CL2021002249A1 - Composiciones de partículas de sílice mesoporosa para administración viral - Google Patents
Composiciones de partículas de sílice mesoporosa para administración viralInfo
- Publication number
- CL2021002249A1 CL2021002249A1 CL2021002249A CL2021002249A CL2021002249A1 CL 2021002249 A1 CL2021002249 A1 CL 2021002249A1 CL 2021002249 A CL2021002249 A CL 2021002249A CL 2021002249 A CL2021002249 A CL 2021002249A CL 2021002249 A1 CL2021002249 A1 CL 2021002249A1
- Authority
- CL
- Chile
- Prior art keywords
- mesoporous silica
- silica particle
- viral delivery
- particle compositions
- viral vectors
- Prior art date
Links
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 2
- 239000002245 particle Substances 0.000 title 1
- 239000000377 silicon dioxide Substances 0.000 title 1
- 230000003612 virological effect Effects 0.000 title 1
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 239000013603 viral vector Substances 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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- A61K47/642—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a cytokine, e.g. IL2, chemokine, growth factors or interferons being the inactive part of the conjugate
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- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
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- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
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- C12N2501/23—Interleukins [IL]
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Abstract
La presente invención se refiere generalmente al uso de composiciones que incluyen partículas de sílice mesoporosa que pueden tener modificación superficial, para la administración de vectores virales. En algunas realizaciones, los vectores virales se usan para transducir linfocitos T para expresar un receptor de antígeno quimérico (CAR), para tratar a un sujeto que tiene una enfermedad, por ejemplo, una enfermedad asociada con la expresión de un antígeno tumoral.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US201962810260P | 2019-02-25 | 2019-02-25 |
Publications (1)
Publication Number | Publication Date |
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CL2021002249A1 true CL2021002249A1 (es) | 2022-04-22 |
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ID=69941486
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JP2021501570A (ja) | 2017-10-18 | 2021-01-21 | ノバルティス アーゲー | 選択的タンパク質分解のための組成物及び方法 |
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CN116601170A (zh) * | 2020-12-10 | 2023-08-15 | 上海药明生物技术有限公司 | 抗p-钙粘蛋白抗体及其用途 |
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CA3126087A1 (en) | 2020-09-03 |
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BR112021016609A2 (pt) | 2021-11-03 |
AR118185A1 (es) | 2021-09-22 |
AR123362A2 (es) | 2022-11-23 |
CN113412127A (zh) | 2021-09-17 |
EP3930763A1 (en) | 2022-01-05 |
KR20210134339A (ko) | 2021-11-09 |
TW202045207A (zh) | 2020-12-16 |
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