AR092934A1 - Formulacion acuosa esteril inyectable a base de acido hialuronico reticulado y de hidroxiapatita para uso terapeutico - Google Patents
Formulacion acuosa esteril inyectable a base de acido hialuronico reticulado y de hidroxiapatita para uso terapeuticoInfo
- Publication number
- AR092934A1 AR092934A1 ARP130103636A ARP130103636A AR092934A1 AR 092934 A1 AR092934 A1 AR 092934A1 AR P130103636 A ARP130103636 A AR P130103636A AR P130103636 A ARP130103636 A AR P130103636A AR 092934 A1 AR092934 A1 AR 092934A1
- Authority
- AR
- Argentina
- Prior art keywords
- injectable sterile
- sterile aqueous
- aqueous formulation
- hyaluronic acid
- injectable
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/42—Phosphorus; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/738—Cross-linked polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Formulación acuosa estéril inyectable absorbible, lista para usar, utilizada con fines terapéuticos bajo la forma de gel viscoelástico cohesivo en partículas, que incluye: i) ácido hialurónico reticulado, o una de sus sales, en una concentración de entre el 1% y el 4% (masa/volumen); la reticulación efectuada permite obtener un gel en base a ácido hialurónico reticulado de una estructura llamada cohesiva y ii) hidroxiapatita en una concentración de entre el 10% y el 70% (masa/volumen); esta hidroxiapatita se presenta bajo la forma de partículas de un tamaño promedio inferior o igual a 650 mm; esta formulación acuosa estéril inyectable posee propiedades viscoelásticas tales que la Tand, a una frecuencia de 1 Hz, es inferior o igual a 0,60. Reivindicación 6: La formulación acuosa estéril inyectable según cualquiera de las reivindicaciones anteriores, caracterizada por el hecho de que la formulación incluye además uno o más materiales cerámicos, como fosfato tricálcico. Reivindicación 8: La formulación acuosa estéril inyectable según cualquiera de las reivindicaciones anteriores, caracterizada por el hecho de que la formulación incluye además uno o más anestésicos. Reivindicación 10: La formulación acuosa estéril inyectable según la reivindicación 9, caracterizada por el hecho de que el anestésico es el clorhidrato de lidocaína. Reivindicación 11: La formulación acuosa estéril inyectable según cualquiera de las reivindicaciones anteriores, caracterizada por el hecho de que la formulación incluye además uno o más antioxidantes. Reivindicación 13: La formulación acuosa estéril inyectable según la reivindicación 11 caracterizada por el hecho de que los polioles incluyen el sorbitol, el glicerol, el manitol o el propilenglicol. Reivindicación 14: La formulación acuosa estéril inyectable según cualquiera de las reivindicaciones anteriores, caracterizada por el hecho de que la formulación incluye además uno o varios factores de crecimiento como los de la familia de las proteínas morfogenéticas óseas (BMPs) o de los factores de crecimiento transformante b (TGF-bs). Reivindicación 15: La fórmula acuosa estéril inyectable según cualquiera de las reivindicaciones precedentes, utilizada en cirugía ortopédica, dental, maxilofacial, ORL, gastroenterológica, urológica o ginecológica. Reivindicación 18: Kit según la reivindicación 17, que se presenta en forma de jeringa, ampolla o frasco. Reivindicación 19: Procedimiento de fabricación de una formulación acuosa estéril inyectable que comprende las etapas que consisten en: preparar una primera mezcla que contenga al menos del 1% al 4% de su peso de ácido hialurónico reticulado o de alguna de sus sales, por formación de enlaces covalentes entre las cadenas del mencionado biopolímero por medio de moléculas bi- o polifuncionales. La reticulación efectuada permite obtener un gel a base de ácido hialurónico reticulado de una estructura llamada monofásica o cohesiva, b) purificar esta primera mezcla, c) añadir inmediatamente hidroxiapatita en una concentración entre el 10% y el 70% (masa/volumen), dispersándola de manera homogénea en el gel a base de ácido hialurónico reticulado, d) adecuar el gel así obtenido a una forma lista para ser usada, e) esterilizar el producto con calor húmedo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1259582 | 2012-10-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR092934A1 true AR092934A1 (es) | 2015-05-06 |
Family
ID=47295067
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP130103636A AR092934A1 (es) | 2012-10-08 | 2013-10-08 | Formulacion acuosa esteril inyectable a base de acido hialuronico reticulado y de hidroxiapatita para uso terapeutico |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20150238525A1 (es) |
| EP (1) | EP2903591B1 (es) |
| JP (1) | JP6476120B2 (es) |
| CN (1) | CN104853742B (es) |
| AR (1) | AR092934A1 (es) |
| BR (1) | BR112015007746A2 (es) |
| CA (1) | CA2885884A1 (es) |
| ES (1) | ES2595252T3 (es) |
| MX (1) | MX2015004165A (es) |
| RU (2) | RU2015109085A (es) |
| TW (1) | TW201427697A (es) |
| WO (1) | WO2014056723A1 (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10434040B2 (en) | 2012-10-08 | 2019-10-08 | Anteis S.A. | Injectable sterile aqueous formulation based on crosslinked hyaluronic acid and hydroxyapatite for aesthetic use |
| WO2014056722A2 (fr) | 2012-10-08 | 2014-04-17 | Anteis S.A. | Formulation aqueuse stérile injectable à base d'acide hyaluronique réticulé et d'hydroxyapatite pour usage esthétique |
| US10463762B2 (en) * | 2012-10-08 | 2019-11-05 | Anteis S.A. | Injectable sterile aqueous formulation based on crosslinked hyaluronic acid and hydroxyapatite for aesthetic use |
| TWI716365B (zh) * | 2014-11-13 | 2021-01-21 | 德商梅茲製藥有限兩合公司 | 注射型真皮填充劑組合物及其套組、製備方法、與使用 |
| FR3044557B1 (fr) * | 2015-12-07 | 2017-12-01 | Benedicte Vincente Gavard Molliard Tauzin | Nouvelle composition injectable; procede de preparation de ladite composition; utilisation de ladite composition |
| US20190216981A1 (en) | 2016-07-27 | 2019-07-18 | Marbelle Threads Ltd. | Threads of cross-linked hyaluronic acid and hydroxyapatite |
| AU2017325038A1 (en) | 2016-09-07 | 2019-04-18 | Allergan Pharmaceuticals International Limited | Injectable gels comprising cross-linked hyaluronic acid and hydroxyapatite, and methods of manufacturing thereof |
| EP3354258A1 (en) | 2017-01-31 | 2018-08-01 | Teoxane SA | Use of a cohesive gel as a matrix material in a periodontal pocket |
| WO2018220283A1 (fr) * | 2017-05-29 | 2018-12-06 | Kh Medtech Sarl | Composition injectable sterile contenant de l'acide hyaluronique reticule et de l'articaine |
| CN107496990A (zh) * | 2017-08-15 | 2017-12-22 | 广东泰宝医疗器械技术研究院有限公司 | 一种可注射的抗菌软骨修复水凝胶及其制备方法 |
| WO2019073386A1 (en) * | 2017-10-10 | 2019-04-18 | E.N.A. Impeccable Skincare Solutions Ltd | MANUFACTURING METHOD AND DERMAL BLEMISHING COMPOSITIONS CONTAINING HYALURONIC ACID AND HYDROXYAPATITE |
| UA125589U (uk) * | 2018-01-03 | 2018-05-10 | Світлана Олександрівна Ларкіна | Композиція для естетичних ін'єкцій |
| WO2019182745A1 (en) | 2018-03-19 | 2019-09-26 | Bryn Pharma, LLC | Epinephrine spray formulations |
| US11672750B2 (en) | 2018-04-13 | 2023-06-13 | Merz Pharma Gmbh & Co. Kgaa | Dermal filler based on crosslinked hyaluronic acid, calcium phosphate material particles and carboxymethyl cellulose, a process for preparing same and uses thereof |
| KR20200046649A (ko) | 2018-10-25 | 2020-05-07 | (주)뉴크레이티브랩 | 혼합상 히알루론산 제조방법 |
| WO2020095079A1 (fr) * | 2018-11-06 | 2020-05-14 | Kylane Laboratoires Sa | Composition injectable contenant de l'acide hyaluronique pour des applications au niveau du corps |
| US20230108822A1 (en) * | 2020-02-06 | 2023-04-06 | Merz Pharma Gmbh & Co. Kgaa | Injectable composition for skin and soft tissue augmentation |
| WO2021247348A1 (en) * | 2020-06-01 | 2021-12-09 | Bone Solutions, Inc. | Bio-material composition and methods of use |
| CN116173251B (zh) * | 2022-12-09 | 2023-12-01 | 上海蓝晶生物科技有限公司 | 一种pha微球注射剂的灭菌方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6537574B1 (en) * | 1992-02-11 | 2003-03-25 | Bioform, Inc. | Soft tissue augmentation material |
| US20020076429A1 (en) * | 1998-01-28 | 2002-06-20 | John F. Wironen | Bone paste subjected to irradiative and thermal treatment |
| JP2002058736A (ja) * | 2000-08-17 | 2002-02-26 | Seikagaku Kogyo Co Ltd | 骨充填用組成物、骨充填用医療用具及び骨充填用キット |
| ITPD20030286A1 (it) * | 2003-11-27 | 2005-05-28 | Fidia Advanced Biopolymers Srl | Strutture composite multistrato contenenti acido ialuronico |
| CN101039683A (zh) * | 2004-08-13 | 2007-09-19 | 血管技术国际有限公司 | 使用透明质酸和透明质酸酶抑制剂的组合物和方法 |
| WO2006020994A2 (en) * | 2004-08-13 | 2006-02-23 | Angiotech International Ag | Compositions and methods using hyaluronic acid and hyluronidase inhibitors |
| EP1909859B1 (en) * | 2005-07-21 | 2017-09-06 | aap Biomaterials GmbH | Method for producing hydroxyapatite particles, in particular subnanodisperse hydroxyapatite particles in a matrix |
| CN101596328A (zh) * | 2008-06-02 | 2009-12-09 | 山东省生物药物研究院 | 一种复合生物材料及其制备方法和应用 |
| FR2938187B1 (fr) * | 2008-11-07 | 2012-08-17 | Anteis Sa | Composition injectable a base d'acide hyaluronique ou l'un de ses sels, de polyols et de lidocaine, sterilisee a la chaleur |
| FR2945949B1 (fr) * | 2009-05-26 | 2011-05-13 | Anteis Sa | Hydrogel injectable permettant une supplementation en glycerol dans la peau sur le long terme. |
| FR2968996B1 (fr) * | 2010-12-17 | 2013-04-12 | Anteis Sa | Formulation aqueuse injectable sterile utilisee en ophtalmologie |
| ITAN20110138A1 (it) * | 2011-10-12 | 2012-01-11 | Regenyal Lab S R L | Sintesi di un gel iniettabile multifasico a base di acido ialuronico monofasico libero e reticolato e di acido ialuronico bifasico associato con idrossiapatite con inibitore della ialuronidasi microincapsulato. |
| WO2014056722A2 (fr) * | 2012-10-08 | 2014-04-17 | Anteis S.A. | Formulation aqueuse stérile injectable à base d'acide hyaluronique réticulé et d'hydroxyapatite pour usage esthétique |
-
2013
- 2013-09-24 BR BR112015007746A patent/BR112015007746A2/pt not_active Application Discontinuation
- 2013-09-24 RU RU2015109085A patent/RU2015109085A/ru not_active Application Discontinuation
- 2013-09-24 CA CA 2885884 patent/CA2885884A1/fr not_active Abandoned
- 2013-09-24 US US14/433,089 patent/US20150238525A1/en not_active Abandoned
- 2013-09-24 EP EP13766119.5A patent/EP2903591B1/fr not_active Not-in-force
- 2013-09-24 JP JP2015534961A patent/JP6476120B2/ja not_active Expired - Fee Related
- 2013-09-24 MX MX2015004165A patent/MX2015004165A/es unknown
- 2013-09-24 RU RU2018134453A patent/RU2018134453A/ru not_active Application Discontinuation
- 2013-09-24 ES ES13766119.5T patent/ES2595252T3/es active Active
- 2013-09-24 WO PCT/EP2013/069877 patent/WO2014056723A1/fr active Application Filing
- 2013-09-24 CN CN201380052557.3A patent/CN104853742B/zh not_active Expired - Fee Related
- 2013-10-08 TW TW102136384A patent/TW201427697A/zh unknown
- 2013-10-08 AR ARP130103636A patent/AR092934A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2015109085A (ru) | 2016-11-27 |
| MX2015004165A (es) | 2015-10-14 |
| JP2015531280A (ja) | 2015-11-02 |
| BR112015007746A2 (pt) | 2017-07-04 |
| CA2885884A1 (fr) | 2014-04-17 |
| EP2903591B1 (fr) | 2016-07-06 |
| EP2903591A1 (fr) | 2015-08-12 |
| CN104853742A (zh) | 2015-08-19 |
| TW201427697A (zh) | 2014-07-16 |
| ES2595252T3 (es) | 2016-12-28 |
| WO2014056723A1 (fr) | 2014-04-17 |
| RU2018134453A (ru) | 2019-05-24 |
| JP6476120B2 (ja) | 2019-02-27 |
| CN104853742B (zh) | 2018-11-30 |
| US20150238525A1 (en) | 2015-08-27 |
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