AR099612A1 - Derivados antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona - Google Patents
Derivados antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-onaInfo
- Publication number
- AR099612A1 AR099612A1 ARP150100626A ARP150100626A AR099612A1 AR 099612 A1 AR099612 A1 AR 099612A1 AR P150100626 A ARP150100626 A AR P150100626A AR P150100626 A ARP150100626 A AR P150100626A AR 099612 A1 AR099612 A1 AR 099612A1
- Authority
- AR
- Argentina
- Prior art keywords
- cycloprop
- hydroxymethyl
- hydroxy
- alkyl
- methyl
- Prior art date
Links
- 230000000844 anti-bacterial effect Effects 0.000 title 1
- -1 1,2-dihydroxyethyl Chemical group 0.000 abstract 43
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 6
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 125000006299 oxetan-3-yl group Chemical group [H]C1([H])OC([H])([H])C1([H])* 0.000 abstract 3
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000006526 (C1-C2) alkyl group Chemical group 0.000 abstract 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- TZGPACAKMCUCKX-UHFFFAOYSA-N 2-hydroxyacetamide Chemical compound NC(=O)CO TZGPACAKMCUCKX-UHFFFAOYSA-N 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- DXASQZJWWGZNSF-UHFFFAOYSA-N n,n-dimethylmethanamine;sulfur trioxide Chemical group CN(C)C.O=S(=O)=O DXASQZJWWGZNSF-UHFFFAOYSA-N 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000005309 thioalkoxy group Chemical group 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14157636 | 2014-03-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR099612A1 true AR099612A1 (es) | 2016-08-03 |
Family
ID=50189621
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP150100626A AR099612A1 (es) | 2014-03-04 | 2015-03-02 | Derivados antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US10106544B2 (OSRAM) |
| EP (1) | EP3114126B1 (OSRAM) |
| JP (1) | JP6516370B2 (OSRAM) |
| KR (1) | KR20160127127A (OSRAM) |
| CN (1) | CN106061977B (OSRAM) |
| AR (1) | AR099612A1 (OSRAM) |
| AU (1) | AU2015226250B2 (OSRAM) |
| BR (1) | BR112016020278A8 (OSRAM) |
| CA (1) | CA2938383A1 (OSRAM) |
| CL (1) | CL2016002207A1 (OSRAM) |
| CY (1) | CY1121362T1 (OSRAM) |
| DK (1) | DK3114126T3 (OSRAM) |
| EA (1) | EA030708B1 (OSRAM) |
| ES (1) | ES2709382T3 (OSRAM) |
| HR (1) | HRP20190013T1 (OSRAM) |
| HU (1) | HUE042371T2 (OSRAM) |
| IL (1) | IL247544A0 (OSRAM) |
| LT (1) | LT3114126T (OSRAM) |
| MA (1) | MA39707B1 (OSRAM) |
| MX (1) | MX2016011380A (OSRAM) |
| PH (1) | PH12016501699A1 (OSRAM) |
| PL (1) | PL3114126T3 (OSRAM) |
| PT (1) | PT3114126T (OSRAM) |
| SA (1) | SA516371717B1 (OSRAM) |
| SG (1) | SG11201607304WA (OSRAM) |
| SI (1) | SI3114126T1 (OSRAM) |
| TR (1) | TR201900393T4 (OSRAM) |
| TW (1) | TW201542556A (OSRAM) |
| UA (1) | UA118868C2 (OSRAM) |
| WO (1) | WO2015132228A1 (OSRAM) |
| ZA (1) | ZA201606794B (OSRAM) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR097617A1 (es) | 2013-09-13 | 2016-04-06 | Actelion Pharmaceuticals Ltd | Derivados antibacterianos del 2h-indazol |
| MA39189A1 (fr) | 2013-12-19 | 2017-06-30 | Actelion Pharmaceuticals Ltd | Dérivés de 1h-indazole et de 1h-indole antibactériens |
| AU2015261540A1 (en) | 2014-05-16 | 2017-01-12 | Idorsia Pharmaceuticals Ltd | Antibacterial quinazoline-4(3h)-one derivatives |
| AR105646A1 (es) * | 2015-08-11 | 2017-10-25 | Actelion Pharmaceuticals Ltd | Agentes antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituida |
| JP2018531902A (ja) * | 2015-08-28 | 2018-11-01 | イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ | 抗菌性縮合ピロリジン−２−オン誘導体 |
| AR105848A1 (es) * | 2015-08-31 | 2017-11-15 | Actelion Pharmaceuticals Ltd | Derivados heterocíclicos antibacterianos |
| AR105889A1 (es) * | 2015-09-03 | 2017-11-22 | Actelion Pharmaceuticals Ltd | Compuestos antibacterianos 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituidos |
| TW201840569A (zh) | 2017-03-01 | 2018-11-16 | 瑞士商愛杜西亞製藥有限公司 | (2r)-n-羥基-4-(6-((1-(2-羥基乙基)氮雜環丁烷-3-基)丁-1,3-二炔-1-基)-3-氧基-1h-吡咯并[1,2-c]咪唑-2(3h)-基)-2-甲基-2-(甲磺醯基)丁醯胺之結晶形式 |
| WO2019038362A1 (en) | 2017-08-24 | 2019-02-28 | Idorsia Pharmaceuticals Ltd | ANTIBACTERIAL PYRROLOIMIDAZOLONES |
| WO2019086452A1 (en) | 2017-10-31 | 2019-05-09 | Idorsia Pharmaceuticals Ltd | Antibacterial heteroaromatic compounds |
| US20240382465A1 (en) * | 2021-08-05 | 2024-11-21 | Zhejiang Hisun Pharmaceutical Co., Ltd. | Aromatic acetylene derivative, and preparation method therefor and use thereof |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI338685B (en) | 2002-03-13 | 2011-03-11 | Array Biopharma Inc | N3 alkylated benzimid azole derivatives as mek inhibitors |
| US7781591B2 (en) | 2006-06-13 | 2010-08-24 | Wyeth Llc | Substituted 3-cyanopyridines as protein kinase inhibitors |
| DE102004017930A1 (de) | 2004-04-14 | 2005-11-03 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Alkin-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel |
| CA2590115A1 (en) | 2004-12-10 | 2006-06-15 | Emory University | 2' and 3' - substituted cyclobutyl nucleoside analogs for the treatment of viral infections and abnormal cellular proliferation |
| JP2008001635A (ja) | 2006-06-22 | 2008-01-10 | Toray Ind Inc | グリシン誘導体及びその用途 |
| DE102008044132A1 (de) | 2008-11-27 | 2010-06-02 | BSH Bosch und Siemens Hausgeräte GmbH | Kältegerät mit zweiseitig anschlagbarer Tür |
| CA2758144C (en) | 2009-04-06 | 2014-05-13 | Daiichi Sankyo Company, Limited | Cyclic compound having substituted phenyl group |
| US8372807B2 (en) | 2009-05-20 | 2013-02-12 | Ardea Biosciences, Inc. | Methods of modulating uric acid levels |
| EP2451790A4 (en) | 2009-07-07 | 2012-12-26 | Anthem Biosciences Private Ltd | INHIBITORS OF HISTONE DEACETYLASE |
| JP5671545B2 (ja) * | 2009-10-13 | 2015-02-18 | ファイザー・インク | 抗菌薬として有用なｃ結合ヒドロキサム酸誘導体 |
| CA2782453C (en) | 2009-12-16 | 2015-11-24 | Matthew Frank Brown | N-linked hydroxamic acid derivatives useful as antibacterial agents |
| KR20140023869A (ko) | 2010-11-10 | 2014-02-27 | 아카오젠, 인코포레이티드 | 하이드록삼산 유도체 및 세균 감염 치료에서의 이들의 사용 |
| WO2012093809A2 (en) | 2011-01-03 | 2012-07-12 | Hanmi Pharm Co., Ltd. | New bicyclic compound for modulating g protein-coupled receptors |
| PH12013501780A1 (en) * | 2011-03-07 | 2019-07-03 | Pfizer | Fluoro-pyridinone derivatives useful as antibacterial agents |
| SG193367A1 (en) * | 2011-04-08 | 2013-10-30 | Pfizer | Isoxazole derivatives useful as antibacterial agents |
| KR20130140164A (ko) * | 2011-04-08 | 2013-12-23 | 화이자 인코포레이티드 | 항박테리아제로서 유용한 이미다졸, 피라졸 및 트라이아졸 유도체 |
| US8859559B2 (en) | 2011-12-20 | 2014-10-14 | Boehringer Ingelheim International Gmbh | Substituted pyrazines and their use in the treatment of disease |
| WO2013170030A1 (en) | 2012-05-09 | 2013-11-14 | Achaogen, Inc. | Antibacterial agents |
| EP2847168A1 (en) | 2012-05-10 | 2015-03-18 | Achaogen, Inc. | Antibacterial agents |
| WO2014165075A1 (en) | 2013-03-12 | 2014-10-09 | Achaogen, Inc. | Antibacterial agents |
| AR097617A1 (es) | 2013-09-13 | 2016-04-06 | Actelion Pharmaceuticals Ltd | Derivados antibacterianos del 2h-indazol |
| MA39189A1 (fr) | 2013-12-19 | 2017-06-30 | Actelion Pharmaceuticals Ltd | Dérivés de 1h-indazole et de 1h-indole antibactériens |
| AU2015261540A1 (en) | 2014-05-16 | 2017-01-12 | Idorsia Pharmaceuticals Ltd | Antibacterial quinazoline-4(3h)-one derivatives |
| AR105646A1 (es) | 2015-08-11 | 2017-10-25 | Actelion Pharmaceuticals Ltd | Agentes antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituida |
| JP2018531902A (ja) | 2015-08-28 | 2018-11-01 | イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ | 抗菌性縮合ピロリジン−２−オン誘導体 |
| AR105848A1 (es) | 2015-08-31 | 2017-11-15 | Actelion Pharmaceuticals Ltd | Derivados heterocíclicos antibacterianos |
| AR105889A1 (es) | 2015-09-03 | 2017-11-22 | Actelion Pharmaceuticals Ltd | Compuestos antibacterianos 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituidos |
| JP2019501896A (ja) | 2015-12-08 | 2019-01-24 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ | 抗菌化合物としての置換ベンザジノン |
-
2015
- 2015-03-02 AR ARP150100626A patent/AR099612A1/es unknown
- 2015-03-03 BR BR112016020278A patent/BR112016020278A8/pt not_active Application Discontinuation
- 2015-03-03 SI SI201530520T patent/SI3114126T1/sl unknown
- 2015-03-03 AU AU2015226250A patent/AU2015226250B2/en not_active Ceased
- 2015-03-03 LT LTEP15707154.9T patent/LT3114126T/lt unknown
- 2015-03-03 US US15/123,184 patent/US10106544B2/en not_active Expired - Fee Related
- 2015-03-03 CA CA2938383A patent/CA2938383A1/en not_active Abandoned
- 2015-03-03 PT PT15707154T patent/PT3114126T/pt unknown
- 2015-03-03 EP EP15707154.9A patent/EP3114126B1/en not_active Not-in-force
- 2015-03-03 HU HUE15707154A patent/HUE042371T2/hu unknown
- 2015-03-03 DK DK15707154.9T patent/DK3114126T3/en active
- 2015-03-03 HR HRP20190013TT patent/HRP20190013T1/hr unknown
- 2015-03-03 CN CN201580011865.0A patent/CN106061977B/zh not_active Expired - Fee Related
- 2015-03-03 UA UAA201609996A patent/UA118868C2/uk unknown
- 2015-03-03 TW TW104106737A patent/TW201542556A/zh unknown
- 2015-03-03 MA MA39707A patent/MA39707B1/fr unknown
- 2015-03-03 JP JP2016555488A patent/JP6516370B2/ja not_active Expired - Fee Related
- 2015-03-03 TR TR2019/00393T patent/TR201900393T4/tr unknown
- 2015-03-03 SG SG11201607304WA patent/SG11201607304WA/en unknown
- 2015-03-03 WO PCT/EP2015/054358 patent/WO2015132228A1/en not_active Ceased
- 2015-03-03 PL PL15707154T patent/PL3114126T3/pl unknown
- 2015-03-03 KR KR1020167027128A patent/KR20160127127A/ko not_active Ceased
- 2015-03-03 ES ES15707154T patent/ES2709382T3/es active Active
- 2015-03-03 MX MX2016011380A patent/MX2016011380A/es unknown
- 2015-03-03 EA EA201691775A patent/EA030708B1/ru not_active IP Right Cessation
-
2016
- 2016-08-23 SA SA516371717A patent/SA516371717B1/ar unknown
- 2016-08-26 PH PH12016501699A patent/PH12016501699A1/en unknown
- 2016-08-30 IL IL247544A patent/IL247544A0/en unknown
- 2016-09-01 CL CL2016002207A patent/CL2016002207A1/es unknown
- 2016-10-03 ZA ZA2016/06794A patent/ZA201606794B/en unknown
-
2019
- 2019-01-30 CY CY20191100131T patent/CY1121362T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |