AR106960A2 - SALES Y POLIMORFOS FARMACÉUTICOS DE UN INHIBIDOR DEL FACTOR Xa - Google Patents
SALES Y POLIMORFOS FARMACÉUTICOS DE UN INHIBIDOR DEL FACTOR XaInfo
- Publication number
- AR106960A2 AR106960A2 ARP160103799A ARP160103799A AR106960A2 AR 106960 A2 AR106960 A2 AR 106960A2 AR P160103799 A ARP160103799 A AR P160103799A AR P160103799 A ARP160103799 A AR P160103799A AR 106960 A2 AR106960 A2 AR 106960A2
- Authority
- AR
- Argentina
- Prior art keywords
- salt
- salts
- clause
- compound
- polymorphes
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 6
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 238000000634 powder X-ray diffraction Methods 0.000 abstract 2
- COVZYZSDYWQREU-UHFFFAOYSA-N Busulfan Chemical compound CS(=O)(=O)OCCCCOS(C)(=O)=O COVZYZSDYWQREU-UHFFFAOYSA-N 0.000 abstract 1
- 108010074860 Factor Xa Proteins 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
- A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Sales que comprenden un compuesto y un ácido que tiene actividad contra el Factor Xa de mamíferos. También se proveen métodos para elaborar dicho compuesto. Reivindicación 1: Una sal, caracterizada porque comprende un compuesto de fórmula (1) y un ácido seleccionado a partir del grupo que consiste en clorhídrico, láctico, maleico, fenoxiacético, propiónico, succínico, adípico, ascórbico, alcanfórico, glucónico, fosfórico, tártrico, cítrico, metansulfónico, fumárico, glicólico, naftaleno-1,5-disulfónico, gentísico y benceno sulfónico. Reivindicación 6: La sal de la cláusula 4, caracterizada porque la sal está representada por medio de la fórmula (2). Reivindicación 8: La sal de la cláusula 7, caracterizada porque tiene un patrón de difracción de rayos X en polvo que tiene al menos cuatro localizaciones de picos característicos aproximados que se seleccionan de 4,9; 9,7; 13,8; 14,1; 15,2; 17,6; 18,5; 20,8; 21,6; 22,7; 24,1; 26,3; 26,8 grados 2q. Reivindicación 9: La sal de la cláusula 7, caracterizada porque tiene un patrón de difracción de rayos X en polvo que tiene al menos ocho localizaciones de picos característicos aproximados que se seleccionan de 4,9; 9,7; 11,8; 13,8; 14,1; 15,2; 17,6; 18,5; 19,9; 20,8; 21,6; 22,7; 24,1; 25,0; 26,3; 26,8 grados 2q.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73522405P | 2005-11-08 | 2005-11-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR106960A2 true AR106960A2 (es) | 2018-03-07 |
Family
ID=38023988
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060104900A AR056787A1 (es) | 2005-11-08 | 2006-11-08 | Sales y polimorfos farmaceuticos de un inhibidor del factor xa |
| ARP160103799A AR106960A2 (es) | 2005-11-08 | 2016-12-12 | SALES Y POLIMORFOS FARMACÉUTICOS DE UN INHIBIDOR DEL FACTOR Xa |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060104900A AR056787A1 (es) | 2005-11-08 | 2006-11-08 | Sales y polimorfos farmaceuticos de un inhibidor del factor xa |
Country Status (20)
| Country | Link |
|---|---|
| US (7) | US7598276B2 (es) |
| EP (2) | EP2431358A1 (es) |
| JP (2) | JP5227178B2 (es) |
| KR (1) | KR101358574B1 (es) |
| CN (2) | CN101304971B (es) |
| AR (2) | AR056787A1 (es) |
| AT (1) | ATE549317T1 (es) |
| AU (1) | AU2006311544B2 (es) |
| BR (1) | BRPI0618362A2 (es) |
| CA (1) | CA2627086C (es) |
| DK (1) | DK1948608T3 (es) |
| ES (1) | ES2384116T3 (es) |
| IL (2) | IL190524A (es) |
| NZ (2) | NZ592533A (es) |
| PE (2) | PE20070717A1 (es) |
| PT (1) | PT1948608E (es) |
| RU (1) | RU2440986C2 (es) |
| TW (1) | TWI443088B (es) |
| WO (1) | WO2007056517A2 (es) |
| ZA (1) | ZA200803820B (es) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2254385T3 (es) | 2000-02-29 | 2006-06-16 | Millennium Pharmaceuticals, Inc. | Benzamidas e inhibidores relacionados del factor xa. |
| US7696352B2 (en) * | 2004-06-18 | 2010-04-13 | Millennium Pharmaceuticals, Inc. | Factor Xa inhibitors |
| JP5020073B2 (ja) | 2004-06-18 | 2012-09-05 | ミレニアム ファーマシューティカルズ インク． | 第Ｘａ因子阻害剤 |
| RU2440986C2 (ru) * | 2005-11-08 | 2012-01-27 | Милленниум Фамэсьютикэлс, Инк. | СОЛЬ ИНГИБИТОРА ФАКТОРА Ха, СПОСОБ ЕЕ ПОЛУЧЕНИЯ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ЕЕ ОСНОВЕ, СОСТОЯЩИЕ ИЗ НАЗВАННОЙ КОМПОЗИЦИИ ТАБЛЕТКА, КАПСУЛА И ЛЕПЕШКА, СПОСОБ ЛЕЧЕНИЯ ТРОМБОЗА И СПОСОБ ИНГИБИРОВАНИЯ КОАГУЛЯЦИИ ОБРАЗЦОВ КРОВИ |
| US20090186810A1 (en) * | 2006-03-27 | 2009-07-23 | Portola Pharmaceuticals, Inc. | Potassium channel modulators and platelet procoagulant activity |
| EA015942B1 (ru) * | 2006-05-05 | 2011-12-30 | Милленниум Фамэсьютикэлс, Инк. | Замещенные имидазолы, композиция на их основе, способ профилактики или лечения нежелательного тромбообразования с их помощью и способ ингибирования коагуляции образцов крови |
| PT2077995E (pt) * | 2006-11-02 | 2012-05-10 | Millennium Pharm Inc | Métodos de sintetizar sais farmacêuticos de um inibidor de fator xa |
| NZ578180A (en) * | 2006-12-08 | 2012-02-24 | Millennium Pharm Inc | Unit dose formulations and methods of treating thrombosis with an oral factor xa inhibitor |
| EP2114930A2 (en) * | 2007-01-05 | 2009-11-11 | Millennium Pharmaceuticals, Inc. | Factor xa inhibitors |
| TWI384986B (zh) * | 2007-01-17 | 2013-02-11 | Lg Life Sciences Ltd | 抗病毒劑之順丁烯二酸單鹽以及含有該單鹽之醫藥組成物 |
| CN101743001B (zh) | 2007-04-13 | 2013-02-06 | 千年药品公司 | 用起因子xa抑制剂作用的化合物的组合抗凝治疗 |
| NZ599556A (en) * | 2007-05-02 | 2013-10-25 | Portola Pharm Inc | Combination therapy with a compound acting as a platelet adp receptor inhibitor |
| EP2193196B1 (en) | 2007-09-28 | 2016-07-13 | Portola Pharmaceuticals, Inc. | Antidotes for factor xa inhibitors and methods of using the same |
| PE20091156A1 (es) * | 2007-12-17 | 2009-09-03 | Astrazeneca Ab | Sales de (3-{[[3-(6-amino-2-butoxi-8-oxo-7,8-dihidro-9h-purin-9-il)propil](3-morfolin-4-ilpropil)amino]metil}fenil)acetato de metilo |
| EP2364165B1 (en) | 2008-11-14 | 2018-01-03 | Portola Pharmaceuticals, Inc. | Antidotes for factor xa inhibitors and methods of using the same in combination with blood coagulating agents |
| LT3604510T (lt) | 2009-03-30 | 2025-07-10 | Alexion Pharmaceuticals, Inc. | Faktoriaus xa inhibitorius neutralizuojančios medžiagos ir jų naudojimo būdai |
| JP6163304B2 (ja) | 2009-07-15 | 2017-07-12 | ポートラ ファーマシューティカルズ， インコーポレイテッド | 第Ｘａ因子インヒビターの解毒剤の単位用量処方物およびその使用方法 |
| US8394964B2 (en) | 2009-12-17 | 2013-03-12 | Millennium Pharmaceuticals, Inc. | Methods of synthesizing factor Xa inhibitors |
| WO2011084652A2 (en) * | 2009-12-17 | 2011-07-14 | Millennium Pharmaceuticals, Inc. | Salts and crystalline forms of a factor xa inhibitor |
| WO2011075602A1 (en) * | 2009-12-17 | 2011-06-23 | Millennium Pharmaceuticals, Inc. | Methods of preparing factor xa inhibitors and salts thereof |
| EA015918B1 (ru) * | 2010-03-03 | 2011-12-30 | Дмитрий Геннадьевич ТОВБИН | УРЕТАНЫ, МОЧЕВИНЫ, АМИДЫ И РОДСТВЕННЫЕ ИНГИБИТОРЫ ФАКТОРА Xa |
| AR082803A1 (es) | 2010-09-01 | 2013-01-09 | Portola Pharm Inc | Metodos y formulaciones para el tratamiento de la trombosis con betrixaban y un inhibidor de la glicoproteina p |
| TW201221128A (en) * | 2010-09-01 | 2012-06-01 | Portola Pharm Inc | Crystalline forms of a factor Xa inhibitor |
| CN102952138B (zh) * | 2011-08-17 | 2016-07-06 | 上海特化医药科技有限公司 | 一种吡唑并嘧啶酮化合物的盐、多晶型物及其药物组合物、制备方法和应用 |
| US20150224091A1 (en) * | 2011-08-31 | 2015-08-13 | Portola Pharmaceuticals, Inc. | Prevention and treatment of thrombosis in medically ill patients |
| US20140346397A1 (en) | 2012-12-27 | 2014-11-27 | Portola Pharmaceuticals, Inc. | Compounds and methods for purification of serine proteases |
| US9200268B2 (en) * | 2012-12-27 | 2015-12-01 | Portola Pharmaceuticals, Inc. | Compounds and methods for purification of serine proteases |
| CN104341343B (zh) * | 2013-07-24 | 2018-09-28 | 四川海思科制药有限公司 | 贝曲西班的晶型及其制备方法和用途 |
| CN105085387A (zh) * | 2014-05-20 | 2015-11-25 | 四川海思科制药有限公司 | 贝曲西班盐及其制备方法和用途 |
| EA202091385A3 (ru) | 2014-08-20 | 2021-06-30 | Портола Фармасьютикалз, Инк. | Лиофилизированные составы для антидота фактора ха |
| WO2017091757A1 (en) | 2015-11-24 | 2017-06-01 | Portola Pharmaceuticals, Inc. | Isotopically enriched betrixaban |
| CN106995405A (zh) * | 2016-01-25 | 2017-08-01 | 重庆医药工业研究院有限责任公司 | 一种贝曲西班马来酸盐无定型物及其制备方法 |
| CN108883160B (zh) | 2016-02-24 | 2022-06-28 | 博尔托拉制药公司 | 因子xa解毒剂的冻干制剂 |
| EP3463352A4 (en) * | 2016-06-02 | 2019-10-30 | Dr. Reddy S Laboratories Limited | POLYMORPH OF BETRIXABAN AND ITS MALEATE SALT |
| EP3254674A1 (en) | 2016-06-08 | 2017-12-13 | Sandoz Ag | Pharmaceutical compositions of betrixaban maleate |
| EP4588932A3 (en) | 2016-06-17 | 2025-10-01 | Alexion Pharmaceuticals, Inc. | Preparation of factor xa derivatives |
| WO2018042320A1 (en) * | 2016-08-30 | 2018-03-08 | Dr. Reddy’S Laboratories Limited | Salts of betrixaban and processes for preparation thereof |
| EP3293174A1 (en) * | 2016-09-09 | 2018-03-14 | Sandoz Ag | Crystalline salts of betrixaban |
| WO2018069936A1 (en) | 2016-10-13 | 2018-04-19 | Mylan Laboratories Limited | Polymorphs and solid dispersion of betrixaban and methods for the preparation thereof |
| CN108017576B (zh) * | 2016-11-01 | 2022-06-21 | 石药集团中奇制药技术（石家庄）有限公司 | 一种贝曲西班及其盐酸盐的制备方法，以及它们的晶型 |
| CN108586325A (zh) * | 2017-03-16 | 2018-09-28 | 上海度德医药科技有限公司 | 一种Betrixaban中间体的制备方法 |
| WO2018229796A2 (en) * | 2017-06-14 | 2018-12-20 | Mylan Laboratories Limited | A process for betrixaban hydrochloride and betrixaban maleate salt |
| CN107868039A (zh) * | 2017-11-27 | 2018-04-03 | 中国药科大学 | 一种贝曲沙班中间体n－（5－氯－2－吡啶基）－2－［（4－氰基苯甲酰基）氨基］－5－甲氧基苯甲酰胺的制备方法 |
| WO2022211680A1 (ru) * | 2021-03-30 | 2022-10-06 | Общество С Ограниченной Ответственностью "Фармадиол" | Способ получения антикоагулянта n-(5-хлорпиридин-2-ил)-2-({4-[этан-имидоил(метил)амино]бензоил}амино)-5-метилбензамид гидрохлорида |
| CN115057854A (zh) * | 2022-04-19 | 2022-09-16 | 河北常山生化药业股份有限公司 | 马来酸阿伐曲泊帕中间体的制备方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2151044A1 (en) | 1992-12-15 | 1994-06-23 | Terence K. Brunck | Novel inhibitors for factor xa |
| GB9226238D0 (en) | 1992-12-16 | 1993-02-10 | Scherer Ltd R P | Encapsulation apparatus and process |
| NZ296210A (en) | 1994-12-02 | 1998-05-27 | Yamanouchi Pharma Co Ltd | Amidinonaphthyl derivatives to inhibit activated blood coagulation factor x |
| US5849759A (en) | 1995-12-08 | 1998-12-15 | Berlex Laboratories, Inc. | Naphthyl-substituted benzimidazole derivatives as anti-coagulants |
| CN1246847A (zh) | 1996-12-23 | 2000-03-08 | 杜邦药品公司 | 作为Xa因子抑制剂的含氮杂芳族化合物 |
| EP1020434A4 (en) | 1997-08-27 | 2000-11-15 | Kissei Pharmaceutical | 3-AMIDINOANILINE DERIVATIVES, INHIBITORS OF THE ACTIVATED BLOOD COINTENANCE FACTOR X AND INTERMEDIATE PRODUCTS FOR PRODUCING BOTH |
| US6140351A (en) | 1997-12-19 | 2000-10-31 | Berlex Laboratories, Inc. | Ortho-anthranilamide derivatives as anti-coagulants |
| DE60040676D1 (de) * | 1999-09-17 | 2008-12-11 | Millennium Pharm Inc | BENZAMIDE UND ÄHNLICHE INHIBITOREN VON FAKTOR Xa |
| US6844367B1 (en) | 1999-09-17 | 2005-01-18 | Millennium Pharmaceuticals, Inc. | Benzamides and related inhibitors of factor Xa |
| ES2254385T3 (es) | 2000-02-29 | 2006-06-16 | Millennium Pharmaceuticals, Inc. | Benzamidas e inhibidores relacionados del factor xa. |
| US6627646B2 (en) * | 2001-07-17 | 2003-09-30 | Sepracor Inc. | Norastemizole polymorphs |
| RU2440986C2 (ru) | 2005-11-08 | 2012-01-27 | Милленниум Фамэсьютикэлс, Инк. | СОЛЬ ИНГИБИТОРА ФАКТОРА Ха, СПОСОБ ЕЕ ПОЛУЧЕНИЯ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ЕЕ ОСНОВЕ, СОСТОЯЩИЕ ИЗ НАЗВАННОЙ КОМПОЗИЦИИ ТАБЛЕТКА, КАПСУЛА И ЛЕПЕШКА, СПОСОБ ЛЕЧЕНИЯ ТРОМБОЗА И СПОСОБ ИНГИБИРОВАНИЯ КОАГУЛЯЦИИ ОБРАЗЦОВ КРОВИ |
| PT2077995E (pt) | 2006-11-02 | 2012-05-10 | Millennium Pharm Inc | Métodos de sintetizar sais farmacêuticos de um inibidor de fator xa |
-
2006
- 2006-11-07 RU RU2008123055/04A patent/RU2440986C2/ru not_active Application Discontinuation
- 2006-11-07 JP JP2008540190A patent/JP5227178B2/ja not_active Expired - Fee Related
- 2006-11-07 CN CN2006800415554A patent/CN101304971B/zh active Active
- 2006-11-07 WO PCT/US2006/043635 patent/WO2007056517A2/en not_active Ceased
- 2006-11-07 ES ES06837238T patent/ES2384116T3/es active Active
- 2006-11-07 BR BRPI0618362-0A patent/BRPI0618362A2/pt not_active Application Discontinuation
- 2006-11-07 KR KR1020087011799A patent/KR101358574B1/ko not_active Expired - Fee Related
- 2006-11-07 PE PE2006001368A patent/PE20070717A1/es active IP Right Grant
- 2006-11-07 AT AT06837238T patent/ATE549317T1/de active
- 2006-11-07 CA CA2627086A patent/CA2627086C/en not_active Expired - Fee Related
- 2006-11-07 EP EP11187927A patent/EP2431358A1/en not_active Withdrawn
- 2006-11-07 PE PE2010000471A patent/PE20110070A1/es not_active Application Discontinuation
- 2006-11-07 EP EP06837238A patent/EP1948608B1/en active Active
- 2006-11-07 PT PT06837238T patent/PT1948608E/pt unknown
- 2006-11-07 DK DK06837238.2T patent/DK1948608T3/da active
- 2006-11-07 NZ NZ592533A patent/NZ592533A/xx not_active IP Right Cessation
- 2006-11-07 AU AU2006311544A patent/AU2006311544B2/en not_active Ceased
- 2006-11-07 US US11/594,280 patent/US7598276B2/en active Active
- 2006-11-07 CN CN201110197429.0A patent/CN102336702B/zh active Active
- 2006-11-07 NZ NZ567992A patent/NZ567992A/en not_active IP Right Cessation
- 2006-11-08 AR ARP060104900A patent/AR056787A1/es not_active Application Discontinuation
- 2006-11-08 TW TW095141382A patent/TWI443088B/zh not_active IP Right Cessation
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2008
- 2008-03-31 IL IL190524A patent/IL190524A/en active IP Right Grant
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2009
- 2009-08-28 US US12/550,291 patent/US8557852B2/en not_active Expired - Fee Related
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2011
- 2011-06-12 IL IL213487A patent/IL213487A0/en unknown
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2012
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- 2012-09-18 JP JP2012204757A patent/JP5662980B2/ja active Active
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2014
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2015
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2016
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2018
- 2018-03-08 US US15/915,940 patent/US20190046510A1/en not_active Abandoned
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