SI3114126T1 - Derivati 1,2-dihidro-3H-pirolo(1,2-C)imidazol-3-ona in njihova uporaba kot antibakterijska sredstva - Google Patents

Derivati 1,2-dihidro-3H-pirolo(1,2-C)imidazol-3-ona in njihova uporaba kot antibakterijska sredstva

Info

Publication number
SI3114126T1
SI3114126T1 SI201530520T SI201530520T SI3114126T1 SI 3114126 T1 SI3114126 T1 SI 3114126T1 SI 201530520 T SI201530520 T SI 201530520T SI 201530520 T SI201530520 T SI 201530520T SI 3114126 T1 SI3114126 T1 SI 3114126T1
Authority
SI
Slovenia
Prior art keywords
pyrrolo
imidazol
dihydro
derivatives
antibacterial agents
Prior art date
Application number
SI201530520T
Other languages
English (en)
Slovenian (sl)
Inventor
Gaelle Chapoux
Jean-Christophe Gauvin
Philippe Panchaud
Jean-Luc Specklin
Jean-Philippe Surivet
Christine Schmitt
Azely Mirre
Original Assignee
Idorsia Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Idorsia Pharmaceuticals Ltd filed Critical Idorsia Pharmaceuticals Ltd
Publication of SI3114126T1 publication Critical patent/SI3114126T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
SI201530520T 2014-03-04 2015-03-03 Derivati 1,2-dihidro-3H-pirolo(1,2-C)imidazol-3-ona in njihova uporaba kot antibakterijska sredstva SI3114126T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14157636 2014-03-04
EP15707154.9A EP3114126B1 (en) 2014-03-04 2015-03-03 1,2-dihydro-3h-pyrrolo[1,2-c]imidazol-3-one derivatives and their use as antibacterial agents
PCT/EP2015/054358 WO2015132228A1 (en) 2014-03-04 2015-03-03 1,2-dihydro-3h-pyrrolo[1,2-c]imidazol-3-one derivatives and their use as antibacterial agents

Publications (1)

Publication Number Publication Date
SI3114126T1 true SI3114126T1 (sl) 2019-01-31

Family

ID=50189621

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201530520T SI3114126T1 (sl) 2014-03-04 2015-03-03 Derivati 1,2-dihidro-3H-pirolo(1,2-C)imidazol-3-ona in njihova uporaba kot antibakterijska sredstva

Country Status (31)

Country Link
US (1) US10106544B2 (OSRAM)
EP (1) EP3114126B1 (OSRAM)
JP (1) JP6516370B2 (OSRAM)
KR (1) KR20160127127A (OSRAM)
CN (1) CN106061977B (OSRAM)
AR (1) AR099612A1 (OSRAM)
AU (1) AU2015226250B2 (OSRAM)
BR (1) BR112016020278A8 (OSRAM)
CA (1) CA2938383A1 (OSRAM)
CL (1) CL2016002207A1 (OSRAM)
CY (1) CY1121362T1 (OSRAM)
DK (1) DK3114126T3 (OSRAM)
EA (1) EA030708B1 (OSRAM)
ES (1) ES2709382T3 (OSRAM)
HR (1) HRP20190013T1 (OSRAM)
HU (1) HUE042371T2 (OSRAM)
IL (1) IL247544A0 (OSRAM)
LT (1) LT3114126T (OSRAM)
MA (1) MA39707B1 (OSRAM)
MX (1) MX2016011380A (OSRAM)
PH (1) PH12016501699A1 (OSRAM)
PL (1) PL3114126T3 (OSRAM)
PT (1) PT3114126T (OSRAM)
SA (1) SA516371717B1 (OSRAM)
SG (1) SG11201607304WA (OSRAM)
SI (1) SI3114126T1 (OSRAM)
TR (1) TR201900393T4 (OSRAM)
TW (1) TW201542556A (OSRAM)
UA (1) UA118868C2 (OSRAM)
WO (1) WO2015132228A1 (OSRAM)
ZA (1) ZA201606794B (OSRAM)

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AR097617A1 (es) 2013-09-13 2016-04-06 Actelion Pharmaceuticals Ltd Derivados antibacterianos del 2h-indazol
MA39189A1 (fr) 2013-12-19 2017-06-30 Actelion Pharmaceuticals Ltd Dérivés de 1h-indazole et de 1h-indole antibactériens
AU2015261540A1 (en) 2014-05-16 2017-01-12 Idorsia Pharmaceuticals Ltd Antibacterial quinazoline-4(3h)-one derivatives
AR105646A1 (es) * 2015-08-11 2017-10-25 Actelion Pharmaceuticals Ltd Agentes antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituida
JP2018531902A (ja) * 2015-08-28 2018-11-01 イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ 抗菌性縮合ピロリジン−２−オン誘導体
AR105848A1 (es) * 2015-08-31 2017-11-15 Actelion Pharmaceuticals Ltd Derivados heterocíclicos antibacterianos
AR105889A1 (es) * 2015-09-03 2017-11-22 Actelion Pharmaceuticals Ltd Compuestos antibacterianos 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituidos
TW201840569A (zh) 2017-03-01 2018-11-16 瑞士商愛杜西亞製藥有限公司 (2r)-n-羥基-4-(6-((1-(2-羥基乙基)氮雜環丁烷-3-基)丁-1,3-二炔-1-基)-3-氧基-1h-吡咯并[1,2-c]咪唑-2(3h)-基)-2-甲基-2-(甲磺醯基)丁醯胺之結晶形式
WO2019038362A1 (en) 2017-08-24 2019-02-28 Idorsia Pharmaceuticals Ltd ANTIBACTERIAL PYRROLOIMIDAZOLONES
WO2019086452A1 (en) 2017-10-31 2019-05-09 Idorsia Pharmaceuticals Ltd Antibacterial heteroaromatic compounds
US20240382465A1 (en) * 2021-08-05 2024-11-21 Zhejiang Hisun Pharmaceutical Co., Ltd. Aromatic acetylene derivative, and preparation method therefor and use thereof

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US7781591B2 (en) 2006-06-13 2010-08-24 Wyeth Llc Substituted 3-cyanopyridines as protein kinase inhibitors
DE102004017930A1 (de) 2004-04-14 2005-11-03 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Alkin-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel
CA2590115A1 (en) 2004-12-10 2006-06-15 Emory University 2' and 3' - substituted cyclobutyl nucleoside analogs for the treatment of viral infections and abnormal cellular proliferation
JP2008001635A (ja) 2006-06-22 2008-01-10 Toray Ind Inc グリシン誘導体及びその用途
DE102008044132A1 (de) 2008-11-27 2010-06-02 BSH Bosch und Siemens Hausgeräte GmbH Kältegerät mit zweiseitig anschlagbarer Tür
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JP5671545B2 (ja) * 2009-10-13 2015-02-18 ファイザー・インク 抗菌薬として有用なｃ結合ヒドロキサム酸誘導体
CA2782453C (en) 2009-12-16 2015-11-24 Matthew Frank Brown N-linked hydroxamic acid derivatives useful as antibacterial agents
KR20140023869A (ko) 2010-11-10 2014-02-27 아카오젠, 인코포레이티드 하이드록삼산 유도체 및 세균 감염 치료에서의 이들의 사용
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PH12013501780A1 (en) * 2011-03-07 2019-07-03 Pfizer Fluoro-pyridinone derivatives useful as antibacterial agents
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WO2014165075A1 (en) 2013-03-12 2014-10-09 Achaogen, Inc. Antibacterial agents
AR097617A1 (es) 2013-09-13 2016-04-06 Actelion Pharmaceuticals Ltd Derivados antibacterianos del 2h-indazol
MA39189A1 (fr) 2013-12-19 2017-06-30 Actelion Pharmaceuticals Ltd Dérivés de 1h-indazole et de 1h-indole antibactériens
AU2015261540A1 (en) 2014-05-16 2017-01-12 Idorsia Pharmaceuticals Ltd Antibacterial quinazoline-4(3h)-one derivatives
AR105646A1 (es) 2015-08-11 2017-10-25 Actelion Pharmaceuticals Ltd Agentes antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituida
JP2018531902A (ja) 2015-08-28 2018-11-01 イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ 抗菌性縮合ピロリジン−２−オン誘導体
AR105848A1 (es) 2015-08-31 2017-11-15 Actelion Pharmaceuticals Ltd Derivados heterocíclicos antibacterianos
AR105889A1 (es) 2015-09-03 2017-11-22 Actelion Pharmaceuticals Ltd Compuestos antibacterianos 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituidos
JP2019501896A (ja) 2015-12-08 2019-01-24 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ 抗菌化合物としての置換ベンザジノン

Also Published As

Publication number Publication date
HRP20190013T1 (hr) 2019-02-22
LT3114126T (lt) 2018-12-27
MX2016011380A (es) 2016-12-07
IL247544A0 (en) 2016-11-30
US10106544B2 (en) 2018-10-23
KR20160127127A (ko) 2016-11-02
BR112016020278A8 (pt) 2017-12-26
CY1121362T1 (el) 2020-05-29
TW201542556A (zh) 2015-11-16
EP3114126B1 (en) 2018-10-31
EA030708B1 (ru) 2018-09-28
UA118868C2 (uk) 2019-03-25
DK3114126T3 (en) 2019-02-25
PT3114126T (pt) 2019-02-06
PH12016501699A1 (en) 2016-10-03
SG11201607304WA (en) 2016-09-29
HUE042371T2 (hu) 2019-06-28
AU2015226250B2 (en) 2018-12-13
CL2016002207A1 (es) 2017-03-24
SA516371717B1 (ar) 2018-10-25
CA2938383A1 (en) 2015-09-11
BR112016020278A2 (OSRAM) 2017-08-15
MA39707A (fr) 2017-01-11
WO2015132228A1 (en) 2015-09-11
JP2017508746A (ja) 2017-03-30
EA201691775A1 (ru) 2017-03-31
TR201900393T4 (tr) 2019-02-21
ES2709382T3 (es) 2019-04-16
CN106061977A (zh) 2016-10-26
US20170107223A1 (en) 2017-04-20
AU2015226250A1 (en) 2016-10-20
AR099612A1 (es) 2016-08-03
MA39707B1 (fr) 2019-01-31
PL3114126T3 (pl) 2019-03-29
CN106061977B (zh) 2018-10-26
JP6516370B2 (ja) 2019-05-22
EP3114126A1 (en) 2017-01-11
ZA201606794B (en) 2018-11-28

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