NO855048L - Fremgangsmaate for fremstilling av et stabilisert nicorandil-preparat. - Google Patents

Fremgangsmaate for fremstilling av et stabilisert nicorandil-preparat.

Info

Publication number
NO855048L
NO855048L NO855048A NO855048A NO855048L NO 855048 L NO855048 L NO 855048L NO 855048 A NO855048 A NO 855048A NO 855048 A NO855048 A NO 855048A NO 855048 L NO855048 L NO 855048L
Authority
NO
Norway
Prior art keywords
preparation
stabilized
procedure
nicorandil
nicorandil preparation
Prior art date
Application number
NO855048A
Other languages
English (en)
Other versions
NO171826C (no
NO171826B (no
Inventor
Yoshimitsu Iida
Takashi Terazono
Shuji Sumida
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of NO855048L publication Critical patent/NO855048L/no
Publication of NO171826B publication Critical patent/NO171826B/no
Publication of NO171826C publication Critical patent/NO171826C/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO855048A 1984-12-17 1985-12-16 Fremgangsmaate for fremstilling av et stabilt nicorandilholdig preparat NO171826C (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP59265888A JPH0653658B2 (ja) 1984-12-17 1984-12-17 安定な錠剤の製造法
JP14968885 1985-07-08
JP21327785 1985-09-26

Publications (3)

Publication Number Publication Date
NO855048L true NO855048L (no) 1986-06-18
NO171826B NO171826B (no) 1993-02-01
NO171826C NO171826C (no) 1993-05-12

Family

ID=27319808

Family Applications (1)

Application Number Title Priority Date Filing Date
NO855048A NO171826C (no) 1984-12-17 1985-12-16 Fremgangsmaate for fremstilling av et stabilt nicorandilholdig preparat

Country Status (23)

Country Link
US (1) US4803213A (no)
EP (1) EP0185347B1 (no)
JP (1) JPH0653658B2 (no)
KR (1) KR930007251B1 (no)
CN (1) CN1007209B (no)
AR (1) AR241515A1 (no)
AT (1) ATE54050T1 (no)
AU (1) AU579431B2 (no)
BA (1) BA98214B1 (no)
CA (1) CA1255227A (no)
DE (1) DE3578373D1 (no)
DK (1) DK167171B1 (no)
FI (1) FI84781C (no)
HK (1) HK65493A (no)
HU (1) HU195731B (no)
IE (1) IE59158B1 (no)
MX (1) MX166095B (no)
NO (1) NO171826C (no)
PT (1) PT81680B (no)
RU (1) RU1811401C (no)
SG (1) SG52493G (no)
YU (1) YU45292B (no)
ZA (1) ZA859390B (no)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5188840A (en) * 1985-09-26 1993-02-23 Chugai Seiyaku Kabushiki Kaisha Slow-release pharmaceutical agent
KR950010150B1 (ko) * 1986-01-14 1995-09-11 쥬우가이세이야꾸 가부시끼가이샤 니코란딜 함유 주사제의 안정화 방법
KR940000232B1 (ko) * 1986-01-17 1994-01-12 쥬우가이세이야꾸 가부시끼가이샤 니코란딜 제제의 안정화 방법
GR871267B (en) * 1986-08-18 1987-12-24 Chugai Pharmaceutical Co Ltd Method for the manufacture of a pharmaceutical preparation for administration by percutaneous absortion
US4940580A (en) * 1986-11-03 1990-07-10 Schering Corporation Sustained release labetalol tablets
CA1322957C (en) * 1988-03-30 1993-10-12 Hitoshi Yamauchi Cyclic amp derivative ointments
JP2535141B2 (ja) * 1995-01-17 1996-09-18 中外製薬株式会社 フマル酸含有徐放性製剤
NZ332313A (en) 1996-04-16 2000-02-28 Bayer Ag D-mannitol and its preparation as a powder of not more than 1 square meter per gram
US6235947B1 (en) * 1997-04-14 2001-05-22 Takeda Chemical Industries, Ltd. D-mannitol and its preparation
PT914818E (pt) 1996-06-14 2005-08-31 Kyowa Hakko Kogyo Kk Comprimido de desintegracao rapida por via intraoral
US8071128B2 (en) * 1996-06-14 2011-12-06 Kyowa Hakko Kirin Co., Ltd. Intrabuccally rapidly disintegrating tablet and a production method of the tablets
KR100481583B1 (ko) * 1996-06-14 2005-07-12 교와 핫꼬 고교 가부시끼가이샤 구강내에서빠르게붕괴하는정제
IT1293835B1 (it) * 1997-08-08 1999-03-10 Foscama Biomed Chim Farma Composizioni farmaceutiche orali in forma solida a cessione modulata contenenti nicorandil e procedimento per la loro preparazione
AU4841700A (en) 1999-05-12 2000-11-21 Nitromed, Inc. Nitrosated and nitrosylated potassium channel activators, compositions and methods of use
KR100483080B1 (ko) * 2001-09-21 2005-04-14 한인규 염산·베타인(betaine·HCl), 판크레아틴, 제2인산 칼슘, 크롬 피콜리네이트, 락토바실러스속·비피도박테리아속·스트렙토코커스속·프럭토 올리고당, 비타민, 미네랄을 유효성분으로 구성된 것을 특징으로 하는 증체개선용 영양강화 사료첨가제
US9358214B2 (en) 2001-10-04 2016-06-07 Adare Pharmaceuticals, Inc. Timed, sustained release systems for propranolol
US8367111B2 (en) * 2002-12-31 2013-02-05 Aptalis Pharmatech, Inc. Extended release dosage forms of propranolol hydrochloride
JP4235149B2 (ja) 2004-07-02 2009-03-11 インターナショナル・ビジネス・マシーンズ・コーポレーション ノートブック型コンピュータ
US8747895B2 (en) * 2004-09-13 2014-06-10 Aptalis Pharmatech, Inc. Orally disintegrating tablets of atomoxetine
US9884014B2 (en) 2004-10-12 2018-02-06 Adare Pharmaceuticals, Inc. Taste-masked pharmaceutical compositions
EP2417969A1 (en) 2004-10-21 2012-02-15 Aptalis Pharmatech, Inc. Taste-masked pharmaceutical compositions with gastrosoluble pore-formers
US20060105038A1 (en) * 2004-11-12 2006-05-18 Eurand Pharmaceuticals Limited Taste-masked pharmaceutical compositions prepared by coacervation
US9161918B2 (en) 2005-05-02 2015-10-20 Adare Pharmaceuticals, Inc. Timed, pulsatile release systems
CN100417381C (zh) * 2006-02-09 2008-09-10 西安力邦医药科技有限责任公司 尼可地尔冻干粉的制备方法
US20090076095A1 (en) * 2007-09-15 2009-03-19 Protia, Llc Deuterium-enriched nicorandil
GB0720516D0 (en) * 2007-10-18 2007-11-28 Cadbury Schweppes Plc Comestible products
NZ600256A (en) 2009-12-02 2014-05-30 Aptalis Pharma Ltd Fexofenadine microcapsules and compositions containing them
WO2011085181A1 (en) * 2010-01-08 2011-07-14 Eurand, Inc. Taste masked topiramate composition and an orally disintegrating tablet comprising the same
CN111606847B (zh) * 2020-05-26 2021-12-31 中国科学院上海药物研究所 尼可地尔与1-羟基-2-萘甲酸的共晶及其制备方法和应用
CN114732792A (zh) * 2022-03-25 2022-07-12 北京诺康达医药科技股份有限公司 一种尼可地尔口腔崩解片及其制备方法
CN115317456A (zh) * 2022-08-17 2022-11-11 北京科源创欣科技有限公司 一种尼可地尔片组合物及其制备方法
CN115282123B (zh) * 2022-09-13 2023-11-03 南京比逊医药科技有限公司 一种稳定的尼可地尔制剂的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3168438A (en) * 1962-08-09 1965-02-02 Synergistics Inc Vasodilation by nitric acid ester derivatives of nicotinic acid
US3332848A (en) * 1963-07-10 1967-07-25 Hoffmann La Roche Microcrystalline cellulose with starch in niacinamide ascorbic acid tablet granulations
US3577491A (en) * 1968-01-02 1971-05-04 Miles Lab Tableting
AU509591B2 (en) * 1976-04-02 1980-05-15 Chugai Seiyaku Kabushiki Kaisha Pyridine derivatives
US4200640A (en) * 1976-04-02 1980-04-29 Chugai Seiyaku Kabushiki Kaisha Nitric ester of N-(2-hydroxyethyl)nicotinamide and pharmaceutical use
JPS599539B2 (ja) * 1979-11-13 1984-03-03 日本化薬株式会社 ニトログリセリン水溶液及びその製造法
US4490377A (en) * 1980-07-29 1984-12-25 Syntex (U.S.A.) Inc. Acid stabilized compositions of thieno-pyridine derived compounds
ATE22530T1 (de) * 1980-07-29 1986-10-15 Sanofi Sa Durch saeure stabilisierte mischungen von thienopyridinderivaten und verfahren zum verhindern der zersetzung solcher verbindungen.
US4382091A (en) * 1981-04-30 1983-05-03 Syntex (U.S.A.) Inc. Stabilization of 1-substituted imidazole derivatives in talc
JPS5885819A (ja) * 1981-11-17 1983-05-23 Chugai Pharmaceut Co Ltd 気管支拡張剤
DK150008C (da) * 1981-11-20 1987-05-25 Benzon As Alfred Fremgangsmaade til fremstilling af et farmaceutisk oralt polydepotpraeparat
DE3244178A1 (de) * 1982-11-30 1984-05-30 Bayer Ag, 5090 Leverkusen 1,4-dihydropyridinderivate, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln

Also Published As

Publication number Publication date
PT81680A (en) 1986-01-01
IE853176L (en) 1986-06-17
CN85109190A (zh) 1986-07-16
FI855032A0 (fi) 1985-12-17
KR930007251B1 (ko) 1993-08-04
NO171826C (no) 1993-05-12
BA98214B1 (bs) 1999-08-02
AU5076285A (en) 1986-06-26
DK583385D0 (da) 1985-12-16
PT81680B (pt) 1988-11-30
DK167171B1 (da) 1993-09-13
JPS61143316A (ja) 1986-07-01
EP0185347B1 (en) 1990-06-27
EP0185347A2 (en) 1986-06-25
FI84781C (fi) 1992-01-27
AU579431B2 (en) 1988-11-24
DE3578373D1 (de) 1990-08-02
FI855032A (fi) 1986-06-18
HK65493A (en) 1993-07-16
EP0185347A3 (en) 1987-04-22
SG52493G (en) 1993-08-06
AR241515A1 (es) 1992-08-31
KR860004633A (ko) 1986-07-11
NO171826B (no) 1993-02-01
DK583385A (da) 1986-06-18
HU195731B (en) 1988-07-28
YU197385A (en) 1988-04-30
RU1811401C (ru) 1993-04-23
HUT40567A (en) 1987-01-28
ZA859390B (en) 1986-08-27
US4803213A (en) 1989-02-07
FI84781B (fi) 1991-10-15
ATE54050T1 (de) 1990-07-15
MX166095B (es) 1992-12-18
JPH0653658B2 (ja) 1994-07-20
CN1007209B (zh) 1990-03-21
YU45292B (en) 1992-05-28
CA1255227A (en) 1989-06-06
IE59158B1 (en) 1994-01-12

Similar Documents

Publication Publication Date Title
NO855048L (no) Fremgangsmaate for fremstilling av et stabilisert nicorandil-preparat.
NO874764D0 (no) Fremgangsmaate for fremstilling av 2-aminopurinderivater.
NO880262L (no) Fremgangsmaate for fremstilling av b avermectiner.
NO885454L (no) Fremgangsmaate for fremstilling av triklormonosilan.
NO894210L (no) Fremgangsmaate for fremstilling av kinolyloxazol-2-oner.
NO892204D0 (no) Fremgangsmaate for fremstilling av imidazokinoxalin-forbindelser.
NO870866L (no) Fremgangsmÿte for fremstilling av et terapeutisk kombinasjonspreparat.
NO855067L (no) Fremgangsmaate for fremstilling av n-formyl-alfa-aspartyl-fenylalanin.
NO895032D0 (no) Fremgangsmaate for fremstilling av 2-benzotiazoliner.
NO164030C (no) Fremgangsmaate for fremstilling av imidazo-rifamycin-derivater.
NO853066L (no) Fremgansmaate til fremstilling av 3-karbonyl-1-aminoalkyl-1h-indoler.
NO890159D0 (no) Fremgangsmaate for fremstilling av 1-alkyl-5-nitroimidazoler.
NO165637C (no) Fremgangsmaate for fremstilling av etoksylert lignitt.
NO895040L (no) Fremgangsmaate for fremstilling av polyhydroxybenzyloxypropanolaminer.
NO882257L (no) Fremgangsmaate for fremstilling av et glidelaasbaand.
NO161353C (no) Fremgangsmaate for fremstilling av pastiller.
FI841074A (fi) Anordning foer framstaellning av potatis a la paris och liknande potatisar av olika storlekar och former.
ES537947A0 (es) Procedimiento de preparacion de un derivado de piracina.
NO161911C (no) Fremgangsmaate for fremstilling av sulfonater.
NO851774L (no) Fremgangsmaate for fremstilling av en 2-oksindol-1-karboksamid-forbindelse.
NO166709C (no) Fremgangsmaate for fremstilling av akrylamider.
NO851319L (no) Fremgangsmaate for fremstilling av eburnanderivater.
NO162816C (no) Fremgangsmaate for fremstilling av et dialkanolyksybenzylidendialkanoat.
FI841208A0 (fi) Anordning foer tvaettning av en saengliggande patient.
NO903304D0 (no) Fremgangsmaate for fremstilling av 3-karbonyl-1-aminoalkyl-1h-indoler.

Legal Events

Date Code Title Description
MK1K Patent expired