AR084705A1 - Formas cristalinas de n-[2-[[(2,3-difluorofenil)metil]tio]-6-{[(1r,2s)-2,3-dihidroxi-1-metilpropil]oxi}-4-pirimidinil]-1-azetidinsulfonamida - Google Patents

Formas cristalinas de n-[2-[[(2,3-difluorofenil)metil]tio]-6-{[(1r,2s)-2,3-dihidroxi-1-metilpropil]oxi}-4-pirimidinil]-1-azetidinsulfonamida

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Publication number
AR084705A1
AR084705A1 ARP110102510A ARP110102510A AR084705A1 AR 084705 A1 AR084705 A1 AR 084705A1 AR P110102510 A ARP110102510 A AR P110102510A AR P110102510 A ARP110102510 A AR P110102510A AR 084705 A1 AR084705 A1 AR 084705A1
Authority
AR
Argentina
Prior art keywords
azetidinsulfonamide
difluorophenyl
methylpropyl
pyrimidinyl
methyl
Prior art date
Application number
ARP110102510A
Other languages
English (en)
Inventor
Britt Anne Ingela Gullberg
Thomas Peter Larsson
Jeffrey Paul Stonehouse
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR084705A1 publication Critical patent/AR084705A1/es

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Abstract

Se proporcionan formas cristalinas de anhidrato de N-[2-[[(2,3-difluorofenil)metil]tio]-6-{[(1R,2S)-2,3-dihidroxi-1-metilpropil]oxi}-4-pirimidinil]-1-azetidinsulfonamida. Tales compuestos/formas pueden ser útiles en el tratamiento de una enfermedad/afección en la que es beneficioso modular la actividad de los receptores de quimiocinas.
ARP110102510A 2010-07-13 2011-07-13 Formas cristalinas de n-[2-[[(2,3-difluorofenil)metil]tio]-6-{[(1r,2s)-2,3-dihidroxi-1-metilpropil]oxi}-4-pirimidinil]-1-azetidinsulfonamida AR084705A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US36372610P 2010-07-13 2010-07-13

Publications (1)

Publication Number Publication Date
AR084705A1 true AR084705A1 (es) 2013-06-05

Family

ID=44358090

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP110102510A AR084705A1 (es) 2010-07-13 2011-07-13 Formas cristalinas de n-[2-[[(2,3-difluorofenil)metil]tio]-6-{[(1r,2s)-2,3-dihidroxi-1-metilpropil]oxi}-4-pirimidinil]-1-azetidinsulfonamida

Country Status (16)

Country Link
US (2) US8748603B2 (es)
EP (1) EP2593448A1 (es)
JP (1) JP2013531027A (es)
KR (1) KR20130103483A (es)
CN (1) CN103097377A (es)
AR (1) AR084705A1 (es)
AU (1) AU2011278115B2 (es)
BR (1) BR112013000788A2 (es)
CA (1) CA2804162A1 (es)
MX (1) MX2013000289A (es)
MY (1) MY167869A (es)
RU (1) RU2548044C2 (es)
SG (1) SG186859A1 (es)
TW (1) TWI496773B (es)
UY (1) UY33506A (es)
WO (1) WO2012007748A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6262286A (ja) * 1985-09-13 1987-03-18 株式会社東芝 沸騰水型原子炉炉心
WO2012007748A1 (en) * 2010-07-13 2012-01-19 Astrazeneca Ab New crystalline forms of n-[2-[[(2,3-difluoropheny)methyl)thio]-6-{[(1r,2s)-2,3-dihydroxy-1- methylpropyl]oxy}-4-pyrimidinyl]-1-azetidinesulfonamide
PE20141944A1 (es) 2011-07-12 2014-12-24 Astrazeneca Ab N-(6-((2r,3s)-3,4-dihidroxibutan-2-iloxi)-2-(4-fluorobenciltio)pirimidin-4-il)-3-metilacetidina-1-sulfonamida como moduladores del receptor de quimiocina
EP3141235A1 (en) * 2012-12-06 2017-03-15 IP Gesellschaft für Management mbH N-(6-((2r,3s)-3,4-dihydroxybutan-2-yloxy)-2-(4-fluorobenzylthio)pyrimidin-4-yl)-3-methylazetidine-l -sulfonamide
CN103113333B (zh) * 2012-12-20 2015-07-08 浙江普洛康裕制药有限公司 一种维生素c乙基醚的合成方法
WO2016079049A1 (en) * 2014-11-17 2016-05-26 Medimmune Limited Therapeutic combinations and methods for treating neoplasia
CA3017345A1 (en) 2016-03-11 2017-09-14 Ardea Biosciences, Inc. Cxcr-2 inhibitors for treating crystal arthropathy disorders

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2083567C1 (ru) * 1991-04-25 1997-07-10 Ф.Хоффманн-Ля Рош Аг Производные арилсульфонамида или их соли и фармацевтическая композиция, проявляющая ангиопротекторное, антигипертензивное и вазоспазмолитическое, в частности противоишемическое, действие
GB0217431D0 (en) 2002-07-27 2002-09-04 Astrazeneca Ab Novel compounds
CA2578441C (en) * 2004-08-28 2013-01-08 Astrazeneca Ab Pyrimidine sulphonamide derivatives as chemokine receptor modulators
EP2315754A1 (en) 2008-07-16 2011-05-04 AstraZeneca AB Pyrimidyl sulfonaminde derivative and its use for the treatment of chemokine mediated diseases
EP2310354A2 (de) 2008-07-25 2011-04-20 Basf Se 3-aminomethyl-1-cyclohexylamin und ein verfahren zu dessen herstellung
WO2012007748A1 (en) * 2010-07-13 2012-01-19 Astrazeneca Ab New crystalline forms of n-[2-[[(2,3-difluoropheny)methyl)thio]-6-{[(1r,2s)-2,3-dihydroxy-1- methylpropyl]oxy}-4-pyrimidinyl]-1-azetidinesulfonamide
PE20141944A1 (es) 2011-07-12 2014-12-24 Astrazeneca Ab N-(6-((2r,3s)-3,4-dihidroxibutan-2-iloxi)-2-(4-fluorobenciltio)pirimidin-4-il)-3-metilacetidina-1-sulfonamida como moduladores del receptor de quimiocina

Also Published As

Publication number Publication date
US20140235606A1 (en) 2014-08-21
CN103097377A (zh) 2013-05-08
WO2012007748A1 (en) 2012-01-19
RU2013103754A (ru) 2014-08-20
AU2011278115A1 (en) 2013-01-24
MX2013000289A (es) 2013-03-08
SG186859A1 (en) 2013-02-28
JP2013531027A (ja) 2013-08-01
UY33506A (es) 2012-02-29
US8748603B2 (en) 2014-06-10
US20120015927A1 (en) 2012-01-19
TW201209041A (en) 2012-03-01
TWI496773B (zh) 2015-08-21
MY167869A (en) 2018-09-26
KR20130103483A (ko) 2013-09-23
CA2804162A1 (en) 2012-01-19
AU2011278115B2 (en) 2014-11-06
EP2593448A1 (en) 2013-05-22
BR112013000788A2 (pt) 2017-09-26
RU2548044C2 (ru) 2015-04-10

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