AR094942A1 - Métodos para preparar derivados de un ácido graso - Google Patents

Métodos para preparar derivados de un ácido graso

Info

Publication number
AR094942A1
AR094942A1 ARP140100656A ARP140100656A AR094942A1 AR 094942 A1 AR094942 A1 AR 094942A1 AR P140100656 A ARP140100656 A AR P140100656A AR P140100656 A ARP140100656 A AR P140100656A AR 094942 A1 AR094942 A1 AR 094942A1
Authority
AR
Argentina
Prior art keywords
formula
icosa
pentayloxy
methods
fatty acid
Prior art date
Application number
ARP140100656A
Other languages
English (en)
Inventor
Skjret Tore
Hovland Ragnar
Original Assignee
Skjaeret Tore
Hovland Ragnar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Skjaeret Tore, Hovland Ragnar filed Critical Skjaeret Tore
Publication of AR094942A1 publication Critical patent/AR094942A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/367—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/47—Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Métodos para la síntesis eficiente de derivados de ácidos grasos y sus intermediarios. Reivindicación 1: Un método para preparar ácido 2-((5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaeniloxi)butanoico de fórmula (3) a partir de un derivado de EPA de la fórmula (1) que comprende los pasos de a) reducir el derivado de EPA de la fórmula (1) donde -C(=O)X representa a un ácido carboxílico o un éster carboxílico, a su correspondiente alcohol (5Z,8Z,11Z,14Z,172)-icosa-5,8,11,14,17-pentaen-1-ol de fórmula (2) por reducción con un agente reductor; b) aislar el alcohol de fórmula (2) del paso a); c) hacer reaccionar el alcohol aislado de fórmula (2) del paso b) con ácido 2-bromobutírico para formar ácido 2-((5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaeniloxi)butanoico de fórmula (3); d) aislar el ácido 2-((5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaeniloxi)butanoico de fórmula (3) del paso c); y e) opcionalmente purificar el ácido 2-((5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaeniloxi)butanoico de fórmula (3).
ARP140100656A 2013-02-28 2014-02-28 Métodos para preparar derivados de un ácido graso AR094942A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361770601P 2013-02-28 2013-02-28

Publications (1)

Publication Number Publication Date
AR094942A1 true AR094942A1 (es) 2015-09-09

Family

ID=50972746

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP140100656A AR094942A1 (es) 2013-02-28 2014-02-28 Métodos para preparar derivados de un ácido graso

Country Status (15)

Country Link
US (1) US9365482B2 (es)
EP (1) EP2961727B1 (es)
JP (2) JP6325580B2 (es)
KR (1) KR102179351B1 (es)
CN (2) CN105102414B (es)
AR (1) AR094942A1 (es)
AU (1) AU2014222390B2 (es)
DK (1) DK2961727T3 (es)
ES (1) ES2619714T3 (es)
HR (1) HRP20170383T1 (es)
HU (1) HUE031763T2 (es)
PL (1) PL2961727T3 (es)
PT (1) PT2961727T (es)
TW (1) TWI624453B (es)
WO (1) WO2014132135A2 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20200096791A (ko) 2017-12-06 2020-08-13 바스프 에이에스 비알콜성 지방간염 치료용 지방산 유도체
EP3796901A2 (en) 2018-05-23 2021-03-31 Northsea Therapeutics B.V. Structurally modified fatty acids for improving glycemic control and treating inflammatory bowel disease
JP2023554524A (ja) 2020-12-22 2023-12-27 ノースシー セラピューティクス ベスローテン フェンノートシャップ 非アルコール性脂肪性肝炎の治療のための酸素含有構造強化脂肪酸を含む組合せ療法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0791217B2 (ja) * 1988-11-21 1995-10-04 宇部興産株式会社 光学活性な２−フェノキシブタン酸の製造法
BRPI0718393A2 (pt) * 2006-11-03 2013-11-26 Pronova Biopharma Norge As Álcoois de ácido graxo
WO2009134147A1 (en) 2008-05-02 2009-11-05 Pronova Biopharma Norge As Lipid compositions containing derivatives of epa and dha an their use thereof
WO2010033466A1 (en) * 2008-09-16 2010-03-25 Phenomix Corporation Macrocyclic inhibitors of hepatitis c protease
CA2760877C (en) * 2009-05-08 2020-09-08 Pronova Biopharma Norge As Polyunsaturated fatty acids for the treatment of diseases related to cardiovascular, metabolic and inflammatory disease areas
EP2248798A1 (en) * 2009-05-08 2010-11-10 Pronova BioPharma Norge AS Novel lipid compounds
ES2618604T3 (es) * 2010-11-05 2017-06-21 Pronova Biopharma Norge As Métodos de tratamiento usando compuestos lipídicos

Also Published As

Publication number Publication date
CN105102414A (zh) 2015-11-25
JP6325580B2 (ja) 2018-05-16
WO2014132135A2 (en) 2014-09-04
PT2961727T (pt) 2017-03-08
JP2018127479A (ja) 2018-08-16
TW201500342A (zh) 2015-01-01
HUE031763T2 (en) 2017-07-28
EP2961727B1 (en) 2016-12-28
DK2961727T3 (en) 2017-03-13
US9365482B2 (en) 2016-06-14
CN105102414B (zh) 2017-08-04
EP2961727A2 (en) 2016-01-06
KR20160002732A (ko) 2016-01-08
AU2014222390B2 (en) 2018-05-31
HRP20170383T1 (hr) 2017-05-05
CN107673964B (zh) 2021-03-23
KR102179351B1 (ko) 2020-11-18
CN107673964A (zh) 2018-02-09
TWI624453B (zh) 2018-05-21
PL2961727T3 (pl) 2017-06-30
US20160009625A1 (en) 2016-01-14
WO2014132135A3 (en) 2014-11-27
AU2014222390A1 (en) 2015-09-17
JP2016508523A (ja) 2016-03-22
ES2619714T3 (es) 2017-06-26

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