AR088110A2 - Uso de un inmunoconjugado que comprende un anticuerpo anti-erbb2 para la manufactura de un medicamento - Google Patents
Uso de un inmunoconjugado que comprende un anticuerpo anti-erbb2 para la manufactura de un medicamentoInfo
- Publication number
- AR088110A2 AR088110A2 ARP120103682A ARP120103682A AR088110A2 AR 088110 A2 AR088110 A2 AR 088110A2 AR P120103682 A ARP120103682 A AR P120103682A AR P120103682 A ARP120103682 A AR P120103682A AR 088110 A2 AR088110 A2 AR 088110A2
- Authority
- AR
- Argentina
- Prior art keywords
- antibody
- maitansinoid
- immunocate
- playing
- understanding
- Prior art date
Links
Classifications
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
- G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
- Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
Abstract
Reivindicación 1: Uso de una cantidad efectiva de un inmunconjugado que comprende un anticuerpo anti-ErbB2 conjugado a un maitansinoide caracterizado porque es para la preparación de un medicamento para la terapia adyuvante de un cáncer HER2 positivo en un sujeto humano, luego de cirugía definitiva. Reivindicación 4: El uso de acuerdo con la reivindicación 3, caracterizado porque el anticuerpo es huMAb4D5-8. Reivindicación 5: El uso de acuerdo con la reivindicación 4, caracterizado porque el maitansinoide es DM1 que tiene la estructura de fórmula (1) y caracterizado porque el anticuerpo está unido químicamente al maitansinoide vía un grupo disulfuro o tioéter en R tal como se señala en la estructura. Reivindicación 8: El uso de acuerdo con la reivindicación 5 ó 7, caracterizado porque el anticuerpo y el maitansinoide están conjugados mediante succinimidil-4-(N-maleimidometil)ciclohexano-1-carboxilato.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US68112505P | 2005-05-13 | 2005-05-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR088110A2 true AR088110A2 (es) | 2014-05-07 |
Family
ID=37450489
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AR20060101586A AR054254A1 (es) | 2005-05-13 | 2006-04-21 | Terapia adyuvante con trastuzumab (herceptin registrado) |
ARP120103682A AR088110A2 (es) | 2005-05-13 | 2012-10-03 | Uso de un inmunoconjugado que comprende un anticuerpo anti-erbb2 para la manufactura de un medicamento |
ARP170101287A AR109246A2 (es) | 2005-05-13 | 2017-05-15 | USO DE UN INMUNOCONJUGADO QUE COMPRENDE UN ANTICUERPO ANTI-ErbB2 PARA LA MANUFACTURA DE UN MEDICAMENTO |
ARP170101322A AR108615A2 (es) | 2005-05-13 | 2017-05-17 | Terapia adyuvante con herceptin® |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AR20060101586A AR054254A1 (es) | 2005-05-13 | 2006-04-21 | Terapia adyuvante con trastuzumab (herceptin registrado) |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP170101287A AR109246A2 (es) | 2005-05-13 | 2017-05-15 | USO DE UN INMUNOCONJUGADO QUE COMPRENDE UN ANTICUERPO ANTI-ErbB2 PARA LA MANUFACTURA DE UN MEDICAMENTO |
ARP170101322A AR108615A2 (es) | 2005-05-13 | 2017-05-17 | Terapia adyuvante con herceptin® |
Country Status (6)
Country | Link |
---|---|
US (5) | US8591897B2 (es) |
JP (9) | JP2006316040A (es) |
AR (4) | AR054254A1 (es) |
BR (1) | BRPI0601736A (es) |
CA (2) | CA2540547C (es) |
MX (1) | MX344809B (es) |
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JP2020094061A (ja) | 2020-06-18 |
BRPI0601736A (pt) | 2007-05-15 |
AR054254A1 (es) | 2007-06-13 |
CA2790058C (en) | 2019-01-15 |
JP2017132806A (ja) | 2017-08-03 |
JP2017132805A (ja) | 2017-08-03 |
JP2013163694A (ja) | 2013-08-22 |
JP2015187168A (ja) | 2015-10-29 |
JP2006316040A (ja) | 2006-11-24 |
AR108615A2 (es) | 2018-09-12 |
JP6133668B2 (ja) | 2017-05-24 |
JP2019011374A (ja) | 2019-01-24 |
US20120003217A1 (en) | 2012-01-05 |
CA2540547A1 (en) | 2006-11-13 |
CA2540547C (en) | 2016-08-16 |
JP2022093642A (ja) | 2022-06-23 |
US8597654B2 (en) | 2013-12-03 |
CA2790058A1 (en) | 2006-11-13 |
US20060275305A1 (en) | 2006-12-07 |
US8591897B2 (en) | 2013-11-26 |
US20180236093A1 (en) | 2018-08-23 |
MX344809B (es) | 2017-01-09 |
JP2013144718A (ja) | 2013-07-25 |
US20200155701A1 (en) | 2020-05-21 |
US20140086940A1 (en) | 2014-03-27 |
AR109246A2 (es) | 2018-11-14 |
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