ATE40994T1 - L-n-n-propylpipekolsaeure-2,6-xylidid und dessen herstellung. - Google Patents

L-n-n-propylpipekolsaeure-2,6-xylidid und dessen herstellung.

Info

Publication number
ATE40994T1
ATE40994T1 AT83902297T AT83902297T ATE40994T1 AT E40994 T1 ATE40994 T1 AT E40994T1 AT 83902297 T AT83902297 T AT 83902297T AT 83902297 T AT83902297 T AT 83902297T AT E40994 T1 ATE40994 T1 AT E40994T1
Authority
AT
Austria
Prior art keywords
xylidide
acid
propylpipecolic
yield
pipecolic
Prior art date
Application number
AT83902297T
Other languages
English (en)
Inventor
Af Ekenstam Bo Thuresson
Christer Bovin
Original Assignee
Astra Laekemedel Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Laekemedel Ab filed Critical Astra Laekemedel Ab
Application granted granted Critical
Publication of ATE40994T1 publication Critical patent/ATE40994T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT83902297T 1983-08-01 1983-08-01 L-n-n-propylpipekolsaeure-2,6-xylidid und dessen herstellung. ATE40994T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/NO1983/000029 WO1985000599A1 (en) 1983-08-01 1983-08-01 L-N-n-PROPYLPIPECOLIC ACID-2,6-XYLIDIDE AND METHOD FOR PREPARING THE SAME
EP83902297A EP0151110B1 (de) 1983-08-01 1983-08-01 L-n-n-propylpipekolsäure-2,6-xylidid und dessen herstellung

Publications (1)

Publication Number Publication Date
ATE40994T1 true ATE40994T1 (de) 1989-03-15

Family

ID=19907251

Family Applications (1)

Application Number Title Priority Date Filing Date
AT83902297T ATE40994T1 (de) 1983-08-01 1983-08-01 L-n-n-propylpipekolsaeure-2,6-xylidid und dessen herstellung.

Country Status (12)

Country Link
EP (1) EP0151110B1 (de)
JP (1) JPS60502054A (de)
AT (1) ATE40994T1 (de)
AU (1) AU560367B2 (de)
CY (1) CY1623A (de)
DE (1) DE3379266D1 (de)
DK (1) DK153546C (de)
FI (1) FI80020C (de)
HK (1) HK98391A (de)
MY (1) MY101904A (de)
SG (1) SG87991G (de)
WO (1) WO1985000599A1 (de)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE451840B (sv) * 1986-01-03 1987-11-02 Astra Laekemedel Ab Optiskt rent monohydrat av s-(-)-1-propyl-2',6'-pipekoloxylididhydroklorid, sett att framstella denna och farmaceutiska beredningar for lokalbedovning
US5047541A (en) * 1987-02-06 1991-09-10 Fisons Corporation 2-azacyclocarboxamide derivatives
PT86249B (pt) * 1987-02-06 1991-02-08 Fisons Corp Processo de preparacao de derivados de azaciclocarboxamida
SE9000288D0 (sv) * 1990-01-26 1990-01-26 Astra Ab New use
FR2702220B1 (fr) * 1993-03-03 1995-05-12 Synthelabo Dédoublement enzymatique de dérivés de 4-alkyl-2-pipéridine-carboxylate et utilisation des composés obtenus, comme intermédiaires de synthèse.
SE9302218D0 (sv) * 1993-06-28 1993-06-28 Ab Astra New use
ES2082703B1 (es) * 1993-11-04 1996-12-16 Inst Investigacion Desarrollo Nuevos derivados de ciclopropilo, procedimientos para su preparacion y aplicaciones.
AU694569B2 (en) * 1994-10-25 1998-07-23 Darwin Discovery Limited Process for preparing levobupivacaine and analogues thereof
GB9504876D0 (en) * 1995-03-10 1995-04-26 Chiroscience Ltd Compounds and process
SE9501808D0 (sv) * 1995-05-16 1995-05-16 Astra Ab New process
GB9704351D0 (en) * 1997-03-03 1997-04-23 Chiroscience Ltd Levobupivacaine and its use
US7799337B2 (en) 1997-07-21 2010-09-21 Levin Bruce H Method for directed intranasal administration of a composition
SE9800139D0 (sv) 1998-01-21 1998-01-21 Astra Ab New use
JPWO2003024930A1 (ja) 2001-09-10 2004-12-24 メルシャン株式会社 ピペコリン酸アミド誘導体の製造方法
US7683175B2 (en) 2005-06-06 2010-03-23 Navinta, Llc Process of making optically pure L-pipecolic acid and process of making anesthetics and intermediates therefrom
ITMI20051144A1 (it) * 2005-06-17 2006-12-18 Molteni & C Dei Fratellei Alit "procedimento per la preparazione d'una soluzione iniettabile di (2s)-n-(2;6-dimetil-fenil)-1-propil-2-piperidincarbossiamide"
US20090187024A1 (en) * 2006-04-25 2009-07-23 Dishman Pharmaceuticals And Chemicals Ltd. Ropivacaine hydrochloride anhydrate and the preparation thereof
EP2446903B1 (de) 2006-11-20 2019-10-09 President and Fellows of Harvard College Zusammensetzungen zur Behandlung von Juckreiz
KR100844336B1 (ko) * 2007-01-16 2008-07-07 하나제약 주식회사 레보부피바카인 및 이의 염산염의 신규한 제조방법
US8227114B2 (en) 2007-07-05 2012-07-24 Samsung Sdi Co., Ltd. Preparing method of negative active material for non-aqueous electrolyte secondary battery and negative active material prepared thereby
WO2009044404A1 (en) * 2007-10-01 2009-04-09 Ramniwas Goel Process for the preparation of (s)-ropivacaine hydrochloride monohydrate
WO2009089841A1 (en) * 2008-01-15 2009-07-23 Pharmathen S.A. Process for the preparation of (s)-1-alkyl-2',6'-pipecoloxylidide compound
US8473062B2 (en) 2008-05-01 2013-06-25 Autonomic Technologies, Inc. Method and device for the treatment of headache
US8412336B2 (en) 2008-12-29 2013-04-02 Autonomic Technologies, Inc. Integrated delivery and visualization tool for a neuromodulation system
US8494641B2 (en) 2009-04-22 2013-07-23 Autonomic Technologies, Inc. Implantable neurostimulator with integral hermetic electronic enclosure, circuit substrate, monolithic feed-through, lead assembly and anchoring mechanism
US9320908B2 (en) 2009-01-15 2016-04-26 Autonomic Technologies, Inc. Approval per use implanted neurostimulator
US20120172429A1 (en) 2009-07-10 2012-07-05 Woolf Clifford J Permanently charged sodium and calcium channel blockers as anti- inflammatory agents
RU2504538C2 (ru) * 2012-04-17 2014-01-20 Государственное бюджетное образовательное учреждение высшего профессионального образования "Пермская государственная фармацевтическая академия" Министерства здравоохранения и социального развития Российской Федерации (ГБОУ ВПО ПГФА Минздравсоцразвития России) 2,6-диметиланилид n-циклогексилпирролидин-2-карбоновой кислоты гидрохлорид, проявляющий активность при поверхностной, инфильтрационной и проводниковой анестезии
US9108942B1 (en) 2014-11-05 2015-08-18 Mahesh Kandula Compositions and methods for the treatment of moderate to severe pain
CN103073484B (zh) * 2013-01-28 2014-10-22 山东诚创医药技术开发有限公司 一种甲哌卡因及其光学对映体的制备方法
US9333187B1 (en) 2013-05-15 2016-05-10 Cellix Bio Private Limited Compositions and methods for the treatment of inflammatory bowel disease
SG11201509782TA (en) 2013-06-04 2015-12-30 Cellix Bio Private Ltd Compositions and methods for the treatment of diabetes and pre-diabetes
CN103304471B (zh) * 2013-07-12 2015-02-04 四川省惠达药业有限公司 一种甲磺酸罗哌卡因化合物、其制备方法及其药物组合物
US9096537B1 (en) 2014-12-31 2015-08-04 Mahesh Kandula Compositions and methods for the treatment of mucositis
NZ736131A (en) 2014-09-26 2019-04-26 Cellix Bio Private Ltd Compositions and methods for the treatment of epilepsy and neurological disorders
JP6698643B2 (ja) 2014-09-29 2020-05-27 セリックス バイオ プライヴェート リミテッドＣｅｌｌｉｘ Ｂｉｏ Ｐｒｉｖａｔｅ Ｌｉｍｉｔｅｄ 多発性硬化症の治療のための組成物及び方法
US9173877B1 (en) * 2014-11-05 2015-11-03 Cellix Bio Private Limited Compositions and methods for the treatment of local pain
US9932294B2 (en) 2014-12-01 2018-04-03 Cellix Bio Private Limited Compositions and methods for the treatment of multiple sclerosis
EP3242869B1 (de) 2015-01-06 2021-10-27 Cellixbio Private Limited Zusammensetzungen und verfahren zur behandlung von entzündungen und schmerzen
US11021443B2 (en) 2015-08-03 2021-06-01 President And Fellows Of Harvard College Charged ion channel blockers and methods for use
US10786485B1 (en) 2019-03-11 2020-09-29 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
US10780083B1 (en) 2019-03-11 2020-09-22 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
CA3129111A1 (en) 2019-03-11 2020-09-17 Bridget M. Cole Charged ion channel blockers and methods for use
MA55320A (fr) 2019-03-11 2022-01-19 Nocion Therapeutics Inc Bloqueurs de canaux ioniques substitués par un ester et méthodes d'utilisation
JP7692834B2 (ja) 2019-03-11 2025-06-16 ノシオン セラピューティクス，インコーポレイテッド 荷電したイオンチャンネル遮断薬および使用方法
US10933055B1 (en) 2019-11-06 2021-03-02 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
CN114828845A (zh) 2019-11-06 2022-07-29 诺西恩医疗公司 带电的离子通道阻滞剂及其使用方法
US12162851B2 (en) 2020-03-11 2024-12-10 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
EP4118070A4 (de) 2020-03-11 2024-04-10 Nocion Therapeutics, Inc. Geladene ionenkanalblocker und verfahren zur verwendung
CN112294809B (zh) * 2020-11-20 2022-03-29 四川大学华西医院 一种低毒性局部麻醉药及其制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE341404B (de) * 1967-05-18 1971-12-27 Sterling Drug Inc

Also Published As

Publication number Publication date
DK153546B (da) 1988-07-25
EP0151110B1 (de) 1989-03-01
DK135685D0 (da) 1985-03-26
JPS60502054A (ja) 1985-11-28
FI80020B (fi) 1989-12-29
FI851266A0 (fi) 1985-03-29
WO1985000599A1 (en) 1985-02-14
FI851266L (fi) 1985-03-29
EP0151110A1 (de) 1985-08-14
JPH0559903B2 (de) 1993-09-01
FI80020C (fi) 1990-04-10
DK153546C (da) 1988-12-05
AU1779683A (en) 1985-03-04
CY1623A (en) 1992-07-10
SG87991G (en) 1991-11-22
MY101904A (en) 1992-02-15
DE3379266D1 (en) 1989-04-06
DK135685A (da) 1985-03-26
AU560367B2 (en) 1987-04-02
HK98391A (en) 1991-12-13

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time