AR241515A1 - Procedimiento de preparacion de composiciones farmaceuticas estables que contienen nicorandil. - Google Patents
Procedimiento de preparacion de composiciones farmaceuticas estables que contienen nicorandil.Info
- Publication number
- AR241515A1 AR241515A1 AR85302556A AR30255685A AR241515A1 AR 241515 A1 AR241515 A1 AR 241515A1 AR 85302556 A AR85302556 A AR 85302556A AR 30255685 A AR30255685 A AR 30255685A AR 241515 A1 AR241515 A1 AR 241515A1
- Authority
- AR
- Argentina
- Prior art keywords
- production
- acid
- sugar
- preparation
- nicorandil preparation
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO DE PREPARACION DE COMPOSICIONES FARMACEUTICAS ESTABLES QUE CONTINEN NICORANDIL DE FORMULA I. COMPRENDE LAS ETAPAS OPERATORIAS DE MEZCLAR NICORANDIL CON UN AZUCAR FINAMENTE DESMENUZADO Y/O CON UN ACIDO ORGANICO EN POLVO, ELEGIDO ENTRE LOS ACIDOS FUMARICO, OXALICO, SALICILICO, TARTARICO, GLUTARICO Y ACIDO DIBASICOS EQUIVALENTES, Y PROCESAR LA COMPOSICION A PARTIR DE LA MEZCLA. EL AZUCAR ESTA ELEGIDO ENTRE MANITOL, LACTOSA, SACAROSA, GLUCOSA, GALACTOSA, MALTOSA Y FRUCTOSA.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP59265888A JPH0653658B2 (ja) | 1984-12-17 | 1984-12-17 | 安定な錠剤の製造法 |
JP14968885 | 1985-07-08 | ||
JP21327785 | 1985-09-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR241515A1 true AR241515A1 (es) | 1992-08-31 |
Family
ID=27319808
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AR85302556A AR241515A1 (es) | 1984-12-17 | 1985-12-12 | Procedimiento de preparacion de composiciones farmaceuticas estables que contienen nicorandil. |
Country Status (23)
Country | Link |
---|---|
US (1) | US4803213A (es) |
EP (1) | EP0185347B1 (es) |
JP (1) | JPH0653658B2 (es) |
KR (1) | KR930007251B1 (es) |
CN (1) | CN1007209B (es) |
AR (1) | AR241515A1 (es) |
AT (1) | ATE54050T1 (es) |
AU (1) | AU579431B2 (es) |
BA (1) | BA98214B1 (es) |
CA (1) | CA1255227A (es) |
DE (1) | DE3578373D1 (es) |
DK (1) | DK167171B1 (es) |
FI (1) | FI84781C (es) |
HK (1) | HK65493A (es) |
HU (1) | HU195731B (es) |
IE (1) | IE59158B1 (es) |
MX (1) | MX166095B (es) |
NO (1) | NO171826C (es) |
PT (1) | PT81680B (es) |
RU (1) | RU1811401C (es) |
SG (1) | SG52493G (es) |
YU (1) | YU45292B (es) |
ZA (1) | ZA859390B (es) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5188840A (en) * | 1985-09-26 | 1993-02-23 | Chugai Seiyaku Kabushiki Kaisha | Slow-release pharmaceutical agent |
KR950010150B1 (ko) * | 1986-01-14 | 1995-09-11 | 쥬우가이세이야꾸 가부시끼가이샤 | 니코란딜 함유 주사제의 안정화 방법 |
KR940000232B1 (ko) * | 1986-01-17 | 1994-01-12 | 쥬우가이세이야꾸 가부시끼가이샤 | 니코란딜 제제의 안정화 방법 |
GR871267B (en) * | 1986-08-18 | 1987-12-24 | Chugai Pharmaceutical Co Ltd | Method for the manufacture of a pharmaceutical preparation for administration by percutaneous absortion |
US4940580A (en) * | 1986-11-03 | 1990-07-10 | Schering Corporation | Sustained release labetalol tablets |
CA1322957C (en) * | 1988-03-30 | 1993-10-12 | Hitoshi Yamauchi | Cyclic amp derivative ointments |
JP2535141B2 (ja) * | 1995-01-17 | 1996-09-18 | 中外製薬株式会社 | フマル酸含有徐放性製剤 |
DK0902777T4 (da) | 1996-04-16 | 2004-10-11 | Takeda Chemical Industries Ltd | D-mannitol og dets fremstilling |
US6235947B1 (en) * | 1997-04-14 | 2001-05-22 | Takeda Chemical Industries, Ltd. | D-mannitol and its preparation |
US8071128B2 (en) | 1996-06-14 | 2011-12-06 | Kyowa Hakko Kirin Co., Ltd. | Intrabuccally rapidly disintegrating tablet and a production method of the tablets |
US20010014340A1 (en) * | 1996-06-14 | 2001-08-16 | Motohiro Ohta | Intrabuccally rapidly disintegrating tablet |
KR100481583B1 (ko) * | 1996-06-14 | 2005-07-12 | 교와 핫꼬 고교 가부시끼가이샤 | 구강내에서빠르게붕괴하는정제 |
IT1293835B1 (it) * | 1997-08-08 | 1999-03-10 | Foscama Biomed Chim Farma | Composizioni farmaceutiche orali in forma solida a cessione modulata contenenti nicorandil e procedimento per la loro preparazione |
US6417207B1 (en) | 1999-05-12 | 2002-07-09 | Nitromed, Inc. | Nitrosated and nitrosylated potassium channel activators, compositions and methods of use |
KR100483080B1 (ko) * | 2001-09-21 | 2005-04-14 | 한인규 | 염산·베타인(betaine·HCl), 판크레아틴, 제2인산 칼슘, 크롬 피콜리네이트, 락토바실러스속·비피도박테리아속·스트렙토코커스속·프럭토 올리고당, 비타민, 미네랄을 유효성분으로 구성된 것을 특징으로 하는 증체개선용 영양강화 사료첨가제 |
US9358214B2 (en) | 2001-10-04 | 2016-06-07 | Adare Pharmaceuticals, Inc. | Timed, sustained release systems for propranolol |
US8367111B2 (en) * | 2002-12-31 | 2013-02-05 | Aptalis Pharmatech, Inc. | Extended release dosage forms of propranolol hydrochloride |
JP4235149B2 (ja) | 2004-07-02 | 2009-03-11 | インターナショナル・ビジネス・マシーンズ・コーポレーション | ノートブック型コンピュータ |
US8747895B2 (en) * | 2004-09-13 | 2014-06-10 | Aptalis Pharmatech, Inc. | Orally disintegrating tablets of atomoxetine |
US9884014B2 (en) | 2004-10-12 | 2018-02-06 | Adare Pharmaceuticals, Inc. | Taste-masked pharmaceutical compositions |
NZ728442A (en) * | 2004-10-21 | 2018-05-25 | Adare Pharmaceuticals Inc | Taste-masked pharmaceutical compositions with gastrosoluble pore-formers |
US20060105038A1 (en) * | 2004-11-12 | 2006-05-18 | Eurand Pharmaceuticals Limited | Taste-masked pharmaceutical compositions prepared by coacervation |
US9161918B2 (en) | 2005-05-02 | 2015-10-20 | Adare Pharmaceuticals, Inc. | Timed, pulsatile release systems |
CN100417381C (zh) * | 2006-02-09 | 2008-09-10 | 西安力邦医药科技有限责任公司 | 尼可地尔冻干粉的制备方法 |
US20090076095A1 (en) * | 2007-09-15 | 2009-03-19 | Protia, Llc | Deuterium-enriched nicorandil |
GB0720516D0 (en) * | 2007-10-18 | 2007-11-28 | Cadbury Schweppes Plc | Comestible products |
MX2012006240A (es) | 2009-12-02 | 2012-10-03 | Aptalis Pharma Ltd | Microcapsulas de fexofenadina y composiciones que contienen las mismas. |
UY33173A (es) * | 2010-01-08 | 2011-07-29 | Eurand Inc | |
CN111606847B (zh) * | 2020-05-26 | 2021-12-31 | 中国科学院上海药物研究所 | 尼可地尔与1-羟基-2-萘甲酸的共晶及其制备方法和应用 |
CN114732792A (zh) * | 2022-03-25 | 2022-07-12 | 北京诺康达医药科技股份有限公司 | 一种尼可地尔口腔崩解片及其制备方法 |
CN115317456A (zh) * | 2022-08-17 | 2022-11-11 | 北京科源创欣科技有限公司 | 一种尼可地尔片组合物及其制备方法 |
CN115282123B (zh) * | 2022-09-13 | 2023-11-03 | 南京比逊医药科技有限公司 | 一种稳定的尼可地尔制剂的制备方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3168438A (en) * | 1962-08-09 | 1965-02-02 | Synergistics Inc | Vasodilation by nitric acid ester derivatives of nicotinic acid |
US3332848A (en) * | 1963-07-10 | 1967-07-25 | Hoffmann La Roche | Microcrystalline cellulose with starch in niacinamide ascorbic acid tablet granulations |
US3577491A (en) * | 1968-01-02 | 1971-05-04 | Miles Lab | Tableting |
US4200640A (en) * | 1976-04-02 | 1980-04-29 | Chugai Seiyaku Kabushiki Kaisha | Nitric ester of N-(2-hydroxyethyl)nicotinamide and pharmaceutical use |
AU509591B2 (en) * | 1976-04-02 | 1980-05-15 | Chugai Seiyaku Kabushiki Kaisha | Pyridine derivatives |
JPS599539B2 (ja) * | 1979-11-13 | 1984-03-03 | 日本化薬株式会社 | ニトログリセリン水溶液及びその製造法 |
US4490377A (en) * | 1980-07-29 | 1984-12-25 | Syntex (U.S.A.) Inc. | Acid stabilized compositions of thieno-pyridine derived compounds |
EP0045238B1 (en) * | 1980-07-29 | 1986-10-01 | Sanofi S.A. | Acid stabilized compositions of thieno-pyridine derived compounds and process for preventing degradation of such compounds |
US4382091A (en) * | 1981-04-30 | 1983-05-03 | Syntex (U.S.A.) Inc. | Stabilization of 1-substituted imidazole derivatives in talc |
JPS5885819A (ja) * | 1981-11-17 | 1983-05-23 | Chugai Pharmaceut Co Ltd | 気管支拡張剤 |
DK150008C (da) * | 1981-11-20 | 1987-05-25 | Benzon As Alfred | Fremgangsmaade til fremstilling af et farmaceutisk oralt polydepotpraeparat |
DE3244178A1 (de) * | 1982-11-30 | 1984-05-30 | Bayer Ag, 5090 Leverkusen | 1,4-dihydropyridinderivate, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
-
1984
- 1984-12-17 JP JP59265888A patent/JPH0653658B2/ja not_active Expired - Lifetime
-
1985
- 1985-12-04 AU AU50762/85A patent/AU579431B2/en not_active Expired
- 1985-12-06 CA CA000497114A patent/CA1255227A/en not_active Expired
- 1985-12-09 ZA ZA859390A patent/ZA859390B/xx unknown
- 1985-12-12 AR AR85302556A patent/AR241515A1/es active
- 1985-12-16 EP EP85116032A patent/EP0185347B1/en not_active Expired - Lifetime
- 1985-12-16 HU HU854801A patent/HU195731B/hu unknown
- 1985-12-16 NO NO855048A patent/NO171826C/no not_active IP Right Cessation
- 1985-12-16 DK DK583385A patent/DK167171B1/da not_active IP Right Cessation
- 1985-12-16 DE DE8585116032T patent/DE3578373D1/de not_active Expired - Lifetime
- 1985-12-16 AT AT85116032T patent/ATE54050T1/de not_active IP Right Cessation
- 1985-12-16 IE IE317685A patent/IE59158B1/en not_active IP Right Cessation
- 1985-12-16 RU SU853993193A patent/RU1811401C/ru active
- 1985-12-16 KR KR1019850009452A patent/KR930007251B1/ko not_active IP Right Cessation
- 1985-12-16 PT PT81680A patent/PT81680B/pt unknown
- 1985-12-17 CN CN85109190A patent/CN1007209B/zh not_active Expired
- 1985-12-17 YU YU1973/85A patent/YU45292B/xx unknown
- 1985-12-17 FI FI855032A patent/FI84781C/fi not_active IP Right Cessation
- 1985-12-17 MX MX000985A patent/MX166095B/es unknown
-
1988
- 1988-01-21 US US07/147,129 patent/US4803213A/en not_active Expired - Lifetime
-
1993
- 1993-04-23 SG SG52493A patent/SG52493G/en unknown
- 1993-07-08 HK HK654/93A patent/HK65493A/xx not_active IP Right Cessation
-
1998
- 1998-04-27 BA BA980214A patent/BA98214B1/bs active
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