AR094684A1 - Triterpenoides de c-19 modificados, con actividad inhibidora de la maduración del vih - Google Patents
Triterpenoides de c-19 modificados, con actividad inhibidora de la maduración del vihInfo
- Publication number
- AR094684A1 AR094684A1 ARP140100400A ARP140100400A AR094684A1 AR 094684 A1 AR094684 A1 AR 094684A1 AR P140100400 A ARP140100400 A AR P140100400A AR P140100400 A ARP140100400 A AR P140100400A AR 094684 A1 AR094684 A1 AR 094684A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- group
- substituted
- cycloalkyl
- heteroaryl
- Prior art date
Links
- -1 MODIFIED C-19 TRITERPENOIDS Chemical class 0.000 title abstract 5
- 230000035800 maturation Effects 0.000 title abstract 2
- 230000002401 inhibitory effect Effects 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 34
- 125000000217 alkyl group Chemical group 0.000 abstract 19
- 125000001072 heteroaryl group Chemical group 0.000 abstract 17
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 10
- 125000003118 aryl group Chemical group 0.000 abstract 8
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 125000003107 substituted aryl group Chemical group 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- NAWXUBYGYWOOIX-SFHVURJKSA-N (2s)-2-[[4-[2-(2,4-diaminoquinazolin-6-yl)ethyl]benzoyl]amino]-4-methylidenepentanedioic acid Chemical compound C1=CC2=NC(N)=NC(N)=C2C=C1CCC1=CC=C(C(=O)N[C@@H](CC(=C)C(O)=O)C(O)=O)C=C1 NAWXUBYGYWOOIX-SFHVURJKSA-N 0.000 abstract 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- 125000006564 (C4-C8) cycloalkyl group Chemical group 0.000 abstract 1
- KUVIULQEHSCUHY-XYWKZLDCSA-N Beclometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(=O)CC)(OC(=O)CC)[C@@]1(C)C[C@@H]2O KUVIULQEHSCUHY-XYWKZLDCSA-N 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 101150008563 spir gene Proteins 0.000 abstract 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361761403P | 2013-02-06 | 2013-02-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR094684A1 true AR094684A1 (es) | 2015-08-19 |
Family
ID=50150818
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP140100400A AR094684A1 (es) | 2013-02-06 | 2014-02-06 | Triterpenoides de c-19 modificados, con actividad inhibidora de la maduración del vih |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20140221361A1 (enExample) |
| EP (1) | EP2953960A1 (enExample) |
| JP (1) | JP6186010B2 (enExample) |
| KR (1) | KR20150115881A (enExample) |
| CN (1) | CN105121454A (enExample) |
| AR (1) | AR094684A1 (enExample) |
| AU (1) | AU2014215468B2 (enExample) |
| BR (1) | BR112015018491A2 (enExample) |
| CA (1) | CA2900124A1 (enExample) |
| EA (1) | EA027371B1 (enExample) |
| IL (1) | IL240289A0 (enExample) |
| MX (1) | MX2015010003A (enExample) |
| SG (1) | SG11201505639SA (enExample) |
| TW (1) | TW201443073A (enExample) |
| WO (1) | WO2014123889A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8906889B2 (en) * | 2012-02-15 | 2014-12-09 | Bristol-Myers Squibb Company | C-3 cycloalkenyl triterpenoids with HIV maturation inhibitory activity |
| KR20180028534A (ko) | 2015-07-28 | 2018-03-16 | 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 | Hiv 감염을 예방하거나 치료하기 위한 베투인 유도체 |
| RU2018105352A (ru) | 2015-07-28 | 2019-08-29 | ГлаксоСмитКлайн Интеллекчуал Проперти (N2) Лимитед | Производные бетулина для предупреждения или лечения ВИЧ-инфекций |
| WO2017025901A1 (en) * | 2015-08-11 | 2017-02-16 | Hetero Research Foundation | Novel c28-analogues with c3-modifications of triterpene derivatives as hiv inhibitors |
| CN108368071A (zh) | 2015-09-24 | 2018-08-03 | 葛兰素史克知识产权第二有限公司 | 具有hiv成熟抑制活性的化合物 |
| CN108699103A (zh) | 2016-01-20 | 2018-10-23 | 葛兰素史克知识产权第二有限公司 | 具有hiv成熟抑制活性的羽扇烷类的胺衍生物 |
| AR107512A1 (es) * | 2016-02-04 | 2018-05-09 | VIIV HEALTHCARE UK Nº 5 LTD | Triterpenoides modificados en c-3 y c-17 como inhibidores del vih-1 |
| WO2017149518A1 (en) * | 2016-03-04 | 2017-09-08 | Hetero Labs Limited | C-3 novel triterpene with c-17 amine derivatives as hiv inhibitors |
| US10493070B2 (en) | 2016-06-30 | 2019-12-03 | Viiv Healthcare Uk (No. 5) Limited | Azadecalin derivatives as inhibitors of human immunodeficiency virus replication |
| EP3506902A4 (en) * | 2016-08-31 | 2020-04-22 | VIIV Healthcare Company | COMBINATIONS AND USES AND TREATMENTS THEREOF |
| WO2018044853A1 (en) * | 2016-08-31 | 2018-03-08 | Viiv Healthcare Conpany | Combinations and uses and treatments thereof |
| WO2019207460A1 (en) | 2018-04-24 | 2019-10-31 | VIIV Healthcare UK (No.5) Limited | Compounds with hiv maturation inhibitory activity |
| NZ769842A (en) * | 2018-06-29 | 2023-01-27 | Dfh Therapeutics | Triterpene amine derivatives |
| MX2021009584A (es) | 2019-02-11 | 2021-09-23 | Hetero Labs Ltd | Nuevos derivados de triterpeno como inhibidores del virus de la inmunodeficiencia humana (vih). |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2694048B2 (ja) * | 1991-05-09 | 1997-12-24 | 日立建機株式会社 | 建設機械の油圧駆動装置 |
| US5413999A (en) | 1991-11-08 | 1995-05-09 | Merck & Co., Inc. | HIV protease inhibitors useful for the treatment of AIDS |
| FR2683531B1 (fr) * | 1991-11-13 | 1993-12-31 | Rhone Poulenc Rorer Sa | Nouveaux derives du lupane, leur preparation et les compositions pharmaceutiques qui les contiennent. |
| US5679828A (en) | 1995-06-05 | 1997-10-21 | Biotech Research Labs, Inc. | Betulinic acid and dihydrobetulinic acid derivatives and uses therefor |
| US20020137755A1 (en) | 2000-12-04 | 2002-09-26 | Bilodeau Mark T. | Tyrosine kinase inhibitors |
| US20040110785A1 (en) | 2001-02-02 | 2004-06-10 | Tao Wang | Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives |
| US7365221B2 (en) | 2002-09-26 | 2008-04-29 | Panacos Pharmaceuticals, Inc. | Monoacylated betulin and dihydrobetulin derivatives, preparation thereof and use thereof |
| US7745625B2 (en) | 2004-03-15 | 2010-06-29 | Bristol-Myers Squibb Company | Prodrugs of piperazine and substituted piperidine antiviral agents |
| JP2007529544A (ja) | 2004-03-17 | 2007-10-25 | パナコス ファーマシューティカルズ， インコーポレイテッド | ３−ｏ−（３’，３’−ジメチルスクシニル）ベツリン酸の製薬的な塩 |
| TW200628161A (en) | 2004-11-12 | 2006-08-16 | Panacos Pharmaceuticals Inc | Novel betulin derivatives, preparation thereof and use thereof |
| US20110144069A1 (en) | 2006-10-16 | 2011-06-16 | Myriad Genetics, Incorporated | Compounds for treating viral infections |
| CA2714049A1 (en) | 2008-02-14 | 2009-08-20 | Virochem Pharma Inc. | Novel 17.beta. lupane derivatives |
| US9067966B2 (en) | 2009-07-14 | 2015-06-30 | Hetero Research Foundation, Hetero Drugs Ltd. | Lupeol-type triterpene derivatives as antivirals |
| ES2612452T3 (es) | 2010-06-04 | 2017-05-17 | VIIV Healthcare UK (No.5) Limited | Derivados de ácido betulínico C-3 modificados como inhibidores de la maduración del VIH |
| EP2576586B1 (en) * | 2010-06-04 | 2015-08-12 | Bristol-Myers Squibb Company | C-28 amides of modified c-3 betulinic acid derivatives as hiv maturation inhibitors |
| WO2012006190A1 (en) | 2010-06-29 | 2012-01-12 | Huawei Technologies Co., Ltd. | Delegate gateways and proxy for target hosts in large layer 2 and address resolution with duplicated internet protocol addresses |
| ES2653847T3 (es) | 2011-01-31 | 2018-02-09 | Viiv Healthcare Uk (No. 4) Limited | Triterpenoides C-17 y C-3 modificados con actividad inhibitoria contra maduración del VIH |
| CN103339141B (zh) | 2011-01-31 | 2016-08-24 | 百时美施贵宝公司 | 作为hiv成熟抑制剂的c-3修饰的桦木酸衍生物的c-28胺 |
| US8906889B2 (en) | 2012-02-15 | 2014-12-09 | Bristol-Myers Squibb Company | C-3 cycloalkenyl triterpenoids with HIV maturation inhibitory activity |
| WO2013160810A2 (en) * | 2012-04-24 | 2013-10-31 | Hetero Research Foundation | Novel betulinic acid derivatives as hiv inhibitors |
| US8889854B2 (en) | 2012-05-07 | 2014-11-18 | Bristol-Myers Squibb Company | C-17 bicyclic amines of triterpenoids with HIV maturation inhibitory activity |
-
2014
- 2014-02-04 JP JP2015556998A patent/JP6186010B2/ja not_active Expired - Fee Related
- 2014-02-04 CA CA2900124A patent/CA2900124A1/en not_active Abandoned
- 2014-02-04 BR BR112015018491A patent/BR112015018491A2/pt not_active Application Discontinuation
- 2014-02-04 WO PCT/US2014/014647 patent/WO2014123889A1/en not_active Ceased
- 2014-02-04 EP EP14705662.6A patent/EP2953960A1/en not_active Withdrawn
- 2014-02-04 AU AU2014215468A patent/AU2014215468B2/en not_active Ceased
- 2014-02-04 EA EA201591406A patent/EA027371B1/ru not_active IP Right Cessation
- 2014-02-04 US US14/172,389 patent/US20140221361A1/en not_active Abandoned
- 2014-02-04 CN CN201480019576.0A patent/CN105121454A/zh active Pending
- 2014-02-04 KR KR1020157023907A patent/KR20150115881A/ko not_active Withdrawn
- 2014-02-04 SG SG11201505639SA patent/SG11201505639SA/en unknown
- 2014-02-04 MX MX2015010003A patent/MX2015010003A/es unknown
- 2014-02-05 TW TW103103839A patent/TW201443073A/zh unknown
- 2014-02-06 AR ARP140100400A patent/AR094684A1/es unknown
-
2015
- 2015-08-02 IL IL240289A patent/IL240289A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP6186010B2 (ja) | 2017-08-23 |
| TW201443073A (zh) | 2014-11-16 |
| WO2014123889A1 (en) | 2014-08-14 |
| SG11201505639SA (en) | 2015-08-28 |
| CA2900124A1 (en) | 2014-08-14 |
| US20140221361A1 (en) | 2014-08-07 |
| CN105121454A (zh) | 2015-12-02 |
| AU2014215468A1 (en) | 2015-09-24 |
| KR20150115881A (ko) | 2015-10-14 |
| JP2016507558A (ja) | 2016-03-10 |
| AU2014215468B2 (en) | 2017-05-18 |
| MX2015010003A (es) | 2015-10-30 |
| BR112015018491A2 (pt) | 2017-07-18 |
| IL240289A0 (en) | 2015-09-24 |
| EA201591406A1 (ru) | 2015-12-30 |
| EP2953960A1 (en) | 2015-12-16 |
| EA027371B1 (ru) | 2017-07-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |