AR085302A1 - Metodo de produccion de anticuerpos sialilados - Google Patents
Metodo de produccion de anticuerpos sialiladosInfo
- Publication number
- AR085302A1 AR085302A1 ARP120100573A ARP120100573A AR085302A1 AR 085302 A1 AR085302 A1 AR 085302A1 AR P120100573 A ARP120100573 A AR P120100573A AR P120100573 A ARP120100573 A AR P120100573A AR 085302 A1 AR085302 A1 AR 085302A1
- Authority
- AR
- Argentina
- Prior art keywords
- antibody
- domain
- expressing
- stirated
- antibodies
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11305200 | 2011-02-24 | ||
| EP11306090 | 2011-09-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR085302A1 true AR085302A1 (es) | 2013-09-18 |
Family
ID=45774189
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120100573A AR085302A1 (es) | 2011-02-24 | 2012-02-22 | Metodo de produccion de anticuerpos sialilados |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20140046032A1 (OSRAM) |
| EP (1) | EP2678357A1 (OSRAM) |
| JP (1) | JP2014508759A (OSRAM) |
| AR (1) | AR085302A1 (OSRAM) |
| TW (1) | TW201241182A (OSRAM) |
| WO (1) | WO2012113863A1 (OSRAM) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9062106B2 (en) | 2011-04-27 | 2015-06-23 | Abbvie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
| UY34317A (es) | 2011-09-12 | 2013-02-28 | Genzyme Corp | Anticuerpo antireceptor de célula T (alfa)/ß |
| US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
| US9150645B2 (en) | 2012-04-20 | 2015-10-06 | Abbvie, Inc. | Cell culture methods to reduce acidic species |
| US9181572B2 (en) | 2012-04-20 | 2015-11-10 | Abbvie, Inc. | Methods to modulate lysine variant distribution |
| US9505833B2 (en) | 2012-04-20 | 2016-11-29 | Abbvie Inc. | Human antibodies that bind human TNF-alpha and methods of preparing the same |
| US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
| US9790268B2 (en) | 2012-09-12 | 2017-10-17 | Genzyme Corporation | Fc containing polypeptides with altered glycosylation and reduced effector function |
| AU2014249224B2 (en) | 2013-03-11 | 2019-01-17 | Genzyme Corporation | Site-specific antibody-drug conjugation through glycoengineering |
| US9499614B2 (en) | 2013-03-14 | 2016-11-22 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides |
| US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
| EP2855533A4 (en) | 2013-03-15 | 2015-11-25 | Momenta Pharmaceuticals Inc | METHODS RELATING TO CTLA4-FC FUSION PROTEINS |
| EP3719122A1 (en) | 2013-05-02 | 2020-10-07 | Momenta Pharmaceuticals, Inc. | Sialylated glycoproteins |
| US10464996B2 (en) | 2013-05-13 | 2019-11-05 | Momenta Pharmaceuticals, Inc. | Methods for the treatment of neurodegeneration |
| CN105324487B (zh) | 2013-05-29 | 2020-01-17 | 豪夫迈·罗氏有限公司 | 唾液酸化的定量控制 |
| WO2015001033A1 (en) | 2013-07-05 | 2015-01-08 | F. Hoffmann-La Roche Ag | Process for the mono- and bi-sialylation of glycoproteins employing n-terminally truncated beta-galactoside alpha-2,6-sialyltransferase mutants |
| EP2824176A1 (en) | 2013-07-11 | 2015-01-14 | Siamed'xpress | Methods for producing sialylated therapeutic proteins |
| EP3052640A2 (en) | 2013-10-04 | 2016-08-10 | AbbVie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
| US20160257754A1 (en) * | 2013-10-16 | 2016-09-08 | Momenta Pharmaceuticals Inc. | Sialylated glycoproteins |
| US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
| US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
| US20150139988A1 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
| EP3129067B1 (en) | 2014-03-19 | 2023-01-04 | Genzyme Corporation | Site-specific glycoengineering of targeting moieties |
| CN108064266A (zh) | 2014-07-21 | 2018-05-22 | 格利科斯芬兰公司 | 在丝状真菌中具有哺乳动物样n-聚糖的糖蛋白的制备 |
| EP3037527A1 (en) * | 2014-12-22 | 2016-06-29 | F. Hoffmann-La Roche AG | Sialyltransferase without CMP-dependent sialidase activity |
| CN107429237B (zh) | 2014-12-22 | 2021-09-28 | 豪夫迈·罗氏有限公司 | Cmp依赖性的唾液酸酶活性 |
| JP7516047B2 (ja) | 2016-11-23 | 2024-07-16 | アセチロン ファーマシューティカルズ インコーポレイテッド | ヒストン脱アセチル化酵素阻害剤とcd38阻害剤とを含む医薬組み合わせ物及びその使用方法 |
| EP3354278A1 (en) * | 2017-01-31 | 2018-08-01 | Sanofi | Neuronal cell protective effect of antibodies specific for the protofibrillar form of the beta-amyloid peptide |
| FR3080376B1 (fr) * | 2018-04-20 | 2022-12-09 | Lab Francais Du Fractionnement | Autoanticorps hautement sialyles et leurs utilisations |
| AU2020253455A1 (en) | 2019-04-03 | 2021-11-04 | Genzyme Corporation | Anti-alpha beta TCR binding polypeptides with reduced fragmentation |
| TWI869528B (zh) | 2020-01-13 | 2025-01-11 | 美商威特拉公司 | C5ar1抗體分子及其用途 |
| CA3237662A1 (en) * | 2021-11-09 | 2023-05-19 | Amgen Inc. | Production of therapeutic proteins |
| WO2025101901A1 (en) * | 2023-11-10 | 2025-05-15 | The Board Of Trustees Of The Leland Stanford Junior University | Use of sialylated ivig or igg fc region-containing protein for preventing or treating respiratory virus diseases |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
| DE69233482T2 (de) | 1991-05-17 | 2006-01-12 | Merck & Co., Inc. | Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen |
| US5565332A (en) | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
| US5792632A (en) | 1992-05-05 | 1998-08-11 | Institut Pasteur | Nucleotide sequence encoding the enzyme I-SceI and the uses thereof |
| US5474896A (en) | 1992-05-05 | 1995-12-12 | Institut Pasteur | Nucleotide sequence encoding the enzyme I-SceI and the uses thereof |
| US5639641A (en) | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
| US5830729A (en) | 1996-04-18 | 1998-11-03 | Institut Pasteur | I Sce I-induced gene replacement and gene conversion in embryonic stem cells |
| US20020045207A1 (en) * | 1997-10-31 | 2002-04-18 | Lynne A. Krummen | Glycoprotein production process |
| US6750324B1 (en) | 1997-12-02 | 2004-06-15 | Neuralab Limited | Humanized and chimeric N-terminal amyloid beta-antibodies |
| US6761888B1 (en) | 2000-05-26 | 2004-07-13 | Neuralab Limited | Passive immunization treatment of Alzheimer's disease |
| US6737056B1 (en) * | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| WO2002003911A2 (en) | 2000-07-07 | 2002-01-17 | Lars Lannfelt | Prevention and treatment of alzheimer's disease |
| EP1427828B1 (en) | 2001-09-14 | 2010-04-28 | Cellectis | Random integration of a polynucleotide after in vivo linearization |
| AU2004208031B2 (en) | 2003-01-28 | 2009-10-08 | Cellectis | Use of meganucleases for inducing homologous recombination ex vivo and in toto in vertebrate somatic tissues and application thereof. |
| JP2009504569A (ja) * | 2005-06-30 | 2009-02-05 | セントカー・インコーポレーテツド | 向上した治療活性をもつ方法および組成物 |
| CA2626556C (en) | 2005-10-21 | 2016-05-10 | Genzyme Corporation | Antibody-based therapeutics with enhanced adcc activity |
| US20080206246A1 (en) * | 2006-04-05 | 2008-08-28 | Ravetch Jeffrey V | Polypeptides with enhanced anti-inflammatory and decreased cytotoxic properties and relating methods |
| ES2454253T3 (es) | 2005-12-12 | 2014-04-10 | Ac Immune S.A. | Anticuerpos monoclonales específicos de beta A 1-42 con propiedades terapéuticas |
| MX2008012843A (es) | 2006-04-05 | 2009-01-19 | Univ Rockefeller | Polipeptidos con propiedades antiinflamatorias aumentadas y citotoxicas reducidas y metodos relacionados. |
| AU2007317755A1 (en) | 2006-10-27 | 2008-05-15 | The Rockefeller University | Polypeptides with enhanced anti-inflammatory and decreased cytotoxic properties and relating methods |
| JP2010512306A (ja) * | 2006-10-27 | 2010-04-22 | ザ ロックフェラー ユニバーシティー | 抗炎症特性が増強され、細胞毒性特性が減少したポリペプチドおよび関連する方法 |
| AR063975A1 (es) | 2006-11-28 | 2009-03-04 | Centelion | Fusiones fc con receptor para fgf soluble modificadas con actividad biologica mejorada |
| WO2009032661A1 (en) | 2007-08-29 | 2009-03-12 | Sanofi-Aventis | Humanized anti-cxcr5 antibodies, derivatives thereof and their uses |
| RU2571859C2 (ru) | 2007-10-05 | 2015-12-20 | Дженентек, Инк. | Применение антитела против амилоида-бета при глазных заболеваниях |
| JP2011500059A (ja) | 2007-10-15 | 2011-01-06 | セントコア・オーソ・バイオテツク・インコーポレーテツド | ヒト抗アミロイド抗体、組成物、方法及び使用 |
| EP2205752B1 (en) | 2007-10-25 | 2016-08-10 | Sangamo BioSciences, Inc. | Methods and compositions for targeted integration |
| EP2226081A4 (en) | 2007-10-25 | 2011-10-12 | Univ Kagoshima | PEPTIDE VACCINE WITH A MIMIC MOLECULE OF AMYLOID PEPTIDE |
| EP2224000B1 (en) | 2007-10-29 | 2020-05-13 | TAO Health Life Pharma Co., Ltd. | Antibody and use thereof |
| KR101581733B1 (ko) | 2007-11-16 | 2015-12-31 | 더 락커펠러 유니버시티 | 원섬유 형태의 베타아밀로이드 단백질에 대해 특이적인 항체 |
| BRPI0819916A2 (pt) | 2007-12-11 | 2015-05-19 | Glaxo Group Ltd | Proteína de ligação a antígeno, composição farmacêutica, método para tratar um paciente humano afligido com uma doença, anticorpo ou fragmento do mesmo, e, proteína de ligação a antígeno. |
| EP2233502A1 (en) | 2009-03-27 | 2010-09-29 | Deutsches Rheuma-Forschungszentrum Berlin | Sialylated antigen-specific antibodies for treatment or prophylaxis of unwanted inflammatory immune reactions and methods of producing them |
| FR2945538B1 (fr) | 2009-05-12 | 2014-12-26 | Sanofi Aventis | Anticorps humanises specifiques de la forme protofibrillaire du peptide beta-amyloide. |
| US10087236B2 (en) * | 2009-12-02 | 2018-10-02 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
-
2012
- 2012-02-22 AR ARP120100573A patent/AR085302A1/es unknown
- 2012-02-23 US US14/000,035 patent/US20140046032A1/en not_active Abandoned
- 2012-02-23 WO PCT/EP2012/053065 patent/WO2012113863A1/en not_active Ceased
- 2012-02-23 EP EP12706541.5A patent/EP2678357A1/en not_active Withdrawn
- 2012-02-23 TW TW101106076A patent/TW201241182A/zh unknown
- 2012-02-23 JP JP2013554892A patent/JP2014508759A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2014508759A (ja) | 2014-04-10 |
| US20140046032A1 (en) | 2014-02-13 |
| WO2012113863A1 (en) | 2012-08-30 |
| TW201241182A (en) | 2012-10-16 |
| EP2678357A1 (en) | 2014-01-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |