DK153546C - Analogifremgangsmaade til fremstilling af l-n-n-propylpipecolinsyre-2,6-xylidid eller et farmaceutisk acceptabelt, vandoploeseligt salt deraf - Google Patents

Analogifremgangsmaade til fremstilling af l-n-n-propylpipecolinsyre-2,6-xylidid eller et farmaceutisk acceptabelt, vandoploeseligt salt deraf

Info

Publication number
DK153546C
DK153546C DK135685A DK135685A DK153546C DK 153546 C DK153546 C DK 153546C DK 135685 A DK135685 A DK 135685A DK 135685 A DK135685 A DK 135685A DK 153546 C DK153546 C DK 153546C
Authority
DK
Denmark
Prior art keywords
xylidide
acid
analogue
preparation
water soluble
Prior art date
Application number
DK135685A
Other languages
English (en)
Other versions
DK153546B (da
DK135685A (da
DK135685D0 (da
Inventor
Af Ekenstam Bo Thuresson
Christer Bovin
Original Assignee
Astra Laekemedel Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Laekemedel Ab filed Critical Astra Laekemedel Ab
Publication of DK135685A publication Critical patent/DK135685A/da
Publication of DK135685D0 publication Critical patent/DK135685D0/da
Publication of DK153546B publication Critical patent/DK153546B/da
Application granted granted Critical
Publication of DK153546C publication Critical patent/DK153546C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DK135685A 1983-08-01 1985-03-26 Analogifremgangsmaade til fremstilling af l-n-n-propylpipecolinsyre-2,6-xylidid eller et farmaceutisk acceptabelt, vandoploeseligt salt deraf DK153546C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NO8300029 1983-08-01
PCT/NO1983/000029 WO1985000599A1 (en) 1983-08-01 1983-08-01 L-N-n-PROPYLPIPECOLIC ACID-2,6-XYLIDIDE AND METHOD FOR PREPARING THE SAME

Publications (4)

Publication Number Publication Date
DK135685A DK135685A (da) 1985-03-26
DK135685D0 DK135685D0 (da) 1985-03-26
DK153546B DK153546B (da) 1988-07-25
DK153546C true DK153546C (da) 1988-12-05

Family

ID=19907251

Family Applications (1)

Application Number Title Priority Date Filing Date
DK135685A DK153546C (da) 1983-08-01 1985-03-26 Analogifremgangsmaade til fremstilling af l-n-n-propylpipecolinsyre-2,6-xylidid eller et farmaceutisk acceptabelt, vandoploeseligt salt deraf

Country Status (12)

Country Link
EP (1) EP0151110B1 (da)
JP (1) JPS60502054A (da)
AT (1) ATE40994T1 (da)
AU (1) AU560367B2 (da)
CY (1) CY1623A (da)
DE (1) DE3379266D1 (da)
DK (1) DK153546C (da)
FI (1) FI80020C (da)
HK (1) HK98391A (da)
MY (1) MY101904A (da)
SG (1) SG87991G (da)
WO (1) WO1985000599A1 (da)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE451840B (sv) * 1986-01-03 1987-11-02 Astra Laekemedel Ab Optiskt rent monohydrat av s-(-)-1-propyl-2',6'-pipekoloxylididhydroklorid, sett att framstella denna och farmaceutiska beredningar for lokalbedovning
PT86249B (pt) * 1987-02-06 1991-02-08 Fisons Corp Processo de preparacao de derivados de azaciclocarboxamida
US5047541A (en) * 1987-02-06 1991-09-10 Fisons Corporation 2-azacyclocarboxamide derivatives
SE9000288D0 (sv) * 1990-01-26 1990-01-26 Astra Ab New use
FR2702220B1 (fr) * 1993-03-03 1995-05-12 Synthelabo Dédoublement enzymatique de dérivés de 4-alkyl-2-pipéridine-carboxylate et utilisation des composés obtenus, comme intermédiaires de synthèse.
SE9302218D0 (sv) * 1993-06-28 1993-06-28 Ab Astra New use
WO1996012700A1 (en) * 1994-10-25 1996-05-02 Chiroscience Limited Process for preparing levobupivacaine and analogues thereof
GB9504876D0 (en) * 1995-03-10 1995-04-26 Chiroscience Ltd Compounds and process
SE9501808D0 (sv) * 1995-05-16 1995-05-16 Astra Ab New process
GB9704351D0 (en) * 1997-03-03 1997-04-23 Chiroscience Ltd Levobupivacaine and its use
US7799337B2 (en) 1997-07-21 2010-09-21 Levin Bruce H Method for directed intranasal administration of a composition
SE9800139D0 (sv) * 1998-01-21 1998-01-21 Astra Ab New use
US7247729B2 (en) 2001-09-10 2007-07-24 Mercian Corporation Method for producing pipecolamide derivative
US7683175B2 (en) 2005-06-06 2010-03-23 Navinta, Llc Process of making optically pure L-pipecolic acid and process of making anesthetics and intermediates therefrom
ITMI20051144A1 (it) * 2005-06-17 2006-12-18 Molteni & C Dei Fratellei Alit "procedimento per la preparazione d'una soluzione iniettabile di (2s)-n-(2;6-dimetil-fenil)-1-propil-2-piperidincarbossiamide"
US20090187024A1 (en) * 2006-04-25 2009-07-23 Dishman Pharmaceuticals And Chemicals Ltd. Ropivacaine hydrochloride anhydrate and the preparation thereof
US20100099772A1 (en) 2006-11-20 2010-04-22 Bean Bruce P Methods, compositions, and kits for treating pain and pruritis
KR100844336B1 (ko) * 2007-01-16 2008-07-07 하나제약 주식회사 레보부피바카인 및 이의 염산염의 신규한 제조방법
US8227114B2 (en) 2007-07-05 2012-07-24 Samsung Sdi Co., Ltd. Preparing method of negative active material for non-aqueous electrolyte secondary battery and negative active material prepared thereby
WO2009044404A1 (en) * 2007-10-01 2009-04-09 Ramniwas Goel Process for the preparation of (s)-ropivacaine hydrochloride monohydrate
ATE555093T1 (de) * 2008-01-15 2012-05-15 Pharmathen Sa Verfahren zur herstellung einer (s)-1-alkyl-2i,6i-pipecoloxylididverbindung
US8473062B2 (en) 2008-05-01 2013-06-25 Autonomic Technologies, Inc. Method and device for the treatment of headache
US8412336B2 (en) 2008-12-29 2013-04-02 Autonomic Technologies, Inc. Integrated delivery and visualization tool for a neuromodulation system
US8494641B2 (en) 2009-04-22 2013-07-23 Autonomic Technologies, Inc. Implantable neurostimulator with integral hermetic electronic enclosure, circuit substrate, monolithic feed-through, lead assembly and anchoring mechanism
US9320908B2 (en) 2009-01-15 2016-04-26 Autonomic Technologies, Inc. Approval per use implanted neurostimulator
EP3485881B1 (en) 2009-07-10 2024-03-13 President and Fellows of Harvard College Permanently charged sodium and calcium channel blockers as anti-inflammatory agents
RU2504538C2 (ru) * 2012-04-17 2014-01-20 Государственное бюджетное образовательное учреждение высшего профессионального образования "Пермская государственная фармацевтическая академия" Министерства здравоохранения и социального развития Российской Федерации (ГБОУ ВПО ПГФА Минздравсоцразвития России) 2,6-диметиланилид n-циклогексилпирролидин-2-карбоновой кислоты гидрохлорид, проявляющий активность при поверхностной, инфильтрационной и проводниковой анестезии
US9108942B1 (en) 2014-11-05 2015-08-18 Mahesh Kandula Compositions and methods for the treatment of moderate to severe pain
CN103073484B (zh) * 2013-01-28 2014-10-22 山东诚创医药技术开发有限公司 一种甲哌卡因及其光学对映体的制备方法
US9333187B1 (en) 2013-05-15 2016-05-10 Cellix Bio Private Limited Compositions and methods for the treatment of inflammatory bowel disease
WO2014195961A1 (en) 2013-06-04 2014-12-11 Mahesh Kandula Compositions and methods for the treatment of diabetes and pre-diabetes
CN103304471B (zh) * 2013-07-12 2015-02-04 四川省惠达药业有限公司 一种甲磺酸罗哌卡因化合物、其制备方法及其药物组合物
US9096537B1 (en) 2014-12-31 2015-08-04 Mahesh Kandula Compositions and methods for the treatment of mucositis
CA2976314C (en) 2014-09-26 2021-02-23 Cellix Bio Private Limited Compositions and methods for the treatment of epilepsy and neurological disorders
CN107207403A (zh) 2014-09-29 2017-09-26 塞尔利克斯生物私人有限公司 用于治疗多发性硬化的组合物和方法
US9173877B1 (en) * 2014-11-05 2015-11-03 Cellix Bio Private Limited Compositions and methods for the treatment of local pain
US9932294B2 (en) 2014-12-01 2018-04-03 Cellix Bio Private Limited Compositions and methods for the treatment of multiple sclerosis
DK3242869T3 (da) 2015-01-06 2022-01-31 Cellix Bio Private Ltd Sammensætninger og fremgangsmåder til behanding af inflammation og smerte
WO2017024037A1 (en) 2015-08-03 2017-02-09 President And Fellows Of Harvard College Charged ion channel blockers and methods for use
US10786485B1 (en) 2019-03-11 2020-09-29 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
US10780083B1 (en) 2019-03-11 2020-09-22 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
CA3129117A1 (en) 2019-03-11 2020-09-17 Bridget Mccarthy Cole Charged ion channel blockers and methods for use
EP3937945A4 (en) 2019-03-11 2023-01-04 Nocion Therapeutics, Inc. CHARGED ION CHANNEL BLOCKERS AND METHODS OF USE
JP2022527731A (ja) 2019-03-11 2022-06-06 ノシオン セラピューティクス，インコーポレイテッド エステル置換イオンチャンネル遮断薬および使用方法
US10933055B1 (en) 2019-11-06 2021-03-02 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
EP4054559A4 (en) 2019-11-06 2023-11-29 Nocion Therapeutics, Inc. CHARGED ION CHANNEL BLOCKERS AND METHODS OF USE
WO2021183639A1 (en) 2020-03-11 2021-09-16 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
CN112294809B (zh) * 2020-11-20 2022-03-29 四川大学华西医院 一种低毒性局部麻醉药及其制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE341404B (da) * 1967-05-18 1971-12-27 Sterling Drug Inc

Also Published As

Publication number Publication date
DE3379266D1 (en) 1989-04-06
DK153546B (da) 1988-07-25
EP0151110B1 (en) 1989-03-01
HK98391A (en) 1991-12-13
FI851266A0 (fi) 1985-03-29
DK135685A (da) 1985-03-26
WO1985000599A1 (en) 1985-02-14
CY1623A (en) 1992-07-10
JPS60502054A (ja) 1985-11-28
EP0151110A1 (en) 1985-08-14
FI851266L (fi) 1985-03-29
ATE40994T1 (de) 1989-03-15
MY101904A (en) 1992-02-15
DK135685D0 (da) 1985-03-26
SG87991G (en) 1991-11-22
FI80020C (fi) 1990-04-10
FI80020B (fi) 1989-12-29
JPH0559903B2 (da) 1993-09-01
AU1779683A (en) 1985-03-04
AU560367B2 (en) 1987-04-02

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