proteins 0.000 description 1
- 241000254173 Coleoptera Species 0.000 description 1
- 241000272201 Columbiformes Species 0.000 description 1
- UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 description 1
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 description 1
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 241000701832 Enterobacteria phage T3 Species 0.000 description 1
- 241000700572 Entomopoxvirinae Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010069540 Generalised vaccinia Diseases 0.000 description 1
- 108700039691 Genetic Promoter Regions Proteins 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 108060003393 Granulin Proteins 0.000 description 1
- 208000009889 Herpes Simplex Diseases 0.000 description 1
- 101000897493 Homo sapiens C-C motif chemokine 26 Proteins 0.000 description 1
- 241000700588 Human alphaherpesvirus 1 Species 0.000 description 1
- 208000002979 Influenza in Birds Diseases 0.000 description 1
- 229940124873 Influenza virus vaccine Drugs 0.000 description 1
- HHSJMSCOLJVTCX-ZDLURKLDSA-N L-Glutaminyl-L-threonine Chemical compound C[C@@H](O)[C@@H](C(O)=O)NC(=O)[C@@H](N)CCC(N)=O HHSJMSCOLJVTCX-ZDLURKLDSA-N 0.000 description 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
- 125000003798 L-tyrosyl group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H] 0.000 description 1
- 241001415864 Lagopus Species 0.000 description 1
- 241000721703 Lymantria dispar Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- 101710163270 Nuclease Proteins 0.000 description 1
- JLNMSNDDYBZCIB-UHFFFAOYSA-N OOOOS Chemical compound OOOOS JLNMSNDDYBZCIB-UHFFFAOYSA-N 0.000 description 1
- 241000238814 Orthoptera Species 0.000 description 1
- 241000287127 Passeridae Species 0.000 description 1
- 108010076039 Polyproteins Proteins 0.000 description 1
- 208000027954 Poultry disease Diseases 0.000 description 1
- 229940124939 Pox vaccine Drugs 0.000 description 1
- 206010037888 Rash pustular Diseases 0.000 description 1
- 101001009851 Rattus norvegicus Guanylate cyclase 2G Proteins 0.000 description 1
- 241000714233 Rous-associated virus type 1 Species 0.000 description 1
- 206010039509 Scab Diseases 0.000 description 1
- 241000287231 Serinus Species 0.000 description 1
- 101800001271 Surface protein Proteins 0.000 description 1
- 108010059722 Viral Fusion Proteins Proteins 0.000 description 1
- 108700005077 Viral Genes Proteins 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 208000002552 acute disseminated encephalomyelitis Diseases 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 239000011543 agarose gel Substances 0.000 description 1
- 238000000246 agarose gel electrophoresis Methods 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 230000005875 antibody response Effects 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- 206010064097 avian influenza Diseases 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 238000010804 cDNA synthesis Methods 0.000 description 1
- 244000309466 calf Species 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000013553 cell monolayer Substances 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 239000003593 chromogenic compound Substances 0.000 description 1
- 210000003555 cloaca Anatomy 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- NKLPQNGYXWVELD-UHFFFAOYSA-M coomassie brilliant blue Chemical compound [Na+].C1=CC(OCC)=CC=C1NC1=CC=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C=CC(=CC=2)N(CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=C1 NKLPQNGYXWVELD-UHFFFAOYSA-M 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000012217 deletion Methods 0.000 description 1
- 230000037430 deletion Effects 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 229910000397 disodium phosphate Inorganic materials 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 230000008029 eradication Effects 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 239000012894 fetal calf serum Substances 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000012757 fluorescence staining Methods 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 230000036449 good health Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 210000000087 hemolymph Anatomy 0.000 description 1
- 108010077284 hepatitis B surface antigen presurface protein 2 Proteins 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 208000026278 immune system disease Diseases 0.000 description 1
- 238000007901 in situ hybridization Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 229940031551 inactivated vaccine Drugs 0.000 description 1
- 210000003000 inclusion body Anatomy 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 125000001041 indolyl group Chemical group 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 229960003971 influenza vaccine Drugs 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
- 239000000543 intermediate Substances 0.000 description 1
- 238000011005 laboratory method Methods 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
- 210000005265 lung cell Anatomy 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 229960004452 methionine Drugs 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 210000004237 neck muscle Anatomy 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 238000007899 nucleic acid hybridization Methods 0.000 description 1
- 230000002611 ovarian Effects 0.000 description 1
- 210000004681 ovum Anatomy 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000013600 plasmid vector Substances 0.000 description 1
- 208000029561 pustule Diseases 0.000 description 1
- 229940124551 recombinant vaccine Drugs 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 210000001995 reticulocyte Anatomy 0.000 description 1
- 230000018040 scab formation Effects 0.000 description 1
- 238000007790 scraping Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000013207 serial dilution Methods 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 210000000966 temporal muscle Anatomy 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
- 230000010474 transient expression Effects 0.000 description 1
- 239000003656 tris buffered saline Substances 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
- 230000029812 viral genome replication Effects 0.000 description 1
- 230000017613 viral reproduction Effects 0.000 description 1
- 230000006490 viral transcription Effects 0.000 description 1
- 239000013603 viral vector Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 101150069452 z gene Proteins 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24041—Use of virus, viral particle or viral elements as a vector
- C12N2710/24043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18111—Avulavirus, e.g. Newcastle disease virus
- C12N2760/18122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/20011—Rhabdoviridae
- C12N2760/20111—Lyssavirus, e.g. rabies virus
- C12N2760/20122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/20011—Coronaviridae
- C12N2770/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9071187A | 1987-08-28 | 1987-08-28 | |
| US11033587A | 1987-10-20 | 1987-10-20 | |
| US18605488A | 1988-04-25 | 1988-04-25 | |
| US23439088A | 1988-08-23 | 1988-08-23 | |
| PCT/US1988/002816 WO1989003429A1 (en) | 1987-08-28 | 1988-08-24 | Recombinant avipox virus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ATA900788A ATA900788A (de) | 1995-05-15 |
| AT408549B true AT408549B (de) | 2001-12-27 |
Family
ID=27492413
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT0900788A AT408549B (de) | 1987-08-28 | 1988-08-24 | Virushältiger impfstoff, rekombinantes virus und verfahren zum exprimieren eines genproduktes |
Country Status (17)
| Country | Link |
|---|---|
| JP (3) | JP3348156B2 (Direct) |
| KR (1) | KR970011149B1 (Direct) |
| AR (1) | AR241939A1 (Direct) |
| AT (1) | AT408549B (Direct) |
| AU (2) | AU2427588A (Direct) |
| BE (1) | BE1002134A5 (Direct) |
| CH (2) | CH679934A5 (Direct) |
| DE (4) | DE10399032I1 (Direct) |
| DK (1) | DK175904B1 (Direct) |
| FR (1) | FR2621487B1 (Direct) |
| GB (1) | GB2217718B (Direct) |
| IL (1) | IL87581A0 (Direct) |
| IT (1) | IT1229484B (Direct) |
| LU (2) | LU90951I2 (Direct) |
| NL (4) | NL195051C (Direct) |
| NZ (1) | NZ225970A (Direct) |
| WO (1) | WO1989003429A1 (Direct) |
Families Citing this family (121)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5338683A (en) * | 1981-12-24 | 1994-08-16 | Health Research Incorporated | Vaccinia virus containing DNA sequences encoding herpesvirus glycoproteins |
| US5505941A (en) * | 1981-12-24 | 1996-04-09 | Health Research, Inc. | Recombinant avipox virus and method to induce an immune response |
| US7045313B1 (en) | 1982-11-30 | 2006-05-16 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant vaccinia virus containing a chimeric gene having foreign DNA flanked by vaccinia regulatory DNA |
| DE10399032I1 (de) * | 1987-08-28 | 2004-01-29 | Health Research Inc | Rekombinante Viren. |
| US5286639A (en) * | 1987-09-16 | 1994-02-15 | Nippon Zeon Co., Ltd. | Recombinant avipoxvirus |
| DE3813093A1 (de) * | 1988-04-19 | 1989-11-09 | Immuno Ag | Rekombinantes plasmid, verfahren zum herstellen eines rekombinanten avipoxvirus, rekombinantes avipoxvirus und dessen verwendung |
| US5631154A (en) * | 1988-06-10 | 1997-05-20 | Therion Biologics, Incorporated | Self assembled, defective, non-self-propagating lentivirus particles |
| ES2061996T3 (es) * | 1988-06-24 | 1994-12-16 | British Tech Group | Regiones no esenciales de avipoxvirus. |
| US5093258A (en) * | 1988-08-26 | 1992-03-03 | Therion Biologics Corporation | Recombinant fowlpox virus and recombination vector |
| CA2001001A1 (en) * | 1988-10-21 | 1990-04-21 | Matthew M. Binns | Fowlpox virus promoter |
| US6248333B1 (en) | 1990-04-04 | 2001-06-19 | Health Research Inc. | Isolated nucleic acid sequence of equine herpesvirus type 1 glycoprotein D (EHV-1 gD) |
| US5204243A (en) * | 1990-02-14 | 1993-04-20 | Health Research Incorporated | Recombinant poxvirus internal cores |
| US5514375A (en) * | 1990-08-15 | 1996-05-07 | Virogenetics Corporation | Flavivirus recombinant poxvirus vaccine |
| MY109299A (en) * | 1990-08-15 | 1996-12-31 | Virogenetics Corp | Recombinant pox virus encoding flaviviral structural proteins |
| FR2668064B1 (fr) | 1990-10-23 | 1994-12-16 | Transgene Sa | Composition pharmaceutique pour le traitement ou la prevention d'une tumeur maligne. |
| US5759841A (en) * | 1990-11-20 | 1998-06-02 | Virogenetics Corporation | Immunological composition of measles virus utilizing recombinant poxvirus |
| US5756102A (en) * | 1990-11-20 | 1998-05-26 | Virogenetics Corporation | Poxvirus-canine distemper virus (CDV) recombinants and compositions and methods employing the recombinants |
| IE68404B1 (en) * | 1990-11-20 | 1996-06-12 | Virogenetics Corp | Measles virus recombinant poxvirus vaccine |
| US5503834A (en) * | 1990-11-20 | 1996-04-02 | Virogenetics Corporation | Measles virus recombinant poxvirus vaccine |
| US6309647B1 (en) | 1999-07-15 | 2001-10-30 | Aventis Pasteur | Poxvirus—canine dispemper virus (CDV) or measles virus recombinants and compositions and methods employing the recombinants |
| US5338679A (en) * | 1991-01-08 | 1994-08-16 | Her Majesty The Queen In Right Of Canada, As Represented By National Research Council Canada And Forestry Canada | Vertebrate poxvoris expression vector under the control of entomopoxvirus spheroidin gene promoter |
| US5863542A (en) * | 1991-03-07 | 1999-01-26 | Virogenetics Corporation | Recombinant attenuated ALVAC canaryopox virus containing heterologous HIV or SIV inserts |
| US5766598A (en) * | 1991-03-07 | 1998-06-16 | Virogenetics Corporation | Recombinant attenuated ALVAC canarypoxvirus expression vectors containing heterologous DNA segments encoding lentiviral gene products |
| ATE247163T1 (de) * | 1991-03-07 | 2003-08-15 | Virogenetics Corp | Gentechnologisch hergestellter stamm für impfstoffe |
| US5766597A (en) * | 1991-03-07 | 1998-06-16 | Virogenetics Corporation | Malaria recombinant poxviruses |
| US5756101A (en) * | 1991-07-01 | 1998-05-26 | Pasteur Merieux Serums Et Vaccins | Malaria recombinant poxvirus |
| JPH06505397A (ja) * | 1991-03-20 | 1994-06-23 | ヴァイロジェネティクス コーポレイション | マラリア組換体ポックスウイルス |
| ATE241696T1 (de) * | 1991-06-14 | 2003-06-15 | Virogenetics Corp | Rekombinanter hiv-spezifischer impfstoff aus poxviru |
| CA2110505A1 (en) * | 1991-07-26 | 1993-02-18 | Enzo Paoletti | Infectious bursal disease virus recombinant poxvirus vaccine |
| DE69133333T2 (de) * | 1991-08-26 | 2004-07-29 | Baxter Healthcare S.A. | Ein intaktes FPV-tk-Gen enthaltender rekombinanter Virus der Vogelpocken |
| US5443831A (en) * | 1991-10-29 | 1995-08-22 | University Of Delaware | Gene encoding glycoprotein B of Infectious Laryngotracheitis Virus |
| WO1993014219A1 (en) * | 1992-01-13 | 1993-07-22 | Virogenetics Corporation | Marek's disease virus recombinant poxvirus vaccine |
| US6033904A (en) * | 1992-01-13 | 2000-03-07 | Syntro Corporation | Recombinant swinepox virus |
| US6328975B1 (en) | 1992-01-13 | 2001-12-11 | Syntro Corporation | Recombinant swinepox virus |
| US6127163A (en) * | 1992-01-13 | 2000-10-03 | Syntro Corporation | Recombinant swinepox virus |
| US6251403B1 (en) | 1992-01-13 | 2001-06-26 | Syntro Corporation | Recombinant swinepox virus |
| US6497882B1 (en) | 1992-01-13 | 2002-12-24 | Syntro Corporation | Recombinant swinepox virus |
| US5869312A (en) * | 1992-01-13 | 1999-02-09 | Syntro Corporation | Recombinant swinepox virus |
| EP0662139A1 (en) * | 1992-09-21 | 1995-07-12 | Chiron Corporation | Recombinant retroviral vector against felv and/or fiv |
| US6136318A (en) * | 1993-02-26 | 2000-10-24 | Cochran; Mark D. | Recombinant fowlpox viruses and uses thereof |
| US5925358A (en) * | 1993-02-26 | 1999-07-20 | Syntro Corporation | Recombinant fowlpox viruses and uses thereof |
| AU6299594A (en) * | 1993-02-26 | 1994-09-14 | Nippon Zeon Co., Ltd. | Recombinant fowlpox virus s-fpv-043 and uses thereof |
| AU727278B2 (en) * | 1993-02-26 | 2000-12-07 | Syntro Corporation | Recombinant fowlpox viruses and uses thereof II |
| US5496731A (en) * | 1993-03-25 | 1996-03-05 | Xu; Hong-Ji | Broad-spectrum tumor suppressor genes, gene products and methods for tumor suppressor gene therapy |
| US5843742A (en) * | 1994-12-16 | 1998-12-01 | Avigen Incorporated | Adeno-associated derived vector systems for gene delivery and integration into target cells |
| EP0753581A1 (en) | 1995-07-10 | 1997-01-15 | Immuno Ag | Improved recombinant eukaryotic cytoplasmic viruses, method for their production and their use as vaccines |
| US5858373A (en) * | 1995-12-01 | 1999-01-12 | Virogenetics Corporation | Recombinant poxvirus-feline infectious peritionitis virus, compositions thereof and methods for making and using them |
| CA2261989C (en) | 1996-07-25 | 2008-09-30 | Therion Biologics Corporation | Recombinant pox virus for immunization against tumor-associated antigens |
| US6106825A (en) * | 1997-05-07 | 2000-08-22 | University Of Florida | Entomopoxvirus-vertebrate gene delivery vector and method |
| AU3910097A (en) * | 1997-08-05 | 1999-03-01 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Live recombinant vaccine comprising inefficiently or non-replicating vir us |
| US6248582B1 (en) * | 1997-10-08 | 2001-06-19 | Imran Khan | Gene deleted recombinant FeLV proviral DNA for production of vaccines against FeLV |
| JPH11165762A (ja) | 1997-12-01 | 1999-06-22 | Lintec Corp | チップ体搬送用カバーテープおよび封止構造体 |
| US20020147143A1 (en) | 1998-03-18 | 2002-10-10 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
| US20030235557A1 (en) | 1998-09-30 | 2003-12-25 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
| US6200560B1 (en) | 1998-10-20 | 2001-03-13 | Avigen, Inc. | Adeno-associated virus vectors for expression of factor VIII by target cells |
| US6221349B1 (en) | 1998-10-20 | 2001-04-24 | Avigen, Inc. | Adeno-associated vectors for expression of factor VIII by target cells |
| JP2002533124A (ja) | 1998-12-31 | 2002-10-08 | カイロン コーポレイション | Ｈｉｖポリペプチドの改善された発現およびウイルス様粒子の生成 |
| US7935805B1 (en) | 1998-12-31 | 2011-05-03 | Novartis Vaccines & Diagnostics, Inc | Polynucleotides encoding antigenic HIV Type C polypeptides, polypeptides and uses thereof |
| CA2374346C (en) | 1999-06-28 | 2010-06-22 | Jordan J. N. Tang | Inhibitors of memapsin 2 and use thereof |
| JP5502253B2 (ja) | 2000-02-23 | 2014-05-28 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 新規化合物 |
| WO2002000174A2 (en) | 2000-06-28 | 2002-01-03 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
| AU2002305914A1 (en) | 2001-01-12 | 2002-10-21 | Chiron Corporation | Nucleic acid mucosal immunization |
| US6942864B2 (en) * | 2001-03-08 | 2005-09-13 | Akzo Nobel N.V. | Leporipox-based vector vaccines |
| JP4499311B2 (ja) * | 2001-04-27 | 2010-07-07 | シャープ株式会社 | 放送受信端末 |
| CA2446788A1 (en) | 2001-05-09 | 2002-11-14 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of prostate cancer |
| EP2280074A3 (en) | 2001-07-05 | 2011-06-22 | Novartis Vaccines and Diagnostics, Inc. | Polynucleotides encoding antigenic HIV type B and/or type C polypeptides, polypeptides and uses thereof |
| CA2452015C (en) | 2001-07-05 | 2012-07-03 | Chiron Corporation | Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof |
| EP2224012B1 (en) | 2001-12-17 | 2013-01-30 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of inflammatory bowel disease |
| US7960522B2 (en) | 2003-01-06 | 2011-06-14 | Corixa Corporation | Certain aminoalkyl glucosaminide phosphate compounds and their use |
| MXPA05007295A (es) | 2003-01-06 | 2005-09-30 | Corixa Corp | Ciertos compuestos de fosfato de aminoalquil glucosaminida y su uso. |
| CA2525825A1 (en) | 2003-05-15 | 2005-01-27 | Chiron Corporation | Hiv polynucleotides and polypeptides derived from botswana mj4 |
| US7261882B2 (en) | 2003-06-23 | 2007-08-28 | Reagents Of The University Of Colorado | Methods for treating neuropathic pain by administering IL-10 polypeptides |
| NZ553775A (en) | 2004-09-22 | 2010-05-28 | Glaxosmithkline Biolog Sa | Immunogenic composition for use in vaccination against staphylococcei |
| AU2006335256B2 (en) | 2005-11-22 | 2012-10-18 | Novartis Vaccines And Diagnostics, Inc. | Norovirus and sapovirus antigens |
| AU2007239095B2 (en) | 2006-01-09 | 2012-05-03 | The Regents Of The University Of California | Immunostimulatory combinations for vaccine adjuvants |
| WO2007106536A2 (en) | 2006-03-14 | 2007-09-20 | Oregon Health & Science University | Methods for producing an immune response to tuberculosis |
| CA2678404C (en) | 2007-02-28 | 2019-03-19 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Brachyury polypeptides and methods for use |
| WO2009049350A1 (en) | 2007-10-15 | 2009-04-23 | The University Of Queensland | Expression system for modulating an immune response |
| US8691502B2 (en) | 2008-10-31 | 2014-04-08 | Tremrx, Inc. | T-cell vaccination with viral vectors via mechanical epidermal disruption |
| US8425922B2 (en) | 2009-01-05 | 2013-04-23 | EpitoGenesis, Inc. | Adjuvant compositions and methods of use |
| US8664183B2 (en) | 2009-02-27 | 2014-03-04 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | SPANX-B polypeptides and their use |
| US9173930B2 (en) | 2009-11-20 | 2015-11-03 | Oregon Health & Science University | Methods for detecting a mycobacterium tuberculosis infection |
| WO2011106705A2 (en) | 2010-02-26 | 2011-09-01 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Dna-protein vaccination protocols |
| US9795658B2 (en) | 2010-04-20 | 2017-10-24 | Admedus Vaccines Pty Ltd | Expression system for modulating an immune response |
| US9428565B2 (en) | 2011-01-31 | 2016-08-30 | The General Hospital Corporation | Treatment and bioluminescent visualization using multimodal TRAIL molecules |
| WO2012151272A2 (en) | 2011-05-02 | 2012-11-08 | Tremrx, Inc. | T-cell vaccination with viral vectors via mechanical epidermal disruption |
| CN103608030A (zh) | 2011-06-21 | 2014-02-26 | 昂科发克特公司 | 用于治疗和诊断癌症的组合物和方法 |
| CN107837394A (zh) | 2011-06-24 | 2018-03-27 | 埃皮托吉尼西斯有限公司 | 作为抗原特异性免疫调节剂的包含选择的载体、维生素、单宁和类黄酮的组合的药物组合物 |
| US20150004144A1 (en) | 2011-12-02 | 2015-01-01 | The General Hospital Corporation | Differentiation into brown adipocytes |
| WO2014035474A1 (en) | 2012-08-30 | 2014-03-06 | The General Hospital Corporation | Compositions and methods for treating cancer |
| ES2752190T3 (es) | 2012-09-14 | 2020-04-03 | Us Health | Proteína Brachyury, vectores adenovirales que codifican proteína Brachyury y su uso |
| WO2014043535A1 (en) | 2012-09-14 | 2014-03-20 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Compositions for the treatment of cancer |
| CA2909706C (en) | 2013-04-17 | 2023-02-14 | Genzyme Corporation | Use of an il17 inhibitor for treating and preventing macular degeneration |
| US9988617B2 (en) | 2013-05-21 | 2018-06-05 | President And Fellows Of Harvard College | Engineered heme-binding compositions and uses thereof |
| EP3068783B1 (en) | 2013-11-15 | 2020-09-23 | The Board of Trustees of the Leland Stanford Junior University | Agonists of hypocretin receptor 2 for use for treating heart failure |
| CN106163573A (zh) | 2014-02-06 | 2016-11-23 | 建新公司 | 用于治疗和预防黄斑变性的组合物及方法 |
| EP3194446B1 (en) | 2014-09-18 | 2022-10-26 | Cedars-Sinai Medical Center | Compositions and methods for treating fibrosis |
| JP2018511655A (ja) | 2015-03-20 | 2018-04-26 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | ボルデテラ属に対するワクチン接種における使用のための免疫原性組成物 |
| WO2016168601A1 (en) | 2015-04-17 | 2016-10-20 | Khalid Shah | Agents, systems and methods for treating cancer |
| US20180110823A1 (en) | 2015-04-22 | 2018-04-26 | Cedars-Sinai Medical Center | Enterically delivered bitter oligopeptides for the treatment for type 2 diabetes |
| EP4276106A3 (en) | 2015-05-13 | 2024-01-24 | The United States of America as represented by the Secretary of the Department of Health and Human Services | Methods and compositions for inducing an immune response using conserved element constructs |
| WO2016196366A1 (en) | 2015-05-29 | 2016-12-08 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Extension of replicative lifespan in diseases of premature aging using p53 isoforms |
| EP3313863B1 (en) | 2015-06-29 | 2020-12-23 | The Board of Trustees of the Leland Stanford Junior University | Degron fusion constructs and methods for controlling protein production |
| US10596248B2 (en) | 2015-12-09 | 2020-03-24 | Jingang Medicine (Australia) Pty Ltd | Immunomodulating composition for treatment |
| NZ749593A (en) | 2016-06-20 | 2025-10-31 | Univ Leland Stanford Junior | Circular rnas and their use in immunomodulation |
| US11285191B2 (en) | 2016-07-26 | 2022-03-29 | The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Immunostimulatory compositions and uses therefor |
| US12416015B2 (en) | 2017-09-15 | 2025-09-16 | The Board Of Trustees Of The Leland Stanford Junior University | Multiplex production and barcoding of genetically engineered cells |
| US10917454B1 (en) | 2019-08-01 | 2021-02-09 | Rohde & Schwarz Gmbh & Co. Kg | System and method for ATC voice quality assurance |
| WO2023070072A1 (en) | 2021-10-21 | 2023-04-27 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Retroelement-generated transcription factor decoys |
| WO2023077147A2 (en) | 2021-11-01 | 2023-05-04 | Pellis Therapeutics, Inc. | T-cell vaccines for patients with reduced humoral immunity |
| US20250043269A1 (en) | 2021-11-03 | 2025-02-06 | The J. David Gladstone Institutes, a testamentary trust established under the Will of J. David Glad | Precise Genome Editing Using Retrons |
| WO2023141602A2 (en) | 2022-01-21 | 2023-07-27 | Renagade Therapeutics Management Inc. | Engineered retrons and methods of use |
| EP4499839A1 (en) | 2022-03-25 | 2025-02-05 | The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone | Methods of assessing engineered retron activity, and uses thereof |
| US20250215422A1 (en) | 2022-03-25 | 2025-07-03 | The J. David Gladstone Institutes, a testamentary trust established under the Will of J. David Glads | RT-DNA Fidelity and Retron Genome Editing |
| WO2023183627A1 (en) | 2022-03-25 | 2023-09-28 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Production of reverse transcribed dna (rt-dna) using a retron reverse transcriptase from exogenous rna |
| MA71557A (fr) | 2022-07-18 | 2025-05-30 | Renagade Therapeutics Management Inc. | Composants d'édition génique, systèmes et procédés d'utilisation |
| WO2024044673A1 (en) | 2022-08-24 | 2024-02-29 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Dual cut retron editors for genomic insertions and deletions |
| WO2024044723A1 (en) | 2022-08-25 | 2024-02-29 | Renagade Therapeutics Management Inc. | Engineered retrons and methods of use |
| WO2024233791A1 (en) | 2023-05-11 | 2024-11-14 | Seelos Therapeutics, Inc. | Methods of treating neurodegenerative disorders |
| WO2025081042A1 (en) | 2023-10-12 | 2025-04-17 | Renagade Therapeutics Management Inc. | Nickase-retron template-based precision editing system and methods of use |
| WO2025155753A2 (en) | 2024-01-17 | 2025-07-24 | Renagade Therapeutics Management Inc. | Improved gene editing system, guides, and methods |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0110385A2 (en) * | 1982-11-30 | 1984-06-13 | THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce | Process for producing poxvirus recombinants for expression of foreign genes |
| WO1986000528A1 (en) * | 1984-07-05 | 1986-01-30 | Genex Corporation | Cloned gene and method for making and using the same |
| US4603112A (en) * | 1981-12-24 | 1986-07-29 | Health Research, Incorporated | Modified vaccinia virus |
| WO1986005806A1 (en) * | 1985-03-29 | 1986-10-09 | National Research Development Corporation | Infectious bronchitis virus spike protein |
| WO1988002022A1 (en) * | 1986-09-22 | 1988-03-24 | Commonwealth Scientific And Industrial Research Or | Recombinant poxviruses |
| EP0261940A2 (en) * | 1986-09-23 | 1988-03-30 | Applied Biotechnology, Inc. | Pseudorabies vaccines and DNA vectors for recombination with pox viruses |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK489481A (da) * | 1980-11-10 | 1982-05-11 | Searle & Co | Plasmidvektor og frmgangsmaade til fremstilling deraf |
| FR2563434B1 (fr) * | 1984-04-25 | 1986-07-25 | Transgene Sa | Vaccin contre la rage et procede pour sa preparation |
| DD235669A1 (de) * | 1985-03-26 | 1986-05-14 | Akad Wissenschaften Ddr | Verfahren zur herstellung eines blv-kodierten huellproteins |
| EP0213894A3 (en) * | 1985-08-23 | 1987-10-21 | Advanced Genetics Research Institute | Defective viral particle vaccines and methods for their use |
| AU607399B2 (en) * | 1985-09-09 | 1991-03-07 | Cetus Corporation | Infectious recombinant virus vaccine for feline leukemia |
| GR862412B (en) * | 1985-09-25 | 1987-01-23 | Oncogen | Vaccines and immuinoassays for acquired immune deficiency syndrome |
| AU602875B2 (en) * | 1985-12-18 | 1990-11-01 | British Technology Group Limited | Newcastle disease virus gene clones |
| AU8075787A (en) * | 1986-09-22 | 1988-04-07 | Australian National University, The | Recombinant poxviruses |
| AU605567B2 (en) * | 1987-03-11 | 1991-01-17 | Nippon Zeon Co., Ltd. | Recombinant avipoxvirus |
| DE10399032I1 (de) * | 1987-08-28 | 2004-01-29 | Health Research Inc | Rekombinante Viren. |
| GB8724885D0 (en) * | 1987-10-23 | 1987-11-25 | Binns M M | Fowlpox virus promotors |
| FR2632863B2 (fr) * | 1987-10-29 | 1990-08-31 | Transgene Sa | Virus du fowlpox recombinant et vaccins derives de ces virus |
| ES2061996T3 (es) * | 1988-06-24 | 1994-12-16 | British Tech Group | Regiones no esenciales de avipoxvirus. |
| AT400955B (de) * | 1989-03-08 | 1996-05-28 | Health Research Inc | Rekombinantes pockenvirus-wirtsselektionssystem |
| EP0550553B1 (en) * | 1990-09-25 | 2000-07-12 | Cantab Pharmaceuticals Research Limited | Viral defective vaccine produced by transcomplementing cell line |
-
1987
- 1987-08-24 DE DE2003199032 patent/DE10399032I1/de active Pending
- 1987-08-24 DE DE2003199031 patent/DE10399031I1/de active Pending
-
1988
- 1988-08-24 AT AT0900788A patent/AT408549B/de not_active IP Right Cessation
- 1988-08-24 WO PCT/US1988/002816 patent/WO1989003429A1/en not_active Ceased
- 1988-08-24 AU AU24275/88A patent/AU2427588A/en not_active Abandoned
- 1988-08-24 NL NL8820679A patent/NL195051C/nl not_active IP Right Cessation
- 1988-08-24 JP JP50771588A patent/JP3348156B2/ja not_active Expired - Lifetime
- 1988-08-24 GB GB8908921A patent/GB2217718B/en not_active Expired - Lifetime
- 1988-08-24 KR KR1019890700753A patent/KR970011149B1/ko not_active Expired - Lifetime
- 1988-08-24 DE DE2002199049 patent/DE10299049I1/de active Pending
- 1988-08-24 CH CH1444/91A patent/CH679934A5/de not_active IP Right Cessation
- 1988-08-24 CH CH1652/89A patent/CH679933A5/de not_active IP Right Cessation
- 1988-08-24 DE DE3890874A patent/DE3890874C5/de not_active Expired - Lifetime
- 1988-08-28 IL IL87581A patent/IL87581A0/xx not_active IP Right Cessation
- 1988-08-29 BE BE8800978A patent/BE1002134A5/fr not_active IP Right Cessation
- 1988-08-29 AR AR88311787A patent/AR241939A1/es active
- 1988-08-29 NZ NZ225970A patent/NZ225970A/xx unknown
- 1988-08-29 IT IT8821772A patent/IT1229484B/it active
- 1988-08-29 FR FR888811334A patent/FR2621487B1/fr not_active Expired - Lifetime
-
1989
- 1989-04-27 DK DK198902036A patent/DK175904B1/da active Protection Beyond IP Right Term
-
1995
- 1995-04-05 AU AU16288/95A patent/AU690210B2/en not_active Expired
-
2001
- 2001-10-09 JP JP2001311076A patent/JP2002186494A/ja active Pending
-
2002
- 2002-03-15 JP JP2002071416A patent/JP3826055B2/ja not_active Expired - Lifetime
- 2002-09-04 LU LU90951C patent/LU90951I2/fr unknown
-
2003
- 2003-07-09 NL NL300130C patent/NL300130I2/nl unknown
- 2003-09-05 LU LU91039C patent/LU91039I2/fr unknown
- 2003-11-25 NL NL300138C patent/NL300138I2/nl unknown
- 2003-11-25 NL NL300139C patent/NL300139I1/nl unknown
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4603112A (en) * | 1981-12-24 | 1986-07-29 | Health Research, Incorporated | Modified vaccinia virus |
| EP0110385A2 (en) * | 1982-11-30 | 1984-06-13 | THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce | Process for producing poxvirus recombinants for expression of foreign genes |
| WO1986000528A1 (en) * | 1984-07-05 | 1986-01-30 | Genex Corporation | Cloned gene and method for making and using the same |
| WO1986005806A1 (en) * | 1985-03-29 | 1986-10-09 | National Research Development Corporation | Infectious bronchitis virus spike protein |
| WO1988002022A1 (en) * | 1986-09-22 | 1988-03-24 | Commonwealth Scientific And Industrial Research Or | Recombinant poxviruses |
| EP0261940A2 (en) * | 1986-09-23 | 1988-03-30 | Applied Biotechnology, Inc. | Pseudorabies vaccines and DNA vectors for recombination with pox viruses |
Non-Patent Citations (13)
| Title |
|---|
| AVIAN DISEASES, VOL. 30, NO. 1, 1985; S. 24-27 * |
| BIOESSAYS, VOL. 5, 1986; S. 249-251 * |
| BIOTECHNOLOGY: POTENTIALS AND LIMITATIONS, DAHLENS KONFERENZEN 1986; S. 155 U. 161-162 * |
| JOURNAL OF GENERAL VIROLOGY, VOL. 67, 1986; S. 1591-1600 * |
| JOURNAL OF GENERAL VIROLOGY, VOL. 67, 1986; S. 6563 * |
| JOURNAL OF VIROLOGY, VOL. 62, 1988; S. 367 * |
| NATURE, VOL. 317, 1985; S. 813-815 * |
| VIROLOGY, VOL. 156, 1987; S. 335 * |
| VIROLOGY, VOL. 160, 1987; S. 203 * |
| VIRUS GENES, VOL. 1, 1987; S. 7-21 * |
| VIRUS RESEARCH, VOL. 10, 1988; S. 343 * |
| VIRUS RESEARCH, VOL. 10, 1988; S. 65 * |
| ZBL. BAKT. HYG., I. ABT. ORIG. B 167, 1978; S. 375-390 * |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AT408549B (de) | Virushältiger impfstoff, rekombinantes virus und verfahren zum exprimieren eines genproduktes | |
| US5174993A (en) | Recombinant avipox virus and immunological use thereof | |
| US5505941A (en) | Recombinant avipox virus and method to induce an immune response | |
| DE4090565C2 (de) | Rekombinantes Herpesvirus-Pockenvirus-Vakzin | |
| AT400955B (de) | Rekombinantes pockenvirus-wirtsselektionssystem | |
| DE69532068T2 (de) | Rekombinanter lebender Vogel-Impfstoff, der ein Truthahn-Herpesvirus Vektor gebraucht | |
| DE69535359T2 (de) | Rekombinantes herpesvirus aus trufhähnen und seine verwendungen | |
| DE60314823T3 (de) | Modifizierte variante des vaccinia ankara virus als impfstoff für neugeborene | |
| DE69533305T2 (de) | Lebende rekombinante Vogelvakzine auf eines Vogelherpesvirus gegründet, gegen Gumborokrankheit | |
| DE68920610T2 (de) | Rekombinantes Virus der Marekschen Krankheit und Vakzin. | |
| DE69735594T2 (de) | Rekombinanter schweinepockenvirus | |
| DE4192786B4 (de) | Masernvirus-Rekombinanter Pockenvirus-Impfstoff | |
| DE69627526T2 (de) | Rekombinantes pockenvirus der infektiösen peritonitis der katze, dessen zusammensetzungen und methoden zur herstellung und verwendung | |
| DE69435081T2 (de) | Rekombinanter adenovirusvektor für geflügel | |
| DE3752182T2 (de) | Abgeschwächte herpesviren, herpesviren, die eine für aminosäuresequenzen kodierende fremd-dns enthalten, sowie impfstoffe, die diese enthalten | |
| DE69627109T2 (de) | REKOMBINANTES HERPESVIRUS UNTER DER VERWENDUNG DES gB GENPROMOTERS | |
| Smith et al. | Development and trial of a bovine herpesvirus 1‐thymidine kinase deletion virus as a vaccine | |
| WO2007115385A2 (en) | Transfer plasmidic vector and recombinant canarypox virus | |
| CA2084064A1 (en) | Recombinant pigeon pox virus vaccine | |
| CA1341403C (en) | Recombinant a vipox virus | |
| AU761321B2 (en) | Recombinant viruses, vaccines containing them and in vitro cell cultures thereof | |
| DK175980B1 (da) | Recombinante vacciniavira og anvendelsen af samme | |
| AU725985B2 (en) | Recombinant virus | |
| DD297997A5 (de) | Proteine, vakzine und nukleinsaeuren | |
| DK176068B1 (da) | Rekombinant kanaripoxvirus og anvendelsen af samme |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| SZA | Application filed for a certificate of protection |
Free format text: SZ 31/2002, 20020906 |
|
| SZA | Application filed for a certificate of protection |
Free format text: ERZEUGNIS: INFLUENZA A/EQUI-2/KENTUCKY/94-REKOMBINANTE DES KANARIENPOCKENVIRUS IN KOMBINATION MIT INFLUENZA A/EQUI-2/NEWMARKET/2/93-REKOMBINATE DES KANARIENPOCKENVIRUS UND MIT CLOSTRIDIUM TETANI-TOXOID Spc suppl protection certif: SZ 26/2003 Filing date: 20030904 Free format text: ERZEUGNIS: INFLUENZA A/EQUI-2/KENTUCKY/94-REKOMBINANTE DES KANARIENPOCKENVIRUS IN KOMBINATION MIT INFLUENZA A/EQUI-2/NEWMARKET/2/93-REKOMBINATE DES KANARIENPOCKENVIRUS Spc suppl protection certif: SZ 27/2003 Filing date: 20030904 |
|
| EZF | Grant of a certificate of protection |
Free format text: SZ 27/2003, 20030904, EXPIRES:20130824 Spc suppl protection certif: SZ 27/2003 Filing date: 20030904 Expiry date: 20130824 Free format text: SZ 31/2002, 20020906, EXPIRES:20130824 Spc suppl protection certif: SZ 31/2002 Filing date: 20020906 Expiry date: 20130824 Free format text: SZ 26/2003, 20030904, EXPIRES:20130824 Spc suppl protection certif: SZ 26/2003 Filing date: 20030904 Expiry date: 20130824 |
|
| ELA | Expired due to lapse of time | ||
| SPCX | Expiry of an spc |
Free format text: PRODUCT NAME: INFLUENZA A/EQUI-2/KENTUCKY/94 (H3N8) - REKOMBINANTE DES KANARIENPOCKENVIRUS UND INFLUENZA A/EQUI-2/NEWMARKET/2/93 (H3N8) -REKOMBINANTE DES KANARIENPOCKENVIRUS; REGISTRATION NO/DATE: EU/2/03/038/001-004 20030306 Spc suppl protection certif: 26/2003 Filing date: 20030904 Expiry date: 20080824 Extension date: 20130824 Effective date: 20130824 Free format text: PRODUCT NAME: INFLUENZA A/EQUI-2/KENTUCKY/94 (H3N8) -REKOMBINANTE DES KANARIENPOCKENVIRUS UND INFLUENZA A/EQUI-2/NEWMARKET/2/93 (H3N8) - REKOMBINANTE DES KANARIENPOCKENVIRUS; REGISTRATION NO/DATE: EU/2/03/037/001-004 20030306 Spc suppl protection certif: 27/2003 Filing date: 20030904 Expiry date: 20080824 Extension date: 20130824 Effective date: 20130824 Free format text: PRODUCT NAME: ENV- UND GAG-FELV UMFASSENDE REKOMBINANTEN DES KANARIENPOCKENVIRUS; NAT. REGISTRATIONNO/DATE: EU/2/02/031/001 UND EU/2/02/031/002 20020308; FIRST REGISTRATION: EU EU/2/02/031/001 UND 20020308 Spc suppl protection certif: 31/2002 Filing date: 20020906 Expiry date: 20080824 Extension date: 20130824 Effective date: 20130824 |