AR086201A1 - Hongos filamentosos que tienen un fenotipo de viscosidad alterado - Google Patents
Hongos filamentosos que tienen un fenotipo de viscosidad alteradoInfo
- Publication number
- AR086201A1 AR086201A1 ARP120101367A ARP120101367A AR086201A1 AR 086201 A1 AR086201 A1 AR 086201A1 AR P120101367 A ARP120101367 A AR P120101367A AR P120101367 A ARP120101367 A AR P120101367A AR 086201 A1 AR086201 A1 AR 086201A1
- Authority
- AR
- Argentina
- Prior art keywords
- cells
- strain
- altered
- variant
- filamentous
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/36—Adaptation or attenuation of cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/07—Nucleotidyltransferases (2.7.7)
- C12Y207/07013—Mannose-1-phosphate guanylyltransferase (2.7.7.13)
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Cell Biology (AREA)
- Botany (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Se describen composiciones y métodos relacionados con hongos filamentosos variantes que tienen características de crecimiento alteradas. Dichas variantes son bien adecuadas para el crecimiento en cultivos sumergidos, por ej., para la producción a gran escala de enzimas y otras proteínas para aplicaciones comerciales.Reivindicación 1: Una cepa variante de hongo filamentoso derivada de una cepa parental, comprendiendo la cepa variante una alteración genética que hace que las células de la cepa variante produzcan una cantidad alterada de proteína Mpg1 funcional en comparación con células de la cepa parental, donde las células de la cepa variante producen durante la fermentación aeróbica en cultivo sumergido un caldo celular que (i) requiere una cantidad alterada de agitación para mantener un contenido preseleccionado de oxígeno disuelto en comparación con las células de la cepa parental, y/o (ii) mantiene un contenido de oxígeno disuelto alterado en una cantidad preseleccionada de agitación, en comparación con las células de la cepa parental.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161478162P | 2011-04-22 | 2011-04-22 | |
| US201161478160P | 2011-04-22 | 2011-04-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR086201A1 true AR086201A1 (es) | 2013-11-27 |
Family
ID=46018123
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120101367A AR086201A1 (es) | 2011-04-22 | 2012-04-20 | Hongos filamentosos que tienen un fenotipo de viscosidad alterado |
| ARP120101366A AR086200A1 (es) | 2011-04-22 | 2012-04-20 | Hongos filamentosos que tienen un fenotipo de viscosidad alterado |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120101366A AR086200A1 (es) | 2011-04-22 | 2012-04-20 | Hongos filamentosos que tienen un fenotipo de viscosidad alterado |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US9725726B2 (es) |
| EP (3) | EP3000870B1 (es) |
| JP (2) | JP6042866B2 (es) |
| KR (2) | KR101993939B1 (es) |
| CN (2) | CN103517916B (es) |
| AR (2) | AR086201A1 (es) |
| AU (3) | AU2012245402B2 (es) |
| BR (2) | BR112013025430A2 (es) |
| CA (2) | CA2833541C (es) |
| DK (3) | DK2699588T3 (es) |
| WO (2) | WO2012145595A1 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9587242B2 (en) * | 2011-04-22 | 2017-03-07 | Danisco Us Inc. | Filamentous fungi having an altered viscosity phenotype |
| BR112013025430A2 (pt) * | 2011-04-22 | 2016-11-29 | Danisco Us Inc | "cepas variantes de fundos filamentosos tendo modificação genética para maior produção de proteína mpg1 e crescimento alterado e seu método de produção". |
| US20180215797A1 (en) * | 2015-08-13 | 2018-08-02 | Glykos Finland Oy | Regulatory Protein Deficient Trichoderma Cells and Methods of Use Thereof |
| WO2019209576A1 (en) | 2018-04-24 | 2019-10-31 | Danisco Us Inc | Filamentous fungal strains comprising reduced viscosity phenotypes |
| CN112654704A (zh) * | 2018-07-30 | 2021-04-13 | 丹尼斯科美国公司 | 包含蛋白质生产率提高表型的突变和遗传修饰的丝状真菌菌株及其方法 |
| WO2020027010A1 (ja) | 2018-07-30 | 2020-02-06 | 東レ株式会社 | トリコデルマ属糸状菌の変異株およびタンパク質の製造方法 |
| KR20220097451A (ko) | 2019-11-08 | 2022-07-07 | 다니스코 유에스 인크. | 향상된 단백질 생산성 표현형을 포함하는 진균 균주 및 이의 방법 |
| FR3104169B1 (fr) * | 2019-12-04 | 2022-10-21 | Ifp Energies Now | Souche de champignon ayant une viscosite diminuee |
| CN113881586B (zh) * | 2021-09-27 | 2023-03-10 | 四川大学 | 耐高温、耐高糖、耐高盐酿酒酵母菌株及构建方法和应用 |
| CN118109437B (zh) * | 2024-04-29 | 2024-07-09 | 北京中医药大学深圳医院(龙岗) | 一种来自菌类中药的gdp-甘露糖焦磷酸化酶及其编码基因和应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI972909A0 (fi) | 1997-07-09 | 1997-07-09 | Valtion Teknillinen | Oekad produktion av avsoendrade proteiner genom rekombinatjaestceller |
| US7189538B2 (en) * | 1999-03-24 | 2007-03-13 | Genencor International, Inc. | Hyphal growth in fungi |
| MXPA02001061A (es) | 1999-07-30 | 2003-04-10 | Hoffmann La Roche | Medios novedoso para transformar hongos y su uso para producir proteina heterologa. |
| NZ521990A (en) | 2000-04-13 | 2004-11-26 | Emalfarb Mark Aaron | Novel expression-regulating sequences and expression products in the field of filamentous fungi |
| US6936449B2 (en) * | 2001-03-14 | 2005-08-30 | Genencor International, Inc. | Regulatable growth of filamentous fungi |
| JP2005501526A (ja) * | 2001-05-25 | 2005-01-20 | インサイト・ゲノミックス・インコーポレイテッド | 糖質結合タンパク質 |
| US6902921B2 (en) | 2001-10-30 | 2005-06-07 | 454 Corporation | Sulfurylase-luciferase fusion proteins and thermostable sulfurylase |
| WO2005001036A2 (en) | 2003-05-29 | 2005-01-06 | Genencor International, Inc. | Novel trichoderma genes |
| US9180998B2 (en) | 2007-09-11 | 2015-11-10 | Cold Chain Technologies, Inc. | Insulated pallet shipper and methods of making and using the same |
| CA2717799A1 (en) * | 2008-03-07 | 2009-09-17 | Timothy C. Dodge | Expression of catalase in trichoderma |
| KR102004003B1 (ko) * | 2010-08-25 | 2019-07-25 | 다니스코 유에스 인크. | 변경된 점성 표현형을 갖는 사상균 |
| US9587242B2 (en) * | 2011-04-22 | 2017-03-07 | Danisco Us Inc. | Filamentous fungi having an altered viscosity phenotype |
| BR112013025430A2 (pt) * | 2011-04-22 | 2016-11-29 | Danisco Us Inc | "cepas variantes de fundos filamentosos tendo modificação genética para maior produção de proteína mpg1 e crescimento alterado e seu método de produção". |
-
2012
- 2012-04-20 BR BR112013025430A patent/BR112013025430A2/pt not_active Application Discontinuation
- 2012-04-20 AU AU2012245402A patent/AU2012245402B2/en active Active
- 2012-04-20 KR KR1020137030514A patent/KR101993939B1/ko active IP Right Grant
- 2012-04-20 AR ARP120101367A patent/AR086201A1/es unknown
- 2012-04-20 EP EP15189224.7A patent/EP3000870B1/en active Active
- 2012-04-20 EP EP12717559.4A patent/EP2663633B1/en active Active
- 2012-04-20 DK DK12718831.6T patent/DK2699588T3/en active
- 2012-04-20 BR BR112013025203A patent/BR112013025203A2/pt not_active Application Discontinuation
- 2012-04-20 US US14/111,615 patent/US9725726B2/en active Active
- 2012-04-20 EP EP12718831.6A patent/EP2699588B1/en active Active
- 2012-04-20 JP JP2014506563A patent/JP6042866B2/ja active Active
- 2012-04-20 DK DK15189224.7T patent/DK3000870T3/en active
- 2012-04-20 CA CA2833541A patent/CA2833541C/en active Active
- 2012-04-20 WO PCT/US2012/034403 patent/WO2012145595A1/en active Application Filing
- 2012-04-20 AR ARP120101366A patent/AR086200A1/es unknown
- 2012-04-20 AU AU2012245322A patent/AU2012245322A1/en not_active Abandoned
- 2012-04-20 CN CN201280019757.4A patent/CN103517916B/zh active Active
- 2012-04-20 DK DK12717559.4T patent/DK2663633T3/en active
- 2012-04-20 CA CA2833660A patent/CA2833660C/en active Active
- 2012-04-20 WO PCT/US2012/034379 patent/WO2012145584A1/en active Application Filing
- 2012-04-20 US US14/112,879 patent/US9725727B2/en active Active
- 2012-04-20 JP JP2014506565A patent/JP6042868B2/ja active Active
- 2012-04-20 CN CN201280019678.3A patent/CN103502431B/zh active Active
- 2012-04-20 KR KR1020137030769A patent/KR101952470B1/ko active IP Right Grant
-
2017
- 2017-04-26 AU AU2017202753A patent/AU2017202753A1/en not_active Abandoned
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| FB | Suspension of granting procedure |