MX394835B - Metodos para la preparacion de compuestos heterociclicos de 1,3-benzodioxol. - Google Patents

Metodos para la preparacion de compuestos heterociclicos de 1,3-benzodioxol.

Info

Publication number
MX394835B
MX394835B MX2019013979A MX2019013979A MX394835B MX 394835 B MX394835 B MX 394835B MX 2019013979 A MX2019013979 A MX 2019013979A MX 2019013979 A MX2019013979 A MX 2019013979A MX 394835 B MX394835 B MX 394835B
Authority
MX
Mexico
Prior art keywords
preparation
methods
heterocyclic compounds
benzodioxole
benzodioxole heterocyclic
Prior art date
Application number
MX2019013979A
Other languages
English (en)
Other versions
MX2019013979A (es
Inventor
Allan Carsten Dahl
Bjørn Metzler
Esben Paul Krogh Olsen
Johan Eriksson Bajtner
Original Assignee
Union Therapeutics As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Union Therapeutics As filed Critical Union Therapeutics As
Publication of MX2019013979A publication Critical patent/MX2019013979A/es
Publication of MX394835B publication Critical patent/MX394835B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J21/00—Catalysts comprising the elements, oxides, or hydroxides of magnesium, boron, aluminium, carbon, silicon, titanium, zirconium, or hafnium
    • B01J21/16—Clays or other mineral silicates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La presente invención se relaciona con métodos nuevos para la preparación de compuestos heterocíclicos de 1,3-benzodioxol de la fórmula (I). Los compuestos son útiles como inhibidores de PDE4. (I).
MX2019013979A 2017-06-20 2018-06-19 Metodos para la preparacion de compuestos heterociclicos de 1,3-benzodioxol. MX394835B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17176767 2017-06-20
PCT/EP2018/066229 WO2018234299A1 (en) 2017-06-20 2018-06-19 Methods for the preparation of 1,3-benzodioxole heterocyclic compounds

Publications (2)

Publication Number Publication Date
MX2019013979A MX2019013979A (es) 2020-07-13
MX394835B true MX394835B (es) 2025-03-24

Family

ID=59091413

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019013979A MX394835B (es) 2017-06-20 2018-06-19 Metodos para la preparacion de compuestos heterociclicos de 1,3-benzodioxol.

Country Status (14)

Country Link
US (2) US11220514B2 (es)
EP (1) EP3642210B1 (es)
JP (2) JP2020524131A (es)
KR (1) KR102676384B1 (es)
CN (2) CN118344381A (es)
AU (1) AU2018286964B2 (es)
BR (1) BR112019025028A2 (es)
CA (1) CA3064033A1 (es)
DK (1) DK3642210T3 (es)
ES (1) ES2998512T3 (es)
IL (1) IL271399B (es)
MX (1) MX394835B (es)
TW (1) TWI774791B (es)
WO (1) WO2018234299A1 (es)

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PT3390407T (pt) 2015-12-18 2023-11-03 Union Therapeutics As Métodos para a preparação de compostos heterocíclicos de 1,3-benzodioxole
KR102676384B1 (ko) 2017-06-20 2024-06-20 유니온 테라퓨틱스 에이/에스 1,3-벤조디옥솔 헤테로시클릭 화합물의 제조방법
PT3724196T (pt) 2017-12-15 2023-01-13 Union Therapeutics As Azetidina di-hidrotienopiridinas substituídas e a sua utilização como inibidores de fosfodiesterase
FI3911304T3 (fi) 2019-01-15 2023-09-25 Union Therapeutics As Fosfodiesteraasin estäjiä sisältäviä muutettuja tablettiformulaatioita
EP4313043A1 (en) 2021-03-22 2024-02-07 UNION therapeutics A/S Treatment of hidradenitis suppurativa with orismilast
CN114105865A (zh) * 2021-12-07 2022-03-01 江苏宝众宝达药业股份有限公司 一种3,4,5-三氯吡啶的合成工艺
GB202205715D0 (en) 2022-04-19 2022-06-01 Union Therapeutics As Treatment of neutrophilic dermatoses
GB202306662D0 (en) 2023-05-05 2023-06-21 Union Therapeutics As Dosage regimen
GB202306663D0 (en) 2023-05-05 2023-06-21 Union Therapeutics As Combination therapy

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ATE325110T1 (de) 1995-05-19 2006-06-15 Kyowa Hakko Kogyo Kk Sauerstoff enthaltende heterocyclische verbindungen
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JPH1159216A (ja) 1997-08-26 1999-03-02 Fuji Heavy Ind Ltd ４輪駆動車の動力配分制御装置
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MY146022A (en) 2006-12-22 2012-06-15 Leo Pharma As Substituted acetophenones useful as pde4 inhibitors
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JP2013523792A (ja) 2010-04-08 2013-06-17 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｐｄｅ４阻害剤及びｅｐ４受容体アンタゴニストを含有する医薬の組み合わせ
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RU2768746C2 (ru) 2016-12-12 2022-03-24 Юнион Терапьютикс А/С Замещенные пиразолоазепин-4-оны и их применение в качестве ингибиторов фосфодиэстеразы
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KR102676384B1 (ko) 2017-06-20 2024-06-20 유니온 테라퓨틱스 에이/에스 1,3-벤조디옥솔 헤테로시클릭 화합물의 제조방법
JP7216719B2 (ja) 2017-09-20 2023-02-01 ユニオン・セラピューティクス・アクティエセルスカブ 置換ジヒドロチエノピリミジンおよびホスホジエステラーゼ阻害剤としてのその使用
EP3724195B1 (en) 2017-12-15 2023-12-27 UNION therapeutics A/S Substituted tetrahydropyran dihydrothienopyrimidines and their use as phosphodiesterase inhibitors
ES2968822T3 (es) 2017-12-15 2024-05-14 Union Therapeutics As Azetidina dihidrotienopirimidinas sustituidas y su uso como inhibidores de la fosfodiesterasa
PT3724196T (pt) 2017-12-15 2023-01-13 Union Therapeutics As Azetidina di-hidrotienopiridinas substituídas e a sua utilização como inibidores de fosfodiesterase
FI3911304T3 (fi) 2019-01-15 2023-09-25 Union Therapeutics As Fosfodiesteraasin estäjiä sisältäviä muutettuja tablettiformulaatioita
EP4313043A1 (en) 2021-03-22 2024-02-07 UNION therapeutics A/S Treatment of hidradenitis suppurativa with orismilast

Also Published As

Publication number Publication date
CN110741005B (zh) 2024-04-12
RU2019138518A3 (es) 2022-04-14
US12084457B2 (en) 2024-09-10
JP2023029877A (ja) 2023-03-07
CN110741005A (zh) 2020-01-31
US11220514B2 (en) 2022-01-11
WO2018234299A1 (en) 2018-12-27
IL271399B (en) 2022-07-01
RU2019138518A (ru) 2021-07-20
AU2018286964A1 (en) 2019-12-05
ES2998512T3 (en) 2025-02-20
US20220162227A1 (en) 2022-05-26
KR102676384B1 (ko) 2024-06-20
US20210147440A1 (en) 2021-05-20
IL271399A (en) 2020-01-30
EP3642210A1 (en) 2020-04-29
AU2018286964B2 (en) 2022-04-14
MX2019013979A (es) 2020-07-13
TW201904975A (zh) 2019-02-01
TWI774791B (zh) 2022-08-21
EP3642210B1 (en) 2024-11-13
JP2020524131A (ja) 2020-08-13
JP7549635B2 (ja) 2024-09-11
BR112019025028A2 (pt) 2020-06-16
DK3642210T3 (da) 2024-12-09
CA3064033A1 (en) 2018-12-27
KR20200013784A (ko) 2020-02-07
CN118344381A (zh) 2024-07-16

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