EA201692063A1 - Спиросоединения мочевины в качестве противовирусных соединений против rsv - Google Patents

Спиросоединения мочевины в качестве противовирусных соединений против rsv

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Publication number
EA201692063A1
EA201692063A1 EA201692063A EA201692063A EA201692063A1 EA 201692063 A1 EA201692063 A1 EA 201692063A1 EA 201692063 A EA201692063 A EA 201692063A EA 201692063 A EA201692063 A EA 201692063A EA 201692063 A1 EA201692063 A1 EA 201692063A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
urea
spira
virus
against rsv
Prior art date
Application number
EA201692063A
Other languages
English (en)
Other versions
EA030996B1 (ru
Inventor
Лили Ху
Самюэль Доминик ДЕМЭН
Сандрин Мари Элен Вендевилль
Абделлах Тахри
Пьер Жан-Мари Бернар Рабуассон
Original Assignee
Янссен Сайенсиз Айрлэнд Юси
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Сайенсиз Айрлэнд Юси filed Critical Янссен Сайенсиз Айрлэнд Юси
Publication of EA201692063A1 publication Critical patent/EA201692063A1/ru
Publication of EA030996B1 publication Critical patent/EA030996B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Изобретение относится к новым замещенным азетидинильным или пиперидинильным спиросоединениям мочевины формулы (I), обладающим противовирусной активностью, в частности, обладающим ингибирующей активностью в отношении репликации респираторно-синцитиального вируса (RSV). Настоящее изобретение дополнительно относится к получению таких новых соединений, композиций, содержащих эти соединения, а также к соединениям для применения в лечении инфекции, вызванной респираторно-синцитиальным вирусом.
EA201692063A 2014-04-14 2015-04-13 Спиросоединения мочевины в качестве противовирусных соединений против rsv EA030996B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14164596 2014-04-14
PCT/EP2015/057949 WO2015158653A1 (en) 2014-04-14 2015-04-13 Spiro urea compounds as rsv antiviral compounds

Publications (2)

Publication Number Publication Date
EA201692063A1 true EA201692063A1 (ru) 2017-02-28
EA030996B1 EA030996B1 (ru) 2018-10-31

Family

ID=50513690

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201692063A EA030996B1 (ru) 2014-04-14 2015-04-13 Спиросоединения мочевины в качестве противовирусных соединений против rsv

Country Status (11)

Country Link
US (1) US9738652B2 (ru)
EP (1) EP3131905B1 (ru)
JP (1) JP6492105B2 (ru)
KR (1) KR102328280B1 (ru)
CN (1) CN106164077B (ru)
AU (1) AU2015248936B2 (ru)
CA (1) CA2943144C (ru)
EA (1) EA030996B1 (ru)
ES (1) ES2669995T3 (ru)
TW (1) TWI671299B (ru)
WO (1) WO2015158653A1 (ru)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2914541A1 (en) * 2013-08-15 2015-02-19 F. Hoffmann-La Roche Ag Novel aza-oxo-indoles for the treatment and prophylaxis of respiratory syncytial virus infection
ES2821649T3 (es) 2015-06-08 2021-04-27 Shangdong Danhong Pharmaceutical Co Ltd Método para preparar derivados de imidazol e intermedios de los mismos y formas cristalinas
FR3067028B1 (fr) * 2017-06-06 2019-07-12 Adpuerivitam Modulateurs de recepteurs nmda, compositions les comprenant et utilisation de ces composes dans le traitement de maladies impliquant le systeme nerveux central
GB201721812D0 (en) * 2017-12-22 2018-02-07 Reviral Ltd Pharmaceutical compounds
EP3846846A4 (en) 2018-09-06 2022-08-03 Cidara Therapeutics, Inc. COMPOSITIONS AND METHODS FOR THE TREATMENT OF VIRUS INFECTION
AU2020291940A1 (en) * 2019-06-13 2022-02-10 Cidara Therapeutics, Inc. Compositions and methods for the treatment of respiratory syncytial virus
EP4192512A1 (en) 2020-08-06 2023-06-14 Cidara Therapeutics, Inc. Methods for the synthesis of protein-drug conjugates

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20050068A1 (es) 2003-02-06 2005-03-11 Novartis Ag 2-cianopirrolopirimidinas como inhibidores de la catepsina s
GB0304640D0 (en) 2003-02-28 2003-04-02 Novartis Ag Organic compounds
JP2007514718A (ja) 2003-12-18 2007-06-07 テイボテク・フアーマシユーチカルズ・リミテツド 呼吸器シンシチウムウイルス複製のインヒビターとしてのアミノ−ベンズイミダゾール誘導体
TWI515187B (zh) 2010-12-16 2016-01-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之吲哚類
TWI501967B (zh) 2010-12-16 2015-10-01 Janssen R&D Ireland 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類
TWI541241B (zh) 2010-12-16 2016-07-11 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之咪唑并吡啶類
TWI527814B (zh) 2010-12-16 2016-04-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類
TWI530495B (zh) 2010-12-16 2016-04-21 健生科學愛爾蘭無限公司 苯并咪唑呼吸道融合病毒抑制劑
CN102516263B (zh) * 2011-10-25 2015-04-08 南方医科大学 一种螺三环类化合物及其制备方法、以及含该类化合物的药物组合物及其应用
GB201119538D0 (en) * 2011-11-10 2011-12-21 Viral Ltd Pharmaceutical compounds
HUE033476T2 (en) * 2012-10-16 2017-12-28 Janssen Sciences Ireland Uc Anti-RSV Antibodies

Also Published As

Publication number Publication date
JP6492105B2 (ja) 2019-03-27
CA2943144C (en) 2022-06-07
AU2015248936A1 (en) 2016-10-06
WO2015158653A1 (en) 2015-10-22
TWI671299B (zh) 2019-09-11
AU2015248936B2 (en) 2019-01-17
CN106164077B (zh) 2018-09-21
US9738652B2 (en) 2017-08-22
CN106164077A (zh) 2016-11-23
CA2943144A1 (en) 2015-10-22
KR102328280B1 (ko) 2021-11-17
ES2669995T3 (es) 2018-05-29
EA030996B1 (ru) 2018-10-31
JP2017511351A (ja) 2017-04-20
TW201625616A (zh) 2016-07-16
US20170044172A1 (en) 2017-02-16
KR20160136445A (ko) 2016-11-29
EP3131905A1 (en) 2017-02-22
EP3131905B1 (en) 2018-02-28

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