MX344809B - Terapia adyuvante con herceptin. - Google Patents
Terapia adyuvante con herceptin.Info
- Publication number
- MX344809B MX344809B MX2013009514A MX2013009514A MX344809B MX 344809 B MX344809 B MX 344809B MX 2013009514 A MX2013009514 A MX 2013009514A MX 2013009514 A MX2013009514 A MX 2013009514A MX 344809 B MX344809 B MX 344809B
- Authority
- MX
- Mexico
- Prior art keywords
- adjuvant therapy
- herceptin
- herceptin adjuvant
- present application
- breast cancer
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
- G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
- Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Primary Health Care (AREA)
- Mycology (AREA)
- Endocrinology (AREA)
- Medical Informatics (AREA)
- Reproductive Health (AREA)
- Communicable Diseases (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Business, Economics & Management (AREA)
- Tourism & Hospitality (AREA)
- Human Resources & Organizations (AREA)
Abstract
La presente invención se refiere a el uso de un inmunoconjugado que comprende un anticuerpo anti-ErbB2 que se une al dominio IV de HER2 unido por trastuzumab conjugado aun maitansionoide en la preparación de un medicamento para el tratamiento de un sujeto humano que presenta cáncer positivo a HER2, en donde el tratamiento comprende administrar al sujeto humano, después de cirugía definitiva, quimioteprapia basada en antraciclina ciclofosfamida (AC), seguido por administración de una cantidad eficaz de un inmunoconjugado en combinación con una cantidad eficaz de un segundo anticuerpo anti-ErbB2, el cual es un inhibidor de dimerización de HER2.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68112505P | 2005-05-13 | 2005-05-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX344809B true MX344809B (es) | 2017-01-09 |
Family
ID=37450489
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2013009514A MX344809B (es) | 2005-05-13 | 2006-04-21 | Terapia adyuvante con herceptin. |
| MX2018000183A MX383973B (es) | 2005-05-13 | 2006-04-21 | Uso de un inmunoconjugado que comprende un anticuerpo anti-erbb2 que se une a her2 dominio iv unido por trastuzumab conjugado a un maitansinoide. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018000183A MX383973B (es) | 2005-05-13 | 2006-04-21 | Uso de un inmunoconjugado que comprende un anticuerpo anti-erbb2 que se une a her2 dominio iv unido por trastuzumab conjugado a un maitansinoide. |
Country Status (6)
| Country | Link |
|---|---|
| US (5) | US8591897B2 (es) |
| JP (9) | JP2006316040A (es) |
| AR (4) | AR054254A1 (es) |
| BR (1) | BRPI0601736A (es) |
| CA (2) | CA2790058C (es) |
| MX (2) | MX344809B (es) |
Families Citing this family (86)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA9811162B (en) | 1997-12-12 | 2000-06-07 | Genentech Inc | Treatment with anti-ERBB2 antibodies. |
| KR20080038458A (ko) * | 2000-05-19 | 2008-05-06 | 제넨테크, 인크. | ErbB 길항제에 의한 암 치료요법에 대한 효과적인반응의 가능성을 개선시키기 위한 유전자 검출 분석 |
| US8088387B2 (en) | 2003-10-10 | 2012-01-03 | Immunogen Inc. | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
| SV2006002143A (es) * | 2004-06-16 | 2006-01-26 | Genentech Inc | Uso de un anticuerpo para el tratamiento del cancer resistente al platino |
| KR20180004850A (ko) | 2004-07-22 | 2018-01-12 | 제넨테크, 인크. | Her2 항체 조성물 |
| JO3000B1 (ar) | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
| ZA200704796B (en) * | 2004-12-07 | 2008-11-26 | Genentech Inc | Selecting patients for therapy with a HER inhibitor |
| PL1846030T3 (pl) | 2005-01-21 | 2019-05-31 | Genentech Inc | Ustalone dawkowanie przeciwciał her |
| EP3195879A1 (en) | 2005-02-23 | 2017-07-26 | Genentech, Inc. | Extending time to disease progression or survival in cancer patients |
| PE20070207A1 (es) | 2005-07-22 | 2007-03-09 | Genentech Inc | Tratamiento combinado de los tumores que expresan el her |
| AR059096A1 (es) | 2006-01-20 | 2008-03-12 | Genentech Inc | Anticuerpos anti- efrina -b2 y metodos que usan estos |
| EP1913958B1 (en) * | 2006-08-03 | 2009-12-23 | Sanofi-Aventis | Antitumor compositions containing acetylcyclopropyl docetaxel and trastuzumab |
| US20100104566A1 (en) * | 2007-01-29 | 2010-04-29 | Nerviano Medical Sciences S.R.L. | Antitumor combination comprising a morpholinyl anthracycline and an antibody |
| WO2008109440A2 (en) | 2007-03-02 | 2008-09-12 | Genentech, Inc. | Predicting response to a her dimerisation inhibitor based on low her3 expression |
| KR100972618B1 (ko) * | 2007-10-19 | 2010-07-27 | 국립암센터 | 허셉틴을 이용한 유방암 진단 키트, 조성물 및 이들을이용하여 허셉틴 민감성 her2 과발현 세포를 검출하는방법 |
| US10416162B2 (en) * | 2007-12-20 | 2019-09-17 | Monogram Biosciences, Inc. | Her2 diagnostic methods |
| TWI472339B (zh) | 2008-01-30 | 2015-02-11 | Genentech Inc | 包含結合至her2結構域ii之抗體及其酸性變異體的組合物 |
| KR20160066557A (ko) | 2008-03-14 | 2016-06-10 | 제넨테크, 인크. | 약물 저항성과 관련된 유전적 변이 |
| NZ621433A (en) * | 2008-03-18 | 2015-10-30 | Genentech Inc | Combinations of an anti-her2 antibody-drug conjugate and chemotherapeutic agents, and methods of use |
| WO2009131673A1 (en) * | 2008-04-25 | 2009-10-29 | Ludwig Institute For Cancer Research Ltd. | Targeted treatment for subjects with estrogen receptor negative and progesterone receptor negative breast cancers |
| ES2342646B1 (es) * | 2008-06-02 | 2011-04-26 | Institut De Recerca Hospital Universitari Vall Hebron | Metodo de diagnostico de canceres que expresan el receptor her-2 o sus variantes truncadas. |
| BRPI0812682A2 (pt) | 2008-06-16 | 2010-06-22 | Genentech Inc | tratamento de cáncer de mama metastático |
| CN102170907A (zh) | 2008-08-05 | 2011-08-31 | 东丽株式会社 | 用于治疗和预防癌症的药物组合物 |
| BRPI0911925B8 (pt) | 2008-08-05 | 2024-02-06 | Toray Industries | Método para detectar um câncer |
| MX2011004467A (es) | 2008-10-31 | 2011-07-28 | Biogen Idec Inc | Moleculas de objetivo light y usos de las mismas. |
| CA2764386C (en) | 2008-12-01 | 2018-05-01 | Laboratory Corporation Of America Holdings | P95-her2 antibodies and uses thereof |
| US20120128732A1 (en) * | 2008-12-11 | 2012-05-24 | Vuong Trieu | Combinations and modes of administration of therapeutic agents and combination therapy |
| EP2387711B1 (en) | 2009-01-15 | 2015-04-22 | Laboratory Corporation of America Holdings | Methods of determining patient response by measurement of her-3 |
| CN102439452B (zh) * | 2009-01-15 | 2015-04-15 | 美国控股实验室公司 | 通过测量her-2表达确定患者应答的方法 |
| BR112012002064A2 (pt) * | 2009-07-31 | 2017-05-09 | Endocyte Inc | método para determinar se ec145 é indicado para o tratamento de um paciente com um tumor ovariano ou um tumor de pulmão; método para prever uma resposta de um tumor ovariano ou um tumor de pulmão de um paciente a terapia com ec145; método de tratamento de câncer ovariano resistente à platina em um paciente necessitando dele; uso de ec145 em combinação com doxorrubicina lipossômica peguilada; uso de ec145 para a fabricação de um medicamento; método para obter um benefício clínico comparado a tratamento com uma quantidade terapêutica de doxorrubicina lipossômica peguilada no tratamento de câncer ovariano resistente à platina em um paciente necessitando dele; método para selecionar um paciente para tratamento; composição farmacêutica; unidade de dosagem, método para determinar se um paciente com um tumor tem receptores de folato funcionalmente ativos presentes no tumor do paciente; método de tratamento de um tumor epitelial expressando receptor de folato em um paciente necessitando dele; e; método para obter um benefício clínico no tratamento de um tumor epitelial expressando receptor de folato em um paciente necessitando dele |
| US9345661B2 (en) | 2009-07-31 | 2016-05-24 | Genentech, Inc. | Subcutaneous anti-HER2 antibody formulations and uses thereof |
| PL2532743T3 (pl) | 2010-02-04 | 2015-09-30 | Toray Industries | Kompozycja farmaceutyczna do leczenia i/lub zapobiegania raka |
| ES2583777T3 (es) | 2010-02-04 | 2016-09-22 | Toray Industries, Inc. | Composición farmacéutica que comprende anticuerpos anti CAPRIN-1 para el tratamiento y/o la prevención del cáncer |
| JP5845899B2 (ja) | 2010-02-04 | 2016-01-20 | 東レ株式会社 | 癌の治療及び/又は予防用医薬組成物 |
| EP2532366B1 (en) | 2010-02-04 | 2016-09-07 | Toray Industries, Inc. | Pharmaceutical composition for treating and/or preventing cancer |
| MX2012008991A (es) | 2010-02-04 | 2012-09-07 | Toray Industries | Medicamento para tratar y/o prevenir el cancer. |
| JP5742714B2 (ja) | 2010-02-04 | 2015-07-01 | 東レ株式会社 | 癌の治療及び/又は予防用医薬組成物 |
| CN103476407A (zh) * | 2010-12-09 | 2013-12-25 | 霍夫曼-拉罗奇有限公司 | 用帕利他赛和曲妥珠单抗-mcc-dm1治疗her2阳性癌症 |
| BR112014002618B1 (pt) | 2011-08-04 | 2022-09-20 | Toray Industries, Inc | Anticorpo, composição farmacêutica, dna, uso de um anticorpo e uso de uma composição farmacêutica |
| RU2610428C2 (ru) | 2011-08-04 | 2017-02-10 | Торэй Индастриз, Инк. | Фармацевтическая композиция для лечения и/или профилактики злокачественной опухоли |
| ES2634249T3 (es) | 2011-08-04 | 2017-09-27 | Toray Industries, Inc. | Composición farmacéutica para el tratamiento y/o la profilaxis del cáncer |
| DK2740489T3 (en) | 2011-08-04 | 2017-01-16 | Toray Industries | Pharmaceutical composition for the treatment and / or prevention of pancreatic cancer |
| EP2741085B1 (en) | 2011-08-04 | 2017-04-05 | Toray Industries, Inc. | Method for detecting pancreatic cancer |
| WO2013018883A1 (ja) | 2011-08-04 | 2013-02-07 | 東レ株式会社 | 癌の治療及び/又は予防用医薬組成物 |
| TR201802089T4 (tr) | 2011-08-04 | 2018-03-21 | Toray Industries | Kanserin tedavisi ve/veya önlenmesi amacına yönelik ilaç bileşimi. |
| ES3023516T3 (en) | 2011-10-14 | 2025-06-02 | Hoffmann La Roche | Uses for and article of manufacture including her2 dimerization inhibitor pertuzumab |
| CN104114581B (zh) | 2012-02-21 | 2018-11-30 | 东丽株式会社 | 癌的治疗和/或预防用药物组合物 |
| IN2014KN01715A (es) | 2012-02-21 | 2015-10-23 | Toray Industries | |
| WO2013125636A1 (ja) | 2012-02-21 | 2013-08-29 | 東レ株式会社 | 癌の治療及び/又は予防用医薬組成物 |
| HUE045461T2 (hu) | 2012-02-21 | 2019-12-30 | Toray Industries | Gyógyászati készítmény rák kezelésére |
| ES2656620T3 (es) | 2012-03-30 | 2018-02-27 | Toray Industries, Inc. | Composición farmacéutica para el tratamiento y/o la prevención del cáncer de hígado |
| JP6107655B2 (ja) | 2012-03-30 | 2017-04-05 | 東レ株式会社 | 胆嚢癌の治療及び/又は予防用医薬組成物 |
| JP6244912B2 (ja) | 2012-07-19 | 2017-12-13 | 東レ株式会社 | 癌の検出方法 |
| HUE043162T2 (hu) | 2012-07-19 | 2019-08-28 | Toray Industries | Eljárás rák detektálására |
| US10195288B2 (en) | 2012-10-11 | 2019-02-05 | Daiichi Sankyo Company, Limited | Antibody-drug conjugate |
| WO2014169067A1 (en) * | 2013-04-09 | 2014-10-16 | Merrimack Pharmaceuticals, Inc. | Compositions for improving outcomes of liposomal chemotherapy |
| CA2907776C (en) | 2013-04-16 | 2020-04-14 | Genentech, Inc. | Pertuzumab variants and evaluation thereof |
| TR201819812T4 (tr) | 2013-08-09 | 2019-01-21 | Toray Industries | Kanserin Tedavisi Ve/Veya Önlenmesi Amacına Yönelik Farmasötik Bileşim |
| EP3973995A1 (en) * | 2014-01-31 | 2022-03-30 | Daiichi Sankyo Company, Limited | Anti-her2 antibody-drug conjugate |
| KR20160141857A (ko) | 2014-04-25 | 2016-12-09 | 제넨테크, 인크. | 트라스투주맙-mcc-dm1 및 퍼투주맙을 이용하는 초기 유방암의 치료방법 |
| US9808528B2 (en) | 2014-06-18 | 2017-11-07 | Mersana Therapeutics, Inc. | Protein-polymer-drug conjugates and methods of using same |
| TWI695011B (zh) | 2014-06-18 | 2020-06-01 | 美商梅爾莎納醫療公司 | 抗her2表位之單株抗體及其使用之方法 |
| HRP20241134T1 (hr) | 2015-05-30 | 2024-11-22 | F. Hoffmann-La Roche Ag | Metode liječenja her2-pozitivnog prethodno neliječenog metastatskog raka dojke |
| SI3319995T1 (sl) * | 2015-07-07 | 2019-07-31 | F. Hoffmann-La Roche Ag | Kombinirana terapija s konjugatom protitelo anti-HER-2 in zdravilo ter zaviralcem bcl-2 |
| US11554138B2 (en) | 2015-07-16 | 2023-01-17 | The University Of Hong Kong | Bismuth(III) complexes as adjuvants in the treatment of cancer using platinum-based chemotherapy |
| WO2017087280A1 (en) | 2015-11-16 | 2017-05-26 | Genentech, Inc. | Methods of treating her2-positive cancer |
| CA3032810A1 (en) * | 2016-08-02 | 2018-02-08 | Curirx Inc. | Methods for the preparation of liposomes |
| RU2758669C2 (ru) * | 2016-09-27 | 2021-11-01 | Вертекс Фармасьютикалз Инкорпорейтед | Способ лечения рака с применением сочетания днк-поражающих агентов и ингибиторов днк-пк |
| CA3046092A1 (en) | 2016-12-28 | 2018-07-05 | Genentech, Inc. | Treatment of advanced her2 expressing cancer |
| CN117752782A (zh) | 2017-01-17 | 2024-03-26 | 豪夫迈·罗氏有限公司 | 皮下her2抗体配制剂 |
| FI3582806T3 (fi) | 2017-02-20 | 2023-09-07 | Dragonfly Therapeutics Inc | Her2:ta, nkg2d:tä ja cd16:ta sitovia proteiineja |
| KR20190096384A (ko) | 2017-03-02 | 2019-08-19 | 제넨테크, 인크. | Her2-양성 유방암 어쥬번트 치료 |
| EP3615695A1 (en) | 2017-04-24 | 2020-03-04 | Genentech, Inc. | Erbb2/her2 mutations in the transmebrane or juxtamembrane domain |
| JP7122757B2 (ja) | 2017-07-06 | 2022-08-22 | 学校法人京都薬科大学 | 腎ターゲティング型薬物送達用担体 |
| US11884733B2 (en) | 2018-02-08 | 2024-01-30 | Dragonfly Therapeutics, Inc. | Antibody variable domains targeting the NKG2D receptor |
| EA202091888A1 (ru) | 2018-08-08 | 2020-10-23 | Драгонфлай Терапьютикс, Инк. | Вариабельные домены антител, нацеленные на рецептор nkg2d |
| CN109739435B (zh) * | 2018-12-03 | 2023-10-13 | 中科恒运股份有限公司 | 文件存储和更新方法及装置 |
| IL299376A (en) | 2020-06-29 | 2023-02-01 | Genentech Inc | Fixed dose combination of pertuzumab plus transtuzumab |
| IL303350A (en) | 2020-12-04 | 2023-08-01 | Macrogenics Inc | Pharmaceutical compositions of a her2/neu antibody and use of the same |
| WO2022187539A1 (en) | 2021-03-03 | 2022-09-09 | Dragonfly Therapeutics, Inc. | Methods of treating cancer using multi-specific binding proteins that bind nkg2d, cd16 and a tumor-associated antigen |
| US20240238440A1 (en) | 2021-04-29 | 2024-07-18 | Hyslink Therapeutics | Preparation method for and application of antibody conjugated drug |
| TW202313125A (zh) | 2021-06-17 | 2023-04-01 | 大陸商明慧醫藥(杭州)有限公司 | 一種抗腫瘤化合物及其應用 |
| WO2023139293A1 (en) | 2022-01-24 | 2023-07-27 | Novimmune Sa | Composition and methods for the selective activation of cytokine signaling pathways |
| JP2025509702A (ja) | 2022-03-14 | 2025-04-11 | ラムキャップ バイオ ガンマ エージー | GPC3陽性悪性細胞を標的殺傷するための二重特異性GPC3xCD28抗体およびGPC3xCD3抗体ならびにそれらの組み合わせ |
| WO2024230772A1 (zh) * | 2023-05-09 | 2024-11-14 | 江苏康宁杰瑞生物制药有限公司 | 包含抗her2双特异性抗体的联合治疗药物及其用途 |
| WO2025019254A1 (en) | 2023-07-14 | 2025-01-23 | Guardant Health, Inc. | Classification of breast tumors using dna methylation from liquid biopsy |
Family Cites Families (92)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4935341A (en) | 1986-06-04 | 1990-06-19 | Whitehead Institute For Biomedical Research | Detection of point mutations in neu genes |
| US7838216B1 (en) | 1986-03-05 | 2010-11-23 | The United States Of America, As Represented By The Department Of Health And Human Services | Human gene related to but distinct from EGF receptor gene |
| US5401638A (en) | 1986-06-04 | 1995-03-28 | Oncogene Science, Inc. | Detection and quantification of neu related proteins in the biological fluids of humans |
| US4968603A (en) | 1986-12-31 | 1990-11-06 | The Regents Of The University Of California | Determination of status in neoplastic disease |
| US5824311A (en) | 1987-11-30 | 1998-10-20 | Trustees Of The University Of Pennsylvania | Treatment of tumors with monoclonal antibodies against oncogene antigens |
| US5720937A (en) | 1988-01-12 | 1998-02-24 | Genentech, Inc. | In vivo tumor detection assay |
| WO1989006692A1 (en) | 1988-01-12 | 1989-07-27 | Genentech, Inc. | Method of treating tumor cells by inhibiting growth factor receptor function |
| EP0474727B1 (en) | 1989-05-19 | 1997-07-23 | Genentech, Inc. | Her2 extracellular domain |
| US5705157A (en) | 1989-07-27 | 1998-01-06 | The Trustees Of The University Of Pennsylvania | Methods of treating cancerous cells with anti-receptor antibodies |
| CA2042064C (en) | 1989-08-04 | 2008-10-21 | Susan G. Stuart | C-erbb-2 external domain:gp75 |
| US6884418B1 (en) | 1989-08-04 | 2005-04-26 | Berlex Laboratories, Inc. | Use of ligand-mimicking agents and anti-neoplastic drugs in cancer therapy |
| US5183884A (en) | 1989-12-01 | 1993-02-02 | United States Of America | Dna segment encoding a gene for a receptor related to the epidermal growth factor receptor |
| US5571894A (en) | 1991-02-05 | 1996-11-05 | Ciba-Geigy Corporation | Recombinant antibodies specific for a growth factor receptor |
| IL101943A0 (en) | 1991-05-24 | 1992-12-30 | Genentech Inc | Structure,production and use of heregulin |
| DE69233254T2 (de) | 1991-06-14 | 2004-09-16 | Genentech, Inc., South San Francisco | Humanisierter Heregulin Antikörper |
| US6800738B1 (en) | 1991-06-14 | 2004-10-05 | Genentech, Inc. | Method for making humanized antibodies |
| WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| US5939531A (en) | 1991-07-15 | 1999-08-17 | Novartis Corp. | Recombinant antibodies specific for a growth factor receptor |
| EP0656367A1 (en) | 1991-08-22 | 1995-06-07 | Becton, Dickinson and Company | Method and composition for cancer therapy and for prognosticating responses to cancer theraphy |
| JP3951062B2 (ja) | 1991-09-19 | 2007-08-01 | ジェネンテック・インコーポレーテッド | 少なくとも遊離のチオールとして存在するシステインを有する抗体フラグメントの大腸菌での発現、2官能性F(ab’)2抗体の産生のための使用 |
| US5288477A (en) | 1991-09-27 | 1994-02-22 | Becton, Dickinson And Company | Method for prognosticating response to cancer therapy |
| FI941572A7 (fi) * | 1991-10-07 | 1994-05-27 | Oncologix Inc | Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenete lmä |
| DE69334351D1 (de) | 1992-02-06 | 2011-05-12 | Novartis Vaccines & Diagnostic | Biosynthetisches Bindeprotein für Tumormarker |
| WO1994009022A1 (en) | 1992-10-09 | 1994-04-28 | Oncor, Inc. | Methods for the detection of chromosome structural abnormalities by in situ hybridization to fixed tissue |
| US6733752B1 (en) * | 1994-03-30 | 2004-05-11 | The Trustees Of The University Of Pennsylvania | Prevention of tumors with monoclonal antibodies against neu |
| US6811779B2 (en) | 1994-02-10 | 2004-11-02 | Imclone Systems Incorporated | Methods for reducing tumor growth with VEGF receptor antibody combined with radiation and chemotherapy |
| US20030108545A1 (en) | 1994-02-10 | 2003-06-12 | Patricia Rockwell | Combination methods of inhibiting tumor growth with a vascular endothelial growth factor receptor antagonist |
| US5910486A (en) | 1994-09-06 | 1999-06-08 | Uab Research Foundation | Methods for modulating protein function in cells using, intracellular antibody homologues |
| US5804396A (en) | 1994-10-12 | 1998-09-08 | Sugen, Inc. | Assay for agents active in proliferative disorders |
| US5846749A (en) | 1994-10-12 | 1998-12-08 | The Regents Of The University Of California | Quantitative measurement of tissue protein identified by immunohistochemistry and standardized protein determination |
| US6214388B1 (en) | 1994-11-09 | 2001-04-10 | The Regents Of The University Of California | Immunoliposomes that optimize internalization into target cells |
| US5783404A (en) | 1995-04-13 | 1998-07-21 | Amgen Inc. | Methods and compositions for determining HER-2/neu expression using monoclonal antibodies |
| US6410690B1 (en) | 1995-06-07 | 2002-06-25 | Medarex, Inc. | Therapeutic compounds comprised of anti-Fc receptor antibodies |
| EP0873363B1 (en) | 1995-06-14 | 2010-10-06 | The Regents of The University of California | High affinity human antibodies to tumor antigens |
| US6267958B1 (en) | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
| US6685940B2 (en) | 1995-07-27 | 2004-02-03 | Genentech, Inc. | Protein formulation |
| US5783186A (en) | 1995-12-05 | 1998-07-21 | Amgen Inc. | Antibody-induced apoptosis |
| US5925519A (en) | 1996-06-03 | 1999-07-20 | The Regents Of The University Of California | Genetic alterations associated with prostate cancer |
| US5922845A (en) | 1996-07-11 | 1999-07-13 | Medarex, Inc. | Therapeutic multispecific compounds comprised of anti-Fcα receptor antibodies |
| ES2293661T3 (es) | 1996-11-27 | 2008-03-16 | Genentech, Inc. | Purificacion por afinidad de polipeptido en una matriz de proteinas a. |
| US20020076695A1 (en) | 1997-04-04 | 2002-06-20 | Jeffrey S. Ross | Methods for treating prostate cancer |
| US5994071A (en) | 1997-04-04 | 1999-11-30 | Albany Medical College | Assessment of prostate cancer |
| ZA9811162B (en) | 1997-12-12 | 2000-06-07 | Genentech Inc | Treatment with anti-ERBB2 antibodies. |
| US6358682B1 (en) | 1998-01-26 | 2002-03-19 | Ventana Medical Systems, Inc. | Method and kit for the prognostication of breast cancer |
| US20020192211A1 (en) | 1998-03-17 | 2002-12-19 | Hudziak Robert M. | Method of treating tumor cells by inhibiting growth factor receptor function |
| DE69938923D1 (de) | 1998-03-27 | 2008-07-31 | Genentech Inc | Synergie zwischen apo-2 ligand und antikörper gegen her-2 |
| KR101036414B1 (ko) | 1998-05-06 | 2011-05-23 | 제넨테크, 인크. | 이온 교환 크로마토그래피에 의한 단백질 정제 방법 |
| SE512710C2 (sv) | 1998-07-08 | 2000-05-02 | Ericsson Telefon Ab L M | Kapsel för högeffekttransistorchip för höga frekvenser innefattande en elektriskt och termiskt ledande fläns |
| US6573043B1 (en) | 1998-10-07 | 2003-06-03 | Genentech, Inc. | Tissue analysis and kits therefor |
| DE60041808D1 (de) | 1999-01-27 | 2009-04-30 | Cornell Res Foundation Inc | Behandlung von mit her-2/neu-überexprimierung einhergehendem krebs |
| US6333348B1 (en) | 1999-04-09 | 2001-12-25 | Aventis Pharma S.A. | Use of docetaxel for treating cancers |
| WO2000069460A1 (en) * | 1999-05-14 | 2000-11-23 | Genentech, Inc. | TREATMENT WITH ANTI-ErbB2 ANTIBODIES |
| JP3485252B2 (ja) | 1999-06-16 | 2004-01-13 | インターナショナル・ビジネス・マシーンズ・コーポレーション | 情報処理方法、情報端末支援サーバ、コラボレーション・システム、情報処理プログラムを格納する記憶媒体 |
| US20040013667A1 (en) | 1999-06-25 | 2004-01-22 | Genentech, Inc. | Treatment with anti-ErbB2 antibodies |
| ES2662581T3 (es) * | 1999-06-25 | 2018-04-09 | Immunogen, Inc. | Métodos de tratamiento usando conjugados de anticuerpo anti-ErbB-maitansinoide |
| US6949245B1 (en) * | 1999-06-25 | 2005-09-27 | Genentech, Inc. | Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies |
| US20030086924A1 (en) | 1999-06-25 | 2003-05-08 | Genentech, Inc. | Treatment with anti-ErbB2 antibodies |
| KR20090126330A (ko) * | 1999-08-27 | 2009-12-08 | 제넨테크, 인크. | 항-ErbB2 항체 투여 치료 방법 |
| WO2001024763A2 (en) | 1999-10-01 | 2001-04-12 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
| US7303749B1 (en) | 1999-10-01 | 2007-12-04 | Immunogen Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
| AU2001254672A1 (en) | 2000-02-29 | 2001-09-12 | Janssen Pharmaceutica N.V. | Farnesyl protein transferase inhibitor combinations with an her2 antibody |
| US7097840B2 (en) * | 2000-03-16 | 2006-08-29 | Genentech, Inc. | Methods of treatment using anti-ErbB antibody-maytansinoid conjugates |
| US6632979B2 (en) | 2000-03-16 | 2003-10-14 | Genentech, Inc. | Rodent HER2 tumor model |
| US6767541B2 (en) | 2000-03-20 | 2004-07-27 | The Regents Of The University Of California | HER-2/neu overexpression abrogates growth inhibitory pathways |
| GB0008368D0 (en) | 2000-04-06 | 2000-05-24 | Astrazeneca Ab | Combination product |
| US20030152572A1 (en) | 2000-04-06 | 2003-08-14 | Yoshimi Homma | Diagnostic and therapeutic agents for rheumatoid arthritis |
| US7306801B2 (en) | 2000-05-15 | 2007-12-11 | Health Research, Inc. | Methods of therapy for cancers characterized by overexpression of the HER2 receptor protein |
| KR20080038458A (ko) | 2000-05-19 | 2008-05-06 | 제넨테크, 인크. | ErbB 길항제에 의한 암 치료요법에 대한 효과적인반응의 가능성을 개선시키기 위한 유전자 검출 분석 |
| TWI317285B (en) | 2000-07-28 | 2009-11-21 | Dainippon Sumitomo Pharma Co | New use and kit for remedies for cancer |
| US6984494B2 (en) | 2000-08-15 | 2006-01-10 | Genentech, Inc. | Analytical method |
| US6602670B2 (en) | 2000-12-01 | 2003-08-05 | Response Genetics, Inc. | Method of determining a chemotherapeutic regimen based on ERCC1 expression |
| US7005278B2 (en) | 2001-03-02 | 2006-02-28 | Danenberg Kathleen D | Method of determining dihydropyrimidine dehydrogenase gene expression |
| JP2004536561A (ja) | 2000-12-01 | 2004-12-09 | レスポンス ジェネティクス,インコーポレイティド | 上皮増殖因子受容体及びHER2−neu遺伝子発現並びにそれらのレベルと生存との相関関係を決定する方法 |
| US6582919B2 (en) | 2001-06-11 | 2003-06-24 | Response Genetics, Inc. | Method of determining epidermal growth factor receptor and HER2-neu gene expression and correlation of levels thereof with survival rates |
| US20020142328A1 (en) | 2000-12-01 | 2002-10-03 | Danenberg Kathleen D. | Method of determining a chemotherapeutic regimen by assaying gene expression in primary tumors |
| AU2002239486A1 (en) | 2000-12-08 | 2002-06-18 | Uab Research Foundation | Combination radiation therapy and chemotherapy in conjuction with administration of growth factor receptor antibody |
| WO2002087619A1 (en) | 2001-04-27 | 2002-11-07 | Takeda Chemical Industries, Ltd. | Preventive/therapeutic method for cancer |
| US20030068318A1 (en) | 2001-09-28 | 2003-04-10 | O'brien Timothy | Treatment of uterine serous papillary cancer |
| US20030175845A1 (en) | 2002-03-13 | 2003-09-18 | Kalbag Suresh M. | Use of sulfitolysis in high performance peptide mapping |
| US20030190689A1 (en) | 2002-04-05 | 2003-10-09 | Cell Signaling Technology,Inc. | Molecular profiling of disease and therapeutic response using phospho-specific antibodies |
| JP2005522514A (ja) | 2002-04-10 | 2005-07-28 | ジェネンテック・インコーポレーテッド | 抗her2抗体改変体 |
| ITTO20020340A1 (it) | 2002-04-19 | 2003-10-20 | Biother Di Contardi Gabriella | Localizzazione del recettore her2 mediante anticorpo umanizzato biotinilato. |
| US20030202973A1 (en) | 2002-04-29 | 2003-10-30 | Dr. George Pieczenik | Treatment of refractory human tumors with epidermal growth factor receptor and HER1 mitogenic ligand (EGFRML) antagonists |
| JP4773719B2 (ja) | 2002-05-17 | 2011-09-14 | アベンティス・ファーマ・ソシエテ・アノニム | 乳癌および卵巣癌のアジュバント療法におけるドセタキセル/ドキソルビシン/シクロホスファミドの使用 |
| HUP0600340A3 (en) | 2002-07-15 | 2011-06-28 | Genentech Inc | Methods for identifying tumors that are responsive to treatment with anti-erbb2 antibodies |
| US20040013297A1 (en) | 2002-07-18 | 2004-01-22 | Roger Lo | Method for performing color gamut compression |
| WO2004024866A2 (en) | 2002-09-11 | 2004-03-25 | Genentech, Inc. | Protein purification |
| EP1572972A4 (en) | 2002-11-21 | 2007-11-21 | Genentech Inc | THERAPY OF NON-MALIGNER DISEASES OR DISORDER WITH ANTI-ERBB2 ANTIBODIES |
| US20040231909A1 (en) | 2003-01-15 | 2004-11-25 | Tai-Yang Luh | Motorized vehicle having forward and backward differential structure |
| CA2930485C (en) * | 2003-05-14 | 2018-04-10 | Immunogen, Inc. | Maytansinoid-antibody conjugate compositions |
| US8088387B2 (en) | 2003-10-10 | 2012-01-03 | Immunogen Inc. | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
| BRPI0510883B8 (pt) | 2004-06-01 | 2021-05-25 | Genentech Inc | composto conjugado de droga e anticorpo, composição farmacêutica, método de fabricação de composto conjugado de droga e anticorpo e usos de uma formulação, de um conjugado de droga e anticorpo e um agente quimioterapêutico e de uma combinação |
-
2005
- 2005-10-25 JP JP2005310518A patent/JP2006316040A/ja active Pending
-
2006
- 2006-03-21 CA CA2790058A patent/CA2790058C/en active Active
- 2006-03-21 CA CA2540547A patent/CA2540547C/en active Active
- 2006-04-06 US US11/400,638 patent/US8591897B2/en active Active
- 2006-04-21 AR AR20060101586A patent/AR054254A1/es unknown
- 2006-04-21 MX MX2013009514A patent/MX344809B/es unknown
- 2006-04-21 MX MX2018000183A patent/MX383973B/es unknown
- 2006-04-25 BR BRPI0601736-3A patent/BRPI0601736A/pt not_active Application Discontinuation
-
2011
- 2011-08-08 US US13/205,523 patent/US8597654B2/en active Active
-
2012
- 2012-10-03 AR ARP120103682A patent/AR088110A2/es unknown
-
2013
- 2013-04-25 JP JP2013092728A patent/JP6133668B2/ja not_active Expired - Lifetime
- 2013-05-24 JP JP2013109685A patent/JP2013163694A/ja active Pending
- 2013-10-25 US US14/063,885 patent/US20140086940A1/en not_active Abandoned
-
2015
- 2015-07-14 JP JP2015140158A patent/JP2015187168A/ja not_active Withdrawn
-
2017
- 2017-02-09 US US15/428,807 patent/US20180236093A1/en not_active Abandoned
- 2017-04-27 JP JP2017088352A patent/JP2017132806A/ja active Pending
- 2017-04-27 JP JP2017088351A patent/JP2017132805A/ja not_active Withdrawn
- 2017-05-15 AR ARP170101287A patent/AR109246A2/es unknown
- 2017-05-17 AR ARP170101322A patent/AR108615A2/es unknown
-
2018
- 2018-10-25 JP JP2018200936A patent/JP2019011374A/ja active Pending
-
2020
- 2020-01-30 US US16/777,345 patent/US20200155701A1/en not_active Abandoned
- 2020-03-11 JP JP2020041610A patent/JP2020094061A/ja not_active Withdrawn
-
2022
- 2022-05-02 JP JP2022075920A patent/JP2022093642A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2006316040A (ja) | 2006-11-24 |
| US20180236093A1 (en) | 2018-08-23 |
| CA2540547C (en) | 2016-08-16 |
| JP2019011374A (ja) | 2019-01-24 |
| JP2017132805A (ja) | 2017-08-03 |
| JP2015187168A (ja) | 2015-10-29 |
| CA2540547A1 (en) | 2006-11-13 |
| US8591897B2 (en) | 2013-11-26 |
| US20200155701A1 (en) | 2020-05-21 |
| AR109246A2 (es) | 2018-11-14 |
| US20140086940A1 (en) | 2014-03-27 |
| AR054254A1 (es) | 2007-06-13 |
| BRPI0601736A (pt) | 2007-05-15 |
| JP2022093642A (ja) | 2022-06-23 |
| JP6133668B2 (ja) | 2017-05-24 |
| MX383973B (es) | 2025-03-14 |
| JP2013144718A (ja) | 2013-07-25 |
| JP2017132806A (ja) | 2017-08-03 |
| US20060275305A1 (en) | 2006-12-07 |
| CA2790058A1 (en) | 2006-11-13 |
| AR088110A2 (es) | 2014-05-07 |
| CA2790058C (en) | 2019-01-15 |
| AR108615A2 (es) | 2018-09-12 |
| US20120003217A1 (en) | 2012-01-05 |
| US8597654B2 (en) | 2013-12-03 |
| JP2013163694A (ja) | 2013-08-22 |
| JP2020094061A (ja) | 2020-06-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX383973B (es) | Uso de un inmunoconjugado que comprende un anticuerpo anti-erbb2 que se une a her2 dominio iv unido por trastuzumab conjugado a un maitansinoide. | |
| IL179401A0 (en) | Therapy of platinum-resistant cancer | |
| IL258880A (en) | Diarylhydantoin compounds | |
| IL182423A0 (en) | Disubstituted pyrazolobenzodiazepines useful as inhibitors for cdk2 and angiogesis, and for the treatment of breast, colon, lung and prostate cancer | |
| SG160412A1 (en) | Anti-igfr1 antibody therapeutic combinations | |
| WO2007016548A3 (en) | Micro-rna-based methods and compositions for the diagnosis, prognosis and treatment of breast cancer | |
| NZ579478A (en) | Epha3 antibodies for the treatment of solid tumors | |
| WO2004110245A3 (en) | Combination therapy for cancer treatment | |
| IL189377A0 (en) | Combinations comprising dmxaa for the treatment of cancer | |
| IL189376A0 (en) | Combinations comprising dmxaa for the treatment of cancer | |
| MX2007005988A (es) | Procedimiento sintetico para compuestos de eter aminociclohexilico. | |
| IL187792A0 (en) | 4-anilino-3-quinolinecarbonitriles for the treatment of cancer | |
| EP1615897A4 (en) | PYRIMIDINONE COMPOUNDS AS CALCILYTICA | |
| ZA200805522B (en) | Dioxoiane dérivates for the treatment of cancer | |
| WO2003079977A3 (en) | Novel compositions and methods in cancer associated with altered expression of mcm3ap | |
| HK1115317A (zh) | 含二甲氧杂蒽醋酸的治癌用化合物 | |
| HK1115546A (en) | Combinations comprising dmxaa for the treatment of cancer | |
| GB0517386D0 (en) | Combinations for the treatment of cancer | |
| HK1113749A (en) | 4-anilino-3-quinolinecarbonitriles for the treatment of cancer | |
| HK1109394A (en) | Pyrazolylamino substituted quinazoles for the treatment of cancer | |
| UA101379C2 (en) | Amidophenoxyindazoles useful in the treatment of cancer | |
| HK1098075A (en) | Improved adjuvant therapy of g250-expressing tumors |