EA201791108A1 - Антибактериальные бензотиазольные производные - Google Patents

Антибактериальные бензотиазольные производные

Info

Publication number
EA201791108A1
EA201791108A1 EA201791108A EA201791108A EA201791108A1 EA 201791108 A1 EA201791108 A1 EA 201791108A1 EA 201791108 A EA201791108 A EA 201791108A EA 201791108 A EA201791108 A EA 201791108A EA 201791108 A1 EA201791108 A1 EA 201791108A1
Authority
EA
Eurasian Patent Office
Prior art keywords
substituted
antibacterial
benzoiazolic
derivatives
cycloprop
Prior art date
Application number
EA201791108A
Other languages
English (en)
Other versions
EA031534B1 (ru
Inventor
Кристин Шмитт
Жан-Люк Спеклен
Жан-Филипп Сюриве
Галль Шапу
Азели Мирре
Original Assignee
Идорсиа Фармасьютиклз Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Идорсиа Фармасьютиклз Лтд. filed Critical Идорсиа Фармасьютиклз Лтд.
Publication of EA201791108A1 publication Critical patent/EA201791108A1/ru
Publication of EA031534B1 publication Critical patent/EA031534B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Изобретение относится к антибактериальным соединениям формулы Iгде Rозначает группу M, при этом M означает одну из групп Mи M, представленных нижегде A означает связь или C≡C; Rозначает H или галоген; Rозначает H или галоген; Rозначает H, алкокси, гидроксиалкокси, гидроксиалкил, дигидроксиалкил, 2-гидроксиацетамидо, замещенный циклопроп-1-ил или замещенный оксетан-3-ил; и Rозначает гидроксиалкил, дигидроксиалкил, аминоалкил, диалкиламиноалкил, замещенный циклопроп-1-ил, замещенный циклобутан-1-ил, замещенный оксетан-3-ил, 3-гидрокситиетан-3-ил, замещенный азетидин-3-ил, транс-{цис-3,4-дигидрокси)-циклопент-1-ил, 3-гидроксиметилбицикло[1,1,1]пентан-1-ил, 4-гидрокситетрагидро-2H-пиран-4-ил, (3R,6S)-3-аминотетрагидро-2H-пиран-6-ил, пиперидин-4-ил или 1-(2-гидроксиацетил)пиперидин-4-ил; и их солям.
EA201791108A 2014-11-19 2015-11-18 Антибактериальные бензотиазольные производные EA031534B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP2014075009 2014-11-19
PCT/IB2015/058919 WO2016079688A1 (en) 2014-11-19 2015-11-18 Antibacterial benzothiazole derivatives

Publications (2)

Publication Number Publication Date
EA201791108A1 true EA201791108A1 (ru) 2017-11-30
EA031534B1 EA031534B1 (ru) 2019-01-31

Family

ID=54705241

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201791108A EA031534B1 (ru) 2014-11-19 2015-11-18 Антибактериальные бензотиазольные производные

Country Status (19)

Country Link
US (1) US20170355687A1 (ru)
EP (1) EP3221300B1 (ru)
JP (1) JP2018500292A (ru)
KR (1) KR20170086079A (ru)
CN (1) CN107001300A (ru)
AR (1) AR102687A1 (ru)
AU (1) AU2015349005A1 (ru)
BR (1) BR112017010474A2 (ru)
CA (1) CA2963875A1 (ru)
CL (1) CL2017001276A1 (ru)
EA (1) EA031534B1 (ru)
HK (1) HK1243411A1 (ru)
IL (1) IL252269A0 (ru)
MX (1) MX2017006413A (ru)
PH (1) PH12017500907A1 (ru)
SG (1) SG11201703992YA (ru)
TW (1) TW201625569A (ru)
UA (1) UA118722C2 (ru)
WO (1) WO2016079688A1 (ru)

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AR105646A1 (es) * 2015-08-11 2017-10-25 Actelion Pharmaceuticals Ltd Agentes antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituida
AR105848A1 (es) * 2015-08-31 2017-11-15 Actelion Pharmaceuticals Ltd Derivados heterocíclicos antibacterianos
AR105889A1 (es) 2015-09-03 2017-11-22 Actelion Pharmaceuticals Ltd Compuestos antibacterianos 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituidos
KR20190009324A (ko) * 2016-05-17 2019-01-28 이도르시아 파마슈티컬스 리미티드 6-(부타-1,3-디인-1-일)벤조[d]티아졸 유도체
JP7414282B2 (ja) 2017-12-07 2024-01-16 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン Ｎｓｄファミリー阻害物質及びそれによる治療の方法

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JPS50121218A (ru) * 1974-03-01 1975-09-23
JPH09118660A (ja) * 1995-04-10 1997-05-06 Takeda Chem Ind Ltd 芳香族ヒドロキサム酸誘導体、製造法および剤
GB9609794D0 (en) * 1996-05-10 1996-07-17 Smithkline Beecham Plc Novel compounds
US20040224952A1 (en) 2003-05-07 2004-11-11 Cowart Marlon D. Fused bicyclic-substituted amines as histamine-3 receptor ligands
WO2006063281A2 (en) 2004-12-10 2006-06-15 Emory University 2' and 3' - substituted cyclobutyl nucleoside analogs for the treatment of viral infections and abnormal cellular proliferation
DE102008044132A1 (de) 2008-11-27 2010-06-02 BSH Bosch und Siemens Hausgeräte GmbH Kältegerät mit zweiseitig anschlagbarer Tür
EP2432468A2 (en) 2009-05-20 2012-03-28 Ardea Biosciences, Inc. Methods of modulating uric acid levels
CA2774250C (en) * 2009-10-13 2013-12-17 Pfizer Inc. C-linked hydroxamic acid derivatives useful as antibacterial agents
PL2512474T3 (pl) 2009-12-16 2015-03-31 Pfizer N-przyłączone pochodne kwasu hydroksamowego użyteczne jako środki przeciwbakteryjne
AR083760A1 (es) 2010-11-10 2013-03-20 Achaogen Inc Agentes antibacterianos y composiciones farmaceuticas
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JP6407288B2 (ja) 2013-12-19 2018-10-17 イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ 抗菌性１ｈ−インダゾール及び１ｈ−インドール誘導体

Also Published As

Publication number Publication date
HK1243411A1 (zh) 2018-07-13
US20170355687A1 (en) 2017-12-14
IL252269A0 (en) 2017-07-31
WO2016079688A1 (en) 2016-05-26
JP2018500292A (ja) 2018-01-11
CL2017001276A1 (es) 2018-02-16
MX2017006413A (es) 2017-09-12
CA2963875A1 (en) 2016-05-26
UA118722C2 (uk) 2019-02-25
AR102687A1 (es) 2017-03-15
TW201625569A (zh) 2016-07-16
SG11201703992YA (en) 2017-06-29
PH12017500907A1 (en) 2017-11-27
AU2015349005A1 (en) 2017-07-06
EA031534B1 (ru) 2019-01-31
EP3221300A1 (en) 2017-09-27
KR20170086079A (ko) 2017-07-25
BR112017010474A2 (pt) 2017-12-26
EP3221300B1 (en) 2019-03-20
CN107001300A (zh) 2017-08-01

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM RU