AR092983A1 - Procedimiento de sintesis del 3-(2-bromo-4,5-dimetoxifenil)propanonitrilo, y aplicacion a la sintesis de la ivabradina y de sus sales de adicion a un acido farmaceuticamente aceptable - Google Patents

Procedimiento de sintesis del 3-(2-bromo-4,5-dimetoxifenil)propanonitrilo, y aplicacion a la sintesis de la ivabradina y de sus sales de adicion a un acido farmaceuticamente aceptable

Info

Publication number
AR092983A1
AR092983A1 ARP130103695A ARP130103695A AR092983A1 AR 092983 A1 AR092983 A1 AR 092983A1 AR P130103695 A ARP130103695 A AR P130103695A AR P130103695 A ARP130103695 A AR P130103695A AR 092983 A1 AR092983 A1 AR 092983A1
Authority
AR
Argentina
Prior art keywords
synthesis
compound
formula
dimetoxifenil
propanonitrile
Prior art date
Application number
ARP130103695A
Other languages
English (en)
Inventor
Del Pilar Carranza Maria
Isabel Garcia Aranda Maria
Lorenzo Gonzalez Jose
Sanchez Frederic
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47356189&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR092983(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Servier Lab filed Critical Servier Lab
Publication of AR092983A1 publication Critical patent/AR092983A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Reivindicación 1: Procedimiento de síntesis del compuesto de fórmula (1) caracterizado porque el compuesto de fórmula (2) se somete a la acción de la N-bromosuccinimida en presencia de un disolvente orgánico para dar lugar al compuesto de fórmula (1). Reivindicación 5: Procedimiento según la reivindicación 1, caracterizado porque el compuesto de fórmula (2) se prepara a partir del compuesto de fórmula (3) que se transforma en compuesto de fórmula (4) en presencia de un iluro de fósforo y de una base en un disolvente orgánico, que se transforma en compuesto de fórmula (2) por una reacción de reducción en presencia de un agente donador de hidruro en un disolvente orgánico o una mezcla de disolventes orgánicos.
ARP130103695A 2012-10-12 2013-10-11 Procedimiento de sintesis del 3-(2-bromo-4,5-dimetoxifenil)propanonitrilo, y aplicacion a la sintesis de la ivabradina y de sus sales de adicion a un acido farmaceuticamente aceptable AR092983A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1259745A FR2996845A1 (fr) 2012-10-12 2012-10-12 Nouveau procede de synthese du 3-(2-bromo-4,5-dimethoxyphenyl)propanenitrile, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable

Publications (1)

Publication Number Publication Date
AR092983A1 true AR092983A1 (es) 2015-05-13

Family

ID=47356189

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP130103695A AR092983A1 (es) 2012-10-12 2013-10-11 Procedimiento de sintesis del 3-(2-bromo-4,5-dimetoxifenil)propanonitrilo, y aplicacion a la sintesis de la ivabradina y de sus sales de adicion a un acido farmaceuticamente aceptable

Country Status (35)

Country Link
US (1) US8779121B2 (es)
EP (1) EP2719689B1 (es)
JP (1) JP5793171B2 (es)
KR (1) KR101567887B1 (es)
CN (1) CN103724228B (es)
AR (1) AR092983A1 (es)
AU (1) AU2013237671C1 (es)
BR (1) BR102013026030A2 (es)
CA (1) CA2829428C (es)
CY (1) CY1117315T1 (es)
DK (1) DK2719689T3 (es)
EA (1) EA024408B1 (es)
ES (1) ES2564959T3 (es)
FR (1) FR2996845A1 (es)
GE (1) GEP20156320B (es)
HK (2) HK1191318A1 (es)
HR (1) HRP20160200T1 (es)
HU (1) HUE027867T2 (es)
MA (1) MA35597B1 (es)
MD (1) MD4335C1 (es)
ME (1) ME02329B (es)
MX (1) MX2013011705A (es)
MY (1) MY160147A (es)
NZ (1) NZ616558A (es)
PL (1) PL2719689T3 (es)
PT (1) PT2719689E (es)
RS (1) RS54536B1 (es)
SA (1) SA113340924B1 (es)
SG (1) SG2013074570A (es)
SI (1) SI2719689T1 (es)
TW (1) TWI500597B (es)
UA (1) UA117655C2 (es)
UY (1) UY35068A (es)
WO (1) WO2014057228A1 (es)
ZA (1) ZA201307601B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3101010A1 (en) 2015-06-03 2016-12-07 Urquima S.A. New method for the preparation of highly pure ivabradine base and salts thereof

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0043194A3 (en) * 1980-06-19 1982-03-31 FISONS plc Bicyclo-octatriene derivatives, pharmaceutical compositions containing them and processes and intermediates for their production
US4618683A (en) * 1982-06-01 1986-10-21 Abbott Laboratories Tetrahydro-6,7-dimethoxy-1H-benz[e]isoinodolines useful in the treatment of hypertension and as sedatives
JPS61130253A (ja) * 1984-11-28 1986-06-18 Otsuka Pharmaceut Factory Inc ナフトキノン誘導体
EP0403980A1 (en) * 1989-06-19 1990-12-27 Kyorin Pharmaceutical Co., Ltd. Novel cyclic anthranilic acid carboxylic acid derivatives
JPH06263688A (ja) * 1991-09-04 1994-09-20 Otsuka Pharmaceut Factory Inc フェナンスレン誘導体
FR2681862B1 (fr) * 1991-09-27 1993-11-12 Adir Cie Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent.
JP3186419B2 (ja) * 1993-03-26 2001-07-11 富士レビオ株式会社 ４−フルオロビフェニル誘導体
CN1228775A (zh) * 1996-05-14 1999-09-15 葛兰素集团有限公司 作为时间生物学药物的苯并呋喃和苯并吡喃
FR2763588B1 (fr) * 1997-05-23 1999-07-09 Cird Galderma Composes triaromatiques, compositions les contenant et utilisations
SK2792004A3 (en) * 2001-12-13 2004-11-03 Egyt Gyogyszervegyeszeti Gyar Process for the preparation of tofisopam and new intermediates
EP1569912B1 (en) * 2002-12-03 2015-04-29 Pharmacyclics, Inc. 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors
KR100613810B1 (ko) * 2004-12-17 2006-08-17 주식회사 두산 전계 발광 소자용 화합물 및 이를 포함하는 유기 전계발광소자
CN101407474B (zh) * 2008-11-18 2011-12-14 东华大学 一种2-溴-4,5-二甲氧基苯丙腈的制备方法
WO2011008597A1 (en) * 2009-07-14 2011-01-20 Schering Corporation Dihydroimidazoisoquinoline derivatives useful as pde10 inhibitors
HUP1000245A2 (en) * 2010-05-07 2011-11-28 Richter Gedeon Nyrt Industrial process for the production ivabradin salts

Also Published As

Publication number Publication date
SA113340924B1 (ar) 2015-07-09
CA2829428C (fr) 2016-04-19
NZ616558A (en) 2014-10-31
EP2719689A1 (fr) 2014-04-16
KR101567887B1 (ko) 2015-11-10
CN103724228A (zh) 2014-04-16
SG2013074570A (en) 2014-05-29
EA024408B1 (ru) 2016-09-30
US8779121B2 (en) 2014-07-15
UA117655C2 (uk) 2018-09-10
ES2564959T3 (es) 2016-03-30
ME02329B (me) 2016-06-20
SI2719689T1 (sl) 2016-04-29
GEP20156320B (en) 2015-07-10
PL2719689T3 (pl) 2016-08-31
RS54536B1 (en) 2016-06-30
CA2829428A1 (fr) 2014-04-12
MX2013011705A (es) 2014-04-25
HUE027867T2 (en) 2016-11-28
DK2719689T3 (en) 2016-03-29
MA35597B1 (fr) 2014-11-01
HK1191318A1 (zh) 2014-07-25
EP2719689B1 (fr) 2015-12-23
HRP20160200T1 (hr) 2016-03-25
WO2014057228A1 (fr) 2014-04-17
PT2719689E (pt) 2016-02-04
BR102013026030A2 (pt) 2014-10-29
AU2013237671C1 (en) 2017-06-15
EA201301020A1 (ru) 2014-06-30
CN103724228B (zh) 2016-04-20
MD20130071A2 (en) 2014-04-30
JP2014080421A (ja) 2014-05-08
HK1193409A1 (zh) 2014-09-19
ZA201307601B (en) 2014-07-30
AU2013237671B2 (en) 2017-03-02
JP5793171B2 (ja) 2015-10-14
US20140107334A1 (en) 2014-04-17
FR2996845A1 (fr) 2014-04-18
TWI500597B (zh) 2015-09-21
KR20140047538A (ko) 2014-04-22
AU2013237671A1 (en) 2014-05-01
MY160147A (en) 2017-02-28
CY1117315T1 (el) 2017-04-26
UY35068A (es) 2014-05-30
MD4335B1 (ro) 2015-03-31
MD4335C1 (ro) 2015-10-31
TW201414705A (zh) 2014-04-16

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