DE3379266D1 - L-n-n-propylpipecolic acid-2,6-xylidide and method for preparing the same - Google Patents
L-n-n-propylpipecolic acid-2,6-xylidide and method for preparing the sameInfo
- Publication number
- DE3379266D1 DE3379266D1 DE8383902297T DE3379266T DE3379266D1 DE 3379266 D1 DE3379266 D1 DE 3379266D1 DE 8383902297 T DE8383902297 T DE 8383902297T DE 3379266 T DE3379266 T DE 3379266T DE 3379266 D1 DE3379266 D1 DE 3379266D1
- Authority
- DE
- Germany
- Prior art keywords
- xylidide
- acid
- propylpipecolic
- preparing
- same
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/NO1983/000029 WO1985000599A1 (en) | 1983-08-01 | 1983-08-01 | L-N-n-PROPYLPIPECOLIC ACID-2,6-XYLIDIDE AND METHOD FOR PREPARING THE SAME |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3379266D1 true DE3379266D1 (en) | 1989-04-06 |
Family
ID=19907251
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8383902297T Expired DE3379266D1 (en) | 1983-08-01 | 1983-08-01 | L-n-n-propylpipecolic acid-2,6-xylidide and method for preparing the same |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0151110B1 (de) |
JP (1) | JPS60502054A (de) |
AT (1) | ATE40994T1 (de) |
AU (1) | AU560367B2 (de) |
CY (1) | CY1623A (de) |
DE (1) | DE3379266D1 (de) |
DK (1) | DK153546C (de) |
FI (1) | FI80020C (de) |
HK (1) | HK98391A (de) |
MY (1) | MY101904A (de) |
SG (1) | SG87991G (de) |
WO (1) | WO1985000599A1 (de) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE451840B (sv) * | 1986-01-03 | 1987-11-02 | Astra Laekemedel Ab | Optiskt rent monohydrat av s-(-)-1-propyl-2',6'-pipekoloxylididhydroklorid, sett att framstella denna och farmaceutiska beredningar for lokalbedovning |
PT86249B (pt) * | 1987-02-06 | 1991-02-08 | Fisons Corp | Processo de preparacao de derivados de azaciclocarboxamida |
US5047541A (en) * | 1987-02-06 | 1991-09-10 | Fisons Corporation | 2-azacyclocarboxamide derivatives |
SE9000288D0 (sv) * | 1990-01-26 | 1990-01-26 | Astra Ab | New use |
FR2702220B1 (fr) * | 1993-03-03 | 1995-05-12 | Synthelabo | Dédoublement enzymatique de dérivés de 4-alkyl-2-pipéridine-carboxylate et utilisation des composés obtenus, comme intermédiaires de synthèse. |
SE9302218D0 (sv) * | 1993-06-28 | 1993-06-28 | Ab Astra | New use |
WO1996012700A1 (en) * | 1994-10-25 | 1996-05-02 | Chiroscience Limited | Process for preparing levobupivacaine and analogues thereof |
GB9504876D0 (en) * | 1995-03-10 | 1995-04-26 | Chiroscience Ltd | Compounds and process |
SE9501808D0 (sv) * | 1995-05-16 | 1995-05-16 | Astra Ab | New process |
GB9704351D0 (en) * | 1997-03-03 | 1997-04-23 | Chiroscience Ltd | Levobupivacaine and its use |
US7799337B2 (en) | 1997-07-21 | 2010-09-21 | Levin Bruce H | Method for directed intranasal administration of a composition |
SE9800139D0 (sv) * | 1998-01-21 | 1998-01-21 | Astra Ab | New use |
US7247729B2 (en) | 2001-09-10 | 2007-07-24 | Mercian Corporation | Method for producing pipecolamide derivative |
US7683175B2 (en) | 2005-06-06 | 2010-03-23 | Navinta, Llc | Process of making optically pure L-pipecolic acid and process of making anesthetics and intermediates therefrom |
ITMI20051144A1 (it) * | 2005-06-17 | 2006-12-18 | Molteni & C Dei Fratellei Alit | "procedimento per la preparazione d'una soluzione iniettabile di (2s)-n-(2;6-dimetil-fenil)-1-propil-2-piperidincarbossiamide" |
US20090187024A1 (en) * | 2006-04-25 | 2009-07-23 | Dishman Pharmaceuticals And Chemicals Ltd. | Ropivacaine hydrochloride anhydrate and the preparation thereof |
US20100099772A1 (en) | 2006-11-20 | 2010-04-22 | Bean Bruce P | Methods, compositions, and kits for treating pain and pruritis |
KR100844336B1 (ko) * | 2007-01-16 | 2008-07-07 | 하나제약 주식회사 | 레보부피바카인 및 이의 염산염의 신규한 제조방법 |
US8227114B2 (en) | 2007-07-05 | 2012-07-24 | Samsung Sdi Co., Ltd. | Preparing method of negative active material for non-aqueous electrolyte secondary battery and negative active material prepared thereby |
WO2009044404A1 (en) * | 2007-10-01 | 2009-04-09 | Ramniwas Goel | Process for the preparation of (s)-ropivacaine hydrochloride monohydrate |
ATE555093T1 (de) * | 2008-01-15 | 2012-05-15 | Pharmathen Sa | Verfahren zur herstellung einer (s)-1-alkyl-2i,6i-pipecoloxylididverbindung |
US8473062B2 (en) | 2008-05-01 | 2013-06-25 | Autonomic Technologies, Inc. | Method and device for the treatment of headache |
US8412336B2 (en) | 2008-12-29 | 2013-04-02 | Autonomic Technologies, Inc. | Integrated delivery and visualization tool for a neuromodulation system |
US8494641B2 (en) | 2009-04-22 | 2013-07-23 | Autonomic Technologies, Inc. | Implantable neurostimulator with integral hermetic electronic enclosure, circuit substrate, monolithic feed-through, lead assembly and anchoring mechanism |
US9320908B2 (en) | 2009-01-15 | 2016-04-26 | Autonomic Technologies, Inc. | Approval per use implanted neurostimulator |
EP3485881B1 (de) | 2009-07-10 | 2024-03-13 | President and Fellows of Harvard College | Permanent geladene natrium- und calciumkanalblocker als entzündungshemmende mittel |
RU2504538C2 (ru) * | 2012-04-17 | 2014-01-20 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Пермская государственная фармацевтическая академия" Министерства здравоохранения и социального развития Российской Федерации (ГБОУ ВПО ПГФА Минздравсоцразвития России) | 2,6-диметиланилид n-циклогексилпирролидин-2-карбоновой кислоты гидрохлорид, проявляющий активность при поверхностной, инфильтрационной и проводниковой анестезии |
US9108942B1 (en) | 2014-11-05 | 2015-08-18 | Mahesh Kandula | Compositions and methods for the treatment of moderate to severe pain |
CN103073484B (zh) * | 2013-01-28 | 2014-10-22 | 山东诚创医药技术开发有限公司 | 一种甲哌卡因及其光学对映体的制备方法 |
US9333187B1 (en) | 2013-05-15 | 2016-05-10 | Cellix Bio Private Limited | Compositions and methods for the treatment of inflammatory bowel disease |
WO2014195961A1 (en) | 2013-06-04 | 2014-12-11 | Mahesh Kandula | Compositions and methods for the treatment of diabetes and pre-diabetes |
CN103304471B (zh) * | 2013-07-12 | 2015-02-04 | 四川省惠达药业有限公司 | 一种甲磺酸罗哌卡因化合物、其制备方法及其药物组合物 |
US9096537B1 (en) | 2014-12-31 | 2015-08-04 | Mahesh Kandula | Compositions and methods for the treatment of mucositis |
CA2976314C (en) | 2014-09-26 | 2021-02-23 | Cellix Bio Private Limited | Compositions and methods for the treatment of epilepsy and neurological disorders |
CN107207403A (zh) | 2014-09-29 | 2017-09-26 | 塞尔利克斯生物私人有限公司 | 用于治疗多发性硬化的组合物和方法 |
US9173877B1 (en) * | 2014-11-05 | 2015-11-03 | Cellix Bio Private Limited | Compositions and methods for the treatment of local pain |
US9932294B2 (en) | 2014-12-01 | 2018-04-03 | Cellix Bio Private Limited | Compositions and methods for the treatment of multiple sclerosis |
DK3242869T3 (da) | 2015-01-06 | 2022-01-31 | Cellix Bio Private Ltd | Sammensætninger og fremgangsmåder til behanding af inflammation og smerte |
WO2017024037A1 (en) | 2015-08-03 | 2017-02-09 | President And Fellows Of Harvard College | Charged ion channel blockers and methods for use |
US10786485B1 (en) | 2019-03-11 | 2020-09-29 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
US10780083B1 (en) | 2019-03-11 | 2020-09-22 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
CA3129117A1 (en) | 2019-03-11 | 2020-09-17 | Bridget Mccarthy Cole | Charged ion channel blockers and methods for use |
EP3937945A4 (de) | 2019-03-11 | 2023-01-04 | Nocion Therapeutics, Inc. | Geladene ionenkanalblocker und verfahren zur verwendung |
JP2022527731A (ja) | 2019-03-11 | 2022-06-06 | ノシオン セラピューティクス,インコーポレイテッド | エステル置換イオンチャンネル遮断薬および使用方法 |
US10933055B1 (en) | 2019-11-06 | 2021-03-02 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
EP4054559A4 (de) | 2019-11-06 | 2023-11-29 | Nocion Therapeutics, Inc. | Geladene ionenkanalblocker und verfahren zur verwendung |
WO2021183639A1 (en) | 2020-03-11 | 2021-09-16 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
CN112294809B (zh) * | 2020-11-20 | 2022-03-29 | 四川大学华西医院 | 一种低毒性局部麻醉药及其制备方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE341404B (de) * | 1967-05-18 | 1971-12-27 | Sterling Drug Inc |
-
1983
- 1983-08-01 DE DE8383902297T patent/DE3379266D1/de not_active Expired
- 1983-08-01 AU AU17796/83A patent/AU560367B2/en not_active Expired
- 1983-08-01 EP EP83902297A patent/EP0151110B1/de not_active Expired
- 1983-08-01 AT AT83902297T patent/ATE40994T1/de not_active IP Right Cessation
- 1983-08-01 JP JP58502459A patent/JPS60502054A/ja active Granted
- 1983-08-01 WO PCT/NO1983/000029 patent/WO1985000599A1/en active IP Right Grant
-
1985
- 1985-03-26 DK DK135685A patent/DK153546C/da not_active IP Right Cessation
- 1985-03-29 FI FI851266A patent/FI80020C/fi not_active IP Right Cessation
-
1987
- 1987-09-28 MY MYPI87001989A patent/MY101904A/en unknown
-
1991
- 1991-10-22 SG SG879/91A patent/SG87991G/en unknown
- 1991-12-05 HK HK983/91A patent/HK98391A/xx not_active IP Right Cessation
-
1992
- 1992-07-10 CY CY1623A patent/CY1623A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
DK153546B (da) | 1988-07-25 |
EP0151110B1 (de) | 1989-03-01 |
HK98391A (en) | 1991-12-13 |
FI851266A0 (fi) | 1985-03-29 |
DK135685A (da) | 1985-03-26 |
WO1985000599A1 (en) | 1985-02-14 |
DK153546C (da) | 1988-12-05 |
CY1623A (en) | 1992-07-10 |
JPS60502054A (ja) | 1985-11-28 |
EP0151110A1 (de) | 1985-08-14 |
FI851266L (fi) | 1985-03-29 |
ATE40994T1 (de) | 1989-03-15 |
MY101904A (en) | 1992-02-15 |
DK135685D0 (da) | 1985-03-26 |
SG87991G (en) | 1991-11-22 |
FI80020C (fi) | 1990-04-10 |
FI80020B (fi) | 1989-12-29 |
JPH0559903B2 (de) | 1993-09-01 |
AU1779683A (en) | 1985-03-04 |
AU560367B2 (en) | 1987-04-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |