CO5601001A2 - Agentes de produccion de imagenes dirigidas a integrinas - Google Patents
Agentes de produccion de imagenes dirigidas a integrinasInfo
- Publication number
- CO5601001A2 CO5601001A2 CO04080978A CO04080978A CO5601001A2 CO 5601001 A2 CO5601001 A2 CO 5601001A2 CO 04080978 A CO04080978 A CO 04080978A CO 04080978 A CO04080978 A CO 04080978A CO 5601001 A2 CO5601001 A2 CO 5601001A2
- Authority
- CO
- Colombia
- Prior art keywords
- ligand
- integrins
- nanoparticles
- pat
- images directed
- Prior art date
Links
- 102000006495 integrins Human genes 0.000 title abstract 3
- 108010044426 integrins Proteins 0.000 title abstract 3
- 239000003446 ligand Substances 0.000 abstract 5
- 239000002105 nanoparticle Substances 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000000839 emulsion Substances 0.000 abstract 2
- 239000012634 fragment Substances 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
- A61K47/6907—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a microemulsion, nanoemulsion or micelle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
- A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
- A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
- A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
- A61K49/1833—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with a small organic molecule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nanotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Radiology & Medical Imaging (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Acoustics & Sound (AREA)
- Dispersion Chemistry (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Optics & Photonics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
1.- Un método para suministrar una emulsión que comprende nanopartículas a un tejido objetivo, en donde dicho tejido objetivo se caracteriza por altos niveles de integrina avß3, cuyo método comprende administrar a un sujeto que comprende tal tejido una emulsión de nanopartículas en donde dichas nanopartículas están acopladas a un ligando específico para una integrina avß3, con la condición de que dicho ligando es diferente a un anticuerpo o fragmento de éste.2.- El método de la reivindicación 1, en donde dicho ligando es un ligando no péptido.3.- El método de la reivindicación 2, en donde el ligando es un compuesto de fórmula (1) como se estableció en la U.S. 6,130,231, o un compuesto como se estableció en la reivindicación 1 de la patente U. S. 6,153,628 o la patente U.S. 6,322,770; todas incorporadas aquí como referencia.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35139002P | 2002-01-24 | 2002-01-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO5601001A2 true CO5601001A2 (es) | 2006-01-31 |
Family
ID=27613494
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO04080978A CO5601001A2 (es) | 2002-01-24 | 2004-08-19 | Agentes de produccion de imagenes dirigidas a integrinas |
Country Status (14)
Country | Link |
---|---|
US (3) | US7255875B2 (es) |
EP (2) | EP2269659A1 (es) |
JP (2) | JP4731117B2 (es) |
KR (1) | KR100978126B1 (es) |
CN (2) | CN100356984C (es) |
AU (2) | AU2003209392B2 (es) |
BR (1) | BR0307206A (es) |
CA (1) | CA2474386C (es) |
CO (1) | CO5601001A2 (es) |
MX (1) | MXPA04007188A (es) |
NZ (1) | NZ534500A (es) |
TR (1) | TR200401834T2 (es) |
WO (1) | WO2003062198A1 (es) |
ZA (1) | ZA200406686B (es) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20010003580A1 (en) | 1998-01-14 | 2001-06-14 | Poh K. Hui | Preparation of a lipid blend and a phospholipid suspension containing the lipid blend |
US7220401B2 (en) * | 1999-09-24 | 2007-05-22 | Barnes-Jewish Hospital | Blood clot-targeted nanoparticles |
US20080247943A1 (en) * | 1999-09-24 | 2008-10-09 | Gregory Lanza | Blood Clot-Targeted Nanoparticles |
US7951061B2 (en) * | 2001-07-25 | 2011-05-31 | Allan Foreman | Devices for targeted delivery of thermotherapy, and methods related thereto |
US7731648B2 (en) * | 2001-07-25 | 2010-06-08 | Aduro Biotech | Magnetic nanoscale particle compositions, and therapeutic methods related thereto |
CN100356984C (zh) * | 2002-01-24 | 2007-12-26 | 巴内斯-朱威胥医院 | 整联蛋白靶向的影像剂 |
US6869591B2 (en) * | 2002-03-26 | 2005-03-22 | Barnes-Jewish Hospital | Paramagnetic particles that provide improved relaxivity |
AU2004263136A1 (en) * | 2003-08-08 | 2005-02-17 | Barnes-Jewish Hospital | Emulsion particles for imaging and therapy and methods of use thereof |
CA2559889A1 (en) * | 2004-01-16 | 2005-08-25 | Barnes-Jewish Hospital | Targeted atherosclerosis treatment |
CN101031287A (zh) * | 2004-03-02 | 2007-09-05 | 麻省理工学院 | 纳米细胞药物递送系统 |
US20070053845A1 (en) * | 2004-03-02 | 2007-03-08 | Shiladitya Sengupta | Nanocell drug delivery system |
AU2005253962A1 (en) * | 2004-06-09 | 2005-12-29 | Kereos, Inc. | Lipophilic derivatives of chelate monoamides |
US20060047025A1 (en) * | 2004-06-29 | 2006-03-02 | Matthew Piazza | Viscous materials and method for producing |
WO2006096499A2 (en) * | 2005-03-04 | 2006-09-14 | Washington University | Mr coronary angiography with a fluorinated nanoparticle contrast agent at 1.5 t |
WO2006099445A2 (en) * | 2005-03-14 | 2006-09-21 | Massachusetts Institute Of Technology | Nanocells for diagnosis and treatment of diseases and disorders |
FR2883562B1 (fr) | 2005-03-24 | 2009-02-27 | Guerbet Sa | Chelates lipophiles et leur utilisation en imagerie |
CA2602385A1 (en) * | 2005-03-29 | 2006-10-05 | The Research Foundation Of State University Of New York | Hybrid inorganic nanoparticles, methods of using and methods of making |
ATE455307T1 (de) * | 2005-04-26 | 2010-01-15 | Koninkl Philips Electronics Nv | Verfahren zur verwendung von cest-kontrastmitteln bei der magnetresonanztomographie |
US8306603B2 (en) * | 2005-04-26 | 2012-11-06 | Koninklijke Philips Electronics N.V. | MRI involving contrast agent with time modulated contrast enhancement |
JP2007079857A (ja) * | 2005-09-13 | 2007-03-29 | Canon Inc | サーバー装置、クライアント装置及びそれらの制御方法、コンピュータプログラム、記憶媒体 |
EP2308513A3 (de) * | 2005-11-16 | 2011-11-23 | Signalomics GmbH | Fluoreszenz-Nanopartikel |
ES2627998T3 (es) | 2005-11-16 | 2017-08-01 | Exchange Imaging Technologies Gmbh | Nanopartículas fluorescentes |
AU2006320488A1 (en) * | 2005-12-02 | 2007-06-07 | Barnes-Jewish Hospital | Methods to ameliorate and image angioplasty-induced vascular injury |
WO2007079437A2 (en) * | 2006-01-03 | 2007-07-12 | Kereos, Inc. | Combination antitumor therapies |
US20070232909A1 (en) * | 2006-03-28 | 2007-10-04 | Washington University | Ultrasonic Characterization of Internal Body Conditions Using Information Theoretic Signal Receivers |
US8003078B2 (en) | 2006-03-29 | 2011-08-23 | Barnes-Jewish Hospital | Targeted MR imaging agents |
CA2650574A1 (en) * | 2006-04-27 | 2007-11-08 | Barnes-Jewish Hospital | Detection and imaging of target tissue |
CA2667209A1 (en) * | 2006-10-24 | 2008-06-12 | Kereos, Inc. | Improved linkers for anchoring targeting ligands |
EP2080767A4 (en) * | 2006-11-09 | 2012-03-28 | Daiichi Sankyo Co Ltd | COMPOSITION FOR THE INTRODUCTION OF NUCLEIC ACID |
AU2008206064A1 (en) * | 2007-01-19 | 2008-07-24 | Triton Biosystems, Inc. | Thermotherapy susceptors and methods of using same |
US20080305046A1 (en) * | 2007-02-16 | 2008-12-11 | Ali Hafezi-Moghadam | Molecular imaging methods for diagnosis and evaluation of ocular and systemic diseases |
US8372427B2 (en) | 2007-03-05 | 2013-02-12 | Abbott Cardiovascular Systems Inc. | Therapeutic composition with enhanced endothelium targeting |
AU2008222822A1 (en) | 2007-03-05 | 2008-09-12 | Washington University | Nanoparticle delivery systems for membrane-integrating peptides |
FR2914304B1 (fr) | 2007-03-28 | 2012-11-16 | Guerbet Sa | Composes pour le diagnostic de maladies liees a l'expression de vcam. |
FR2914303A1 (fr) | 2007-03-28 | 2008-10-03 | Guerbet Sa | Composes pour le diagnostic de l'apoptose. |
WO2009151788A2 (en) * | 2008-04-22 | 2009-12-17 | The Washington University | Universal anchor peptide for nanoparticles |
US9125949B2 (en) * | 2008-12-30 | 2015-09-08 | University Of North Texas | Direct utilization of plasma proteins for the in vivo assembly of protein-drug/imaging agent conjugates, nanocarriers and coatings for biomaterials |
FR2942227B1 (fr) | 2009-02-13 | 2011-04-15 | Guerbet Sa | Utilisation de tampons pour la complexation de radionucleides |
EP2485768A1 (en) * | 2009-10-07 | 2012-08-15 | Sanford-Burnham Medical Research Institute | Methods and compositions related to clot-binding lipid compounds |
WO2011071778A1 (en) | 2009-12-07 | 2011-06-16 | Mayo Foundation For Medical Education And Research | Device for the delineation of cardiovascular or other anatomical structures |
FR2968562B1 (fr) | 2010-12-14 | 2013-01-11 | Guerbet Sa | Composes pour le diagnostic de maladies liees a l'expression de muc5ac |
FR2968999B1 (fr) | 2010-12-20 | 2013-01-04 | Guerbet Sa | Nanoemulsion de chelate pour irm |
SG10202010626PA (en) * | 2011-03-31 | 2020-11-27 | Schaefer Konstanze | Perfluorinated compounds for the non-viral transfer of nucleic acids |
WO2012177837A2 (en) | 2011-06-21 | 2012-12-27 | Immunogen, Inc. | Novel maytansinoid derivatives with peptide linker and conjugates thereof |
FR2980365B1 (fr) | 2011-09-26 | 2016-02-12 | Guerbet Sa | Nanoemulsions, leur procede de preparation, et leur utilisation comme agent de contraste. |
FR2980364B1 (fr) | 2011-09-26 | 2018-08-31 | Guerbet | Nanoemulsions et leur utilisation comme agents de contraste |
FR3000688B1 (fr) * | 2013-01-08 | 2016-09-30 | Centre Nat De La Rech Scient - Cnrs - | Procede pour activer une reaction chimique, melange activable par ce procede et dispostiif pour la mise en oeuvre de ce procede |
FR3001154B1 (fr) | 2013-01-23 | 2015-06-26 | Guerbet Sa | Magneto-emulsion vectorisee |
WO2014186435A2 (en) | 2013-05-14 | 2014-11-20 | University Of Georgia Research Foundation, Inc. | Compositions and methods for reducing neointima formation |
CA2947494C (en) | 2014-05-02 | 2020-10-20 | Research Institute At Nationwide Children's Hospital | Compositions and methods for anti-lyst immunomodulation |
US10449269B2 (en) | 2016-08-29 | 2019-10-22 | Yale University | Particle conjugated prosthetic patches and methods of making and using thereof |
NZ759001A (en) * | 2017-04-28 | 2023-03-31 | Texas Children’s Hospital | Targeting nanoparticles |
WO2019232362A1 (en) * | 2018-05-31 | 2019-12-05 | University Of South Florida | Nanoparticle delivery system for diseases associated with major basement membrane components of blood vessels accessible from blood stream |
WO2020007822A1 (en) | 2018-07-02 | 2020-01-09 | Conservatoire National Des Arts Et Metiers (Cnam) | Bismuth metallic (0) nanoparticles, process of manufacturing and uses thereof |
CN110433296A (zh) * | 2019-08-16 | 2019-11-12 | 哈尔滨医科大学 | 一种19f-mr/荧光多模式分子成像及载药的诊疗一体化纳米探针及制备方法和应用 |
EP4351654A1 (en) * | 2021-06-09 | 2024-04-17 | Crinetics Pharmaceuticals, Inc. | Non-peptide targeted therapeutics and uses thereof |
Family Cites Families (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US613023A (en) | 1898-10-25 | Wire clothes-pin | ||
AU6621586A (en) | 1985-11-18 | 1987-06-02 | University Of Texas System, The | Polychelating agents for image and spectral enhancement (and spectral shift) |
US5077036A (en) | 1986-01-14 | 1991-12-31 | Alliance Pharmaceutical Corp. | Biocompatible stable fluorocarbon emulsions for contrast enhancement and oxygen transport comprising 40-125% wt./volume fluorocarbon combined with a phospholipid |
US4927623A (en) | 1986-01-14 | 1990-05-22 | Alliance Pharmaceutical Corp. | Dissolution of gas in a fluorocarbon liquid |
US5171755A (en) | 1988-04-29 | 1992-12-15 | Hemagen/Pfc | Emulsions of highly fluorinated organic compounds |
US5114703A (en) | 1989-05-30 | 1992-05-19 | Alliance Pharmaceutical Corp. | Percutaneous lymphography using particulate fluorocarbon emulsions |
US5087440A (en) | 1989-07-31 | 1992-02-11 | Salutar, Inc. | Heterocyclic derivatives of DTPA used for magnetic resonance imaging |
US5542935A (en) | 1989-12-22 | 1996-08-06 | Imarx Pharmaceutical Corp. | Therapeutic delivery systems related applications |
US5409688A (en) | 1991-09-17 | 1995-04-25 | Sonus Pharmaceuticals, Inc. | Gaseous ultrasound contrast media |
US5304325A (en) | 1991-11-13 | 1994-04-19 | Hemagen/Pfc | Emulsions containing alkyl- or alkylglycerophosphoryl choline surfactants and methods of use |
US5403575A (en) | 1991-12-12 | 1995-04-04 | Hemagen/Pfc | Highly fluorinated, chloro-substituted organic compound-containing emulsions and methods of using them |
JPH08504811A (ja) * | 1992-12-24 | 1996-05-28 | ヘマジェン/ピーエフシー | フルオロカーボンのエマルジョン |
IL106578A (en) | 1993-08-03 | 2000-08-13 | Yissum Res Dev Co | Pharmaceutical compositions for drug targeting |
EP0702677A1 (en) | 1994-04-08 | 1996-03-27 | BRACCO International B.V. | Aromatic amide compounds and metal chelates thereof |
US5571498A (en) | 1994-06-02 | 1996-11-05 | Hemagen/Pfc | Emulsions of paramagnetic contrast agents for magnetic resonance imaging (MRI). |
US5614170A (en) | 1994-11-30 | 1997-03-25 | Hemagen/Pfc | Paramagnetic complexes of N-alkyl-N-hydroxylamides of organic acids and emulsions containing same for magnetic resonance imaging (MRI) |
US5520904A (en) * | 1995-01-27 | 1996-05-28 | Mallinckrodt Medical, Inc. | Calcium/oxyanion-containing particles with a polymerical alkoxy coating for use in medical diagnostic imaging |
JP4215820B2 (ja) * | 1995-06-07 | 2009-01-28 | イマアーレクス・フアーマシユーチカル・コーポレーシヨン | 診断的および治療的使用のための新規な標的化組成物 |
US6521211B1 (en) | 1995-06-07 | 2003-02-18 | Bristol-Myers Squibb Medical Imaging, Inc. | Methods of imaging and treatment with targeted compositions |
US5958371A (en) | 1995-06-08 | 1999-09-28 | Barnes-Jewish Hospital | Site specific binding system, nuclear imaging compositions and methods |
US5780010A (en) | 1995-06-08 | 1998-07-14 | Barnes-Jewish Hospital | Method of MRI using avidin-biotin conjugated emulsions as a site specific binding system |
US6821506B2 (en) * | 1995-06-08 | 2004-11-23 | Barnes-Jewish Hospital | Site specific binding system, imaging compositions and methods |
US5690907A (en) | 1995-06-08 | 1997-11-25 | The Jewish Hospital Of St. Louis | Avidin-biotin conjugated emulsions as a site specific binding system |
WO1998023608A1 (en) * | 1996-11-27 | 1998-06-04 | Dupont Pharmaceuticals Company | Novel integrin receptor antagonists |
JP2001521520A (ja) | 1997-04-11 | 2001-11-06 | ジー.ディー.サール アンド カンパニー | 抗α▲下v▼β▲下3▼インテグリン抗体アンタゴニスト |
JP2001524481A (ja) | 1997-11-26 | 2001-12-04 | デュポン ファーマシューティカルズ カンパニー | αVβ3アンタゴニストとしての1,3,4−チアジアゾール類および1,3,4−オキサジアゾール類 |
IL138093A0 (en) | 1998-03-31 | 2001-10-31 | Du Pont Pharm Co | Pharmaceuticals for the imaging of angiogenic disorders |
US6056939A (en) | 1998-08-28 | 2000-05-02 | Desreux; Jean F. | Self-assembling heteropolymetallic chelates as imaging agents and radiopharmaceuticals |
EP1140864A2 (en) | 1998-12-18 | 2001-10-10 | Du Pont Pharmaceuticals Company | Vitronectin receptor antagonist pharmaceuticals |
DE69936148T2 (de) | 1998-12-18 | 2008-01-24 | Bristol-Myers Squibb Pharma Co. | Vitronektinrezeptorantagonist-arzneimittel |
CA2727746A1 (en) * | 1998-12-18 | 2000-06-22 | Bristol-Myers Squibb Pharma Company | Quinolone vitronectin receptor antagonist pharmaceuticals |
ATE290879T1 (de) * | 1999-08-18 | 2005-04-15 | Altarex Medical Corp | Therapeutische antikörper gegen das muc-1 antigen und verfahren zu deren verwendung |
WO2001097848A2 (en) | 2000-06-21 | 2001-12-27 | Bristol-Myers Squibb Pharma Company | Vitronectin receptor antagonist pharmaceuticals |
AU2002241576A1 (en) | 2000-11-20 | 2002-06-11 | Board Of Regents University Of Texas System | Paramagnetic metal ion-based macrocyclic contrast agents |
US7179449B2 (en) | 2001-01-30 | 2007-02-20 | Barnes-Jewish Hospital | Enhanced ultrasound detection with temperature-dependent contrast agents |
HUP0401904A3 (en) * | 2001-08-08 | 2009-01-28 | Bristol Myers Squibb Pharma Co | Simultaneous imaging of cardiac perfusion and a vitronectin receptor targeted imaging agent |
CN100356984C (zh) * | 2002-01-24 | 2007-12-26 | 巴内斯-朱威胥医院 | 整联蛋白靶向的影像剂 |
-
2003
- 2003-01-24 CN CNB038068575A patent/CN100356984C/zh not_active Expired - Fee Related
- 2003-01-24 US US10/351,463 patent/US7255875B2/en not_active Expired - Fee Related
- 2003-01-24 NZ NZ534500A patent/NZ534500A/en unknown
- 2003-01-24 JP JP2003562080A patent/JP4731117B2/ja not_active Expired - Fee Related
- 2003-01-24 KR KR1020047011515A patent/KR100978126B1/ko not_active IP Right Cessation
- 2003-01-24 CA CA2474386A patent/CA2474386C/en not_active Expired - Fee Related
- 2003-01-24 AU AU2003209392A patent/AU2003209392B2/en not_active Ceased
- 2003-01-24 MX MXPA04007188A patent/MXPA04007188A/es unknown
- 2003-01-24 TR TR2004/01834T patent/TR200401834T2/xx unknown
- 2003-01-24 EP EP10185536A patent/EP2269659A1/en not_active Withdrawn
- 2003-01-24 WO PCT/US2003/002380 patent/WO2003062198A1/en active Application Filing
- 2003-01-24 BR BR0307206-1A patent/BR0307206A/pt not_active Expired - Fee Related
- 2003-01-24 EP EP03707550A patent/EP1572639A4/en not_active Withdrawn
- 2003-01-24 CN CNA2007101667648A patent/CN101249269A/zh active Pending
-
2004
- 2004-08-19 CO CO04080978A patent/CO5601001A2/es not_active Application Discontinuation
- 2004-08-23 ZA ZA200406686A patent/ZA200406686B/en unknown
-
2005
- 2005-12-16 US US11/305,416 patent/US7344698B2/en not_active Expired - Fee Related
-
2008
- 2008-01-09 US US11/971,818 patent/US7566442B2/en not_active Expired - Fee Related
-
2009
- 2009-01-09 AU AU2009200095A patent/AU2009200095A1/en not_active Abandoned
-
2010
- 2010-07-30 JP JP2010171706A patent/JP5444154B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2474386C (en) | 2011-07-05 |
US7255875B2 (en) | 2007-08-14 |
US20080175792A1 (en) | 2008-07-24 |
US20040058951A1 (en) | 2004-03-25 |
US7566442B2 (en) | 2009-07-28 |
KR100978126B1 (ko) | 2010-08-26 |
JP2010248248A (ja) | 2010-11-04 |
WO2003062198A1 (en) | 2003-07-31 |
CN100356984C (zh) | 2007-12-26 |
US7344698B2 (en) | 2008-03-18 |
EP1572639A4 (en) | 2006-08-09 |
BR0307206A (pt) | 2004-12-21 |
JP5444154B2 (ja) | 2014-03-19 |
TR200401834T2 (tr) | 2005-10-21 |
WO2003062198A8 (en) | 2003-11-06 |
MXPA04007188A (es) | 2005-10-18 |
CA2474386A1 (en) | 2003-07-31 |
AU2003209392B2 (en) | 2008-10-09 |
WO2003062198A3 (en) | 2005-08-04 |
EP2269659A1 (en) | 2011-01-05 |
KR20040090986A (ko) | 2004-10-27 |
EP1572639A1 (en) | 2005-09-14 |
JP2005525319A (ja) | 2005-08-25 |
ZA200406686B (en) | 2005-09-19 |
JP4731117B2 (ja) | 2011-07-20 |
US20060147380A1 (en) | 2006-07-06 |
CN101249269A (zh) | 2008-08-27 |
NZ534500A (en) | 2007-07-27 |
CN1738815A (zh) | 2006-02-22 |
AU2009200095A1 (en) | 2009-02-05 |
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