AR082187A1 - Derivados heterociclicos de dihidro-piridina, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de la infeccion por vhc - Google Patents
Derivados heterociclicos de dihidro-piridina, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de la infeccion por vhcInfo
- Publication number
- AR082187A1 AR082187A1 ARP110102412A ARP110102412A AR082187A1 AR 082187 A1 AR082187 A1 AR 082187A1 AR P110102412 A ARP110102412 A AR P110102412A AR P110102412 A ARP110102412 A AR P110102412A AR 082187 A1 AR082187 A1 AR 082187A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- alkoxy
- halogen
- hydrogen
- independently
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Reivindicación 1: Compuesto según la fórmula (1), en la que: X es CH o N; R1 se selecciona de entre el grupo que consiste de las fórmulas (2), (3), (4), (5) y (6), en la que R5 es hidrógeno o alquilo C1-3, y el resto de fórmula (2) se sustituye opcionalmente con halógeno, alquilo C1-6, haloalquilo C1-3, alcoxi C1-6 o hidroxi; R2 es (a) arilo, (b) heteroarilo o (c) NRaRb, en el que dicho arilo y dicho heteroarilo opcionalmente se sustituyen independientemente con uno a tres sustituyentes seleccionados de entre el grupo que consiste de hidroxi, alcoxi C1-6, alquilo C1-6, hidroxialquilo C1-6, halógeno, (CH2)nNRcRd, ciano, alcoxicarbonilo C1-6, carbamoilo, N-alquilcarbamoilo, N,N-dialquilcarbamoilo, (CH2)0-2CO2H, SO2NH2, alquilsulfinilo C1-6 y alquilsulfonilo C1-6; Ra y Rb, conjuntamente con el nitrógeno al que se encuentran unidos son una amina cíclica sustituida independientemente con (CH2)nNRcRd, en el que n es un número entre cero y dos, y además se encuentra opcionalmente sustituido con uno o dos grupos seleccionados independientemente de entre alquilo C1-6 ó halógeno; Rc y Rd son, independientemente, hidrógeno, alquilo C1-6, haloalquilo C1-6, acilo C1-6, O2SR4, en el que R4 es alquilo C1-6, haloalquilo C1-6, cicloalquilo C3-7, cicloalquil C3-7-alquilo C1-3, alcoxi C1-6-alquilo C1-6, -SO2-NReRf; Re y Rf son (i) independientemente hidrógeno, alquilo C1-3 ó (CH2)2-6NRgRh, o (ii) conjuntamente con el nitrógeno al que se encuentran unidos son (CH2)2X5(CH2)2, en el que X5 es O ó NRg y Rg son hidrógeno, alquilo C1-3, acilo C1-3 o alquilsulfonilo C1-3; R3 es CF3, CH2CF3, cicloalquilo C3-5, halógeno, alcoxi C1-6, haloalcoxi C1-3, CHR4aR4b o CR4aR4bR4c en los que: (i) R4a, R4b y R4c se seleccionan independientemente de entre alquilo C1-3, CD3, alcoxi C1-2, fluoroalquilo C1-2, hidroxialquilo C1-3, ciano o hidroxi, o (ii) conjuntamente, R4a y R4b son alquileno C2-4 y R4c es hidrógeno, alquilo C1-3, CD3, alcoxi C1-2, halógeno, hidroxialquilo C1-3, ciano o fluoroalquilo C1-2, o R4a y R4b conjuntamente con el carbono al que se encuentran unidos son 3-oxetanilo o tetrahidrofurán-2-ilo; o una sal farmacéuticamente aceptable de los mismos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36222010P | 2010-07-07 | 2010-07-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR082187A1 true AR082187A1 (es) | 2012-11-21 |
Family
ID=44532771
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP110102412A AR082187A1 (es) | 2010-07-07 | 2011-07-06 | Derivados heterociclicos de dihidro-piridina, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de la infeccion por vhc |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8329712B2 (es) |
| EP (1) | EP2590960B1 (es) |
| JP (1) | JP5651239B2 (es) |
| KR (1) | KR101445506B1 (es) |
| CN (1) | CN102971305B (es) |
| AR (1) | AR082187A1 (es) |
| BR (1) | BR112013000245A2 (es) |
| CA (1) | CA2801670A1 (es) |
| ES (1) | ES2481411T3 (es) |
| HK (1) | HK1183030A1 (es) |
| MX (1) | MX2012014235A (es) |
| RU (1) | RU2572558C2 (es) |
| TW (1) | TWI423975B (es) |
| WO (1) | WO2012004212A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112013003113A2 (pt) * | 2010-08-13 | 2019-09-24 | Hoffmann La Roche | compostos antivirais heterocíclicos |
| EP3535261B1 (en) * | 2016-11-03 | 2020-08-05 | F. Hoffmann-La Roche AG | Novel tetrahydropyridopyrimidines for the treatment and prophylaxis of hepatitis b virus infection |
| KR102645467B1 (ko) | 2018-10-18 | 2024-03-11 | 삼성디스플레이 주식회사 | 표시장치의 제조방법 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2029472C1 (ru) * | 1989-09-26 | 1995-02-27 | Сумитомо Кемикал Компани Лимитед | Производные урацила, промежуточные соединения, гербицидная композиция и способ борьбы с сорняками |
| WO2006014187A2 (en) * | 2004-03-10 | 2006-02-09 | Primet Precision Materials, Inc. | Methods for using multi-carbide grinding media |
| GB0428475D0 (en) * | 2004-12-30 | 2005-02-02 | 4 Aza Bioscience Nv | Pyrido(3,2-D)pyrimidine derivatives and pharmaceutical compositions useful as medicines for the treatment of autoimmune disorders |
| CA2612788A1 (en) | 2005-06-24 | 2006-12-28 | Steven Cesar Alfons De Jonghe | Pyrido(3,2-d)pyrimidines and pharmaceutical compositions useful for treating hepatitis c |
| US8673929B2 (en) * | 2006-07-20 | 2014-03-18 | Gilead Sciences, Inc. | 4,6-di- and 2,4,6-trisubstituted quinazoline derivatives and pharmaceutical compositions useful for treating viral infections |
| US8338435B2 (en) * | 2006-07-20 | 2012-12-25 | Gilead Sciences, Inc. | Substituted pyrido(3,2-D) pyrimidines and pharmaceutical compositions for treating viral infections |
| BRPI0815811A2 (pt) * | 2007-08-29 | 2015-02-18 | Schering Corp | Derivados de indol substituído e métodos de uso dos mesmos |
| CA2699989C (en) * | 2007-09-17 | 2014-03-25 | Abbott Laboratories | N-phenyl-dioxo-hydro pyrimidines useful as hepatitis c virus (hcv) inhibitor |
| UY31344A1 (es) | 2007-09-17 | 2009-04-30 | Metansulfonamidas n-(3-ter-butil-5-(2,4-dioxo-3,4-dihidropirimidin-1(2h)-il)-2-metoxi-aril) sustituidas, solvatos, hidratos, formas cristalinas y sus sales farmacéuticamente aceptables,proceso de preparación,composiciones y aplicaciones. | |
| JP2012503620A (ja) * | 2008-09-26 | 2012-02-09 | エフ．ホフマン−ラ ロシュ アーゲー | Ｈｃｖを処置するためのピリンまたはピラジン誘導体 |
| TWI428332B (zh) * | 2009-06-09 | 2014-03-01 | Hoffmann La Roche | 雜環抗病毒化合物 |
-
2011
- 2011-07-04 WO PCT/EP2011/061180 patent/WO2012004212A1/en active Application Filing
- 2011-07-04 JP JP2013517328A patent/JP5651239B2/ja not_active Expired - Fee Related
- 2011-07-04 EP EP11738413.1A patent/EP2590960B1/en not_active Not-in-force
- 2011-07-04 RU RU2013102400/04A patent/RU2572558C2/ru not_active IP Right Cessation
- 2011-07-04 BR BR112013000245A patent/BR112013000245A2/pt not_active IP Right Cessation
- 2011-07-04 KR KR1020137003125A patent/KR101445506B1/ko not_active IP Right Cessation
- 2011-07-04 MX MX2012014235A patent/MX2012014235A/es unknown
- 2011-07-04 CA CA2801670A patent/CA2801670A1/en not_active Abandoned
- 2011-07-04 CN CN201180033328.8A patent/CN102971305B/zh not_active Expired - Fee Related
- 2011-07-04 ES ES11738413.1T patent/ES2481411T3/es active Active
- 2011-07-06 AR ARP110102412A patent/AR082187A1/es unknown
- 2011-07-06 US US13/177,220 patent/US8329712B2/en not_active Expired - Fee Related
- 2011-07-06 TW TW100123934A patent/TWI423975B/zh not_active IP Right Cessation
-
2013
- 2013-09-09 HK HK13110430.2A patent/HK1183030A1/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2013530198A (ja) | 2013-07-25 |
| WO2012004212A1 (en) | 2012-01-12 |
| MX2012014235A (es) | 2013-01-28 |
| RU2013102400A (ru) | 2014-08-20 |
| CN102971305B (zh) | 2016-02-03 |
| US8329712B2 (en) | 2012-12-11 |
| KR20130036316A (ko) | 2013-04-11 |
| ES2481411T3 (es) | 2014-07-30 |
| US20120009144A1 (en) | 2012-01-12 |
| RU2572558C2 (ru) | 2016-01-20 |
| TW201206932A (en) | 2012-02-16 |
| EP2590960A1 (en) | 2013-05-15 |
| CN102971305A (zh) | 2013-03-13 |
| CA2801670A1 (en) | 2012-01-12 |
| TWI423975B (zh) | 2014-01-21 |
| EP2590960B1 (en) | 2014-06-11 |
| KR101445506B1 (ko) | 2014-09-26 |
| BR112013000245A2 (pt) | 2016-05-24 |
| JP5651239B2 (ja) | 2015-01-07 |
| HK1183030A1 (zh) | 2013-12-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |