AR086201A1 - Hongos filamentosos que tienen un fenotipo de viscosidad alterado - Google Patents

Hongos filamentosos que tienen un fenotipo de viscosidad alterado

Info

Publication number
AR086201A1
AR086201A1 ARP120101367A ARP120101367A AR086201A1 AR 086201 A1 AR086201 A1 AR 086201A1 AR P120101367 A ARP120101367 A AR P120101367A AR P120101367 A ARP120101367 A AR P120101367A AR 086201 A1 AR086201 A1 AR 086201A1
Authority
AR
Argentina
Prior art keywords
cells
strain
altered
variant
filamentous
Prior art date
Application number
ARP120101367A
Other languages
English (en)
Original Assignee
Danisco Us Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Danisco Us Inc filed Critical Danisco Us Inc
Publication of AR086201A1 publication Critical patent/AR086201A1/es

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/36Adaptation or attenuation of cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14Fungi; Culture media therefor
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/12Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241Nucleotidyltransferases (2.7.7)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y207/00Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/07Nucleotidyltransferases (2.7.7)
    • C12Y207/07013Mannose-1-phosphate guanylyltransferase (2.7.7.13)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Botany (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Se describen composiciones y métodos relacionados con hongos filamentosos variantes que tienen características de crecimiento alteradas. Dichas variantes son bien adecuadas para el crecimiento en cultivos sumergidos, por ej., para la producción a gran escala de enzimas y otras proteínas para aplicaciones comerciales.Reivindicación 1: Una cepa variante de hongo filamentoso derivada de una cepa parental, comprendiendo la cepa variante una alteración genética que hace que las células de la cepa variante produzcan una cantidad alterada de proteína Mpg1 funcional en comparación con células de la cepa parental, donde las células de la cepa variante producen durante la fermentación aeróbica en cultivo sumergido un caldo celular que (i) requiere una cantidad alterada de agitación para mantener un contenido preseleccionado de oxígeno disuelto en comparación con las células de la cepa parental, y/o (ii) mantiene un contenido de oxígeno disuelto alterado en una cantidad preseleccionada de agitación, en comparación con las células de la cepa parental.
ARP120101367A 2011-04-22 2012-04-20 Hongos filamentosos que tienen un fenotipo de viscosidad alterado AR086201A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161478162P 2011-04-22 2011-04-22
US201161478160P 2011-04-22 2011-04-22

Publications (1)

Publication Number Publication Date
AR086201A1 true AR086201A1 (es) 2013-11-27

Family

ID=46018123

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP120101367A AR086201A1 (es) 2011-04-22 2012-04-20 Hongos filamentosos que tienen un fenotipo de viscosidad alterado
ARP120101366A AR086200A1 (es) 2011-04-22 2012-04-20 Hongos filamentosos que tienen un fenotipo de viscosidad alterado

Family Applications After (1)

Application Number Title Priority Date Filing Date
ARP120101366A AR086200A1 (es) 2011-04-22 2012-04-20 Hongos filamentosos que tienen un fenotipo de viscosidad alterado

Country Status (11)

Country Link
US (2) US9725726B2 (es)
EP (3) EP3000870B1 (es)
JP (2) JP6042866B2 (es)
KR (2) KR101993939B1 (es)
CN (2) CN103517916B (es)
AR (2) AR086201A1 (es)
AU (3) AU2012245402B2 (es)
BR (2) BR112013025430A2 (es)
CA (2) CA2833541C (es)
DK (3) DK2699588T3 (es)
WO (2) WO2012145595A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9587242B2 (en) * 2011-04-22 2017-03-07 Danisco Us Inc. Filamentous fungi having an altered viscosity phenotype
BR112013025430A2 (pt) * 2011-04-22 2016-11-29 Danisco Us Inc "cepas variantes de fundos filamentosos tendo modificação genética para maior produção de proteína mpg1 e crescimento alterado e seu método de produção".
US20180215797A1 (en) * 2015-08-13 2018-08-02 Glykos Finland Oy Regulatory Protein Deficient Trichoderma Cells and Methods of Use Thereof
WO2019209576A1 (en) 2018-04-24 2019-10-31 Danisco Us Inc Filamentous fungal strains comprising reduced viscosity phenotypes
CN112654704A (zh) * 2018-07-30 2021-04-13 丹尼斯科美国公司 包含蛋白质生产率提高表型的突变和遗传修饰的丝状真菌菌株及其方法
WO2020027010A1 (ja) 2018-07-30 2020-02-06 東レ株式会社 トリコデルマ属糸状菌の変異株およびタンパク質の製造方法
KR20220097451A (ko) 2019-11-08 2022-07-07 다니스코 유에스 인크. 향상된 단백질 생산성 표현형을 포함하는 진균 균주 및 이의 방법
FR3104169B1 (fr) * 2019-12-04 2022-10-21 Ifp Energies Now Souche de champignon ayant une viscosite diminuee
CN113881586B (zh) * 2021-09-27 2023-03-10 四川大学 耐高温、耐高糖、耐高盐酿酒酵母菌株及构建方法和应用
CN118109437B (zh) * 2024-04-29 2024-07-09 北京中医药大学深圳医院(龙岗) 一种来自菌类中药的gdp-甘露糖焦磷酸化酶及其编码基因和应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI972909A0 (fi) 1997-07-09 1997-07-09 Valtion Teknillinen Oekad produktion av avsoendrade proteiner genom rekombinatjaestceller
US7189538B2 (en) * 1999-03-24 2007-03-13 Genencor International, Inc. Hyphal growth in fungi
MXPA02001061A (es) 1999-07-30 2003-04-10 Hoffmann La Roche Medios novedoso para transformar hongos y su uso para producir proteina heterologa.
NZ521990A (en) 2000-04-13 2004-11-26 Emalfarb Mark Aaron Novel expression-regulating sequences and expression products in the field of filamentous fungi
US6936449B2 (en) * 2001-03-14 2005-08-30 Genencor International, Inc. Regulatable growth of filamentous fungi
JP2005501526A (ja) * 2001-05-25 2005-01-20 インサイト・ゲノミックス・インコーポレイテッド 糖質結合タンパク質
US6902921B2 (en) 2001-10-30 2005-06-07 454 Corporation Sulfurylase-luciferase fusion proteins and thermostable sulfurylase
WO2005001036A2 (en) 2003-05-29 2005-01-06 Genencor International, Inc. Novel trichoderma genes
US9180998B2 (en) 2007-09-11 2015-11-10 Cold Chain Technologies, Inc. Insulated pallet shipper and methods of making and using the same
CA2717799A1 (en) * 2008-03-07 2009-09-17 Timothy C. Dodge Expression of catalase in trichoderma
KR102004003B1 (ko) * 2010-08-25 2019-07-25 다니스코 유에스 인크. 변경된 점성 표현형을 갖는 사상균
US9587242B2 (en) * 2011-04-22 2017-03-07 Danisco Us Inc. Filamentous fungi having an altered viscosity phenotype
BR112013025430A2 (pt) * 2011-04-22 2016-11-29 Danisco Us Inc "cepas variantes de fundos filamentosos tendo modificação genética para maior produção de proteína mpg1 e crescimento alterado e seu método de produção".

Also Published As

Publication number Publication date
CA2833541C (en) 2021-04-27
AR086200A1 (es) 2013-11-27
BR112013025203A2 (pt) 2016-11-29
CA2833541A1 (en) 2012-10-26
JP2014513531A (ja) 2014-06-05
US20140094587A1 (en) 2014-04-03
EP3000870B1 (en) 2018-01-24
US9725726B2 (en) 2017-08-08
EP3000870A1 (en) 2016-03-30
EP2663633B1 (en) 2016-02-24
KR20140033053A (ko) 2014-03-17
AU2017202753A1 (en) 2017-05-18
DK3000870T3 (en) 2018-04-30
CA2833660A1 (en) 2012-10-26
KR101993939B1 (ko) 2019-06-27
KR101952470B1 (ko) 2019-02-26
US9725727B2 (en) 2017-08-08
AU2012245402B2 (en) 2017-09-28
DK2663633T3 (en) 2016-05-23
CN103517916B (zh) 2017-05-10
JP6042868B2 (ja) 2016-12-14
EP2699588A1 (en) 2014-02-26
EP2663633A1 (en) 2013-11-20
DK2699588T3 (en) 2017-03-13
WO2012145595A1 (en) 2012-10-26
CN103517916A (zh) 2014-01-15
US20140099721A1 (en) 2014-04-10
JP2014513529A (ja) 2014-06-05
AU2012245322A1 (en) 2013-08-22
CN103502431B (zh) 2016-07-06
BR112013025430A2 (pt) 2016-11-29
JP6042866B2 (ja) 2016-12-14
EP2699588B1 (en) 2016-11-30
WO2012145584A1 (en) 2012-10-26
CA2833660C (en) 2020-08-04
KR20140033048A (ko) 2014-03-17
CN103502431A (zh) 2014-01-08
AU2012245402A1 (en) 2013-08-22

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