PT2719689E - Novo processo de síntese do 3-(2-bromo-4-5-dimetoxifenil)propanonitrilo, e aplicação à síntese da ivabradina e dos seus sais de adição a um ácido aceitável do ponto de vista farmacêutico - Google Patents

Novo processo de síntese do 3-(2-bromo-4-5-dimetoxifenil)propanonitrilo, e aplicação à síntese da ivabradina e dos seus sais de adição a um ácido aceitável do ponto de vista farmacêutico Download PDF

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Publication number
PT2719689E
PT2719689E PT131882284T PT13188228T PT2719689E PT 2719689 E PT2719689 E PT 2719689E PT 131882284 T PT131882284 T PT 131882284T PT 13188228 T PT13188228 T PT 13188228T PT 2719689 E PT2719689 E PT 2719689E
Authority
PT
Portugal
Prior art keywords
synthesising
propanenitrile
dimethoxyphenyl
bromo
pharmaceutically acceptable
Prior art date
Application number
PT131882284T
Other languages
English (en)
Portuguese (pt)
Inventor
Maria Del Pilar Carranza
Maria Isabel Garcia Aranda
José Lorenzo Gonzalez
Frédéric Sanchez
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Application filed by Servier Lab filed Critical Servier Lab
Publication of PT2719689E publication Critical patent/PT2719689E/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
PT131882284T 2012-10-12 2013-10-11 Novo processo de síntese do 3-(2-bromo-4-5-dimetoxifenil)propanonitrilo, e aplicação à síntese da ivabradina e dos seus sais de adição a um ácido aceitável do ponto de vista farmacêutico PT2719689E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1259745A FR2996845A1 (fr) 2012-10-12 2012-10-12 Nouveau procede de synthese du 3-(2-bromo-4,5-dimethoxyphenyl)propanenitrile, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable

Publications (1)

Publication Number Publication Date
PT2719689E true PT2719689E (pt) 2016-02-04

Family

ID=47356189

Family Applications (1)

Application Number Title Priority Date Filing Date
PT131882284T PT2719689E (pt) 2012-10-12 2013-10-11 Novo processo de síntese do 3-(2-bromo-4-5-dimetoxifenil)propanonitrilo, e aplicação à síntese da ivabradina e dos seus sais de adição a um ácido aceitável do ponto de vista farmacêutico

Country Status (35)

Country Link
US (1) US8779121B2 (es)
EP (1) EP2719689B1 (es)
JP (1) JP5793171B2 (es)
KR (1) KR101567887B1 (es)
CN (1) CN103724228B (es)
AR (1) AR092983A1 (es)
AU (1) AU2013237671C1 (es)
BR (1) BR102013026030A2 (es)
CA (1) CA2829428C (es)
CY (1) CY1117315T1 (es)
DK (1) DK2719689T3 (es)
EA (1) EA024408B1 (es)
ES (1) ES2564959T3 (es)
FR (1) FR2996845A1 (es)
GE (1) GEP20156320B (es)
HK (2) HK1191318A1 (es)
HR (1) HRP20160200T1 (es)
HU (1) HUE027867T2 (es)
MA (1) MA35597B1 (es)
MD (1) MD4335C1 (es)
ME (1) ME02329B (es)
MX (1) MX2013011705A (es)
MY (1) MY160147A (es)
NZ (1) NZ616558A (es)
PL (1) PL2719689T3 (es)
PT (1) PT2719689E (es)
RS (1) RS54536B1 (es)
SA (1) SA113340924B1 (es)
SG (1) SG2013074570A (es)
SI (1) SI2719689T1 (es)
TW (1) TWI500597B (es)
UA (1) UA117655C2 (es)
UY (1) UY35068A (es)
WO (1) WO2014057228A1 (es)
ZA (1) ZA201307601B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3101010A1 (en) 2015-06-03 2016-12-07 Urquima S.A. New method for the preparation of highly pure ivabradine base and salts thereof

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0043194A3 (en) * 1980-06-19 1982-03-31 FISONS plc Bicyclo-octatriene derivatives, pharmaceutical compositions containing them and processes and intermediates for their production
US4618683A (en) * 1982-06-01 1986-10-21 Abbott Laboratories Tetrahydro-6,7-dimethoxy-1H-benz[e]isoinodolines useful in the treatment of hypertension and as sedatives
JPS61130253A (ja) * 1984-11-28 1986-06-18 Otsuka Pharmaceut Factory Inc ナフトキノン誘導体
EP0403980A1 (en) * 1989-06-19 1990-12-27 Kyorin Pharmaceutical Co., Ltd. Novel cyclic anthranilic acid carboxylic acid derivatives
JPH06263688A (ja) * 1991-09-04 1994-09-20 Otsuka Pharmaceut Factory Inc フェナンスレン誘導体
FR2681862B1 (fr) * 1991-09-27 1993-11-12 Adir Cie Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent.
JP3186419B2 (ja) * 1993-03-26 2001-07-11 富士レビオ株式会社 ４−フルオロビフェニル誘導体
CA2253802A1 (en) * 1996-05-14 1997-11-20 Peter Charles North Benzofurans and benzopyrans as chronobiological agents
FR2763588B1 (fr) * 1997-05-23 1999-07-09 Cird Galderma Composes triaromatiques, compositions les contenant et utilisations
CZ2004792A3 (cs) * 2001-12-13 2004-12-15 EGIS Gyógyszergyár Rt. Způsob přípravy farmaceutických meziproduktů
PT1569912E (pt) * 2002-12-03 2015-09-15 Pharmacyclics Llc Derivados 2-(2-hidroxibifenil-3-il)-1h-benzoimidazole-5- carboxamidina como inibidores do fator viia
KR100613810B1 (ko) * 2004-12-17 2006-08-17 주식회사 두산 전계 발광 소자용 화합물 및 이를 포함하는 유기 전계발광소자
CN101407474B (zh) * 2008-11-18 2011-12-14 东华大学 一种2-溴-4,5-二甲氧基苯丙腈的制备方法
WO2011008597A1 (en) * 2009-07-14 2011-01-20 Schering Corporation Dihydroimidazoisoquinoline derivatives useful as pde10 inhibitors
HUP1000245A2 (en) * 2010-05-07 2011-11-28 Richter Gedeon Nyrt Industrial process for the production ivabradin salts

Also Published As

Publication number Publication date
HK1193409A1 (zh) 2014-09-19
CN103724228B (zh) 2016-04-20
CA2829428C (fr) 2016-04-19
MD4335C1 (ro) 2015-10-31
CA2829428A1 (fr) 2014-04-12
SI2719689T1 (sl) 2016-04-29
ME02329B (me) 2016-06-20
KR20140047538A (ko) 2014-04-22
WO2014057228A1 (fr) 2014-04-17
TW201414705A (zh) 2014-04-16
US8779121B2 (en) 2014-07-15
MY160147A (en) 2017-02-28
SG2013074570A (en) 2014-05-29
MA35597B1 (fr) 2014-11-01
HUE027867T2 (en) 2016-11-28
TWI500597B (zh) 2015-09-21
AR092983A1 (es) 2015-05-13
NZ616558A (en) 2014-10-31
ES2564959T3 (es) 2016-03-30
KR101567887B1 (ko) 2015-11-10
AU2013237671C1 (en) 2017-06-15
AU2013237671A1 (en) 2014-05-01
CY1117315T1 (el) 2017-04-26
JP2014080421A (ja) 2014-05-08
MD4335B1 (ro) 2015-03-31
BR102013026030A2 (pt) 2014-10-29
EP2719689B1 (fr) 2015-12-23
US20140107334A1 (en) 2014-04-17
HRP20160200T1 (hr) 2016-03-25
AU2013237671B2 (en) 2017-03-02
EP2719689A1 (fr) 2014-04-16
MX2013011705A (es) 2014-04-25
RS54536B1 (en) 2016-06-30
HK1191318A1 (zh) 2014-07-25
UY35068A (es) 2014-05-30
JP5793171B2 (ja) 2015-10-14
ZA201307601B (en) 2014-07-30
GEP20156320B (en) 2015-07-10
SA113340924B1 (ar) 2015-07-09
UA117655C2 (uk) 2018-09-10
DK2719689T3 (en) 2016-03-29
FR2996845A1 (fr) 2014-04-18
EA201301020A1 (ru) 2014-06-30
CN103724228A (zh) 2014-04-16
PL2719689T3 (pl) 2016-08-31
MD20130071A2 (en) 2014-04-30
EA024408B1 (ru) 2016-09-30

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