ATE40994T1 - L-n-n-propylpipekolsaeure-2,6-xylidid und dessen herstellung. - Google Patents
L-n-n-propylpipekolsaeure-2,6-xylidid und dessen herstellung.Info
- Publication number
- ATE40994T1 ATE40994T1 AT83902297T AT83902297T ATE40994T1 AT E40994 T1 ATE40994 T1 AT E40994T1 AT 83902297 T AT83902297 T AT 83902297T AT 83902297 T AT83902297 T AT 83902297T AT E40994 T1 ATE40994 T1 AT E40994T1
- Authority
- AT
- Austria
- Prior art keywords
- xylidide
- acid
- propylpipecolic
- yield
- pipecolic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/NO1983/000029 WO1985000599A1 (en) | 1983-08-01 | 1983-08-01 | L-N-n-PROPYLPIPECOLIC ACID-2,6-XYLIDIDE AND METHOD FOR PREPARING THE SAME |
EP83902297A EP0151110B1 (de) | 1983-08-01 | 1983-08-01 | L-n-n-propylpipekolsäure-2,6-xylidid und dessen herstellung |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE40994T1 true ATE40994T1 (de) | 1989-03-15 |
Family
ID=19907251
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT83902297T ATE40994T1 (de) | 1983-08-01 | 1983-08-01 | L-n-n-propylpipekolsaeure-2,6-xylidid und dessen herstellung. |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0151110B1 (de) |
JP (1) | JPS60502054A (de) |
AT (1) | ATE40994T1 (de) |
AU (1) | AU560367B2 (de) |
CY (1) | CY1623A (de) |
DE (1) | DE3379266D1 (de) |
DK (1) | DK153546C (de) |
FI (1) | FI80020C (de) |
HK (1) | HK98391A (de) |
MY (1) | MY101904A (de) |
SG (1) | SG87991G (de) |
WO (1) | WO1985000599A1 (de) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE451840B (sv) * | 1986-01-03 | 1987-11-02 | Astra Laekemedel Ab | Optiskt rent monohydrat av s-(-)-1-propyl-2',6'-pipekoloxylididhydroklorid, sett att framstella denna och farmaceutiska beredningar for lokalbedovning |
PT86249B (pt) * | 1987-02-06 | 1991-02-08 | Fisons Corp | Processo de preparacao de derivados de azaciclocarboxamida |
US5047541A (en) * | 1987-02-06 | 1991-09-10 | Fisons Corporation | 2-azacyclocarboxamide derivatives |
SE9000288D0 (sv) * | 1990-01-26 | 1990-01-26 | Astra Ab | New use |
FR2702220B1 (fr) * | 1993-03-03 | 1995-05-12 | Synthelabo | Dédoublement enzymatique de dérivés de 4-alkyl-2-pipéridine-carboxylate et utilisation des composés obtenus, comme intermédiaires de synthèse. |
SE9302218D0 (sv) | 1993-06-28 | 1993-06-28 | Ab Astra | New use |
PT788481E (pt) * | 1994-10-25 | 2004-01-30 | Darwin Discovery Ltd | Processo para preparacao de levobupivacaina e seus analogos |
GB9504876D0 (en) * | 1995-03-10 | 1995-04-26 | Chiroscience Ltd | Compounds and process |
SE9501808D0 (sv) * | 1995-05-16 | 1995-05-16 | Astra Ab | New process |
GB9704351D0 (en) * | 1997-03-03 | 1997-04-23 | Chiroscience Ltd | Levobupivacaine and its use |
US7799337B2 (en) | 1997-07-21 | 2010-09-21 | Levin Bruce H | Method for directed intranasal administration of a composition |
SE9800139D0 (sv) | 1998-01-21 | 1998-01-21 | Astra Ab | New use |
JPWO2003024930A1 (ja) * | 2001-09-10 | 2004-12-24 | メルシャン株式会社 | ピペコリン酸アミド誘導体の製造方法 |
US7683175B2 (en) | 2005-06-06 | 2010-03-23 | Navinta, Llc | Process of making optically pure L-pipecolic acid and process of making anesthetics and intermediates therefrom |
ITMI20051144A1 (it) * | 2005-06-17 | 2006-12-18 | Molteni & C Dei Fratellei Alit | "procedimento per la preparazione d'una soluzione iniettabile di (2s)-n-(2;6-dimetil-fenil)-1-propil-2-piperidincarbossiamide" |
EP2010491A1 (de) * | 2006-04-25 | 2009-01-07 | Disham Pharmaceuticals and Chemicals Ltd. | Ropivacainhydrochlorid-anhydrat und dessen herstellung |
EP2101819B1 (de) | 2006-11-20 | 2013-01-09 | President and Fellows of Harvard College | Verfahren, zusammensetzungen und sets zur behandlung von schmerzen und pruritis |
KR100844336B1 (ko) * | 2007-01-16 | 2008-07-07 | 하나제약 주식회사 | 레보부피바카인 및 이의 염산염의 신규한 제조방법 |
US8227114B2 (en) | 2007-07-05 | 2012-07-24 | Samsung Sdi Co., Ltd. | Preparing method of negative active material for non-aqueous electrolyte secondary battery and negative active material prepared thereby |
WO2009044404A1 (en) * | 2007-10-01 | 2009-04-09 | Ramniwas Goel | Process for the preparation of (s)-ropivacaine hydrochloride monohydrate |
PT2234974E (pt) * | 2008-01-15 | 2012-05-29 | Pharmathen Sa | Processo para a preparação do composto (s)-l-alquil-2',6'- pipecoloxilidida |
US8473062B2 (en) | 2008-05-01 | 2013-06-25 | Autonomic Technologies, Inc. | Method and device for the treatment of headache |
US8412336B2 (en) | 2008-12-29 | 2013-04-02 | Autonomic Technologies, Inc. | Integrated delivery and visualization tool for a neuromodulation system |
US8494641B2 (en) | 2009-04-22 | 2013-07-23 | Autonomic Technologies, Inc. | Implantable neurostimulator with integral hermetic electronic enclosure, circuit substrate, monolithic feed-through, lead assembly and anchoring mechanism |
US9320908B2 (en) | 2009-01-15 | 2016-04-26 | Autonomic Technologies, Inc. | Approval per use implanted neurostimulator |
EP2995303A1 (de) | 2009-07-10 | 2016-03-16 | President and Fellows of Harvard College | Permanent geladene natrium- und calciumkanalblocker als entzündungshemmende mittel |
RU2504538C2 (ru) * | 2012-04-17 | 2014-01-20 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Пермская государственная фармацевтическая академия" Министерства здравоохранения и социального развития Российской Федерации (ГБОУ ВПО ПГФА Минздравсоцразвития России) | 2,6-диметиланилид n-циклогексилпирролидин-2-карбоновой кислоты гидрохлорид, проявляющий активность при поверхностной, инфильтрационной и проводниковой анестезии |
US9108942B1 (en) | 2014-11-05 | 2015-08-18 | Mahesh Kandula | Compositions and methods for the treatment of moderate to severe pain |
CN103073484B (zh) * | 2013-01-28 | 2014-10-22 | 山东诚创医药技术开发有限公司 | 一种甲哌卡因及其光学对映体的制备方法 |
US9333187B1 (en) | 2013-05-15 | 2016-05-10 | Cellix Bio Private Limited | Compositions and methods for the treatment of inflammatory bowel disease |
SG11201509782TA (en) | 2013-06-04 | 2015-12-30 | Cellix Bio Private Ltd | Compositions and methods for the treatment of diabetes and pre-diabetes |
CN103304471B (zh) * | 2013-07-12 | 2015-02-04 | 四川省惠达药业有限公司 | 一种甲磺酸罗哌卡因化合物、其制备方法及其药物组合物 |
US9096537B1 (en) | 2014-12-31 | 2015-08-04 | Mahesh Kandula | Compositions and methods for the treatment of mucositis |
WO2016046835A1 (en) | 2014-09-26 | 2016-03-31 | Cellix Bio Private Limited | Compositions and methods for the treatment of epilepsy and neurological disorders |
SG11201702554QA (en) | 2014-09-29 | 2017-04-27 | Cellix Bio Private Ltd | Compositions and methods for the treatment of multiple sclerosis |
US9173877B1 (en) * | 2014-11-05 | 2015-11-03 | Cellix Bio Private Limited | Compositions and methods for the treatment of local pain |
US9932294B2 (en) | 2014-12-01 | 2018-04-03 | Cellix Bio Private Limited | Compositions and methods for the treatment of multiple sclerosis |
CN110845355A (zh) | 2015-01-06 | 2020-02-28 | 塞尔利克斯生物私人有限公司 | 用于治疗炎症和疼痛的组合物和方法 |
KR20180069782A (ko) | 2015-08-03 | 2018-06-25 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 하전 이온 채널 블록커 및 이용 방법 |
KR20210145164A (ko) | 2019-03-11 | 2021-12-01 | 녹시온 테라퓨틱스 인코포레이티드 | 에스테르 치환된 이온 채널 차단제 및 사용 방법 |
US10786485B1 (en) | 2019-03-11 | 2020-09-29 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
AU2020234961A1 (en) | 2019-03-11 | 2021-09-30 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
US10780083B1 (en) | 2019-03-11 | 2020-09-22 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
CA3129131A1 (en) | 2019-03-11 | 2020-09-17 | Bridget Mccarthy Cole | Charged ion channel blockers and methods for use |
EP4054586A4 (de) | 2019-11-06 | 2023-11-22 | Nocion Therapeutics, Inc. | Geladene ionenkanalblocker und verfahren zur verwendung |
US10842798B1 (en) | 2019-11-06 | 2020-11-24 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
KR20230022830A (ko) | 2020-03-11 | 2023-02-16 | 녹시온 테라퓨틱스 인코포레이티드 | 하전된 이온 채널 차단제 및 사용 방법 |
CN112294809B (zh) * | 2020-11-20 | 2022-03-29 | 四川大学华西医院 | 一种低毒性局部麻醉药及其制备方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE341404B (de) * | 1967-05-18 | 1971-12-27 | Sterling Drug Inc |
-
1983
- 1983-08-01 DE DE8383902297T patent/DE3379266D1/de not_active Expired
- 1983-08-01 AU AU17796/83A patent/AU560367B2/en not_active Expired
- 1983-08-01 JP JP58502459A patent/JPS60502054A/ja active Granted
- 1983-08-01 WO PCT/NO1983/000029 patent/WO1985000599A1/en active IP Right Grant
- 1983-08-01 EP EP83902297A patent/EP0151110B1/de not_active Expired
- 1983-08-01 AT AT83902297T patent/ATE40994T1/de not_active IP Right Cessation
-
1985
- 1985-03-26 DK DK135685A patent/DK153546C/da not_active IP Right Cessation
- 1985-03-29 FI FI851266A patent/FI80020C/fi not_active IP Right Cessation
-
1987
- 1987-09-28 MY MYPI87001989A patent/MY101904A/en unknown
-
1991
- 1991-10-22 SG SG879/91A patent/SG87991G/en unknown
- 1991-12-05 HK HK983/91A patent/HK98391A/xx not_active IP Right Cessation
-
1992
- 1992-07-10 CY CY1623A patent/CY1623A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
DK135685D0 (da) | 1985-03-26 |
AU1779683A (en) | 1985-03-04 |
EP0151110B1 (de) | 1989-03-01 |
DK153546B (da) | 1988-07-25 |
WO1985000599A1 (en) | 1985-02-14 |
FI80020C (fi) | 1990-04-10 |
JPH0559903B2 (de) | 1993-09-01 |
FI851266A0 (fi) | 1985-03-29 |
DK135685A (da) | 1985-03-26 |
CY1623A (en) | 1992-07-10 |
FI851266L (fi) | 1985-03-29 |
JPS60502054A (ja) | 1985-11-28 |
DE3379266D1 (en) | 1989-04-06 |
SG87991G (en) | 1991-11-22 |
DK153546C (da) | 1988-12-05 |
AU560367B2 (en) | 1987-04-02 |
HK98391A (en) | 1991-12-13 |
EP0151110A1 (de) | 1985-08-14 |
MY101904A (en) | 1992-02-15 |
FI80020B (fi) | 1989-12-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
EELA | Cancelled due to lapse of time |