BR112013025434A2 - "cepas variantes de fundos filamentosos tendo modificação genética para maior produção de proteína tps2 e crescimento alterado e seu método de produção" - Google Patents

"cepas variantes de fundos filamentosos tendo modificação genética para maior produção de proteína tps2 e crescimento alterado e seu método de produção"

Info

Publication number
BR112013025434A2
BR112013025434A2 BR112013025434A BR112013025434A BR112013025434A2 BR 112013025434 A2 BR112013025434 A2 BR 112013025434A2 BR 112013025434 A BR112013025434 A BR 112013025434A BR 112013025434 A BR112013025434 A BR 112013025434A BR 112013025434 A2 BR112013025434 A2 BR 112013025434A2
Authority
BR
Brazil
Prior art keywords
variant
increased
genetic modification
production method
altered growth
Prior art date
Application number
BR112013025434A
Other languages
English (en)
Inventor
Elizabeth A Bodie
Robert James Ii Pratt
Original Assignee
Danisco Us Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Danisco Us Inc filed Critical Danisco Us Inc
Publication of BR112013025434A2 publication Critical patent/BR112013025434A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/36—Adaptation or attenuation of cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Botany (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

resumo patente de invenção: "fungos filamentosos que têm um fenótipo de viscosidade alterada". a presente invenção refere-se a composições e métodos relacionados a fungos filamentosos variantes que têm características de crescimento alteradas. essas variantes são bem adaptadas para crescimento em culturas submersas, por exemplo, para produção em larga escala de enzimas e outras proteínas para aplicações comerciais.
BR112013025434A 2011-04-22 2012-04-20 "cepas variantes de fundos filamentosos tendo modificação genética para maior produção de proteína tps2 e crescimento alterado e seu método de produção" BR112013025434A2 (pt)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201161478160P 2011-04-22 2011-04-22
US201161478162P 2011-04-22 2011-04-22
US201161480610P 2011-04-29 2011-04-29
US201161480602P 2011-04-29 2011-04-29
US201161480629P 2011-04-29 2011-04-29
PCT/US2012/034409 WO2012145598A1 (en) 2011-04-22 2012-04-20 Filamentous fungi having an altered viscosity phenotype

Publications (1)

Publication Number Publication Date
BR112013025434A2 true BR112013025434A2 (pt) 2016-11-29

Family

ID=46018122

Family Applications (3)

Application Number Title Priority Date Filing Date
BR112013026535A BR112013026535A2 (pt) 2011-04-22 2012-04-20 "cepas variantes de fundos filamentosos tendo modificação genética para maior produção de proteína crz1 e crescimento alterado e seu método de produção".
BR112013025434A BR112013025434A2 (pt) 2011-04-22 2012-04-20 "cepas variantes de fundos filamentosos tendo modificação genética para maior produção de proteína tps2 e crescimento alterado e seu método de produção"
BR112013026559A BR112013026559A2 (pt) 2011-04-22 2012-04-20 "cepas variantes de fundos filamentosos tendo modificação genética para maior produção de proteína gas1 e crescimento alterado e seu método de produção".

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BR112013026535A BR112013026535A2 (pt) 2011-04-22 2012-04-20 "cepas variantes de fundos filamentosos tendo modificação genética para maior produção de proteína crz1 e crescimento alterado e seu método de produção".

Family Applications After (1)

Application Number Title Priority Date Filing Date
BR112013026559A BR112013026559A2 (pt) 2011-04-22 2012-04-20 "cepas variantes de fundos filamentosos tendo modificação genética para maior produção de proteína gas1 e crescimento alterado e seu método de produção".

Country Status (10)

Country Link
US (3) US9593341B2 (pt)
EP (3) EP2673290B1 (pt)
JP (3) JP6042867B2 (pt)
KR (3) KR101952469B1 (pt)
CN (3) CN103517981B (pt)
AU (4) AU2012245323B2 (pt)
BR (3) BR112013026535A2 (pt)
CA (3) CA2833539C (pt)
DK (3) DK2699668T3 (pt)
WO (3) WO2012145592A1 (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2833539C (en) * 2011-04-22 2021-04-27 Danisco Us Inc. Filamentous fungi having an altered viscosity phenotype
KR101993939B1 (ko) * 2011-04-22 2019-06-27 다니스코 유에스 인크. 변경된 점성 표현형을 갖는 사상균
JP6383359B2 (ja) * 2012-10-22 2018-08-29 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． Ｃｒｚ１突然変異真菌細胞
CA3061984A1 (en) 2017-06-06 2018-12-13 Zymergen Inc. A htp genomic engineering platform for improving fungal strains
KR20210005054A (ko) 2018-04-24 2021-01-13 다니스코 유에스 인크. 점도 감소 표현형을 포함하는 사상성 진균 균주
CA3097071A1 (en) 2018-06-06 2019-12-12 Zymergen Inc. Manipulation of genes involved in signal transduction to control fungal morphology during fermentation and production
EP3801554A4 (en) * 2018-06-08 2022-06-08 Emergy Inc. METHODS OF CULTURING MYCELIUM FUNGAL AND FORMING EDIBLE PRODUCTS THEREOF
BR112021001743A2 (pt) * 2018-07-30 2021-04-27 Toray Industries, Inc. cepas mutantes de um fungo filamentoso do gênero trichoderma e métodos para a produção de uma proteína e para a produção de uma celulase
US20210301276A1 (en) * 2018-07-30 2021-09-30 Danisco Us Inc Mutant and genetically modified filamentous fungal strains comprising enhanced protein productivity phenotypes and methods thereof
BR112021006248A2 (pt) * 2018-10-11 2021-07-06 Toray Industries cepa mutante de trichoderma reesei e métodos para produzir uma proteína e para produzir uma celulase
US20200354756A1 (en) * 2019-04-03 2020-11-12 Danisco Us Inc Disruption of mvb12 in yeast is associated with increased alcohol production and tolerance
FR3104169B1 (fr) * 2019-12-04 2022-10-21 Ifp Energies Now Souche de champignon ayant une viscosite diminuee
EP4103727A2 (en) * 2020-02-14 2022-12-21 Inbiose N.V. Production of glycosylated product in host cells
EP3926039A1 (en) 2020-06-17 2021-12-22 AB Enzymes GmbH Use of a nuclease for reducing the viscosity and/or preventing an increase in viscosity of a fermentation broth
US11479779B2 (en) 2020-07-31 2022-10-25 Zymergen Inc. Systems and methods for high-throughput automated strain generation for non-sporulating fungi
CN111944779B (zh) * 2020-08-28 2022-06-21 山东省科学院生物研究所 一种海藻糖合成双功能酶编码基因TvTPS/TPP及其应用

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JP2003518921A (ja) * 1999-07-30 2003-06-17 ネーデルランドセ・オルガニザテイエ・フール・テゲパスト−ナトウールベテンシヤツペリーク・オンデルツエク・テイエヌオー 組換えタンパク質産生のための宿主としてのアスペルギルスソジェ（Ａｓｐｅｒｇｉｌｌｕｓｓｏｊａｅ）の使用
MXPA01012905A (es) * 2000-04-13 2002-11-22 Mark Aaron Emalfarb Clasificacion de alto rendimiento de bibliotecas de adn expresado en hongo filamentos.
US6936449B2 (en) * 2001-03-14 2005-08-30 Genencor International, Inc. Regulatable growth of filamentous fungi
ATE339685T1 (de) * 2002-05-03 2006-10-15 Dsm Ip Assets Bv Prozess für die kontrolle der kontaminationsbeseitigung während des reinigungsprozesses eines durch eine wirtszelle produzierten arzneimittels
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JP4834554B2 (ja) * 2003-11-06 2011-12-14 ジェネンコー・インターナショナル・インク 糸状菌におけるプロテアーゼ抑制剤及びその変異体の発現
CA2638770A1 (en) * 2006-02-28 2007-09-07 Suntory Limited Gene encoding trehalose-6-phosphate phosphatase and use thereof
BR112013004419A2 (pt) 2010-08-25 2016-05-31 Danisco Us Inc fungos filamentosos que têm um fenótipo de viscosidade alterada.
CA2833539C (en) 2011-04-22 2021-04-27 Danisco Us Inc. Filamentous fungi having an altered viscosity phenotype
KR101993939B1 (ko) * 2011-04-22 2019-06-27 다니스코 유에스 인크. 변경된 점성 표현형을 갖는 사상균

Also Published As

Publication number Publication date
AU2017235968B2 (en) 2018-07-05
EP2673290A1 (en) 2013-12-18
CA2833756A1 (en) 2012-10-26
JP6042867B2 (ja) 2016-12-14
CN103502266B (zh) 2016-10-19
WO2012145596A1 (en) 2012-10-26
EP2699668B1 (en) 2017-11-29
WO2012145592A1 (en) 2012-10-26
US9587242B2 (en) 2017-03-07
AU2012245323B2 (en) 2017-06-29
US20140220689A1 (en) 2014-08-07
US20140127817A1 (en) 2014-05-08
CN103517981B (zh) 2017-02-15
JP2014513533A (ja) 2014-06-05
US20140315313A1 (en) 2014-10-23
CN103502430A (zh) 2014-01-08
AU2012245325B2 (en) 2017-05-25
AU2012245319A1 (en) 2013-08-22
JP6042869B2 (ja) 2016-12-14
EP2699668A1 (en) 2014-02-26
US9593341B2 (en) 2017-03-14
BR112013026559A2 (pt) 2016-11-29
EP2699667A1 (en) 2014-02-26
AU2012245325A1 (en) 2013-09-19
BR112013026535A2 (pt) 2016-11-29
CA2833539A1 (en) 2012-10-26
DK2699667T3 (en) 2016-08-01
CA2833756C (en) 2021-06-22
WO2012145598A1 (en) 2012-10-26
DK2673290T3 (en) 2016-11-14
KR101952469B1 (ko) 2019-02-26
KR20140033046A (ko) 2014-03-17
CN103517981A (zh) 2014-01-15
US9868958B2 (en) 2018-01-16
JP6042870B2 (ja) 2016-12-14
JP2014513530A (ja) 2014-06-05
EP2673290B1 (en) 2016-07-20
DK2699668T3 (en) 2018-02-26
CN103502430B (zh) 2017-03-29
KR101952467B1 (ko) 2019-02-26
AU2012245323A1 (en) 2013-09-19
AU2017235968A1 (en) 2017-10-19
CA2833765C (en) 2021-05-11
KR20140033047A (ko) 2014-03-17
EP2699667B1 (en) 2016-04-13
JP2014513532A (ja) 2014-06-05
CA2833765A1 (en) 2012-10-26
CA2833539C (en) 2021-04-27
KR20140033049A (ko) 2014-03-17
CN103502266A (zh) 2014-01-08

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

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