AR102687A1 - Derivados de benzotiazol antibacterianos - Google Patents

Derivados de benzotiazol antibacterianos

Info

Publication number
AR102687A1
AR102687A1 ARP150103754A ARP150103754A AR102687A1 AR 102687 A1 AR102687 A1 AR 102687A1 AR P150103754 A ARP150103754 A AR P150103754A AR P150103754 A ARP150103754 A AR P150103754A AR 102687 A1 AR102687 A1 AR 102687A1
Authority
AR
Argentina
Prior art keywords
cycloprop
hydroxymethyl
trans
cis
hydroxyoxetan
Prior art date
Application number
ARP150103754A
Other languages
English (en)
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of AR102687A1 publication Critical patent/AR102687A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Abstract

Reivindicación 1: Un compuesto de fórmula (1), en donde R¹ es el grupo M, en donde M es uno de los grupos MA y MB representados por las fórmulas (2) y (3), en donde A representa un enlace o CºC; R¹A es H o halógeno; R²A es H o halógeno; y R³A es H, alcoxi C₁₋₃, hidroxialcoxi C₂₋₄, hidroxialquilo C₁₋₄, dihidroxialquilo C₂₋₄, 2-hidroxiacetamido, 1-hidroximetil-cicloprop-1-ilo, trans-2-hidroximetil-cicloprop-1-ilo, 3-hidroxioxetan-3-ilo, 3-(hidroxialquil C₁₋₃)oxetan-3-ilo, 3-aminooxetan-3-ilo o 1-aminocicloprop-1-ilo; y en donde R¹B es hidroxialquilo C₁₋₄, dihidroxialquilo C₂₋₄, aminoalquilo C₁₋₄, dialquilamino C₁₋₄alquilo C₁₋₃, 1-amino-cicloprop-1-ilo, 1-hidroximetil-cicloprop-1-ilo, trans-2-hidroximetil-cicloprop-1-ilo, trans-2-aminometil-cicloprop-1-ilo, trans-2-hidroximetil-1-metil-cicloprop-1-ilo, trans-2-hidroximetil-2-metil-cicloprop-1-ilo, cis-1-fluoro-2-(hidroximetil)cicloprop-1-ilo, cis-2-fluoro-2-(hidroximetil)cicloprop-1-ilo, 2-(1,2-dihidroxietil)-cicloprop-1-ilo, 1-(hidroximetil)-ciclobutan-1-ilo, cis-3-(hidroximetil)-1-hidroxi-ciclobutan-1-ilo, 3-hidroxioxetan-3-ilo, 3-hidroxioxetan-3-il-alquilo C₁₋₃, 3-aminooxetan-3-ilo, 3-hidroximetil-oxetan-3-ilo, trans-(cis-3,4-dihidroxi)-ciclopent-1-ilo, 3-hidroximetilbiciclo[1,1,1]pentan-1-ilo, 4-hidroxitetrahidro-2H-piran-4-ilo, (3R,6S)-3-aminotetrahidro-2H-piran-6-ilo, piperidin-4-ilo, 1-(2-hidroxiacetil)piperidin-4-ilo, 3-hidroxitietan-3-ilo, 1-(2-hidroxiacetil)azetidin-3-ilo o 1-glicilazetidin-3-ilo; o una sal de dicho compuesto.
ARP150103754A 2014-11-19 2015-11-18 Derivados de benzotiazol antibacterianos AR102687A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP2014075009 2014-11-19

Publications (1)

Publication Number Publication Date
AR102687A1 true AR102687A1 (es) 2017-03-15

Family

ID=54705241

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP150103754A AR102687A1 (es) 2014-11-19 2015-11-18 Derivados de benzotiazol antibacterianos

Country Status (19)

Country Link
US (1) US20170355687A1 (es)
EP (1) EP3221300B1 (es)
JP (1) JP2018500292A (es)
KR (1) KR20170086079A (es)
CN (1) CN107001300A (es)
AR (1) AR102687A1 (es)
AU (1) AU2015349005A1 (es)
BR (1) BR112017010474A2 (es)
CA (1) CA2963875A1 (es)
CL (1) CL2017001276A1 (es)
EA (1) EA031534B1 (es)
HK (1) HK1243411A1 (es)
IL (1) IL252269A0 (es)
MX (1) MX2017006413A (es)
PH (1) PH12017500907A1 (es)
SG (1) SG11201703992YA (es)
TW (1) TW201625569A (es)
UA (1) UA118722C2 (es)
WO (1) WO2016079688A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR105646A1 (es) 2015-08-11 2017-10-25 Actelion Pharmaceuticals Ltd Agentes antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituida
AR105848A1 (es) * 2015-08-31 2017-11-15 Actelion Pharmaceuticals Ltd Derivados heterocíclicos antibacterianos
AR105889A1 (es) 2015-09-03 2017-11-22 Actelion Pharmaceuticals Ltd Compuestos antibacterianos 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituidos
AU2017267194A1 (en) * 2016-05-17 2019-01-17 Idorsia Pharmaceuticals Ltd 6-(BUTA-1,3-DIYN-1-YL)benzo[D]thiazole derivatives
CA3084809A1 (en) 2017-12-07 2019-06-13 The Regents Of The University Of Michigan Nsd family inhibitors and methods of treatment therewith

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JPS50121218A (es) * 1974-03-01 1975-09-23
JPH09118660A (ja) * 1995-04-10 1997-05-06 Takeda Chem Ind Ltd 芳香族ヒドロキサム酸誘導体、製造法および剤
GB9609794D0 (en) * 1996-05-10 1996-07-17 Smithkline Beecham Plc Novel compounds
US20040224952A1 (en) 2003-05-07 2004-11-11 Cowart Marlon D. Fused bicyclic-substituted amines as histamine-3 receptor ligands
MX2007006961A (es) 2004-12-10 2007-10-04 Univ Emory Analogos nucleosidos de ciclobutilo 2' y 3'-sustituidos para el tratamiento de infeccciones virales y proliferacion celular anormal.
DE102008044132A1 (de) 2008-11-27 2010-06-02 BSH Bosch und Siemens Hausgeräte GmbH Kältegerät mit zweiseitig anschlagbarer Tür
WO2010135536A2 (en) 2009-05-20 2010-11-25 Ardea Biosciences, Inc. Methods of modulating uric acid levels
US8853258B2 (en) * 2009-10-13 2014-10-07 Pfizer Inc. C-linked hydroxamic acid derivatives useful as antibacterial agents
JP5793766B2 (ja) 2009-12-16 2015-10-14 ファイザー・インク 抗菌剤として有用なｎ−結合型ヒドロキサム酸誘導体
EA201390626A1 (ru) 2010-11-10 2013-12-30 Эйкеоджен, Инк. Производные гидроксамовой кислоты и применение указанных производных в лечении бактериальных инфекций
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EP2683689B1 (en) 2011-03-07 2017-04-12 Pfizer Inc Fluoro-pyridinone derivatives useful as antibacterial agents
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EA030730B1 (ru) 2013-12-19 2018-09-28 Идорсиа Фармасьютиклз Лтд Антибактериальные производные 1h-индазола и 1h-индола

Also Published As

Publication number Publication date
BR112017010474A2 (pt) 2017-12-26
AU2015349005A1 (en) 2017-07-06
CA2963875A1 (en) 2016-05-26
SG11201703992YA (en) 2017-06-29
EA031534B1 (ru) 2019-01-31
TW201625569A (zh) 2016-07-16
MX2017006413A (es) 2017-09-12
UA118722C2 (uk) 2019-02-25
WO2016079688A1 (en) 2016-05-26
US20170355687A1 (en) 2017-12-14
HK1243411A1 (zh) 2018-07-13
EP3221300A1 (en) 2017-09-27
JP2018500292A (ja) 2018-01-11
CL2017001276A1 (es) 2018-02-16
CN107001300A (zh) 2017-08-01
KR20170086079A (ko) 2017-07-25
EA201791108A1 (ru) 2017-11-30
EP3221300B1 (en) 2019-03-20
IL252269A0 (en) 2017-07-31
PH12017500907A1 (en) 2017-11-27

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