AR095035A1 - Uso de un agonista del receptor 2 del péptido formilo para la preparación de una composición farmacéutica para el tratamiento de inflamación y enfermedades dérmicas - Google Patents
Uso de un agonista del receptor 2 del péptido formilo para la preparación de una composición farmacéutica para el tratamiento de inflamación y enfermedades dérmicasInfo
- Publication number
- AR095035A1 AR095035A1 ARP140100733A ARP140100733A AR095035A1 AR 095035 A1 AR095035 A1 AR 095035A1 AR P140100733 A ARP140100733 A AR P140100733A AR P140100733 A ARP140100733 A AR P140100733A AR 095035 A1 AR095035 A1 AR 095035A1
- Authority
- AR
- Argentina
- Prior art keywords
- dermal
- treatment
- halogen
- healing
- pharmaceutical composition
- Prior art date
Links
- 230000002500 effect on skin Effects 0.000 title abstract 6
- 206010061218 Inflammation Diseases 0.000 title abstract 3
- 201000010099 disease Diseases 0.000 title abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 3
- 230000004054 inflammatory process Effects 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- 239000000018 receptor agonist Substances 0.000 title 1
- 229940044601 receptor agonist Drugs 0.000 title 1
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 230000035876 healing Effects 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 125000006564 (C4-C8) cycloalkyl group Chemical group 0.000 abstract 1
- 208000002874 Acne Vulgaris Diseases 0.000 abstract 1
- 201000004384 Alopecia Diseases 0.000 abstract 1
- 206010004146 Basal cell carcinoma Diseases 0.000 abstract 1
- 125000000041 C6-C10 aryl group Chemical group 0.000 abstract 1
- 201000009030 Carcinoma Diseases 0.000 abstract 1
- 206010008570 Chloasma Diseases 0.000 abstract 1
- 208000032544 Cicatrix Diseases 0.000 abstract 1
- 206010012438 Dermatitis atopic Diseases 0.000 abstract 1
- 229940125634 FPR2 agonist Drugs 0.000 abstract 1
- 229940102773 Formyl peptide receptor 2 agonist Drugs 0.000 abstract 1
- 208000002260 Keloid Diseases 0.000 abstract 1
- 208000003351 Melanosis Diseases 0.000 abstract 1
- 206010051246 Photodermatosis Diseases 0.000 abstract 1
- 208000012641 Pigmentation disease Diseases 0.000 abstract 1
- 206010036229 Post inflammatory pigmentation change Diseases 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 241001303601 Rosacea Species 0.000 abstract 1
- 206010039793 Seborrhoeic dermatitis Diseases 0.000 abstract 1
- 206010052428 Wound Diseases 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 206010000496 acne Diseases 0.000 abstract 1
- 208000009621 actinic keratosis Diseases 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 231100000360 alopecia Toxicity 0.000 abstract 1
- 201000008937 atopic dermatitis Diseases 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 230000001969 hypertrophic effect Effects 0.000 abstract 1
- 210000001117 keloid Anatomy 0.000 abstract 1
- 201000001441 melanoma Diseases 0.000 abstract 1
- 230000008845 photoaging Effects 0.000 abstract 1
- 201000004700 rosacea Diseases 0.000 abstract 1
- 231100000241 scar Toxicity 0.000 abstract 1
- 230000037387 scars Effects 0.000 abstract 1
- 208000008742 seborrheic dermatitis Diseases 0.000 abstract 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 201000010153 skin papilloma Diseases 0.000 abstract 1
- 230000008833 sun damage Effects 0.000 abstract 1
- 238000007910 systemic administration Methods 0.000 abstract 1
Classifications
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Abstract
Uso de una cantidad terapéuticamente eficaz de, al menos, un agonista del receptor 2 del péptido formilo para la administración de una composición farmacéutica para el tratamiento de una inflamación dérmica y las enfermedades dérmicas por administración local o sistémica en un sujeto que tiene necesidad de tal tratamiento. Las inflamaciones dérmicas y las enfermedades dérmicas se seleccionan de entre: curación de heridas dérmicas, cicatrices hipertróficas, queloides, quemaduras, la rosácea, la dermatitis atópica, el acné, la psoriasis, la dermatitis seborreica, queratosis actínica, carcinoma de células basales, carcinoma cha células escamosas, el melanoma, las verrugas víricas, foto-envejecimiento, daño solar, melasma, hiper-pigmentación post-inflamatoria, trastornos de la pigmentación alopecia, formas de cicatrización y de no cicatrización. El agonista de FPR2 está representado por la fórmula (1) en donde: R¹ es sec-butilo, arilo C₆₋₁₀, -CH₂-arilo C₆₋₁₀, -CH₂-heterociclo, cicloalquilo C₄₋₈ o cicloalquenilo C₃₋₈ o heterociclo; R² es halógeno o metilo; R³ es halógeno; R⁴ es H, metilo o halógeno; R⁵ es OR o NH₂; y R⁶ es H o alquilo C₂₋₄.
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US201361773778P | 2013-03-06 | 2013-03-06 |
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AR095035A1 true AR095035A1 (es) | 2015-09-16 |
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ARP140100733A AR095035A1 (es) | 2013-03-06 | 2014-03-06 | Uso de un agonista del receptor 2 del péptido formilo para la preparación de una composición farmacéutica para el tratamiento de inflamación y enfermedades dérmicas |
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Country | Link |
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US (5) | US20140256685A1 (es) |
EP (1) | EP2964214A1 (es) |
JP (4) | JP6196328B2 (es) |
KR (2) | KR20210024691A (es) |
CN (2) | CN107714683A (es) |
AR (1) | AR095035A1 (es) |
AU (3) | AU2014226001B2 (es) |
BR (2) | BR122017004256A2 (es) |
CA (3) | CA2899804A1 (es) |
HK (2) | HK1219661A1 (es) |
RU (1) | RU2696487C2 (es) |
TW (1) | TW201446241A (es) |
WO (1) | WO2014138046A1 (es) |
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- 2014-03-04 EP EP14713302.9A patent/EP2964214A1/en not_active Withdrawn
- 2014-03-04 CA CA3114347A patent/CA3114347A1/en not_active Abandoned
- 2014-03-06 AR ARP140100733A patent/AR095035A1/es unknown
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