AR240832A1 - Procedimiento para obtener una nueva modificacion cristalina del 3-amino-1-hidroxi-propan-1,1-difosfonato disodico. - Google Patents

Procedimiento para obtener una nueva modificacion cristalina del 3-amino-1-hidroxi-propan-1,1-difosfonato disodico.

Info

Publication number
AR240832A1
AR240832A1 AR301204A AR30120485A AR240832A1 AR 240832 A1 AR240832 A1 AR 240832A1 AR 301204 A AR301204 A AR 301204A AR 30120485 A AR30120485 A AR 30120485A AR 240832 A1 AR240832 A1 AR 240832A1
Authority
AR
Argentina
Prior art keywords
disodic
diphosphonate
propan
hydroxy
amino
Prior art date
Application number
AR301204A
Other languages
English (en)
Spanish (es)
Other versions
AR240832A2 (es
Original Assignee
Ciba Geigy Ag Y Henkel Kommand
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4263070&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR240832(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ciba Geigy Ag Y Henkel Kommand filed Critical Ciba Geigy Ag Y Henkel Kommand
Application granted granted Critical
Publication of AR240832A2 publication Critical patent/AR240832A2/es
Publication of AR240832A1 publication Critical patent/AR240832A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/16—Esters of thiophosphoric acids or thiophosphorous acids
    • C07F9/165—Esters of thiophosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AR301204A 1984-08-06 1985-08-06 Procedimiento para obtener una nueva modificacion cristalina del 3-amino-1-hidroxi-propan-1,1-difosfonato disodico. AR240832A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH376884 1984-08-06

Publications (2)

Publication Number Publication Date
AR240832A2 AR240832A2 (es) 1991-02-28
AR240832A1 true AR240832A1 (es) 1991-02-28

Family

ID=4263070

Family Applications (4)

Application Number Title Priority Date Filing Date
AR301204A AR240832A1 (es) 1984-08-06 1985-08-06 Procedimiento para obtener una nueva modificacion cristalina del 3-amino-1-hidroxi-propan-1,1-difosfonato disodico.
AR89314300A AR244697A1 (es) 1984-08-06 1989-06-29 Procedimiento para obtener una nueva modificacion cristalina del 3-amino-1-hidroxi-1,1-difosfonato disodico
AR89314299A AR244696A1 (es) 1984-08-06 1989-06-29 Procedimiento para obtener una nueva modificacion cristalina del 3-amino-1-hidroxi-1,1-difosfonato disodico.
AR89314298A AR244698A1 (es) 1984-08-06 1989-06-29 Procedimiento para obtener una nueva modificacion cristalina del 3-amino-1-hidroxi-1,1-difosfonato disodico.

Family Applications After (3)

Application Number Title Priority Date Filing Date
AR89314300A AR244697A1 (es) 1984-08-06 1989-06-29 Procedimiento para obtener una nueva modificacion cristalina del 3-amino-1-hidroxi-1,1-difosfonato disodico
AR89314299A AR244696A1 (es) 1984-08-06 1989-06-29 Procedimiento para obtener una nueva modificacion cristalina del 3-amino-1-hidroxi-1,1-difosfonato disodico.
AR89314298A AR244698A1 (es) 1984-08-06 1989-06-29 Procedimiento para obtener una nueva modificacion cristalina del 3-amino-1-hidroxi-1,1-difosfonato disodico.

Country Status (26)

Country Link
US (2) US4639338A (cs)
EP (1) EP0177443B1 (cs)
JP (1) JPS6143196A (cs)
KR (1) KR940000817B1 (cs)
AR (4) AR240832A1 (cs)
AT (1) ATE47396T1 (cs)
AU (1) AU591066B2 (cs)
CA (1) CA1255694A (cs)
CY (1) CY1570A (cs)
DD (1) DD239597A5 (cs)
DE (1) DE3573783D1 (cs)
DK (1) DK167282B1 (cs)
DO (1) DOP1990004769A (cs)
ES (2) ES8701188A1 (cs)
FI (1) FI79712C (cs)
GR (1) GR851910B (cs)
HK (1) HK42591A (cs)
HU (1) HU193124B (cs)
IE (1) IE58077B1 (cs)
IL (1) IL75990A (cs)
MX (1) MX9203373A (cs)
NO (1) NO165401C (cs)
PH (1) PH24854A (cs)
PT (1) PT80916B (cs)
SG (1) SG91390G (cs)
ZA (1) ZA855892B (cs)

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CH664158A5 (fr) * 1984-07-18 1988-02-15 Symphar Sa Derives propylidenediphosphonates-1,3 substitues en position 2, leur procede de preparation et compositions pharmaceutiques les contenant.
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PH26923A (en) * 1989-03-08 1992-12-03 Ciba Geigy N-substituted amino alkanediphosphonic acids
US4922007A (en) * 1989-06-09 1990-05-01 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
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US5270365A (en) * 1991-12-17 1993-12-14 Merck & Co., Inc. Prevention and treatment of periodontal disease with alendronate
TW237386B (cs) 1992-04-15 1995-01-01 Ciba Geigy
US6406714B1 (en) 1992-12-02 2002-06-18 Merck & Co., Inc. Dry mix formulation for bisphosphonic acids
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JP3266395B2 (ja) * 1993-11-24 2002-03-18 富士写真フイルム株式会社 有機薬品の晶析方法
US20010007863A1 (en) * 1998-06-18 2001-07-12 Merck & Co., Inc. Wet granulation formulation for bisphosphonic acids
TW390813B (en) * 1994-04-29 2000-05-21 Merck & Co Inc Wet granulation formulation for bisphosphonic acids
GB9408775D0 (en) * 1994-05-04 1994-06-22 Ciba Geigy Ag Use of certain methanebisphosphonic acid derivatives to prevent prothesis loosening and prothesis migration
DE19719680A1 (de) 1997-05-09 1998-11-19 Boehringer Mannheim Gmbh Verwendung von Diphosphonsäuren zur präventiven Behandlung von Spätfolgen bei Harnblasenerweiterung oder Harnblasenersatz
DK0891979T3 (da) * 1997-07-15 2005-01-31 Gador Sa Krystallinsk form af N,N-dimethyl-3-amino-1-hydroxypropan-1,1-diphosphonsyre-mononatrium-monohydrat og fremgangsmåde til fremstilling heraf
EP1702924A3 (en) * 1998-08-27 2007-07-18 Teva Pharmaceutical Industries Ltd Novel hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof
AU5698899A (en) * 1998-08-27 2000-03-21 Teva Pharmaceutical Industries Ltd. Novel hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof
EP0998932A1 (de) 1998-10-09 2000-05-10 Boehringer Mannheim Gmbh Feste pharmazeutische Darreichungsform enthaltend Diphosphonsäure oder deren Salze und Verfahren zu ihrer Herstellung
EP0998933A1 (de) 1998-10-09 2000-05-10 Boehringer Mannheim Gmbh Verfahren zur Herstellung von bisphosphonathaltigen pharmazeutischen Zusammensetzungen zur oralen Applikation
DE69907258T2 (de) * 1998-12-10 2003-11-06 Aesgen, Inc. Verfahren zur herstellung von dinatriumpamidronat
US6794536B1 (en) 1998-12-10 2004-09-21 Aesqen, Inc. Method for preparation of disodium pamidronate
US6160165A (en) 1998-12-10 2000-12-12 Aesgen, Inc. Method for preparation of disodium pamidronate
US6315566B1 (en) 1999-05-18 2001-11-13 3M Innovative Properties Company Dental materials
US6143919A (en) * 1999-05-18 2000-11-07 3M Innovative Properties Company Polymerizable acidic compounds and methods of preparation
US6963008B2 (en) * 1999-07-19 2005-11-08 Teva Pharmaceutical Industries Ltd. Hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof
ES2153794B1 (es) * 1999-08-06 2001-10-16 Medichem Sa Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada.
KR100343232B1 (ko) * 1999-12-10 2002-07-10 김재윤 결정성 파미드론산 이나트륨염 수화물과 그의 제조방법
EP1671638A1 (en) * 2000-09-18 2006-06-21 F H Faulding & Co. Limited Disphosphonate solutions
WO2002058708A1 (en) * 2001-01-23 2002-08-01 Gador S.A. Composition comprising bisphosphonates for prevention and/or treatment of metabolic diseases of bones, process for preparing such composition and use thereof
MXPA03009890A (es) 2001-05-02 2004-02-17 Sicor Inc Pamidronato disodico inyectable.
CA2372450A1 (en) * 2001-05-10 2001-09-19 Pharmaceutical Partners Of Canada Inc. Liquid injectable formulation of disodium pamidronate
ITMI20012751A1 (it) * 2001-12-21 2003-06-21 Lyogen Ltd Sale monosodico dell'acido pamidronico e procedimento per la sua preparazione
US20040052843A1 (en) * 2001-12-24 2004-03-18 Lerner E. Itzhak Controlled release dosage forms
EP1465606A4 (en) * 2001-12-24 2009-04-22 Teva Pharma DOSAGE FORM WITH PASTILLE CORE ACTIVE PRINCIPLE COATED IN COMPRESSED ANNULAR BODY OF POWDER OR GRANULAR SUBSTANCE, AND METHOD AND TOOLS FOR PRODUCTION OF SAID DOSAGE FORM
EP2316468A1 (en) 2002-02-22 2011-05-04 Shire LLC Delivery system and methods for protecting and administering dextroamphetamine
US20040138180A1 (en) * 2002-10-03 2004-07-15 Barr Laboratories, Inc. Bisphosphonate composition and process for the preparation thereof
SI1790347T1 (sl) * 2002-12-20 2015-03-31 F. Hoffmann-La Roche Ag Formulacija z visokim odmerkom ibandronata
US20050119230A1 (en) * 2003-09-18 2005-06-02 Alexandra Glausch Pharmaceutical products comprising bisphosphonated
AU2003286309A1 (en) * 2003-12-04 2005-06-24 Mustafa Nevzat Ilac Sanayii A.S. Method for producing pure disodium pamidronate
MY144704A (en) 2004-05-24 2011-10-31 Procter & Gamble Dosage forms of bisphosphonates
US8012949B2 (en) * 2004-10-08 2011-09-06 The Board Of Trustees Of The University Of Illinois Bisphosphonate compounds and methods with enhanced potency for multiple targets including FPPS, GGPPS, and DPPS
EP1802641B8 (en) * 2004-10-08 2012-03-07 The Board Of Trustees Of The University Of Illinois Bisphosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders, and infectious diseases
WO2007109585A2 (en) * 2006-03-17 2007-09-27 The Board Of Trustees Of The University Of Illinois Bisphosphonate compounds and methods
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EP2473172B1 (en) 2009-09-01 2015-04-08 Duke University Bisphosphonate compositions and methods for treating heart failure
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AU2011239935A1 (en) 2010-04-16 2012-11-08 Novartis Ag Methods and compositions for improving implant osseointegration
JP6261512B2 (ja) 2011-11-16 2018-01-17 デューク ユニバーシティ 心機能障害を治療及び／又は低減するためのビスホスホネート組成物並びに方法
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US11654152B2 (en) 2012-05-14 2023-05-23 Antecip Bioventures Ii Llc Compositions for oral administration of zoledronic acid or related compounds for treating disease
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Also Published As

Publication number Publication date
ES545899A0 (es) 1986-11-16
DE3573783D1 (en) 1989-11-23
PT80916B (pt) 1987-12-30
NO853087L (no) 1986-02-07
IE58077B1 (en) 1993-06-30
AR244698A1 (es) 1993-11-30
PH24854A (en) 1990-12-26
FI79712B (fi) 1989-10-31
JPH058717B2 (cs) 1993-02-02
KR860001821A (ko) 1986-03-22
AU4577785A (en) 1986-02-13
DK355485A (da) 1986-02-07
MX9203373A (es) 1992-09-01
ES555602A0 (es) 1987-07-01
PT80916A (en) 1985-09-01
ES8701188A1 (es) 1986-11-16
ATE47396T1 (de) 1989-11-15
EP0177443A1 (de) 1986-04-09
CY1570A (en) 1991-12-20
ZA855892B (en) 1986-03-26
US4639338A (en) 1987-01-27
NO165401C (no) 1991-02-06
NO165401B (no) 1990-10-29
ES8706707A1 (es) 1987-07-01
AU591066B2 (en) 1989-11-30
DOP1990004769A (es) 1999-08-19
FI852986L (fi) 1986-02-07
DD239597A5 (de) 1986-10-01
HUT38361A (en) 1986-05-28
DK167282B1 (da) 1993-10-04
HU193124B (en) 1987-08-28
CA1255694A (en) 1989-06-13
AR240832A2 (es) 1991-02-28
AR244696A1 (es) 1993-11-30
DK355485D0 (da) 1985-08-05
SG91390G (en) 1991-01-18
JPS6143196A (ja) 1986-03-01
AR244697A1 (es) 1993-11-30
GR851910B (cs) 1985-12-03
US4711880A (en) 1987-12-08
EP0177443B1 (de) 1989-10-18
FI852986A0 (fi) 1985-08-02
KR940000817B1 (ko) 1994-02-02
IL75990A (en) 1989-07-31
HK42591A (en) 1991-06-07
FI79712C (fi) 1990-02-12
IE851931L (en) 1986-02-06

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