AR088568A1 - Proceso mejorado para preparar un compuesto intermedio del inhibidor macrociclico de la proteasa tmc 435 - Google Patents
Proceso mejorado para preparar un compuesto intermedio del inhibidor macrociclico de la proteasa tmc 435Info
- Publication number
- AR088568A1 AR088568A1 ARP120104040A ARP120104040A AR088568A1 AR 088568 A1 AR088568 A1 AR 088568A1 AR P120104040 A ARP120104040 A AR P120104040A AR P120104040 A ARP120104040 A AR P120104040A AR 088568 A1 AR088568 A1 AR 088568A1
- Authority
- AR
- Argentina
- Prior art keywords
- compound
- formula
- tmc
- alkyl
- prepare
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 8
- 229960002091 simeprevir Drugs 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- JTZZSQYMACOLNN-VDWJNHBNSA-N simeprevir Chemical compound O=C([C@@]12C[C@H]1\C=C/CCCCN(C)C(=O)[C@H]1[C@H](C(N2)=O)C[C@H](C1)OC=1C2=CC=C(C(=C2N=C(C=1)C=1SC=C(N=1)C(C)C)C)OC)NS(=O)(=O)C1CC1 JTZZSQYMACOLNN-VDWJNHBNSA-N 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- -1 TMC 435 macrocyclic compound Chemical class 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- ZIINQLPKMUUFRP-UHFFFAOYSA-N 2,7-diazabicyclo[12.1.0]pentadeca-1(15),4,6,8,10,12-hexaene-14-carboxylic acid Chemical compound N1CC=CC=NC=CC=CC=CC2(C1=C2)C(=O)O ZIINQLPKMUUFRP-UHFFFAOYSA-N 0.000 abstract 1
- 241000711549 Hepacivirus C Species 0.000 abstract 1
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 125000004494 ethyl ester group Chemical group 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000037361 pathway Effects 0.000 abstract 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 abstract 1
- 125000006684 polyhaloalkyl group Polymers 0.000 abstract 1
- 230000010076 replication Effects 0.000 abstract 1
- 238000006798 ring closing metathesis reaction Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11187025 | 2011-10-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR088568A1 true AR088568A1 (es) | 2014-06-18 |
Family
ID=47221505
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120104040A AR088568A1 (es) | 2011-10-28 | 2012-10-26 | Proceso mejorado para preparar un compuesto intermedio del inhibidor macrociclico de la proteasa tmc 435 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US8981082B2 (enExample) |
| EP (1) | EP2771339B1 (enExample) |
| JP (1) | JP6231482B2 (enExample) |
| KR (1) | KR20140086967A (enExample) |
| CN (1) | CN104053658B (enExample) |
| AR (1) | AR088568A1 (enExample) |
| AU (1) | AU2012327934B2 (enExample) |
| BR (1) | BR112014009849A2 (enExample) |
| CA (1) | CA2848377A1 (enExample) |
| CL (1) | CL2014001043A1 (enExample) |
| EA (1) | EA201490892A1 (enExample) |
| ES (1) | ES2671732T3 (enExample) |
| HK (1) | HK1202120A1 (enExample) |
| IL (1) | IL231892A (enExample) |
| MX (1) | MX347650B (enExample) |
| TW (1) | TWI574960B (enExample) |
| WO (1) | WO2013061285A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA41812A (fr) | 2015-03-27 | 2018-01-30 | Janssen Pharmaceuticals Inc | Procédés et intermédiaires pour la préparation d'un inhibiteur de protéase macrocyclique du vhc |
| WO2017064680A1 (en) * | 2015-10-16 | 2017-04-20 | Lupin Limited | An improved process for the preparation of simeprevir sodium and intermediate thereof |
| CN109846883A (zh) * | 2017-11-30 | 2019-06-07 | 常州寅盛药业有限公司 | 苯并呋喃衍生物与tmc435联合用药物 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20060008877A (ko) | 2003-04-10 | 2006-01-27 | 베링거 인겔하임 인터내셔날 게엠베하 | 루테늄 착물 촉매 존재하의 복분해 반응에 의한거대사이클릭 화합물의 제조방법 |
| PE20070211A1 (es) | 2005-07-29 | 2007-05-12 | Medivir Ab | Compuestos macrociclicos como inhibidores del virus de hepatitis c |
| EP1934243B1 (en) | 2005-09-09 | 2011-05-25 | Boehringer Ingelheim International GmbH | Ring-closing metathesis process for the preparation of macrocyclic peptides |
| CA2708047A1 (en) | 2007-12-06 | 2009-06-11 | Enanta Pharmaceuticals, Inc. | Process for making macrocyclic oximyl hepatitis c protease inhibitors |
| EP2323981B1 (en) * | 2008-08-07 | 2014-03-12 | F. Hoffmann-La Roche AG | Process for the preparation of a macrocycle |
| DK2382198T3 (da) * | 2008-12-23 | 2013-09-30 | Janssen Pharmaceuticals Inc | Fremgangsmåder og mellemprodukter til fremstilling af en makrocyklisk inhibitor af hcv-protease |
-
2012
- 2012-10-26 JP JP2014537794A patent/JP6231482B2/ja not_active Expired - Fee Related
- 2012-10-26 TW TW101139616A patent/TWI574960B/zh not_active IP Right Cessation
- 2012-10-26 CA CA2848377A patent/CA2848377A1/en not_active Abandoned
- 2012-10-26 AU AU2012327934A patent/AU2012327934B2/en not_active Ceased
- 2012-10-26 ES ES12790677.4T patent/ES2671732T3/es active Active
- 2012-10-26 AR ARP120104040A patent/AR088568A1/es unknown
- 2012-10-26 EA EA201490892A patent/EA201490892A1/ru unknown
- 2012-10-26 BR BR112014009849A patent/BR112014009849A2/pt not_active IP Right Cessation
- 2012-10-26 KR KR1020147009887A patent/KR20140086967A/ko not_active Ceased
- 2012-10-26 HK HK15102687.7A patent/HK1202120A1/xx unknown
- 2012-10-26 EP EP12790677.4A patent/EP2771339B1/en active Active
- 2012-10-26 CN CN201280052692.3A patent/CN104053658B/zh not_active Expired - Fee Related
- 2012-10-26 MX MX2014005070A patent/MX347650B/es active IP Right Grant
- 2012-10-26 US US14/350,138 patent/US8981082B2/en not_active Expired - Fee Related
- 2012-10-26 WO PCT/IB2012/055900 patent/WO2013061285A1/en not_active Ceased
-
2014
- 2014-04-03 IL IL231892A patent/IL231892A/en not_active IP Right Cessation
- 2014-04-24 CL CL2014001043A patent/CL2014001043A1/es unknown
-
2015
- 2015-02-09 US US14/616,770 patent/US9328108B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU2012327934A1 (en) | 2014-03-20 |
| EP2771339B1 (en) | 2018-04-18 |
| US20140235852A1 (en) | 2014-08-21 |
| HK1202120A1 (en) | 2015-09-18 |
| US8981082B2 (en) | 2015-03-17 |
| CN104053658B (zh) | 2018-03-13 |
| KR20140086967A (ko) | 2014-07-08 |
| TWI574960B (zh) | 2017-03-21 |
| ES2671732T3 (es) | 2018-06-08 |
| TW201323423A (zh) | 2013-06-16 |
| MX2014005070A (es) | 2014-08-22 |
| EA201490892A1 (ru) | 2014-08-29 |
| CA2848377A1 (en) | 2013-05-02 |
| MX347650B (es) | 2017-05-05 |
| AU2012327934B2 (en) | 2017-06-01 |
| IL231892A0 (en) | 2014-05-28 |
| WO2013061285A1 (en) | 2013-05-02 |
| EP2771339A1 (en) | 2014-09-03 |
| US20150152098A1 (en) | 2015-06-04 |
| CN104053658A (zh) | 2014-09-17 |
| US9328108B2 (en) | 2016-05-03 |
| JP6231482B2 (ja) | 2017-11-15 |
| CL2014001043A1 (es) | 2014-07-25 |
| JP2014530901A (ja) | 2014-11-20 |
| BR112014009849A2 (pt) | 2016-07-05 |
| IL231892A (en) | 2017-09-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |