AR091520A1 - Inhibidores piranopiridona de tanquirasa - Google Patents

Inhibidores piranopiridona de tanquirasa

Info

Publication number
AR091520A1
AR091520A1 ARP130102188A AR091520A1 AR 091520 A1 AR091520 A1 AR 091520A1 AR P130102188 A ARP130102188 A AR P130102188A AR 091520 A1 AR091520 A1 AR 091520A1
Authority
AR
Argentina
Prior art keywords
alkyl
heterocycloalkyl
tanquirasa
pyranopiridone
inhibitors
Prior art date
Application number
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR091520A1 publication Critical patent/AR091520A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C07D491/153—Ortho-condensed systems the condensed system containing two rings with oxygen as ring hetero atom and one ring with nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Los compuestos presentan actividad como agentes anticáncer. Reivindicación 1: Compuesto de fórmula (1) ó (2), en la que: X es, independientemente en cada aparición, N o CH; Y es S, O, CH ó NCH₃; M es S o CH; R¹ es H, alquilo C₁₋₆, cicloalquilo C₃₋₇, C₍CH₃)₂OH, CN, NO₂, CO₂CH₃, CONH₂, NH₂, o halógeno, y R² se selecciona de entre el grupo que consiste de H, alquilo C₁₋₆ opcionalmente sustituido, espiroalquilo C₅₋₁₂, alcoxi C₁₋₆, cicloalquilo C₃₋₇, heterocicloalquilo y heterocicloalquilo sustituido, en el que dicho heterocicloalquilo se sustituye opcionalmente con alquilo C₁₋₆, hidroxialquilo C₁₋₆, alcoxi C₁₋₃-alquilo C₁₋₆, oxetanilo, tetrahidrofuranilo, piranilo o SO₂R³, en el que R³ es alquilo C₁₋₆, hidroxialquilo C₁₋₆, oxetanilo, tetrahidrofuranilo, piranilo, o una sal farmacéuticamente aceptable de los mismos.
ARP130102188 2012-06-20 2013-06-19 Inhibidores piranopiridona de tanquirasa AR091520A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261661915P 2012-06-20 2012-06-20

Publications (1)

Publication Number Publication Date
AR091520A1 true AR091520A1 (es) 2015-02-11

Family

ID=48628700

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP130102188 AR091520A1 (es) 2012-06-20 2013-06-19 Inhibidores piranopiridona de tanquirasa

Country Status (12)

Country Link
US (1) US20140121231A1 (es)
EP (1) EP2864335A1 (es)
JP (1) JP2015520204A (es)
KR (1) KR20150009599A (es)
CN (1) CN104284898A (es)
AR (1) AR091520A1 (es)
BR (1) BR112014031785A2 (es)
CA (1) CA2869239A1 (es)
HK (1) HK1201066A1 (es)
MX (1) MX2014015345A (es)
RU (1) RU2014152792A (es)
WO (1) WO2013189904A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9193689B2 (en) 2012-03-07 2015-11-24 Institute Of Cancer Research: Royal Cancer Hospital (The) 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use
KR20150011838A (ko) * 2012-06-20 2015-02-02 에프. 호프만-라 로슈 아게 탄키라아제 억제제로서의 피롤로피라존
WO2014087165A1 (en) * 2012-12-06 2014-06-12 University Of Bath Tankyrase inhibitors
ES2666729T3 (es) 2013-09-11 2018-05-07 Institute Of Cancer Research: Royal Cancer Hospital (The) Compuestos de isoquinolin-1-ona 3-aril-5-sustituida y su uso terapéutico
WO2015176135A1 (en) * 2014-05-22 2015-11-26 The University Of Sydney Omega-3 analogues
WO2017156350A1 (en) 2016-03-09 2017-09-14 K-Gen, Inc. Methods of cancer treatment

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003014121A1 (en) * 2001-08-07 2003-02-20 Guilford Pharmaceuticals Inc. Compounds, derivatives, compositions, preparation and uses
MXPA06009701A (es) * 2004-02-26 2007-03-26 Inotek Pharmaceuticals Corp Derivados de isoquinolina y metodos de uso de los mismos.
US20060079510A1 (en) * 2004-09-30 2006-04-13 Kristoffer Hellstrand Use of PARP-1 inhibitors for protecting tumorcidal lymphocytes from apoptosis
US7576080B2 (en) 2004-12-23 2009-08-18 Memory Pharmaceuticals Corporation Certain thienopyrimidine derivatives as phosphodiesterase 10 inhibitors
KR100931411B1 (ko) 2005-04-05 2009-12-10 에프. 호프만-라 로슈 아게 1ｈ-피라졸 4-카복실아미드, 이의 제조 방법, 및 이의 11베타-하이드록시스테로이드 탈수소효소로서의 용도
US20080242861A1 (en) 2007-04-02 2008-10-02 Chi-Feng Yen Synthesis of amino-protected cyclohexane-1,4-diyldimethanamine and its derivatives
AU2009274454A1 (en) 2008-04-21 2010-01-28 Merck Sharp & Dohme Corp. Inhibitors of janus kinases

Also Published As

Publication number Publication date
CA2869239A1 (en) 2013-12-27
WO2013189904A1 (en) 2013-12-27
BR112014031785A2 (pt) 2017-06-27
KR20150009599A (ko) 2015-01-26
HK1201066A1 (en) 2015-08-21
CN104284898A (zh) 2015-01-14
EP2864335A1 (en) 2015-04-29
JP2015520204A (ja) 2015-07-16
MX2014015345A (es) 2015-03-05
US20140121231A1 (en) 2014-05-01
RU2014152792A (ru) 2016-08-10

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