AR118185A1 - Composiciones de partículas de sílice mesoporosa para administración viral - Google Patents

Composiciones de partículas de sílice mesoporosa para administración viral

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Publication number
AR118185A1
AR118185A1 ARP200100513A ARP200100513A AR118185A1 AR 118185 A1 AR118185 A1 AR 118185A1 AR P200100513 A ARP200100513 A AR P200100513A AR P200100513 A ARP200100513 A AR P200100513A AR 118185 A1 AR118185 A1 AR 118185A1
Authority
AR
Argentina
Prior art keywords
mesoporous silica
silica particles
composition
lymphocytes
expression
Prior art date
Application number
ARP200100513A
Other languages
English (en)
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of AR118185A1 publication Critical patent/AR118185A1/es

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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K47/642—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a cytokine, e.g. IL2, chemokine, growth factors or interferons being the inactive part of the conjugate
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    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
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Abstract

La presente se refiere generalmente al uso de composiciones que incluyen partículas de sílice mesoporosa que pueden tener modificación superficial, para la administración de vectores virales. En algunas realizaciones, los vectores virales se usan para transducir linfocitos T para expresar un receptor de antígeno quimérico (CAR), para tratar a un sujeto que tiene una enfermedad, por ejemplo, una enfermedad asociada con la expresión de un antígeno tumoral. Reivindicación 5: La composición según la reivindicación 4, en donde la modificación superficial en la primera población de partículas de sílice mesoporosa es -OH (hidroxilo), amina, ácido carboxílico, fosfonato, haluro, azida, alquino, epóxido, sulfhidrilo, polietilenimina, un resto hidrófobo o sales de los mismos, usando opcionalmente un alquilo C₁ a C₂₀ o conector (-O(CH₂-CH₂-)₁₋₂₅. Reivindicación 15: La composición según cualquiera de las reivindicaciones precedentes, que comprende además un compuesto estimulador de linfocitos T o antígeno tumoral. Reivindicación 19: La composición de cualquiera de las reivindicaciones 15 a 18, que comprende además una citocina. Reivindicación 25: Un método que comprende: poner en contacto linfocitos T con una composición que comprende una primera población de partículas de sílice mesoporosa y un vector viral; en donde el vector viral comprende un vector de expresión que comprende un polinucleótido recombinante que comprende una secuencia de control de expresión unida operativamente a una secuencia de nucleótidos a expresar. Reivindicación 103: La composición de la reivindicación 102, en donde el agente activo se conjuga o adsorbe en las partículas de sílice mesoporosa.
ARP200100513A 2019-02-25 2020-02-26 Composiciones de partículas de sílice mesoporosa para administración viral AR118185A1 (es)

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