AR080223A1 - Productos terapeuticos que comprenden dispersiones placentarias vitalizadas - Google Patents
Productos terapeuticos que comprenden dispersiones placentarias vitalizadasInfo
- Publication number
- AR080223A1 AR080223A1 ARP110100510A ARP110100510A AR080223A1 AR 080223 A1 AR080223 A1 AR 080223A1 AR P110100510 A ARP110100510 A AR P110100510A AR P110100510 A ARP110100510 A AR P110100510A AR 080223 A1 AR080223 A1 AR 080223A1
- Authority
- AR
- Argentina
- Prior art keywords
- placental
- tissue
- cells
- product
- factors
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
- A01N1/0221—Freeze-process protecting agents, i.e. substances protecting cells from effects of the physical process, e.g. cryoprotectants, osmolarity regulators like oncotic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/50—Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1825—Fibroblast growth factor [FGF]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1841—Transforming growth factor [TGF]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0605—Cells from extra-embryonic tissues, e.g. placenta, amnion, yolk sac, Wharton's jelly
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/02—Atmosphere, e.g. low oxygen conditions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/02—Coculture with; Conditioned medium produced by embryonic cells
- C12N2502/025—Coculture with; Conditioned medium produced by embryonic cells extra-embryonic cells, e.g. amniotic epithelium, placental cells, Wharton's jelly
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Developmental Biology & Embryology (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Reproductive Health (AREA)
- Wood Science & Technology (AREA)
- Pregnancy & Childbirth (AREA)
- Genetics & Genomics (AREA)
- Gynecology & Obstetrics (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Dentistry (AREA)
- Environmental Sciences (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Producto placentario terapéutico fluido que comprende células de placenta y una dispersion placentaria que comprende factores placentarios. Las células de placenta y la dispersion placentaria derivan de tejido placentario. Un tejido placentario opcionalmente puede ser un amnios, corion, o un corion sin trofoblastos. El producto placentario de la presente invencion es util para tratar aun paciente con una lesion tisular (por ejemplo una herida o quemadura) mediante la aplicacion del producto placentario sobre la lesion. Reivindicacion 1: Un método para fabricar un producto placentario terapéutico caracterizado porque comprende: obtener un primer tejido placentario; obtener células de placenta a partir del primer tejido placentario; obtener un segundo tejido placentario; romper el segundo tejido placentario para formar una dispersion que comprende factores placentarios; y combinar las células de placenta y la dispersion placentaria para formar el producto placentario. Reivindicacion 2: El método de la reivindicacion 1, caracterizado porque el primer tejido placentario es autologo al tejido placentario. Reivindicacion 4: El método de la reivindicacion 3, caracterizado porque el paso de obtener las células de placenta comprende exponer el primer tejido placentario a una proteasa. Reivindicacion 5: El método de la reivindicacion 4, caracterizado porque la proteasa es una colagenasa. Reivindicacion 8: El método de la reivindicacion 7, caracterizado porque el paso de exposicion libera menos de aproximadamente 10% del numero máximo de células de placenta que se pueden liberar. Reivindicacion 9: El método de cualquiera de las reivindicaciones 1 a 8, caracterizado porque el primer tejido placentario y el segundo tejido placentario son un tejido amniotico. Reivindicacion 10: El método de cualquiera de las reivindicaciones 1 a 8, caracterizado porque el primer tejido placentario y el segundo tejido placentario son un tejido coriánico. Reivindicacion 18: El método de cualquiera de las reivindicaciones precedentes, caracterizado porque el producto placentario comprende uno o más miembros que se eligen del grupo que consiste en: una proteína de matriz extracelular; un inhibidor de proteasa; un factor angiogénico; y un factor placentario que promueve la migracion de células epiteliales hacia la herida. Reivindicacion 19: El método de cualquiera de las reivindicaciones precedentes, caracterizado porque los factores placentarios comprenden uno o más inhibidores de proteasa que se eligen del grupo que consiste en metaloproteinasas de matriz (TIMP), alfa-2 macroglobulinas, y trombospondinas. Reivindicacion 21: El método de cualquiera de las reivindicaciones precedentes, caracterizado porque los factores placentarios comprenden uno o más factores angiogénicos que se eligen del grupo que consiste en VEGF y bFGF. Reivindicacion 24: El método de cualquiera de las reivindicaciones precedentes, caracterizado porque el producto placentario comprende uno o más factores que promueven la migracion de células epiteliales hacia la herida que se eligen del grupo que consiste en HGF y KGF. Reivindicacion 25: El método de cualquiera de las reivindicaciones precedentes, caracterizado porque las células de placenta se eligen del grupo que consiste en MSC, ESCs, células progenitoras de mesénquima derivadas de placenta, células madre mesenquimatosas de placenta, fibroblastos, células epiteliales, células mesenquimatosas de placenta, y macrofagos. Reivindicacion 28: El método de cualquiera de las reivindicaciones precedentes, caracterizado porque la dispersion placentaria es un homogenato.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33846410P | 2010-02-18 | 2010-02-18 | |
US33848910P | 2010-02-18 | 2010-02-18 | |
US36956210P | 2010-07-30 | 2010-07-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR080223A1 true AR080223A1 (es) | 2012-03-21 |
Family
ID=44476694
Family Applications (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP110100508A AR080221A1 (es) | 2010-02-18 | 2011-02-18 | Productos de membranas amnioticas inmunocompatibles |
ARP110100506A AR080219A1 (es) | 2010-02-18 | 2011-02-18 | Productos de membranas corionicas inmunocompatibles |
ARP110100509A AR080222A1 (es) | 2010-02-18 | 2011-02-18 | Productos terapeuticos que comprenden dispersiones placentarias vitalizadas |
ARP110100505A AR080218A1 (es) | 2010-02-18 | 2011-02-18 | Productos de membranas corionicas inmunocompatibles |
ARP110100510A AR080223A1 (es) | 2010-02-18 | 2011-02-18 | Productos terapeuticos que comprenden dispersiones placentarias vitalizadas |
ARP110100507A AR080220A1 (es) | 2010-02-18 | 2011-02-18 | Productos de membranas amnioticas inmunocompatibles |
Family Applications Before (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP110100508A AR080221A1 (es) | 2010-02-18 | 2011-02-18 | Productos de membranas amnioticas inmunocompatibles |
ARP110100506A AR080219A1 (es) | 2010-02-18 | 2011-02-18 | Productos de membranas corionicas inmunocompatibles |
ARP110100509A AR080222A1 (es) | 2010-02-18 | 2011-02-18 | Productos terapeuticos que comprenden dispersiones placentarias vitalizadas |
ARP110100505A AR080218A1 (es) | 2010-02-18 | 2011-02-18 | Productos de membranas corionicas inmunocompatibles |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP110100507A AR080220A1 (es) | 2010-02-18 | 2011-02-18 | Productos de membranas amnioticas inmunocompatibles |
Country Status (6)
Country | Link |
---|---|
US (25) | US20110212158A1 (es) |
EP (10) | EP3345998A1 (es) |
AR (6) | AR080221A1 (es) |
CA (7) | CA2790436A1 (es) |
ES (2) | ES2663720T3 (es) |
WO (6) | WO2011103451A1 (es) |
Families Citing this family (100)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2408207A (en) * | 2003-11-24 | 2005-05-25 | Johnson & Johnson Medical Ltd | Wound dressing for the controlled release of therapeutic agents comprising also an inhibitor of a protease enzyme & a linker group cleavable by such an enzyme |
EP1933852B1 (en) | 2005-09-27 | 2018-12-19 | TissueTech, Inc. | Amniotic membrane preparations and purified compositions and methods of use |
US8187639B2 (en) | 2005-09-27 | 2012-05-29 | Tissue Tech, Inc. | Amniotic membrane preparations and purified compositions and anti-angiogenesis treatment |
US8372437B2 (en) | 2006-08-17 | 2013-02-12 | Mimedx Group, Inc. | Placental tissue grafts |
DE102007007664B3 (de) | 2007-02-13 | 2008-03-27 | Mokveld Valves B.V. | Drosselventil |
EP3189731B1 (en) | 2007-09-07 | 2020-01-29 | MiMedx Group, Inc. | Placental tissue grafts and improved methods of preparing and using the same |
US9301679B2 (en) | 2007-11-01 | 2016-04-05 | Dignity Health | Method of detecting neurological disease |
US8721081B2 (en) | 2007-11-01 | 2014-05-13 | Dignity Health | Method of detecting neurological disease |
US9358320B2 (en) | 2008-04-25 | 2016-06-07 | Allosource | Multi-layer tissue patches |
US9480549B2 (en) | 2008-04-25 | 2016-11-01 | Allosource | Multi-layer tissue patches |
US9192695B2 (en) | 2008-11-20 | 2015-11-24 | Allosource | Allografts combined with tissue derived stem cells for bone healing |
WO2010101780A2 (en) * | 2009-03-04 | 2010-09-10 | Peytant Solutions, Inc. | Stents modified with material comprising amnion tissue and corresponding processes |
US20140286911A1 (en) | 2013-03-15 | 2014-09-25 | Allosource | Cell repopulated collagen matrix for soft tissue repair and regeneration |
EP3345998A1 (en) | 2010-02-18 | 2018-07-11 | Osiris Therapeutics, Inc. | Immunocompatible chorionic membrane products |
US9352003B1 (en) | 2010-05-14 | 2016-05-31 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
US8883210B1 (en) | 2010-05-14 | 2014-11-11 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
US20130156863A1 (en) * | 2010-06-30 | 2013-06-20 | Tissuetech, Inc. | Methods of preparing chorion tissue and products derived therefrom |
KR20240042159A (ko) | 2011-02-14 | 2024-04-01 | 미메딕스 그룹 인크. | 마이크로화된 태반 조직 조성물 및 이의 제조 및 사용 방법 |
AU2012217912B2 (en) | 2011-02-14 | 2016-02-11 | Mimedx Group Inc. | Laminated tissue grafts composed of Wharton's jelly and methods of making and using the same |
WO2012149486A1 (en) | 2011-04-28 | 2012-11-01 | Tissuetech, Inc. | Methods of modulating bone remodeling |
ES2822301T3 (es) | 2011-06-10 | 2021-04-30 | Tissuetech Inc | Métodos de procesamiento de tejidos de soporte fetal |
US8932805B1 (en) | 2011-10-31 | 2015-01-13 | BioDlogics, LLC | Birth tissue material and method of preparation |
US9162011B2 (en) | 2011-12-19 | 2015-10-20 | Allosource | Flowable matrix compositions and methods |
WO2013096659A1 (en) * | 2011-12-20 | 2013-06-27 | Cook General Biotechnology Llc | Methods and compositions for storage of animal cells |
US9416410B2 (en) * | 2012-02-14 | 2016-08-16 | Genetics Development Corporation | Cutoff point delta Ct. method for HER2 PCR testing in breast cancer |
US8961617B2 (en) | 2012-03-08 | 2015-02-24 | Liventa Bioscience, Inc. | Amnion and chorion constructs and uses thereof in abdominal surgery |
US20130236506A1 (en) * | 2012-03-08 | 2013-09-12 | AFcell Medical | Amnion and chorion constructs and uses thereof in ob-gyn surgery |
WO2014028657A1 (en) | 2012-08-15 | 2014-02-20 | Mimedx Group, Inc | Reinforced placental tissue grafts and methods of making and using the same |
US9943551B2 (en) | 2012-08-15 | 2018-04-17 | Mimedx Group, Inc. | Tissue grafts composed of micronized placental tissue and methods of making and using the same |
US8904664B2 (en) | 2012-08-15 | 2014-12-09 | Mimedx Group, Inc. | Dehydration device and methods for drying biological materials |
WO2014040026A2 (en) | 2012-09-10 | 2014-03-13 | Wake Forest University Health Sciences | Amniotic membrane and its use in wound healing and tissue engineering constructs |
US9180145B2 (en) | 2012-10-12 | 2015-11-10 | Mimedx Group, Inc. | Compositions and methods for recruiting and localizing stem cells |
US9155799B2 (en) | 2012-11-19 | 2015-10-13 | Mimedx Group, Inc. | Cross-linked collagen with at least one bound antimicrobial agent for in vivo release of the agent |
US8946163B2 (en) | 2012-11-19 | 2015-02-03 | Mimedx Group, Inc. | Cross-linked collagen comprising metallic anticancer agents |
US9662355B2 (en) | 2013-01-18 | 2017-05-30 | Mimedx Group, Inc. | Methods for treating cardiac conditions |
US10206977B1 (en) | 2013-01-18 | 2019-02-19 | Mimedx Group, Inc. | Isolated placental stem cell recruiting factors |
US9616093B2 (en) * | 2013-01-30 | 2017-04-11 | NuTech Medical, Inc. | Placental membrane preparation and methods of making and using same |
US20140212390A1 (en) * | 2013-01-30 | 2014-07-31 | NuTech Medical, Inc. | Placental Membrane Preparation and Methods of Making and Using Same |
EP2951289B1 (en) * | 2013-01-30 | 2019-10-02 | Nutech Medical, Inc. | Placental membrane preparation and methods of making and using same |
US9770472B1 (en) * | 2013-03-08 | 2017-09-26 | Brahm Holdings, Llc | Organ jacket and methods of use |
US11077229B1 (en) | 2013-03-08 | 2021-08-03 | BioDlogics, LLC | Implant coating composition and method of use |
US9446077B2 (en) | 2013-03-13 | 2016-09-20 | Allosource | Fascia fibrous compositions and methods for their use and manufacture |
EP2956825B1 (en) | 2013-03-15 | 2020-06-24 | Apple Inc. | Facilitating transactions with a user account using a wireless device |
US10029030B2 (en) | 2013-03-15 | 2018-07-24 | Mimedx Group, Inc. | Molded placental tissue compositions and methods of making and using the same |
US10039792B1 (en) | 2013-03-16 | 2018-08-07 | Brahm Holdings, Llc | Methods for the treatment of inflammation and pain using human birth tissue material composition |
US10555897B1 (en) | 2013-03-16 | 2020-02-11 | Brahm Holdings Llc | Cosmetic composition and methods of treatment |
US9993506B1 (en) | 2013-03-16 | 2018-06-12 | BioDlogics, Inc. | Methods for the treatment of degenerative disc diseases by human birth tissue material composition |
US9795639B1 (en) | 2013-03-16 | 2017-10-24 | BioDlogics, LLC | Methods for the treatment of erectile dysfunction by human birth tissue material compostion |
US9446142B2 (en) | 2013-05-28 | 2016-09-20 | Mimedx Group, Inc. | Polymer chelator conjugates |
EP3004328A4 (en) * | 2013-05-30 | 2016-12-07 | Cells For Cells | MESENCHYMAL STEM CELLS OF CHORIONIC ORIGIN, CONDITIONED MEDIUM AS AN ANGIOGENESIS INDUCER AND USE THEREOF FOR TREATMENT OF CARDIAC DEGENERATION |
JP6512759B2 (ja) | 2013-08-19 | 2019-05-15 | 国立研究開発法人国立循環器病研究センター | 羊膜間葉系細胞組成物の製造方法及び凍結保存方法、並びに治療剤 |
JP6756612B2 (ja) | 2013-08-30 | 2020-09-16 | ミメディクス グループ インコーポレイテッド | キレーターを含む微粒子化した胎盤性組成物 |
CN104560862B (zh) * | 2013-10-14 | 2019-09-13 | 佛教慈济医疗财团法人 | 分离脂肪组织活细胞方法、医药组合物及其用途、细胞库 |
KR102161901B1 (ko) | 2013-12-06 | 2020-10-05 | 알로소스 | 조직의 시트를 건조하는 방법 |
AU2015206236B2 (en) * | 2014-01-17 | 2020-02-20 | Mimedx Group, Inc. | Method for inducing angiogenesis |
US9856454B2 (en) | 2014-02-27 | 2018-01-02 | Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation | Rapid mincing of adipose tissues to isolate live cells in vitro |
KR20160149292A (ko) * | 2014-05-07 | 2016-12-27 | 오시리스 쎄라퓨틱스, 인크. | 면역적합성 융모막 생성물 |
EP3139936A4 (en) * | 2014-05-07 | 2017-11-15 | Osiris Therapeutics, Inc. | Immunocompatible amniotic membrane products |
JP2017514876A (ja) * | 2014-05-07 | 2017-06-08 | オシリス セラピューティクス,インコーポレイテッド | 治療用胎盤組成物、その製造法及び使用法 |
TW201603818A (zh) | 2014-06-03 | 2016-02-01 | 組織科技股份有限公司 | 組成物及方法 |
EP3185918B1 (en) | 2014-08-28 | 2021-08-18 | MiMedx Group, Inc. | Collagen reinforced tissue grafts |
EP3193953B1 (en) | 2014-09-19 | 2020-03-11 | Osiris Therapeutics, Inc. | Bone repair product and methods of use thereof |
US20160095307A1 (en) * | 2014-10-07 | 2016-04-07 | NuTech Medical, Inc. | Method and composition for hypothermic storage of placental tissue |
US10201573B1 (en) | 2014-10-27 | 2019-02-12 | Brahm Holdings, Llc | Human birth tissue material composition and methods for the treatment of damage associated with a cerebral vascular accident |
US10265438B1 (en) | 2014-11-03 | 2019-04-23 | BioDlogics, LLC | Methods and compositions for the repair and replacement of connective tissue |
US10765705B2 (en) | 2014-11-24 | 2020-09-08 | Prime Merger Sub, Llc | Visco-supplement compositions, and methods of use thereof |
WO2016109826A1 (en) * | 2014-12-31 | 2016-07-07 | Applied Biologics, Llc | Standardized amniotic membrane tissue graft |
TW201642914A (zh) | 2015-02-23 | 2016-12-16 | 組織科技股份有限公司 | 用於治療眼部疾病及失調的裝置及方法 |
TWI720984B (zh) | 2015-05-20 | 2021-03-11 | 美商帝聖工業公司 | 用於防止上皮細胞增生及上皮-間質轉移之組合物及方法 |
EP3334441B1 (en) * | 2015-08-13 | 2021-06-16 | Kamada Ltd. | Compositions derived from cohn fraction paste and use thereof |
KR20180095913A (ko) * | 2015-12-23 | 2018-08-28 | 라이프넷 헬스 | 탈세포화된 태반막 및 이의 제조 방법 및 용도 |
WO2017120371A1 (en) * | 2016-01-08 | 2017-07-13 | Cryolife, Inc. | Human placental tissue graft products, methods, and apparatuses |
TW201733600A (zh) | 2016-01-29 | 2017-10-01 | 帝聖工業公司 | 胎兒扶持組織物及使用方法 |
DK3429689T3 (da) | 2016-03-14 | 2022-01-31 | Plakous Therapeutics Inc | Acellulære placentapræparater |
US11318168B2 (en) | 2016-06-24 | 2022-05-03 | Osiris Therapeutics, Inc. | Human tissue derived compositions and uses thereof |
US20180104282A1 (en) * | 2016-06-24 | 2018-04-19 | Osiris Therapeutics, Inc. | Viable lyophilized compositions derived from human tissues and methods of making the same |
US10271942B2 (en) | 2016-08-24 | 2019-04-30 | Arthrex, Inc. | Tissue use for repair of injury |
US10772986B2 (en) | 2017-01-26 | 2020-09-15 | Allosource | Fascia fibrous compositions and methods for their use and manufacture |
US10960028B2 (en) | 2017-02-01 | 2021-03-30 | Plakous Therapeutics, Inc. | Placental tissue compositions |
CN106834257B (zh) * | 2017-03-23 | 2020-06-30 | 天晴干细胞股份有限公司 | 一种分离胎盘间充质干细胞混合酶及其分离方法 |
WO2018211498A1 (en) | 2017-05-15 | 2018-11-22 | Stem Cell Medicine Ltd. | Treatment of multiple sclerosis with adipose-derived stem cells |
AU2017414803A1 (en) | 2017-05-15 | 2019-12-05 | Mapi Pharma Ltd. | Treatment of multiple sclerosis with long acting glatiramer and adipose-derived stem cells |
CN107254431B (zh) * | 2017-05-25 | 2020-08-18 | 林翠霞 | 一种新型组织工程皮肤制备方法 |
CN107296041B (zh) * | 2017-07-02 | 2020-12-25 | 江西瑞济生物工程技术股份有限公司 | 一种新鲜羊膜保存液及新鲜羊膜保存方法与应用 |
JP2021502814A (ja) | 2017-11-14 | 2021-02-04 | クック・バイオテック・インコーポレイテッドCook Biotech Incorporated | 保存組織製品および関連する方法 |
CN107779429A (zh) * | 2017-12-07 | 2018-03-09 | 陕西九州生物医药科技集团有限公司 | 一种人皮肤组织来源成纤维细胞快速分离培养方法 |
CN109652363A (zh) * | 2018-11-13 | 2019-04-19 | 广东唯泰生物科技有限公司 | 胎盘壁蜕膜间充质干细胞分化为子宫内膜上皮细胞的方法 |
US11511017B2 (en) | 2019-03-12 | 2022-11-29 | Arthrex, Inc. | Ligament reconstruction |
CN110144322A (zh) * | 2019-04-15 | 2019-08-20 | 湖南南华爱世普林生物技术有限公司 | 一种胎盘间充质干细胞快速分离与培养至收获冻存的方法 |
EP3955940A4 (en) * | 2019-04-16 | 2023-01-04 | Lifenet Health | PRODUCTS DERIVED FROM GENITAL TISSUES AND PREPARATION AND USES THEREOF |
CN110141686B (zh) * | 2019-05-07 | 2021-11-02 | 吉林省海创生物科技有限公司 | 一种人脐带间充质干细胞注射液及其面部填充注射方法 |
CN110179679A (zh) * | 2019-06-25 | 2019-08-30 | 贵州医科大学 | 含脐带间充质干细胞培养液提取物的生物养颜修护面膜精华、面膜及其制备方法 |
WO2021003257A1 (en) * | 2019-07-01 | 2021-01-07 | Auxocell Laboratories, Inc. | Methods and compositions for collecting and using placental tissue cells and placental blood cells |
WO2021123320A1 (en) * | 2019-12-20 | 2021-06-24 | Dr. Kalali Prof. Mostafazadeh Dipl. Ing. Miedl (Kmm) Gesellschaft Bürgerlichen Rechts | A composition and its use for a universal therapy against tumor cells |
EP4117626A1 (en) * | 2020-03-12 | 2023-01-18 | Osiris Therapeutics, Inc. | Human tissue derived compositions and uses thereof |
WO2022074523A1 (en) | 2020-10-06 | 2022-04-14 | Osiris Therapeutics, Inc. | Primed placental tissue and uses in regenerative medicine |
US20230301786A1 (en) | 2020-11-06 | 2023-09-28 | Smith & Nephew, Inc. | Graft composite for hip labrum reconstruction |
KR102523933B1 (ko) * | 2021-05-03 | 2023-04-20 | 고려대학교 산학협력단 | 융모막 추출물로부터 분리된 엑소좀을 유효성분으로 포함하는 골형성 촉진용 약학적 조성물 |
WO2023150544A1 (en) * | 2022-02-01 | 2023-08-10 | Seattle Children's Hospital D/B/A Seattle Children's Research Institute | Simplified method of preparing cells for patient administration |
WO2024020135A1 (en) * | 2022-07-21 | 2024-01-25 | Biostem Technologies, Inc. | Collection and quantification of elements per square centimeter in a human placental membrane allograft |
Family Cites Families (69)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8803697D0 (en) | 1988-02-17 | 1988-03-16 | Deltanine Research Ltd | Clinical developments using amniotic membrane cells |
US5891617A (en) * | 1993-09-15 | 1999-04-06 | Organogenesis Inc. | Cryopreservation of harvested skin and cultured skin or cornea equivalents by slow freezing |
US6152142A (en) | 1997-02-28 | 2000-11-28 | Tseng; Scheffer C. G. | Grafts made from amniotic membrane; methods of separating, preserving, and using such grafts in surgeries |
EP1272119B1 (en) | 2000-02-11 | 2010-11-24 | The General Hospital Corporation | Photochemical tissue bonding |
US7582292B2 (en) * | 2000-02-26 | 2009-09-01 | Artecel, Inc. | Adipose tissue derived stromal cells for the treatment of neurological disorders |
US20020039788A1 (en) | 2000-02-29 | 2002-04-04 | Isseroff Roslyn R. | Corneal epithelial graft composites |
US7504374B2 (en) * | 2000-10-24 | 2009-03-17 | Warsaw Orthopedic, Inc. | Method for inducing deposition and maturation of bone comprising a co-therapeutic regimen of LMP-1 and BMP-2 |
US20080152629A1 (en) | 2000-12-06 | 2008-06-26 | James Edinger | Placental stem cell populations |
CA2437957C (en) | 2001-02-14 | 2014-04-22 | Robert J. Hariri | Renovation and repopulation of decellularized tissues and cadaveric organs by stem cells |
NZ527849A (en) * | 2001-02-14 | 2006-09-29 | Anthrogenesis Corp | Post-partum mammalian placenta, its use and placental stem cells therefrom |
EP1390077B1 (en) * | 2001-05-02 | 2014-07-16 | Purdue Research Foundation | Treatment and diagnosis of macrophage mediated disease |
US8021876B2 (en) * | 2001-11-15 | 2011-09-20 | Children's Medical Center Corporation | Methods of isolation, expansion and differentiation of fetal stem cells from chorionic villus, amniotic fluid, and placenta and therapeutic uses thereof |
US20070134261A1 (en) * | 2001-12-03 | 2007-06-14 | Hancock Robert E | Effectors of innate immunity |
US20030187515A1 (en) | 2002-03-26 | 2003-10-02 | Hariri Robert J. | Collagen biofabric and methods of preparing and using the collagen biofabric |
AU2003239159A1 (en) * | 2002-04-19 | 2003-11-03 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Placental derived stem cells and uses thereof |
AU2003269268A1 (en) * | 2002-10-09 | 2004-05-04 | Lorantis Limited | Modulation of immune function |
US7993922B2 (en) * | 2002-10-18 | 2011-08-09 | Reliance Life Sciences Pvt. Ltd. | Three-dimensional tissue equivalent using macromass culture |
EP1660642A4 (en) * | 2003-06-16 | 2006-12-20 | Zephan Biopharmaceuticals Inc | METHODS FOR PREPARING A TRANSPLANTABLE PRODUCT FOR THE TREATMENT OF SKIN DEFECTS |
WO2006071794A2 (en) * | 2004-12-23 | 2006-07-06 | Ethicon Incorporated | Postpartum cells derived from umbilical cord tissue, and methods of making and using the same |
JP5148873B2 (ja) * | 2003-06-27 | 2013-02-20 | エチコン、インコーポレイテッド | 臍帯組織由来の分娩後細胞、及びその作成及び使用方法 |
WO2005021014A1 (fr) | 2003-09-03 | 2005-03-10 | Jiuchang Miao | Preparation d'un amnios biologique conservable a temperature ambiante |
ATE464855T1 (de) * | 2004-03-31 | 2010-05-15 | Cook Inc | Transplantatmaterial und gefässprothese mit extrazellulärer kollagenmatrix und dessen herstellungsverfahren |
US7280326B2 (en) * | 2004-07-30 | 2007-10-09 | Hitachi Global Storage Technologies Netherlands B.V. | Trilayer SAF with current confining layer |
PL369552A1 (pl) | 2004-08-12 | 2006-02-20 | Sgp & Sons Ab | Preparat farmaceutyczny lub/i żywieniowy lub/i laboratoryjny wzmagający, wspomagający funkcjonowanie komórek nerwowych i układu nerwowego oraz zastosowanie preparatu farmaceutycznego lub/i żywieniowego w procesie ochrony funkcji układu nerwowego oraz zastosowanie preparatu do ochrony wzrostu stymulacji namnażania i zapobiegania apoptozie komórek nerwowych |
US20060111778A1 (en) | 2004-10-29 | 2006-05-25 | Michalow Alexander E | Methods of promoting healing of cartilage defects and method of causing stem cells to differentiate by the articular chondrocyte pathway |
WO2006051538A2 (en) * | 2004-11-10 | 2006-05-18 | Hadasit Medical Research Services And Development Ltd. | Cells isolated from placenta, device for isolating same, and uses thereof |
US20060182724A1 (en) * | 2005-02-15 | 2006-08-17 | Riordan Neil H | Method for expansion of stem cells |
WO2006094247A2 (en) * | 2005-03-02 | 2006-09-08 | Tissuetech, Inc. | Amniotic membrane extracts, compositions thereof, and methods of use |
US20070015278A1 (en) * | 2005-04-13 | 2007-01-18 | Yuling Li | Methods of isolating differentiable cells from placental-associated tissue and uses thereof |
WO2007009062A2 (en) | 2005-07-13 | 2007-01-18 | Anthrogenesis Corporation | Treatment of leg ulcers using placenta derived collagen biofabric |
WO2007011693A2 (en) * | 2005-07-14 | 2007-01-25 | Medistem Laboratories, Inc. | Compositions of placentally-derived stem cells for the treatment of cancer |
GB0514567D0 (en) * | 2005-07-15 | 2005-08-24 | Univ Nottingham | Surgical membrane |
WO2007023750A1 (ja) | 2005-08-26 | 2007-03-01 | National University Corporation University Of Toyama | 乾燥羊膜及び羊膜の乾燥処理方法 |
EP1933852B1 (en) * | 2005-09-27 | 2018-12-19 | TissueTech, Inc. | Amniotic membrane preparations and purified compositions and methods of use |
CA2624916A1 (en) * | 2005-10-13 | 2007-04-26 | Anthrogenesis Corporation | Production of oligodendrocytes from placenta-derived stem cells |
JP2009521930A (ja) * | 2005-12-29 | 2009-06-11 | アントフロゲネシス コーポレーション | 胎盤幹細胞及び第2供給源由来幹細胞の共存培養 |
KR20190104428A (ko) * | 2005-12-29 | 2019-09-09 | 안트로제네시스 코포레이션 | 태반 줄기 세포 집단 |
US8871198B2 (en) * | 2006-03-29 | 2014-10-28 | Stemnion, Inc. | Methods related to wound healing |
US20070178159A1 (en) * | 2006-01-30 | 2007-08-02 | Alza Corporation | In-Situ Forming Porous Scaffold |
US20080064098A1 (en) * | 2006-06-05 | 2008-03-13 | Cryo-Cell International, Inc. | Procurement, isolation and cryopreservation of maternal placental cells |
JP2009539378A (ja) * | 2006-06-09 | 2009-11-19 | アントフロゲネシス コーポレーション | 胎盤環境及び幹細胞を培養するためのその使用 |
US8105634B2 (en) * | 2006-08-15 | 2012-01-31 | Anthrogenesis Corporation | Umbilical cord biomaterial for medical use |
US8372437B2 (en) | 2006-08-17 | 2013-02-12 | Mimedx Group, Inc. | Placental tissue grafts |
WO2008042441A1 (en) * | 2006-10-03 | 2008-04-10 | Anthrogenesis Corporation | Use of umbilical cord biomaterial for ocular surgery |
US8071135B2 (en) * | 2006-10-04 | 2011-12-06 | Anthrogenesis Corporation | Placental tissue compositions |
MX354253B (es) * | 2006-10-06 | 2018-02-20 | Anthrogenesis Corp | Composiciones de colageno placentario (telopeptido), natural. |
CN104099290A (zh) | 2006-10-23 | 2014-10-15 | 人类起源公司 | 用胎盘细胞群治疗骨缺损的方法和组合物 |
SI2120977T1 (sl) * | 2007-02-12 | 2014-01-31 | Anthrogenesis Coroporation | Zdravljenje vnetnih bolezni z uporabo placentarnih matičnih celic |
EP2133105A4 (en) | 2007-02-23 | 2012-12-19 | Nat Univ Corp Univ Toyama | MEDICAL REPLACEMENT MEMBRANE, USE THEREOF, AND METHOD FOR REPAIRING MEMBRANE TISSUE IN LIVING BODY |
KR20080104844A (ko) * | 2007-05-29 | 2008-12-03 | 포천중문의과대학교 산학협력단 | 태반-유래 영양막 줄기 세포의 분리방법 |
EP2014767A1 (en) * | 2007-06-15 | 2009-01-14 | Centro di Ricerca E. Menni | T cell immunomodulation by placenta cell preparations |
CA2688504A1 (en) * | 2007-06-18 | 2008-12-24 | Children's Hospital & Research Center At Oakland | Method of isolating stem and progenitor cells from placenta |
RU2010116271A (ru) * | 2007-09-26 | 2011-11-10 | Селджин Селльюлар Терапьютикс (Us) | Ангиогенные клетки из плацентарного перфузата человека |
WO2009045360A2 (en) * | 2007-09-28 | 2009-04-09 | Celgene Cellular Therapeutics | Tumor suppression using human placental perfusate and human placenta-derived intermediate natural killer cells |
WO2009044408A1 (en) | 2007-10-03 | 2009-04-09 | International Centre For Cardio Thoracic And Vascular Diseases (A Unit Of Frontier Lifeline Pvt. Ltd) | A treated amniotic membrane and method of treating amniotic membrane |
AU2008343203B2 (en) * | 2007-12-27 | 2014-07-10 | DePuy Synthes Products, LLC | Treatment of intervertebral disc degeneration using human umbilical cord tissue-derived cells |
AU2009228056B2 (en) | 2008-03-27 | 2015-03-12 | Biolife Solutions, Inc. | Materials and methods for hypothermic collection of whole blood |
KR20110013419A (ko) | 2008-04-25 | 2011-02-09 | 알로소스 | 가공된 양막 조직을 포함하는 유착 방지 배리어 상처 드레싱 및 이를 사용하는 방법 |
US8828376B2 (en) * | 2008-08-20 | 2014-09-09 | Anthrogenesis Corporation | Treatment of stroke using isolated placental cells |
WO2011074208A1 (ja) | 2009-12-18 | 2011-06-23 | 国立大学法人東北大学 | 皮膚真皮又は羊膜透明化による角膜移植材料調製法 |
EP3345998A1 (en) | 2010-02-18 | 2018-07-11 | Osiris Therapeutics, Inc. | Immunocompatible chorionic membrane products |
US20150010609A1 (en) | 2010-02-18 | 2015-01-08 | Osiris Therapeutics, Inc. | Immunocompatible chorionic membrane products |
US20150010610A1 (en) | 2010-02-18 | 2015-01-08 | Osiris Therapeutics, Inc. | Immunocompatible amniotic membrane products |
US20150010506A1 (en) | 2010-02-18 | 2015-01-08 | Osiris Therapeutics, Inc. | Therapeutic placental compositions, methods of making and methods of use |
US8632512B2 (en) | 2010-04-09 | 2014-01-21 | Kci Licensing, Inc. | Apparatuses, methods, and compositions for the treatment and prophylaxis of chronic wounds |
JP2014115445A (ja) | 2012-12-10 | 2014-06-26 | Funai Electric Co Ltd | 光学装置 |
EP3139936A4 (en) | 2014-05-07 | 2017-11-15 | Osiris Therapeutics, Inc. | Immunocompatible amniotic membrane products |
JP2017514876A (ja) | 2014-05-07 | 2017-06-08 | オシリス セラピューティクス,インコーポレイテッド | 治療用胎盤組成物、その製造法及び使用法 |
KR20160149292A (ko) | 2014-05-07 | 2016-12-27 | 오시리스 쎄라퓨틱스, 인크. | 면역적합성 융모막 생성물 |
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