CN104053658B - 用于制备大环蛋白酶抑制剂tmc435的中间体的改良方法 - Google Patents

用于制备大环蛋白酶抑制剂tmc435的中间体的改良方法 Download PDF

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Publication number
CN104053658B
CN104053658B CN201280052692.3A CN201280052692A CN104053658B CN 104053658 B CN104053658 B CN 104053658B CN 201280052692 A CN201280052692 A CN 201280052692A CN 104053658 B CN104053658 B CN 104053658B
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CN
China
Prior art keywords
compound
alkyl
ruthenium
dichloro
bis
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN201280052692.3A
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English (en)
Chinese (zh)
Other versions
CN104053658A (zh
Inventor
A.霍瓦斯
S.沃特斯
D.P.M.德普雷
W.L.J.考克
J.L.J.库佩斯
S.哈鲁特扬彦
G.F.S.比诺特
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Janssen Pharmaceuticals Inc
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Ortho McNeil Janssen Pharmaceuticals Inc
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Application filed by Ortho McNeil Janssen Pharmaceuticals Inc filed Critical Ortho McNeil Janssen Pharmaceuticals Inc
Publication of CN104053658A publication Critical patent/CN104053658A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
CN201280052692.3A 2011-10-28 2012-10-26 用于制备大环蛋白酶抑制剂tmc435的中间体的改良方法 Expired - Fee Related CN104053658B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11187025.9 2011-10-28
EP11187025 2011-10-28
PCT/IB2012/055900 WO2013061285A1 (en) 2011-10-28 2012-10-26 Improved process for preparing an intermediate of the macrocyclic protease inhibitor tmc 435

Publications (2)

Publication Number Publication Date
CN104053658A CN104053658A (zh) 2014-09-17
CN104053658B true CN104053658B (zh) 2018-03-13

Family

ID=47221505

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280052692.3A Expired - Fee Related CN104053658B (zh) 2011-10-28 2012-10-26 用于制备大环蛋白酶抑制剂tmc435的中间体的改良方法

Country Status (17)

Country Link
US (2) US8981082B2 (enExample)
EP (1) EP2771339B1 (enExample)
JP (1) JP6231482B2 (enExample)
KR (1) KR20140086967A (enExample)
CN (1) CN104053658B (enExample)
AR (1) AR088568A1 (enExample)
AU (1) AU2012327934B2 (enExample)
BR (1) BR112014009849A2 (enExample)
CA (1) CA2848377A1 (enExample)
CL (1) CL2014001043A1 (enExample)
EA (1) EA201490892A1 (enExample)
ES (1) ES2671732T3 (enExample)
HK (1) HK1202120A1 (enExample)
IL (1) IL231892A (enExample)
MX (1) MX347650B (enExample)
TW (1) TWI574960B (enExample)
WO (1) WO2013061285A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA41812A (fr) 2015-03-27 2018-01-30 Janssen Pharmaceuticals Inc Procédés et intermédiaires pour la préparation d'un inhibiteur de protéase macrocyclique du vhc
WO2017064680A1 (en) * 2015-10-16 2017-04-20 Lupin Limited An improved process for the preparation of simeprevir sodium and intermediate thereof
CN109846883A (zh) * 2017-11-30 2019-06-07 常州寅盛药业有限公司 苯并呋喃衍生物与tmc435联合用药物

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102112442A (zh) * 2008-08-07 2011-06-29 弗·哈夫曼-拉罗切有限公司 制备大环的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1771257A (zh) * 2003-04-10 2006-05-10 贝林格尔·英格海姆国际有限公司 通过钌络合物催化的易位反应制备大环化合物的方法
PE20070211A1 (es) * 2005-07-29 2007-05-12 Medivir Ab Compuestos macrociclicos como inhibidores del virus de hepatitis c
ATE510846T1 (de) * 2005-09-09 2011-06-15 Boehringer Ingelheim Int Cyclisierendes metatheseverfahren zur herstellung von makrocyclischen peptiden
US8193346B2 (en) 2007-12-06 2012-06-05 Enanta Pharmaceuticals, Inc. Process for making macrocyclic oximyl hepatitis C protease inhibitors
BRPI0923393B1 (pt) 2008-12-23 2018-06-19 Ortho-Mcneil-Janssen Pharmaceuticals, Inc. "processos para preparar um inibidor de protease de hcv macrocíclico e intermediários e uso".

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102112442A (zh) * 2008-08-07 2011-06-29 弗·哈夫曼-拉罗切有限公司 制备大环的方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
RCM Macrocyclization Made Practical: An Efficient Synthesis of HCV Protease Inhibitor BILN 2061;Chutian Shu，等;《ORGANIC LETTERS》;20080223;第10卷(第6期);1303-1306 *

Also Published As

Publication number Publication date
EA201490892A1 (ru) 2014-08-29
US20150152098A1 (en) 2015-06-04
KR20140086967A (ko) 2014-07-08
HK1202120A1 (en) 2015-09-18
BR112014009849A2 (pt) 2016-07-05
AU2012327934A1 (en) 2014-03-20
AU2012327934B2 (en) 2017-06-01
US9328108B2 (en) 2016-05-03
US20140235852A1 (en) 2014-08-21
IL231892A (en) 2017-09-28
TW201323423A (zh) 2013-06-16
TWI574960B (zh) 2017-03-21
ES2671732T3 (es) 2018-06-08
EP2771339B1 (en) 2018-04-18
CN104053658A (zh) 2014-09-17
IL231892A0 (en) 2014-05-28
MX347650B (es) 2017-05-05
CL2014001043A1 (es) 2014-07-25
JP6231482B2 (ja) 2017-11-15
AR088568A1 (es) 2014-06-18
EP2771339A1 (en) 2014-09-03
JP2014530901A (ja) 2014-11-20
WO2013061285A1 (en) 2013-05-02
MX2014005070A (es) 2014-08-22
CA2848377A1 (en) 2013-05-02
US8981082B2 (en) 2015-03-17

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