AR080974A1 - Derivados piridinicos y piperazinicos moduladores de la actividad de los canales del calcio activado por depositos intracelulares(soc), composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento de enfermedades inflamatorias y trastornos inmunes, entre otras. - Google Patents
Derivados piridinicos y piperazinicos moduladores de la actividad de los canales del calcio activado por depositos intracelulares(soc), composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento de enfermedades inflamatorias y trastornos inmunes, entre otras.Info
- Publication number
- AR080974A1 AR080974A1 ARP110101456A ARP110101456A AR080974A1 AR 080974 A1 AR080974 A1 AR 080974A1 AR P110101456 A ARP110101456 A AR P110101456A AR P110101456 A ARP110101456 A AR P110101456A AR 080974 A1 AR080974 A1 AR 080974A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- aryl
- piridinic
- piperazinic
- soc
- Prior art date
Links
- 208000027866 inflammatory disease Diseases 0.000 title 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title 1
- 229910052791 calcium Inorganic materials 0.000 title 1
- 239000011575 calcium Substances 0.000 title 1
- 230000000694 effects Effects 0.000 title 1
- 230000003834 intracellular effect Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 6
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 abstract 5
- 125000001072 heteroaryl group Chemical group 0.000 abstract 5
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 5
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000006716 (C1-C6) heteroalkyl group Chemical group 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000006555 (C3-C5) cycloalkyl group Chemical group 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004404 heteroalkyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
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Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32856910P | 2010-04-27 | 2010-04-27 | |
| US37782510P | 2010-08-27 | 2010-08-27 | |
| US40781910P | 2010-10-28 | 2010-10-28 | |
| US42208810P | 2010-12-10 | 2010-12-10 | |
| US201161430894P | 2011-01-07 | 2011-01-07 | |
| US201161439786P | 2011-02-04 | 2011-02-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR080974A1 true AR080974A1 (es) | 2012-05-23 |
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ID=44816307
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP110101456A AR080974A1 (es) | 2010-04-27 | 2011-04-27 | Derivados piridinicos y piperazinicos moduladores de la actividad de los canales del calcio activado por depositos intracelulares(soc), composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento de enfermedades inflamatorias y trastornos inmunes, entre otras. |
Country Status (13)
| Country | Link |
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| US (3) | US8546403B2 (enExample) |
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- 2011-04-11 PT PT117777912T patent/PT2563776T/pt unknown
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- 2011-04-11 WO PCT/US2011/031992 patent/WO2011139489A2/en not_active Ceased
- 2011-04-11 EP EP11777791.2A patent/EP2563776B1/en active Active
- 2011-04-11 AU AU2011248877A patent/AU2011248877B9/en active Active
- 2011-04-11 JP JP2013507982A patent/JP6112486B2/ja active Active
- 2011-04-12 US US13/085,324 patent/US8546403B2/en active Active
- 2011-04-26 TW TW100114497A patent/TWI574959B/zh active
- 2011-04-27 AR ARP110101456A patent/AR080974A1/es active IP Right Grant
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- 2013-08-23 US US13/975,238 patent/US8980629B2/en active Active
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Also Published As
| Publication number | Publication date |
|---|---|
| PT2563776T (pt) | 2016-09-19 |
| JP2017101044A (ja) | 2017-06-08 |
| CA2797663A1 (en) | 2011-11-10 |
| EP2563776A4 (en) | 2013-09-11 |
| WO2011139489A3 (en) | 2012-01-26 |
| EP2563776B1 (en) | 2016-06-08 |
| JP2013525433A (ja) | 2013-06-20 |
| US20130345240A1 (en) | 2013-12-26 |
| AU2011248877A1 (en) | 2012-12-06 |
| CA2797663C (en) | 2018-10-09 |
| EP2563776A2 (en) | 2013-03-06 |
| US20130345193A1 (en) | 2013-12-26 |
| US9120751B2 (en) | 2015-09-01 |
| AU2011248877B9 (en) | 2015-11-05 |
| TW201141855A (en) | 2011-12-01 |
| JP7066768B2 (ja) | 2022-05-13 |
| JP2019055964A (ja) | 2019-04-11 |
| PL2563776T3 (pl) | 2017-01-31 |
| JP6112486B2 (ja) | 2017-04-12 |
| JP6436463B2 (ja) | 2018-12-12 |
| US8980629B2 (en) | 2015-03-17 |
| DK2563776T3 (en) | 2016-09-19 |
| US8546403B2 (en) | 2013-10-01 |
| AU2011248877B2 (en) | 2015-06-25 |
| HUE029570T2 (en) | 2017-03-28 |
| TWI574959B (zh) | 2017-03-21 |
| US20110263612A1 (en) | 2011-10-27 |
| JP2020114824A (ja) | 2020-07-30 |
| WO2011139489A2 (en) | 2011-11-10 |
| ES2591004T3 (es) | 2016-11-24 |
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