KR20140086967A - 거대고리 프로테아제 저해제 tmc435의 중간체를 제조하는 개선된 방법 - Google Patents

거대고리 프로테아제 저해제 tmc435의 중간체를 제조하는 개선된 방법 Download PDF

Info

Publication number
KR20140086967A
KR20140086967A KR1020147009887A KR20147009887A KR20140086967A KR 20140086967 A KR20140086967 A KR 20140086967A KR 1020147009887 A KR1020147009887 A KR 1020147009887A KR 20147009887 A KR20147009887 A KR 20147009887A KR 20140086967 A KR20140086967 A KR 20140086967A
Authority
KR
South Korea
Prior art keywords
compound
alkyl
ruthenium
reaction
iodide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020147009887A
Other languages
English (en)
Korean (ko)
Inventor
안드라스 호바쓰
스티즌 우이츠
도미니크 파울 미쉘 드프레
보우터 루이스 제이 코우크
요제프 루도 얀 쿠이퍼스
시우자나 하루티우냔
그레고리 파비앙 세바스티앙 비노
Original Assignee
얀센 파마슈티칼즈, 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47221505&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR20140086967(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 얀센 파마슈티칼즈, 인코포레이티드 filed Critical 얀센 파마슈티칼즈, 인코포레이티드
Publication of KR20140086967A publication Critical patent/KR20140086967A/ko
Ceased legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
KR1020147009887A 2011-10-28 2012-10-26 거대고리 프로테아제 저해제 tmc435의 중간체를 제조하는 개선된 방법 Ceased KR20140086967A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11187025 2011-10-28
EP11187025.9 2011-10-28
PCT/IB2012/055900 WO2013061285A1 (en) 2011-10-28 2012-10-26 Improved process for preparing an intermediate of the macrocyclic protease inhibitor tmc 435

Publications (1)

Publication Number Publication Date
KR20140086967A true KR20140086967A (ko) 2014-07-08

Family

ID=47221505

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020147009887A Ceased KR20140086967A (ko) 2011-10-28 2012-10-26 거대고리 프로테아제 저해제 tmc435의 중간체를 제조하는 개선된 방법

Country Status (17)

Country Link
US (2) US8981082B2 (enExample)
EP (1) EP2771339B1 (enExample)
JP (1) JP6231482B2 (enExample)
KR (1) KR20140086967A (enExample)
CN (1) CN104053658B (enExample)
AR (1) AR088568A1 (enExample)
AU (1) AU2012327934B2 (enExample)
BR (1) BR112014009849A2 (enExample)
CA (1) CA2848377A1 (enExample)
CL (1) CL2014001043A1 (enExample)
EA (1) EA201490892A1 (enExample)
ES (1) ES2671732T3 (enExample)
HK (1) HK1202120A1 (enExample)
IL (1) IL231892A (enExample)
MX (1) MX347650B (enExample)
TW (1) TWI574960B (enExample)
WO (1) WO2013061285A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA41812A (fr) 2015-03-27 2018-01-30 Janssen Pharmaceuticals Inc Procédés et intermédiaires pour la préparation d'un inhibiteur de protéase macrocyclique du vhc
WO2017064680A1 (en) * 2015-10-16 2017-04-20 Lupin Limited An improved process for the preparation of simeprevir sodium and intermediate thereof
CN109846883A (zh) * 2017-11-30 2019-06-07 常州寅盛药业有限公司 苯并呋喃衍生物与tmc435联合用药物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20060008877A (ko) 2003-04-10 2006-01-27 베링거 인겔하임 인터내셔날 게엠베하 루테늄 착물 촉매 존재하의 복분해 반응에 의한거대사이클릭 화합물의 제조방법
PE20070211A1 (es) * 2005-07-29 2007-05-12 Medivir Ab Compuestos macrociclicos como inhibidores del virus de hepatitis c
PL1934243T3 (pl) * 2005-09-09 2011-10-31 Boehringer Ingelheim Int Proces metatezy z zamknięciem pierścienia w zastosowaniu do wytwarzania peptydów makrocyklicznych
EP2224920A4 (en) 2007-12-06 2012-05-09 Enanta Pharm Inc PROCESS FOR THE PREPARATION OF MACROCYCLIC OXIMYL HEPATITIS C PROTEASE INHIBITORS
WO2010015545A1 (en) * 2008-08-07 2010-02-11 F. Hoffmann-La Roche Ag Process for the preparation of a macrocycle
WO2010072742A1 (en) 2008-12-23 2010-07-01 Ortho-Mcneil-Janssen Pharmaceuticals, Inc Processes and intermediates for preparing a macrocyclic protease inhibitor of hcv

Also Published As

Publication number Publication date
AR088568A1 (es) 2014-06-18
HK1202120A1 (en) 2015-09-18
ES2671732T3 (es) 2018-06-08
AU2012327934B2 (en) 2017-06-01
CN104053658A (zh) 2014-09-17
BR112014009849A2 (pt) 2016-07-05
US8981082B2 (en) 2015-03-17
TWI574960B (zh) 2017-03-21
JP2014530901A (ja) 2014-11-20
US20150152098A1 (en) 2015-06-04
WO2013061285A1 (en) 2013-05-02
EP2771339B1 (en) 2018-04-18
AU2012327934A1 (en) 2014-03-20
US9328108B2 (en) 2016-05-03
US20140235852A1 (en) 2014-08-21
JP6231482B2 (ja) 2017-11-15
CN104053658B (zh) 2018-03-13
EA201490892A1 (ru) 2014-08-29
EP2771339A1 (en) 2014-09-03
IL231892A (en) 2017-09-28
MX347650B (es) 2017-05-05
TW201323423A (zh) 2013-06-16
IL231892A0 (en) 2014-05-28
CL2014001043A1 (es) 2014-07-25
CA2848377A1 (en) 2013-05-02
MX2014005070A (es) 2014-08-22

Similar Documents

Publication Publication Date Title
JP6957522B2 (ja) Ｂ型肝炎ウイルス疾患の治療および予防のためのキサントン誘導体
CA2710644C (en) Macrocyclic indoles as hepatitis c virus inhibitors
CN111386265A (zh) 作为pd1/pd-l1活化的抑制剂的嘧啶衍生物
KR102654709B1 (ko) 치환된 트리시클릭 헤테로시클릭 화합물
KR102696304B1 (ko) Tnf의 억제제로서 유용한 헤테로시클릭 화합물
JP7604018B2 (ja) 化合物、その薬学的に許容される塩又は立体異性体、及びその使用
KR20170129811A (ko) Tnf의 억제제로서 유용한 트리시클릭 헤테로시클릭 화합물
AU2006244424A1 (en) HIV integrase inhibitors
KR20140086967A (ko) 거대고리 프로테아제 저해제 tmc435의 중간체를 제조하는 개선된 방법
AU2020363354A1 (en) Aryl heterobicyclic compounds as Kv1.3 potassium shaker channel blockers
CN110028508B (zh) 一种抗肿瘤的重氮双环类细胞凋亡蛋白抑制剂
CN115667237A (zh) 作为bet抑制剂的新型杂环化合物
Groenendaal et al. Generation of molecular diversity using a complexity-generating MCR-platform towards triazinane diones
JP2025537520A (ja) 縮合二環化合物
Wahbi et al. REACTION OF LAWESSON’S REAGENT WITH γ-PHOSPHONYL-OXIMES: SYNTHESIS OF NOVEL 1, 2, 5-OXAZAPHOSPHOLINE DERIVATIVES
JP2022545872A (ja) ２―アミノピリミジン化合物ならびにその医薬組成物および用途
Nazarenko et al. Synthesis of 1, 4-benzothiazin-2-yl derivatives of 1, 3-dicarbonyl compounds and benzothiazinone spiro derivatives by the reaction of 2-chloro-1, 4-benzothiazin-3-ones with ‘push–pull’enamines
CN112209896A (zh) 噻唑烷二酮衍生物以及包含其的药物组合物
Magura Photochemical synthesis of dihydroquinolinones and their investigation toward macrocycle synthesis via ring expansion
GB2156348A (en) 4,7-dihydropyrazolo (3,4-b) pyridine derivatives
Enßle et al. Rhodium (II)-catalyzed intramolecular carbonyl ylide formation of α-diazo-β-ketoesters derived from N-phthaloyl-α-amino acids.
CN117295749A (zh) 作为mcl-1抑制剂的大环2-烯丙基四氢呋喃
Cox et al. Intramolecular interactions in carbenes derived during the pyrolysis of N-alkenylisoxazolones
HK40033454A (en) Pyrimidine derivatives as inhibitors of pd1/pd-l1 activation
CN114853761A (zh) 一种含有二氢嘧啶的双功能衍生物及其用途

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20140414

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20171019

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20180910

Patent event code: PE09021S01D

E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 20181114

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 20180910

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I