AR106960A2 - SALES Y POLIMORFOS FARMACÉUTICOS DE UN INHIBIDOR DEL FACTOR Xa - Google Patents

SALES Y POLIMORFOS FARMACÉUTICOS DE UN INHIBIDOR DEL FACTOR Xa

Info

Publication number
AR106960A2
AR106960A2 ARP160103799A ARP160103799A AR106960A2 AR 106960 A2 AR106960 A2 AR 106960A2 AR P160103799 A ARP160103799 A AR P160103799A AR P160103799 A ARP160103799 A AR P160103799A AR 106960 A2 AR106960 A2 AR 106960A2
Authority
AR
Argentina
Prior art keywords
salt
salts
clause
compound
polymorphes
Prior art date
Application number
ARP160103799A
Other languages
English (en)
Inventor
Langlands Graeme
P Kanter James
Grant Craig
Original Assignee
Millennium Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharm Inc filed Critical Millennium Pharm Inc
Publication of AR106960A2 publication Critical patent/AR106960A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Sales que comprenden un compuesto y un ácido que tiene actividad contra el Factor Xa de mamíferos. También se proveen métodos para elaborar dicho compuesto. Reivindicación 1: Una sal, caracterizada porque comprende un compuesto de fórmula (1) y un ácido seleccionado a partir del grupo que consiste en clorhídrico, láctico, maleico, fenoxiacético, propiónico, succínico, adípico, ascórbico, alcanfórico, glucónico, fosfórico, tártrico, cítrico, metansulfónico, fumárico, glicólico, naftaleno-1,5-disulfónico, gentísico y benceno sulfónico. Reivindicación 6: La sal de la cláusula 4, caracterizada porque la sal está representada por medio de la fórmula (2). Reivindicación 8: La sal de la cláusula 7, caracterizada porque tiene un patrón de difracción de rayos X en polvo que tiene al menos cuatro localizaciones de picos característicos aproximados que se seleccionan de 4,9; 9,7; 13,8; 14,1; 15,2; 17,6; 18,5; 20,8; 21,6; 22,7; 24,1; 26,3; 26,8 grados 2q. Reivindicación 9: La sal de la cláusula 7, caracterizada porque tiene un patrón de difracción de rayos X en polvo que tiene al menos ocho localizaciones de picos característicos aproximados que se seleccionan de 4,9; 9,7; 11,8; 13,8; 14,1; 15,2; 17,6; 18,5; 19,9; 20,8; 21,6; 22,7; 24,1; 25,0; 26,3; 26,8 grados 2q.
ARP160103799A 2005-11-08 2016-12-12 SALES Y POLIMORFOS FARMACÉUTICOS DE UN INHIBIDOR DEL FACTOR Xa AR106960A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73522405P 2005-11-08 2005-11-08

Publications (1)

Publication Number Publication Date
AR106960A2 true AR106960A2 (es) 2018-03-07

Family

ID=38023988

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP060104900A AR056787A1 (es) 2005-11-08 2006-11-08 Sales y polimorfos farmaceuticos de un inhibidor del factor xa
ARP160103799A AR106960A2 (es) 2005-11-08 2016-12-12 SALES Y POLIMORFOS FARMACÉUTICOS DE UN INHIBIDOR DEL FACTOR Xa

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ARP060104900A AR056787A1 (es) 2005-11-08 2006-11-08 Sales y polimorfos farmaceuticos de un inhibidor del factor xa

Country Status (20)

Country Link
US (7) US7598276B2 (es)
EP (2) EP1948608B1 (es)
JP (2) JP5227178B2 (es)
KR (1) KR101358574B1 (es)
CN (2) CN101304971B (es)
AR (2) AR056787A1 (es)
AT (1) ATE549317T1 (es)
AU (1) AU2006311544B2 (es)
BR (1) BRPI0618362A2 (es)
CA (1) CA2627086C (es)
DK (1) DK1948608T3 (es)
ES (1) ES2384116T3 (es)
IL (2) IL190524A (es)
NZ (2) NZ592533A (es)
PE (2) PE20110070A1 (es)
PT (1) PT1948608E (es)
RU (1) RU2440986C2 (es)
TW (1) TWI443088B (es)
WO (1) WO2007056517A2 (es)
ZA (1) ZA200803820B (es)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001250783A1 (en) * 2000-02-29 2001-09-12 Cor Therapeutics, Inc. Benzamides and related inhibitors of factor xa
KR101195801B1 (ko) * 2004-06-18 2012-11-05 밀레니엄 파머슈티컬스 인코퍼레이티드 Ｘａ 인자 억제제
US7696352B2 (en) * 2004-06-18 2010-04-13 Millennium Pharmaceuticals, Inc. Factor Xa inhibitors
NZ592533A (en) 2005-11-08 2012-08-31 Millennium Pharm Inc METHOD FOR THE PREPARATION OF N-(5-CHLORO-2-PYRIDINYL)-2-[[4-[(DIMETHYLAMINO) IMINOMETHYL] BENZOYL] AMINO]-5-METHOXY-BENZAMIDE, A FACTOR Xa INHIBITOR
WO2007112367A2 (en) * 2006-03-27 2007-10-04 Portola Pharmaceuticals, Inc. Potassium channel modulators and platelet procoagulant activity
MX2008014193A (es) * 2006-05-05 2009-03-31 Millennium Pharm Inc Inhibidores del factor xa.
ES2550057T3 (es) * 2006-11-02 2015-11-04 Millennium Pharmaceuticals, Inc. Métodos para sintetizar sales farmacéuticas de un inhibidor del Factor Xa
CN105193799A (zh) * 2006-12-08 2015-12-30 米伦纽姆医药公司 使用经口因子xa抑制剂治疗血栓形成的单位剂量调配物和方法
JP2010515691A (ja) * 2007-01-05 2010-05-13 ミレニアム・ファーマシューティカルズ・インコーポレイテッド 第Ｘａ因子阻害剤
TWI384986B (zh) * 2007-01-17 2013-02-11 Lg Life Sciences Ltd 抗病毒劑之順丁烯二酸單鹽以及含有該單鹽之醫藥組成物
EP2155195B1 (en) * 2007-04-13 2014-07-16 Millennium Pharmaceuticals, Inc. Combination anticoagulant therapy with a compound that acts as a factor Xa inhibitor
MX2009011755A (es) * 2007-05-02 2010-02-12 Portola Pharm Inc Terapia de combinacion con un compuesto que actua como un inhibidor del receptor adp de plaquetas.
KR102069498B1 (ko) 2007-09-28 2020-01-23 포톨라 파마슈티컬스, 인코포레이티드 인자 Ｘａ 저해제에 대한 안티도트 및 그것을 사용하는 방법
UY31531A1 (es) * 2007-12-17 2009-08-03 Sales derivadas de 8-oxoadenina composiciones farmacéuticas que las contienen y su uso en terapia como moduladores de receptor tipo toll (tlr)
EP2364165B1 (en) 2008-11-14 2018-01-03 Portola Pharmaceuticals, Inc. Antidotes for factor xa inhibitors and methods of using the same in combination with blood coagulating agents
PL3604510T3 (pl) 2009-03-30 2025-07-28 Alexion Pharmaceuticals, Inc. Antidota na inhibitory czynnika xa i sposoby ich stosowania
PT2453910T (pt) 2009-07-15 2016-12-07 Portola Pharm Inc Formulação de dose unitária de antídoto contra inibidores de fator xa para uso na prevenção de sangramento
CA2784921A1 (en) * 2009-12-17 2011-07-14 Millennium Pharmaceuticals, Inc. Salts and crystalline forms of a factor xa inhibitor
CA2784904C (en) * 2009-12-17 2017-10-10 Millennium Pharmaceuticals, Inc. Methods of synthesizing factor xa inhibitors
US8742120B2 (en) * 2009-12-17 2014-06-03 Millennium Pharmaceuticals, Inc. Methods of preparing factor xa inhibitors and salts thereof
EA015918B1 (ru) * 2010-03-03 2011-12-30 Дмитрий Геннадьевич ТОВБИН УРЕТАНЫ, МОЧЕВИНЫ, АМИДЫ И РОДСТВЕННЫЕ ИНГИБИТОРЫ ФАКТОРА Xa
TW201221128A (en) * 2010-09-01 2012-06-01 Portola Pharm Inc Crystalline forms of a factor Xa inhibitor
TW201240664A (en) 2010-09-01 2012-10-16 Portola Pharm Inc Methods and formulations of treating thrombosis with betrixaban and a P-glycoprotein inhibitor
CN102952138B (zh) * 2011-08-17 2016-07-06 上海特化医药科技有限公司 一种吡唑并嘧啶酮化合物的盐、多晶型物及其药物组合物、制备方法和应用
WO2013033370A1 (en) 2011-08-31 2013-03-07 Portola Pharmaceuticals, Inc. Prevention and treatment of thrombosis in medically ill patients
US20140346397A1 (en) 2012-12-27 2014-11-27 Portola Pharmaceuticals, Inc. Compounds and methods for purification of serine proteases
US9200268B2 (en) * 2012-12-27 2015-12-01 Portola Pharmaceuticals, Inc. Compounds and methods for purification of serine proteases
CN104341343B (zh) * 2013-07-24 2018-09-28 四川海思科制药有限公司 贝曲西班的晶型及其制备方法和用途
CN105085387A (zh) * 2014-05-20 2015-11-25 四川海思科制药有限公司 贝曲西班盐及其制备方法和用途
KR20250150675A (ko) 2014-08-20 2025-10-20 포톨라 파마슈티컬스, 인코포레이티드 인자 xa 해독제용 동결건조된 제형
WO2017091757A1 (en) * 2015-11-24 2017-06-01 Portola Pharmaceuticals, Inc. Isotopically enriched betrixaban
CN106995405A (zh) * 2016-01-25 2017-08-01 重庆医药工业研究院有限责任公司 一种贝曲西班马来酸盐无定型物及其制备方法
CN108883160B (zh) 2016-02-24 2022-06-28 博尔托拉制药公司 因子xa解毒剂的冻干制剂
WO2017208169A1 (en) * 2016-06-02 2017-12-07 Dr. Reddy’S Laboratories Limited Polymorphs of betrixaban & its maleate salt
EP3254674A1 (en) 2016-06-08 2017-12-13 Sandoz Ag Pharmaceutical compositions of betrixaban maleate
JP6959268B2 (ja) 2016-06-17 2021-11-02 ポートラ ファーマシューティカルズ， インコーポレイテッド 第ｘａ因子誘導体の調製
WO2018042320A1 (en) * 2016-08-30 2018-03-08 Dr. Reddy’S Laboratories Limited Salts of betrixaban and processes for preparation thereof
EP3293174A1 (en) 2016-09-09 2018-03-14 Sandoz Ag Crystalline salts of betrixaban
WO2018069936A1 (en) 2016-10-13 2018-04-19 Mylan Laboratories Limited Polymorphs and solid dispersion of betrixaban and methods for the preparation thereof
CN108017576B (zh) * 2016-11-01 2022-06-21 石药集团中奇制药技术（石家庄）有限公司 一种贝曲西班及其盐酸盐的制备方法，以及它们的晶型
CN108586325A (zh) * 2017-03-16 2018-09-28 上海度德医药科技有限公司 一种Betrixaban中间体的制备方法
WO2018229796A2 (en) * 2017-06-14 2018-12-20 Mylan Laboratories Limited A process for betrixaban hydrochloride and betrixaban maleate salt
CN107868039A (zh) * 2017-11-27 2018-04-03 中国药科大学 一种贝曲沙班中间体n－（5－氯－2－吡啶基）－2－［（4－氰基苯甲酰基）氨基］－5－甲氧基苯甲酰胺的制备方法
WO2022211680A1 (ru) * 2021-03-30 2022-10-06 Общество С Ограниченной Ответственностью "Фармадиол" Способ получения антикоагулянта n-(5-хлорпиридин-2-ил)-2-({4-[этан-имидоил(метил)амино]бензоил}амино)-5-метилбензамид гидрохлорида
CN115057854A (zh) * 2022-04-19 2022-09-16 河北常山生化药业股份有限公司 马来酸阿伐曲泊帕中间体的制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2151044A1 (en) 1992-12-15 1994-06-23 Terence K. Brunck Novel inhibitors for factor xa
GB9226238D0 (en) 1992-12-16 1993-02-10 Scherer Ltd R P Encapsulation apparatus and process
DE69529770T2 (de) 1994-12-02 2003-12-24 Yamanouchi Pharmaceutical Co., Ltd. Neues amidinonaphthylderivat oder dessen salz
US5849759A (en) 1995-12-08 1998-12-15 Berlex Laboratories, Inc. Naphthyl-substituted benzimidazole derivatives as anti-coagulants
CN1246847A (zh) 1996-12-23 2000-03-08 杜邦药品公司 作为Xa因子抑制剂的含氮杂芳族化合物
EP1020434A4 (en) 1997-08-27 2000-11-15 Kissei Pharmaceutical 3-AMIDINOANILINE DERIVATIVES, INHIBITORS OF THE ACTIVATED BLOOD COINTENANCE FACTOR X AND INTERMEDIATE PRODUCTS FOR PRODUCING BOTH
US6140351A (en) * 1997-12-19 2000-10-31 Berlex Laboratories, Inc. Ortho-anthranilamide derivatives as anti-coagulants
US6844367B1 (en) * 1999-09-17 2005-01-18 Millennium Pharmaceuticals, Inc. Benzamides and related inhibitors of factor Xa
DE60040676D1 (de) 1999-09-17 2008-12-11 Millennium Pharm Inc BENZAMIDE UND ÄHNLICHE INHIBITOREN VON FAKTOR Xa
AU2001250783A1 (en) * 2000-02-29 2001-09-12 Cor Therapeutics, Inc. Benzamides and related inhibitors of factor xa
US6627646B2 (en) * 2001-07-17 2003-09-30 Sepracor Inc. Norastemizole polymorphs
NZ592533A (en) 2005-11-08 2012-08-31 Millennium Pharm Inc METHOD FOR THE PREPARATION OF N-(5-CHLORO-2-PYRIDINYL)-2-[[4-[(DIMETHYLAMINO) IMINOMETHYL] BENZOYL] AMINO]-5-METHOXY-BENZAMIDE, A FACTOR Xa INHIBITOR
ES2550057T3 (es) 2006-11-02 2015-11-04 Millennium Pharmaceuticals, Inc. Métodos para sintetizar sales farmacéuticas de un inhibidor del Factor Xa

Also Published As

Publication number Publication date
RU2008123055A (ru) 2009-12-20
KR101358574B1 (ko) 2014-02-04
US9555023B2 (en) 2017-01-31
US9061019B2 (en) 2015-06-23
US20070112039A1 (en) 2007-05-17
JP2012246323A (ja) 2012-12-13
PE20070717A1 (es) 2007-08-17
TW200736221A (en) 2007-10-01
IL190524A (en) 2013-02-28
EP1948608B1 (en) 2012-03-14
JP2009514976A (ja) 2009-04-09
US20130064806A1 (en) 2013-03-14
EP1948608A2 (en) 2008-07-30
US20160101089A1 (en) 2016-04-14
PE20110070A1 (es) 2011-03-04
CN102336702B (zh) 2015-02-11
ES2384116T3 (es) 2012-06-29
PT1948608E (pt) 2012-05-24
JP5662980B2 (ja) 2015-02-04
US20170326119A1 (en) 2017-11-16
NZ567992A (en) 2011-05-27
AR056787A1 (es) 2007-10-24
US7598276B2 (en) 2009-10-06
AU2006311544A1 (en) 2007-05-18
CA2627086C (en) 2016-04-05
BRPI0618362A2 (pt) 2011-08-30
EP2431358A1 (en) 2012-03-21
IL213487A0 (en) 2011-07-31
CN101304971A (zh) 2008-11-12
US8557852B2 (en) 2013-10-15
US20140288028A1 (en) 2014-09-25
CN102336702A (zh) 2012-02-01
KR20080065662A (ko) 2008-07-14
AU2006311544B2 (en) 2012-03-08
ZA200803820B (en) 2009-03-25
US20100063113A1 (en) 2010-03-11
US20190046510A1 (en) 2019-02-14
CA2627086A1 (en) 2007-05-18
HK1115131A1 (en) 2008-11-21
WO2007056517A2 (en) 2007-05-18
IL190524A0 (en) 2008-12-29
DK1948608T3 (da) 2012-07-02
ATE549317T1 (de) 2012-03-15
CN101304971B (zh) 2011-09-07
JP5227178B2 (ja) 2013-07-03
NZ592533A (en) 2012-08-31
RU2440986C2 (ru) 2012-01-27
WO2007056517A3 (en) 2008-04-17
TWI443088B (zh) 2014-07-01

Similar Documents

Publication Publication Date Title
AR106960A2 (es) SALES Y POLIMORFOS FARMACÉUTICOS DE UN INHIBIDOR DEL FACTOR Xa
AR103866A2 (es) Composición farmacéutica para la inhibición de la actividad cinasa her-2, compuesto, formas cristalinas aisladas de monohidrato de maleato de (e)-n-{4-[3-cloro-4-(2-piridinilmetoxi)anilino]-3-ciano-7-etoxi-6-quinolinil}-4-(dimetilamino)-2-butenamida, maleato de (e)-n-{4-[3-cloro-4-(2-piridinilmetoxi)anilino]-3-ciano-7-etoxi-6-quinolinil}-4-(dimetilamino)-2-butenamida anhidro y maleato parcialmente hidratado de (e)-n-{4-[3-cloro-4-(2-piridinilmetoxi)anilino]-3-ciano-7-etoxi-6-quinolinil}-4-(dimetilamino)-2-butenamida y métodos para preparar (e)-n-{4-[3-cloro-4-(2-piridinilmetoxi)anilino]-3-ciano-7-etoxi-6-quinolinil}-4-(dimetilamino)-2-butenamida como una sal de maleato y maleato de (e)-n-{4-[3-cloro-4-(2-piridinilmetoxi)anilino]-3-ciano-7-etoxi-6-quinolinil}-4-(dimetilamino)-2-butenamida anhidro
Yusuf et al. Syntheses and anti-depressant activity of 5-amino-1, 3, 4-thiadiazole-2-thiol imines and thiobenzyl derivatives
NO20080728L (no) Nye 1,4-benzotiazepin-1,1-dioksidderivater som har forbedrede egenskaper, fremgangsmate for fremstilling derav, medikamenter inneholdende nevnte forbindelsene og anvendelse derav
GT200600420A (es) Sales novedosas de lisina de derivados de acido 4-((fenoxialquil)tio)-fenoxiacetico
AR060174A1 (es) Un proceso para preparar derivados de tetrahidroquinolina
NO20085068L (no) Fenylamino-benzoksazolsubstituerte karboksylsyrer, fremgangsmate for deres fremstilling og anvendelse derav som medikamenter
AR088372A1 (es) Solucion para administracion oral
ECSP099496A (es) Compuestos inhibidores de fosfofinosítido 3-quinasas y métodos de uso
RU2011138962A (ru) Производные 4-изопропилфенилглюцита в качестве ингибиторов sglt1
UY31917A (es) Compuestos de pirido-pirimidina inhibidores de mtor, composiciones farmaceuticas que los comprenden, procesos para su preparación y su uso como medicamento.
MX2010003849A (es) Antagonistas de cgrp.
AR069491A1 (es) Polimorfos de un inhibidor de c-met/ hgfr
PY0227623A (es) Sales de acido succinico de 5,7,14-triazatetraciclo [10.3.1.02,11.04,9] - hexadeca-2(11),3,5,7,9-pentaeno y composiciones farmaceuticas de las mismas
NO20060653L (no) Isotiazolokinoloner og beslektede forbindelser som anti-infektive midler
MY148953A (en) Substituted biphenyl carboxylic acids and derivatives thereof
ATE465992T1 (de) Beta-kristalline form von perindopril-arginin- salz, verfahren zu dessen herstellung und dieses enthaltende pharmazeutische zubereitungen
UY27673A1 (es) Procedimiento para la preparación de un producto de inhalación en polvo que contiene una sal del antagonista de cgrp,
IL192066A0 (en) Improved method for the production of ramipril
UA92733C2 (ru) Способ получения производных 4-(фенокси-5-метилпиримидин-4-илокси)пиперидин-1-карбоновой кислоты и родственных соединений
AR054735A1 (es) Proceso de obtencion de un derivado de piperazina
EP2451450B1 (en) Inhibitors of proline racemase enzymes for the treatment of Trypanosoma spp infections
DE602006010584D1 (de) Stereoselektive synthese bestimmter trifluormethylsubstituierter alkohole
NO20054389L (no) Cyckloalkyl-substituerte alkansyrederivater, fremgangsmate for fremstilling og anvendelse derav som legemiddel
AR029002A1 (es) Proceso para preparar compuestos de acidos quinolin-2-carboxilicos y de sus sales farmaceuticamente aceptables

Legal Events

Date Code Title Description
FB Suspension of granting procedure