AR108707A1 - ANTICUERPOS ANTI-IgE PARA SER UTILIZADOS EN EL TRATAMIENTO DE LOS TRASTORNOS CAUSADOS POR IgE - Google Patents

ANTICUERPOS ANTI-IgE PARA SER UTILIZADOS EN EL TRATAMIENTO DE LOS TRASTORNOS CAUSADOS POR IgE

Info

Publication number
AR108707A1
AR108707A1 ARP170101588A ARP170101588A AR108707A1 AR 108707 A1 AR108707 A1 AR 108707A1 AR P170101588 A ARP170101588 A AR P170101588A AR P170101588 A ARP170101588 A AR P170101588A AR 108707 A1 AR108707 A1 AR 108707A1
Authority
AR
Argentina
Prior art keywords
ige
antigen binding
binding agent
sec
amino acid
Prior art date
Application number
ARP170101588A
Other languages
English (en)
Inventor
Marta Katarzyna Westwood
Brian John Sutton
James Michael Mdonnell
Xiaofeng Liu
Alistair James Henry
Anna Marie Davies
Thomas Allen Ceska
Ralph Adams
Original Assignee
Ucb Biopharma Sprl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb Biopharma Sprl filed Critical Ucb Biopharma Sprl
Publication of AR108707A1 publication Critical patent/AR108707A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
    • C07K16/4291—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig against IgE
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • Endocrinology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Mycology (AREA)

Abstract

Reivindicación 1: Un anticuerpo anti-IgE o agente de unión al antígeno, que se contacta con un epítopo que comprende, con referencia a la ID. DE SEC. Nº 108, los residuos T373, W374, S375, R376, A377, S378, G379, P381, Q417, C418, R419, T421, P426, R427, A428 de un dominio Ce3 y los residuos D278 y T281 de un dominio Ce2 de la IgE humana. Reivindicación 11: Un anticuerpo anti-IgE o el agente de unión al antígeno, de un modo opcional de acuerdo con las reivindicaciones 1 a 10, que comprende una región variable de cadena pesada que comprende una región determinante de la complementariedad, CDR-H3, con una secuencia de aminoácidos con la Id. de Sec. Nº 18, y una región variable de cadena liviana que comprende una región determinante de la complementariedad, CDR-L1, con una secuencia de aminoácidos con la Id. de Sec. Nº 29, donde la región variable de cadena liviana comprende, asimismo, una región de marco de lectura, FR-L3, con una secuencia de aminoácidos seleccionada de la Id. de Sec. Nº 32 que tiene una, dos, tres, cuatro, cinco, seis, siete o más sustituciones de aminoácidos, para fortalecer la interacción del anticuerpo anti-IgE o del agente de unión al antígeno, con el dominio Ce2 de la IgE humana. Reivindicación 104: Una secuencia de ADN aislada que codifica la o las cadenas pesadas y/o livianas de un anticuerpo anti-IgE o un agente de unión al antígeno, de acuerdo con las reivindicaciones 1 a 103. Reivindicación 105: Un vector de clonación o expresión que comprende una o más secuencias de ADN de acuerdo con la reivindicación 104. Reivindicación 108: Una célula hospedadora que comprende uno o más vectores de clonación o expresión de acuerdo con las reivindicaciones 105 a 107 Reivindicación 111: Una composición farmacéutica que comprende el anticuerpo anti-IgE o el agente de unión al antígeno, de acuerdo con las reivindicaciones 1 a 103, en combinación con uno o más excipientes, diluyentes o portadores farmacéuticamente aceptables. Reivindicación 123: El anticuerpo anti-IgE o el agente de unión al antígeno, de acuerdo con las reivindicaciones 1 a 103, o una composición de acuerdo con las reivindicaciones 102 a 111 para usar en el tratamiento o en la prevención de trastornos asociados con el complejo de la IgE humana y FceRI.
ARP170101588A 2016-06-10 2017-06-09 ANTICUERPOS ANTI-IgE PARA SER UTILIZADOS EN EL TRATAMIENTO DE LOS TRASTORNOS CAUSADOS POR IgE AR108707A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1610198.2A GB201610198D0 (en) 2016-06-10 2016-06-10 Anti-ige antibodies

Publications (1)

Publication Number Publication Date
AR108707A1 true AR108707A1 (es) 2018-09-19

Family

ID=56894897

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP170101588A AR108707A1 (es) 2016-06-10 2017-06-09 ANTICUERPOS ANTI-IgE PARA SER UTILIZADOS EN EL TRATAMIENTO DE LOS TRASTORNOS CAUSADOS POR IgE

Country Status (26)

Country Link
US (2) US11214627B2 (es)
EP (1) EP3468995A1 (es)
JP (2) JP7164439B2 (es)
KR (1) KR102456813B1 (es)
CN (1) CN109379892B (es)
AR (1) AR108707A1 (es)
AU (1) AU2017277600B2 (es)
BR (1) BR112018074838A2 (es)
CA (1) CA3027120A1 (es)
CL (2) CL2018003556A1 (es)
CO (1) CO2018013006A2 (es)
EA (1) EA201990004A1 (es)
EC (1) ECSP19001438A (es)
GB (2) GB201610198D0 (es)
IL (2) IL309516A (es)
MA (1) MA45231A (es)
MX (1) MX2018014761A (es)
PE (1) PE20190212A1 (es)
PH (1) PH12018502574A1 (es)
SG (1) SG11201810199WA (es)
TN (1) TN2018000423A1 (es)
TW (1) TW201802114A (es)
UA (1) UA126468C2 (es)
UY (1) UY37290A (es)
WO (1) WO2017211928A1 (es)
ZA (2) ZA201807822B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE065861T2 (hu) * 2016-08-26 2024-06-28 Sanofi Sa Szelektív könnyûlánc-párosítást elõsegítõ multispecifikus antitestek
US20210115156A1 (en) 2018-04-13 2021-04-22 INSERM (Institut National de la Santé et de la Recherche Médicale) Fc-engineered anti-human ige antibodies and methods of use
MA53903A (fr) * 2018-10-16 2021-08-25 UCB Biopharma SRL Méthode de traitement de la myasthénie grave
GB2589049C (en) * 2019-04-11 2024-02-21 argenx BV Anti-IgE antibodies
JP2022546002A (ja) * 2019-07-11 2022-11-02 武▲漢▼友芝友生物制▲薬▼有限公司 ４価の対称型二重特異性抗体
TW202128748A (zh) 2020-01-24 2021-08-01 日商西斯美股份有限公司 提升抗體對抗原之親和性的方法及其用途
CN113372450A (zh) * 2020-03-10 2021-09-10 北京万华生物工程有限公司 IgE嵌合性双特异性抗体制备及应用
WO2021225980A1 (en) * 2020-05-04 2021-11-11 Dna-Seq, Inc. Methods and systems for determination of an effective therapeutic regimen and drug discovery
WO2021250546A1 (en) 2020-06-09 2021-12-16 University Of Washington Micrornas as predictors of response to anti-ige therapies in chronic spontaneous urticaria
CN111875706B (zh) * 2020-07-16 2021-03-30 广州康盛生物科技股份有限公司 一种抗人IgE蛋白的单域抗体及其应用
WO2022061236A1 (en) * 2020-09-21 2022-03-24 The Board Of Trustees Of The Leland Stanford Junior University High affinity anti-ige antibodies
WO2023061390A1 (en) * 2021-10-12 2023-04-20 United BioPharma, Inc. Treatment of ige-mediated diseases
EP4431528A1 (en) * 2021-10-29 2024-09-18 Longbio Pharma (Suzhou) Co., Ltd. Isolated antigen binding protein and use thereof
CN114028569B (zh) * 2021-12-20 2023-04-28 中国医学科学院基础医学研究所 免疫球蛋白IgE在诊断和/或治疗高血压中的用途
CN114504644B (zh) * 2021-12-24 2024-02-13 北京大学第一医院 抗IgE抗体在用于治疗腺样体肥大中的应用
WO2024003376A1 (en) * 2022-07-01 2024-01-04 Alk-Abelló A/S Displacers of ige-fceri
CN116143932A (zh) * 2022-12-07 2023-05-23 南开大学 一种针对IgE的抗体或其抗原结合片段以及Fc变体
CN116754773B (zh) * 2023-05-15 2024-06-07 江南大学 一种免疫球蛋白e的检测试剂盒

Family Cites Families (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4741900A (en) 1982-11-16 1988-05-03 Cytogen Corporation Antibody-metal ion complexes
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
DE3590766T (es) 1985-03-30 1987-04-23
US6492107B1 (en) 1986-11-20 2002-12-10 Stuart Kauffman Process for obtaining DNA, RNA, peptides, polypeptides, or protein, by recombinant DNA technique
DK336987D0 (da) 1987-07-01 1987-07-01 Novo Industri As Immobiliseringsmetode
US5618920A (en) 1985-11-01 1997-04-08 Xoma Corporation Modular assembly of antibody genes, antibodies prepared thereby and use
DE3600905A1 (de) 1986-01-15 1987-07-16 Ant Nachrichtentech Verfahren zum dekodieren von binaersignalen sowie viterbi-dekoder und anwendungen
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
GB8719042D0 (en) 1987-08-12 1987-09-16 Parker D Conjugate compounds
GB8720833D0 (en) 1987-09-04 1987-10-14 Celltech Ltd Recombinant dna product
DE68913658T3 (de) 1988-11-11 2005-07-21 Stratagene, La Jolla Klonierung von Immunglobulin Sequenzen aus den variablen Domänen
IL162181A (en) 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
GB8907617D0 (en) 1989-04-05 1989-05-17 Celltech Ltd Drug delivery system
CA2057923A1 (en) 1989-05-16 1990-11-17 William D. Huse Co-expression of heteromeric receptors
CA2016841C (en) 1989-05-16 1999-09-21 William D. Huse A method for producing polymers having a preselected activity
CA2016842A1 (en) 1989-05-16 1990-11-16 Richard A. Lerner Method for tapping the immunological repertoire
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
CA2090126C (en) 1990-08-02 2002-10-22 John W. Schrader Methods for the production of proteins with a desired function
DE69233482T2 (de) 1991-05-17 2006-01-12 Merck & Co., Inc. Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen
GB9112536D0 (en) 1991-06-11 1991-07-31 Celltech Ltd Chemical compounds
WO1992022653A1 (en) 1991-06-14 1992-12-23 Genentech, Inc. Method for making humanized antibodies
ES2193136T3 (es) 1991-08-14 2003-11-01 Genentech Inc Variantes de inmunoglubina para receptores especificos de fc epsilon.
ES2136092T3 (es) 1991-09-23 1999-11-16 Medical Res Council Procedimientos para la produccion de anticuerpos humanizados.
GB9120467D0 (en) 1991-09-26 1991-11-06 Celltech Ltd Anti-hmfg antibodies and process for their production
CA2103887C (en) 1991-12-13 2005-08-30 Gary M. Studnicka Methods and materials for preparation of modified antibody variable domains and therapeutic uses thereof
US5639641A (en) 1992-09-09 1997-06-17 Immunogen Inc. Resurfacing of rodent antibodies
FR2716640B1 (fr) 1994-02-28 1996-05-03 Procedes Machines Speciales Dispositif de centrage et de blocage d'une pièce en vue de son rodage à l'aide d'un rodoir à expansion.
CN100360184C (zh) 1995-07-27 2008-01-09 基因技术股份有限公司 稳定等渗的冻干蛋白质制剂
ZA966075B (en) 1995-07-27 1998-01-19 Genentech Inc Protein formulation.
US6267958B1 (en) 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation
ZA971607B (en) * 1996-03-12 1998-08-25 Univ Johns Hopkins Methods of treatment of allergic diseases
US5714352A (en) 1996-03-20 1998-02-03 Xenotech Incorporated Directed switch-mediated DNA recombination
US5980898A (en) 1996-11-14 1999-11-09 The United States Of America As Represented By The U.S. Army Medical Research & Material Command Adjuvant for transcutaneous immunization
GB9625640D0 (en) 1996-12-10 1997-01-29 Celltech Therapeutics Ltd Biological products
US5994511A (en) * 1997-07-02 1999-11-30 Genentech, Inc. Anti-IgE antibodies and methods of improving polypeptides
US6172213B1 (en) * 1997-07-02 2001-01-09 Genentech, Inc. Anti-IgE antibodies and method of improving polypeptides
EP1056471A4 (en) * 1998-01-29 2001-05-30 Tanox Inc TREATMENT OF ATOPIC DERMATITIS USING IgE ANTAGONISTS
GB9812545D0 (en) 1998-06-10 1998-08-05 Celltech Therapeutics Ltd Biological products
AU5020700A (en) * 1999-05-26 2000-12-18 Tanox, Inc. Treating allergic diseases with immunotherapy and ige antagonists
WO2001090190A2 (en) 2000-05-26 2001-11-29 National Research Council Of Canada Single-domain antigen-binding antibody fragments derived from llama antibodies
US6908963B2 (en) 2001-10-09 2005-06-21 Nektar Therapeutics Al, Corporation Thioester polymer derivatives and method of modifying the N-terminus of a polypeptide therewith
GB0129105D0 (en) 2001-12-05 2002-01-23 Celltech R&D Ltd Expression control using variable intergenic sequences
US7993864B2 (en) 2002-12-03 2011-08-09 Ucb Pharma S.A. Assay for identifying antibody producing cells
GB0312481D0 (en) 2003-05-30 2003-07-09 Celltech R&D Ltd Antibodies
GB0315450D0 (en) 2003-07-01 2003-08-06 Celltech R&D Ltd Biological products
GB0315457D0 (en) 2003-07-01 2003-08-06 Celltech R&D Ltd Biological products
PT1644412E (pt) 2003-07-01 2015-12-23 Ucb Biopharma Sprl Fragmentos de anticorpos fab modificados
WO2005014655A2 (en) 2003-08-08 2005-02-17 Fresenius Kabi Deutschland Gmbh Conjugates of hydroxyalkyl starch and a protein
GB0411186D0 (en) 2004-05-19 2004-06-23 Celltech R&D Ltd Biological products
GB0412181D0 (en) 2004-06-01 2004-06-30 Celltech R&D Ltd Biological products
GB0502358D0 (en) 2005-02-04 2005-03-16 Novartis Ag Organic compounds
MY169746A (en) 2005-08-19 2019-05-14 Abbvie Inc Dual variable domain immunoglobulin and uses thereof
GB0619291D0 (en) 2006-09-29 2006-11-08 Ucb Sa Altered antibodies
RU2009140313A (ru) * 2007-04-02 2011-05-10 Эмджен Фримонт Инк. (Us) АНТИТЕЛА ПРОТИВ IgE
MX2009013269A (es) * 2007-06-05 2010-04-21 Univ Yale Inhibidores de receptor de cinasas de tirosina y metodos de uso de los mismos.
EP2195341B1 (en) 2007-09-26 2017-03-22 UCB Biopharma SPRL Dual specificity antibody fusions
EP2245064B1 (en) 2007-12-21 2014-07-23 Medimmune Limited BINDING MEMBERS FOR INTERLEUKIN-4 RECEPTOR ALPHA (IL-4Ralpha)
JP5470817B2 (ja) 2008-03-10 2014-04-16 日産自動車株式会社 電池用電極およびこれを用いた電池、並びにその製造方法
CN101230103B (zh) * 2008-03-25 2011-09-07 中国医药集团总公司四川抗菌素工业研究所 一全人源重组抗-IgE抗体
EA201100527A1 (ru) 2008-09-26 2011-10-31 Юсб Фарма С.А. Биологические продукты
EP2475682B1 (en) 2009-09-10 2018-01-31 UCB Biopharma SPRL Multivalent antibodies
HUE033492T2 (en) 2009-10-26 2017-12-28 Genentech Inc Tests for the detection of antibodies specific for therapeutic anti-verb antibodies and their use in anaphylaxis
JP2013537415A (ja) 2010-08-03 2013-10-03 アッヴィ・インコーポレイテッド 二重可変ドメイン免疫グロブリンおよびその使用
EP2776466B1 (en) * 2011-11-11 2017-08-23 UCB Biopharma SPRL Albumin binding antibodies and binding fragments thereof
BR112014018471A2 (pt) 2012-01-31 2017-07-04 Genentech Inc anticorpos anti-ige m1' e métodos para o seu uso
US20150140608A1 (en) 2012-06-01 2015-05-21 Momenta Pharmaceuticals, Inc. Methods related to omalizumab
JP6136279B2 (ja) 2013-01-15 2017-05-31 株式会社ジェイテクト 転がり軸受装置
TWI503850B (zh) 2013-03-22 2015-10-11 Polytronics Technology Corp 過電流保護元件
WO2015013668A1 (en) * 2013-07-26 2015-01-29 Ke Zhang Anti-immunoglobulin e antibodies and methods of use thereof
TWI510996B (zh) 2013-10-03 2015-12-01 Acer Inc 控制觸控面板的方法以及使用該方法的可攜式電腦
CN104987412A (zh) 2015-07-14 2015-10-21 上海拜豪生物科技有限公司 一种砷-IgE螯合物及其制备方法和应用
WO2017044664A1 (en) * 2015-09-11 2017-03-16 The Board Of Trustees Of The Leland Stanford Junior University Omalizumab resistant ige variants and their use in anti-ige therapy
US9816280B1 (en) 2016-11-02 2017-11-14 Matthew Reitnauer Portable floor

Also Published As

Publication number Publication date
UA126468C2 (uk) 2022-10-12
BR112018074838A2 (pt) 2019-03-26
IL263452A (en) 2019-01-31
CO2018013006A2 (es) 2019-04-30
AU2017277600B2 (en) 2024-08-29
GB201702435D0 (en) 2017-03-29
GB201610198D0 (en) 2016-07-27
RU2019100034A3 (es) 2020-11-20
RU2019100034A (ru) 2020-07-13
EA201990004A1 (ru) 2019-06-28
JP2019522470A (ja) 2019-08-15
CA3027120A1 (en) 2017-12-14
TW201802114A (zh) 2018-01-16
EP3468995A1 (en) 2019-04-17
US20220235146A1 (en) 2022-07-28
KR20190017949A (ko) 2019-02-20
MA45231A (fr) 2021-05-05
WO2017211928A1 (en) 2017-12-14
MX2018014761A (es) 2019-04-25
CN109379892B (zh) 2023-07-04
PH12018502574A1 (en) 2019-10-28
US12054559B2 (en) 2024-08-06
AU2017277600A1 (en) 2019-01-03
CL2018003556A1 (es) 2019-04-05
UY37290A (es) 2018-01-31
AU2017277600A2 (en) 2019-01-17
US20190144565A1 (en) 2019-05-16
JP7164439B2 (ja) 2022-11-01
KR102456813B1 (ko) 2022-10-20
SG11201810199WA (en) 2018-12-28
IL263452B2 (en) 2024-05-01
IL309516A (en) 2024-02-01
IL263452B1 (en) 2024-01-01
ZA201807822B (en) 2020-05-27
ECSP19001438A (es) 2019-01-31
US11214627B2 (en) 2022-01-04
PE20190212A1 (es) 2019-02-07
CL2021002696A1 (es) 2022-06-03
CN109379892A (zh) 2019-02-22
TN2018000423A1 (en) 2020-06-15
JP2023021974A (ja) 2023-02-14
ZA202000803B (en) 2021-08-25

Similar Documents

Publication Publication Date Title
AR108707A1 (es) ANTICUERPOS ANTI-IgE PARA SER UTILIZADOS EN EL TRATAMIENTO DE LOS TRASTORNOS CAUSADOS POR IgE
AR101829A1 (es) Tratamiento de cáncer utilizando un receptor quimérico de antígeno cll-1
AR117911A2 (es) Anticuerpo anti-158p1d7 o fragmento de unión a antígeno del mismo, conjugado fármaco-anticuerpo, composición farmacéutica y sus usos
CL2019001926A1 (es) Anticuerpos anti-tigit y fragmentos de unión a antígeno; composición farmacéutica que los comprende; polinenucleótido que codifica dicho anticuerpo; vector que los comprende, célula hospedera; método para producir dicho anticuerpo o fragmento de unión a antígeno del mismo; y uso en el tratamiento del cáncer. (divisional de solicitud 310-2017).
BR112019005316A2 (pt) anticorpos monoclonais para morte programada 1 (pd-1)
RU2018146533A (ru) Антитела к cd40 и пути их применения
AR075504A1 (es) Moleculas de anticuerpos que tienen especificidad para el ox40 humano
AR108066A1 (es) Receptores quiméricos para cll-1 y métodos de uso de los mismos
EA201892193A1 (ru) Химерные рецепторы к flt3 и способы их применения
MX2019005116A (es) Anticuerpos dirigidos contra la proteina de inmunoglobulina de linfocitos t y de mucina 3 (tim-3).
PE20180481A1 (es) Anticuerpos de union a tau
AR106365A1 (es) Moléculas biespecíficas de unión a antígeno activadoras de células t
AR103868A1 (es) Anticuerpos anti-cd47 como agentes terapéuticos
EA201891084A1 (ru) Антитела к il1rap, биспецифические антигенсвязывающие молекулы, которые связываются с il1rap и cd3, и их применение
EA201590138A1 (ru) Оптимизация антител, которые связывают ген активации лимфоцитов 3 (lag-3), и их применение
AR109264A1 (es) Proteínas de unión semejantes a anticuerpo biespecíficas que se unen específicamente a cd3 y cd123
RU2018138122A (ru) Новая терапия
AR109683A1 (es) Anticuerpos contra el factor xi y sus usos
EA201490020A1 (ru) Растворимые белки для применения в качестве терапевтических средств
EA201600276A1 (ru) Анти-il-17-антитела, способ их получения и способ применения
CY1123275T1 (el) Μορια συνδεσης ειδικα για il-21 και χρησεις αυτων
DOP2013000111A (es) Anticuerpos neutralizadores anti-ccl20
EA201992206A1 (ru) Моноклональное антитело к pd-l1
JP2017508475A5 (es)
AR099625A1 (es) Anticuerpos de il-21