AR124609A1 - Anticuerpos divididos y métodos de uso - Google Patents
Anticuerpos divididos y métodos de usoInfo
- Publication number
- AR124609A1 AR124609A1 ARP220100054A ARP220100054A AR124609A1 AR 124609 A1 AR124609 A1 AR 124609A1 AR P220100054 A ARP220100054 A AR P220100054A AR P220100054 A ARP220100054 A AR P220100054A AR 124609 A1 AR124609 A1 AR 124609A1
- Authority
- AR
- Argentina
- Prior art keywords
- antigen
- domain
- terminus
- antibody
- moiety
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000000427 antigen Substances 0.000 abstract 14
- 102000036639 antigens Human genes 0.000 abstract 14
- 108091007433 antigens Proteins 0.000 abstract 14
- 239000012636 effector Substances 0.000 abstract 6
- 229920001184 polypeptide Polymers 0.000 abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
- A61K51/1048—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell determinant being a carcino embryonic antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3007—Carcino-embryonic Antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Cell Biology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Optics & Photonics (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente invención se refiere a anticuerpos que se unen a antígenos en células diana y que dirigen restos efectores a dichas células, y a métodos de uso de los mismos. Reivindicación 1: Un conjunto de anticuerpos que comprende: i) un primer anticuerpo que comprende: a) un resto de unión a antígeno, en donde el resto de unión a antígeno se une a un antígeno diana; b) un polipéptido que comprende o consiste en un dominio variable de cadena pesada de anticuerpo (VH) de un sitio de unión a antígeno para un resto efector; y c) un dominio Fc que comprende dos subunidades, en donde el polipéptido de (b) se fusiona por su N-terminal al C-terminal del resto de unión a antígeno de (a) y por su C-terminal al N-terminal de una de las subunidades del dominio Fc de (c); y en donde el primer anticuerpo no comprende un dominio VL de un sitio de unión a antígeno para el resto efector; y ii) un segundo anticuerpo que comprende: d) un resto de unión a antígeno, en donde el resto de unión a antígeno se une a un antígeno diana; e) un polipéptido que comprende o consiste en un dominio variable de cadena ligera de anticuerpo (VL) de un sitio de unión a antígeno para el resto efector; y f) un dominio Fc que comprende dos subunidades, en donde el polipéptido de (e) se fusiona por su N-terminal con el C-terminal del resto de unión a antígeno de (d) y por su C-terminal al N-terminal de una de las subunidades del dominio Fc de (f); y en donde el segundo anticuerpo no comprende un dominio VH de un sitio de unión a antígeno para el resto efector; en donde dicho dominio VH del primer anticuerpo y dicho dominio VL del segundo anticuerpo juntos son capaces de formar un sitio de unión a antígeno funcional para el resto efector.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP21151245 | 2021-01-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR124609A1 true AR124609A1 (es) | 2023-04-12 |
Family
ID=74175694
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP220100054A AR124609A1 (es) | 2021-01-12 | 2022-01-12 | Anticuerpos divididos y métodos de uso |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20240082437A1 (es) |
| EP (1) | EP4277705A1 (es) |
| JP (1) | JP2024504931A (es) |
| KR (1) | KR20230131204A (es) |
| CN (1) | CN116829593A (es) |
| AR (1) | AR124609A1 (es) |
| AU (1) | AU2022207615A1 (es) |
| CA (1) | CA3206466A1 (es) |
| CL (1) | CL2023001989A1 (es) |
| CO (1) | CO2023009153A2 (es) |
| CR (1) | CR20230385A (es) |
| IL (1) | IL304224A (es) |
| MX (1) | MX2023008084A (es) |
| PE (1) | PE20240690A1 (es) |
| TW (1) | TW202241962A (es) |
| WO (1) | WO2022152656A1 (es) |
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| GB9014932D0 (en) | 1990-07-05 | 1990-08-22 | Celltech Ltd | Recombinant dna product and method |
| US5846535A (en) | 1990-10-12 | 1998-12-08 | The United States Of America As Represented By The Department Of Health And Human Services | Methods for reducing tumor cell growth by using antibodies with broad tumor reactivity and limited normal tissue reactivity |
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| JP7044700B2 (ja) | 2015-10-02 | 2022-03-30 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | 二重特異性抗ｃｅａｘｃｄ３ ｔ細胞活性化抗原結合分子 |
| CN112807429A (zh) * | 2015-11-19 | 2021-05-18 | 雷维托普有限公司 | 用于对非所要细胞进行重定向杀灭的两组分系统的功能性抗体片段互补作用 |
| WO2019122350A1 (en) * | 2017-12-21 | 2019-06-27 | Gernot Stuhler | Specific dosage regimen for hemibody therapy |
| MX2020010954A (es) | 2018-04-16 | 2020-11-09 | Hoffmann La Roche | Anticuerpos para radionuclidos quelados. |
| AR119382A1 (es) * | 2019-07-12 | 2021-12-15 | Hoffmann La Roche | Anticuerpos de pre-direccionamiento y métodos de uso |
| IL298921A (en) * | 2020-07-10 | 2023-02-01 | Hoffmann La Roche | Antibodies that bind to cancer cells and direct radionuclides to said cells |
-
2022
- 2022-01-10 JP JP2023541914A patent/JP2024504931A/ja active Pending
- 2022-01-10 CA CA3206466A patent/CA3206466A1/en active Pending
- 2022-01-10 MX MX2023008084A patent/MX2023008084A/es unknown
- 2022-01-10 WO PCT/EP2022/050359 patent/WO2022152656A1/en active Application Filing
- 2022-01-10 KR KR1020237023297A patent/KR20230131204A/ko unknown
- 2022-01-10 EP EP22700173.2A patent/EP4277705A1/en active Pending
- 2022-01-10 PE PE2023002036A patent/PE20240690A1/es unknown
- 2022-01-10 US US18/271,835 patent/US20240082437A1/en active Pending
- 2022-01-10 AU AU2022207615A patent/AU2022207615A1/en active Pending
- 2022-01-10 CN CN202280009557.4A patent/CN116829593A/zh active Pending
- 2022-01-10 CR CR20230385A patent/CR20230385A/es unknown
- 2022-01-11 TW TW111101051A patent/TW202241962A/zh unknown
- 2022-01-12 AR ARP220100054A patent/AR124609A1/es unknown
-
2023
- 2023-07-03 IL IL304224A patent/IL304224A/en unknown
- 2023-07-06 CL CL2023001989A patent/CL2023001989A1/es unknown
- 2023-07-10 CO CONC2023/0009153A patent/CO2023009153A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN116829593A (zh) | 2023-09-29 |
| CL2023001989A1 (es) | 2024-02-02 |
| WO2022152656A1 (en) | 2022-07-21 |
| IL304224A (en) | 2023-09-01 |
| MX2023008084A (es) | 2023-07-13 |
| TW202241962A (zh) | 2022-11-01 |
| US20240082437A1 (en) | 2024-03-14 |
| EP4277705A1 (en) | 2023-11-22 |
| CO2023009153A2 (es) | 2023-07-21 |
| JP2024504931A (ja) | 2024-02-02 |
| KR20230131204A (ko) | 2023-09-12 |
| CR20230385A (es) | 2023-09-25 |
| PE20240690A1 (es) | 2024-04-10 |
| CA3206466A1 (en) | 2022-07-21 |
| AU2022207615A1 (en) | 2023-07-13 |
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