ES2544954T3 - Péptidos multiméricos ramificados para diagnóstico y terapia de tumores - Google Patents

Péptidos multiméricos ramificados para diagnóstico y terapia de tumores Download PDF

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Publication number
ES2544954T3
ES2544954T3 ES07722808.8T ES07722808T ES2544954T3 ES 2544954 T3 ES2544954 T3 ES 2544954T3 ES 07722808 T ES07722808 T ES 07722808T ES 2544954 T3 ES2544954 T3 ES 2544954T3
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ES
Spain
Prior art keywords
formula
therapy
tumor diagnosis
multimeric peptides
branched
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES07722808.8T
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English (en)
Inventor
Luisa Bracci
Chiara Falciani
Alessandro Pini
Monica Fabbrini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universita degli Studi di Siena
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Universita degli Studi di Siena
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Publication of ES2544954T3 publication Critical patent/ES2544954T3/es
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C07K7/083—Neurotensin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Un péptido multimérico que tiene las fórmulas generales A o B:**Fórmula** o**Fórmula** en las que n >= 1 a 5, X >=**Fórmula** en la que m >= 1 a 27, o**Fórmula** en la que p >= 1 a 5,**Fórmula** en la que m >= 1-27 y q >= 1 a 5, o,**Fórmula** en la que q >= 1 a 5, o**Fórmula** en la que q >= 1 a 5 W >=**Fórmula** o**Fórmula** o**Fórmula** o**Fórmula** o**Fórmula** y Z >= NH2 u OH, en las que cada péptido tiene una secuencia derivada de Neurotensina (NT), para su uso como agente antitumoral.

Description

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Claims (1)

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ES07722808.8T 2006-02-14 2007-02-13 Péptidos multiméricos ramificados para diagnóstico y terapia de tumores Active ES2544954T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US77369306P 2006-02-14 2006-02-14
US773693P 2006-02-14
PCT/EP2007/001224 WO2007093373A2 (en) 2006-02-14 2007-02-13 Branched multimeric peptides for tumor diagnosis and therapy

Publications (1)

Publication Number Publication Date
ES2544954T3 true ES2544954T3 (es) 2015-09-07

Family

ID=38371865

Family Applications (1)

Application Number Title Priority Date Filing Date
ES07722808.8T Active ES2544954T3 (es) 2006-02-14 2007-02-13 Péptidos multiméricos ramificados para diagnóstico y terapia de tumores

Country Status (3)

Country Link
EP (1) EP1991561B1 (es)
ES (1) ES2544954T3 (es)
WO (1) WO2007093373A2 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2362784A2 (en) * 2008-11-06 2011-09-07 Luisa Bracci Neurotensin-derived branched peptides and uses thereof
EP2374003B1 (en) 2009-01-07 2015-03-11 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the treatment, the prognostic assessment and the detection of breast cancer
WO2012014046A2 (en) * 2010-07-27 2012-02-02 Diego Tesauro Supramolecular aggregates as drug carriers on cell expressing receptors for branched neurotensin
CN103458931A (zh) * 2011-02-10 2013-12-18 国立理工学院高级研究中心 用于癌症的基因疗法的nts-多聚复合纳米颗粒系统
CN103308689B (zh) * 2012-03-08 2017-04-12 思芬构技术有限公司 用于预测雌性对象中患上癌症的风险或诊断癌症的方法
ITRM20130565A1 (it) * 2013-10-14 2015-04-15 Univ Siena Composti anti tnf-alpha e loro usi
WO2017180834A1 (en) * 2016-04-13 2017-10-19 Tarveda Therapeutics, Inc. Neurotensin receptor binding conjugates and formulations thereof
CN109789183A (zh) 2016-09-29 2019-05-21 Aebi有限公司 治疗性多靶向构建体及其用途
WO2020170254A1 (en) * 2019-02-21 2020-08-27 Ramot At Tel-Aviv University Ltd. Treatment of diseases with multimeric peptides

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE39048E1 (en) * 1995-06-07 2006-03-28 Pepscan Systems B.V. Peptide, immunogenic composition and vaccine or medical preparation, a method to immunise animals against the hormone LHRH, and analogs of the LHRH tandem repeat peptide and their use as vaccine
KR100335320B1 (ko) * 1995-06-07 2002-09-13 스티칭 인스티튜트 부르 디에르후데리지 엔 디에르게존드헤이드 황체호르몬방출호르몬에대한향상된펩티드,면역원성조성물및백신또는의학용제제,동물을면역시키는방법,및황체호르몬방출호르몬직렬반복펩티드의유사체및백신으로서이들의용도
US20040202673A1 (en) * 2003-04-08 2004-10-14 Jen-Pin Huang Constructs of branched synthetic peptide immunogens with artificial T helper cell epitopes coupled to B cell epitopes

Also Published As

Publication number Publication date
EP1991561A2 (en) 2008-11-19
WO2007093373A3 (en) 2008-03-06
WO2007093373A2 (en) 2007-08-23
EP1991561B1 (en) 2015-06-17

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