AR075868A1 - 2-acetamido-5-aril-1,2,4-triazolonas sustituidas y su uso - Google Patents

2-acetamido-5-aril-1,2,4-triazolonas sustituidas y su uso

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Publication number
AR075868A1
AR075868A1 ARP100100847A ARP100100847A AR075868A1 AR 075868 A1 AR075868 A1 AR 075868A1 AR P100100847 A ARP100100847 A AR P100100847A AR P100100847 A ARP100100847 A AR P100100847A AR 075868 A1 AR075868 A1 AR 075868A1
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AR
Argentina
Prior art keywords
alkyl
represents hydrogen
cycloalkyl
substituted
trifluoromethyl
Prior art date
Application number
ARP100100847A
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English (en)
Inventor
Chantal Fuerstner
Joerg Keldenich
Peter Kolkhof
Ulf Brueggemeier
Volver Geib
Axel Kretschmer
Armin Kern
Martina Delbeck
Elisabeth Pook
Carsten Schmeck
Hubert Truebel
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Bayer Schering Pharma Ag
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Publication date
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of AR075868A1 publication Critical patent/AR075868A1/es

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    • C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
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Abstract

La presente se refiere a procedimientos para su preparacion, a su uso solas o en combinaciones para el tratamiento y/o la prevencion de enfermedades, así como a su uso para la preparacion de medicamentos para el tratamiento y/o la prevencion de enfermedades, en particular para el tratamiento y/o la prevencion de enfermedades cardiovasculares. Reivindicacion 1: Compuesto de la formula (1) en la que A representa -C(R6AR6B)-* o -C(R6AR6B)-C(R7AR7B)-*, donde * representa el sitio de union a R3, R6A representa hidrogeno, alquilo C1-4 o trifluorometilo; R6B representa hidrogeno o alquilo C1-4; R7A representa hidrogeno, alquilo C1-4 o trifluorometilo; R7B representa hidrogeno o alquilo C1-4; Q representa CH o N; R1 representa alquilo C1-6, alquenilo C2-6, alquinilo C2-6 o cicloalquilo C3-7, pudiendo estar sustituidos el alquilo C1-6, el alquenilo C2-6 y el alquinilo C2-6 con 1 a .3 sustituyentes seleccionados independientemente unos de otros del grupo deuterio, halogeno, ciano, oxo, hidroxilo, trifluorometilo, cicloalquilo C3-7, alcoxi C1-6, trifluorometoxi y fenilo, pudiendo estar sustituido el cicloalquilo C3-7 con 1 o 2 sustituyentes seleccionados independientemente uno de otro del grupo alquilo C1-4, oxo, hidroxilo, alcoxi C1-4 y amino, y pudiendo estar sustituido el alcoxi C1-6 con 1 o 2 sustituyentes seleccionados independientemente uno de otro del grupo amino, hidroxilo, alcoxi C1-4, hidroxicarbonilo y alcoxicarbonilo C1-4 y pudiendo estar sustituido el fenilo con 1 a 3 sustituyentes seleccionados independientemente unos de otros del grupo halogeno, ciano, nitro, alquilo C1-4, trifluorometilo, hidroxilo, hidroximetilo, alcoxi C1-4, trifluorometoxi, alcoxi C1-4-metilo, hidroxicarbonilo, alcoxi C1-4-carbonilo, aminocarbonilo, monoalquil C1-4-aminocarbonilo y dialquil C1-4-aminocarbonilo, y pudiendo estar sustituido el cicloalquilo C3-7 con 1 o 2 sustituyentes seleccionados independientemente uno de otro del grupo fluor, alquilo C1-4, alcoxi C1-4, hidroxilo, amino y oxo, R2 representa benzotienilo, fenilo, tienilo o furilo, pudiendo estar sustituidos el benzotienilo, el fenilo, el tienilo y el furilo con 1 a 3 sustituyentes seleccionados independientemente unos de otros del grupo halogeno, ciano, nitro, alquilo C1-4, trifluorometilo, hidroxi, alcoxi C1-4 y trifluorometoxi, R3 representa trifluorometilo, hidroxilo, trifluorometoxi, alcoxi C1-4, cicloalcoxi C3-7, nitro, amino, NR8-C(=O)-R9, -NR10-SO2-R11, -SO2-NR12R13, -O-C(=O)-NR14R15, -NR16-C(=O)NR17R18, -NR19-C(=O)-OR20; -S(=O)R21, -O-SO2-NR24R25, -NR26-SO2-NR27R28 o -NR30R31 donde R8 representa hidrogeno o alquilo C1-4, R9 representa hidrogeno, alquilo C1-4 o cicloalquilo C3-7 o R8 y R9 conjuntamente con los átomos a los que están unidos, forman un heterociclo de 5 a 7 miembros pudiendo estar sustituido el heterociclo de 5 a 7 miembros con 1 o 2 sustituyentes seleccionados independientemente uno de otro del grupo fluor, alquilo C1-4 y trifluorometilo, R10 representa hidrogeno o alquilo C1-4, R11 representa alquilo C1-4 o cicloalquilo C3-7; o R10 y R11 conjuntamente con los átomos a los que están unidos, forman un heterociclo de 5 a 7 miembros, pudiendo estar sustituido el heterociclo de 5 a 7 miembros con 1 o 2 sustituyentes seleccionados independientemente uno de otro del grupo fluor, alquilo C1-4 y trifluorometilo, R12 representa hidrogeno, alquilo C1-4 o cicloalquilo C3-7; R13 representa hidrogeno, alquilo C1-4 o cicloalquilo C3-7; o R12 y R13 conjuntamente con el átomo de nitrogeno al que están unidos, forman un heterociclo de 4 a 7 miembros, pudiendo estar sustituido el heterociclo de 4 a 7 miembros con 1 o 2 sustituyentes seleccionados independientemente uno de otro del grupo fluor, oxo, hidroxilo, alquilo C1-4 y trifluorometilo, R14 representa hidrogeno, alquilo C1-4 o cicloalquilo C3-7, R15 representa hidrogeno, alquilo C1-4 o cicloalquilo C3-7, o R14 y R15 conjuntamente con el átomo de nitrogeno al que están unidos, forman un heterociclo de 4 a 7 miembros pudiendo estar sustituido el heterociclo de 4 a 7 miembros con 1 o 2 sustituyentes seleccionados independientemente uno de otro del grupo fluor, oxo, hidroxilo, alquilo C1-4 y trifluorometilo, R16 representa hidrogeno o alquilo C1-4, R17 representa hidrogeno, alquilo C1-4 o cicloalquilo C3-7, R18 representa hidrogeno, alquilo C1-4 o cicloalquilo C3-7, o R16 y R17 conjuntamente con los átomos de nitrogeno a los que están unidos, forman un heterociclo de 5 a 7 miembros, pudiendo estar sustituido el heterociclo de 5 a 7 miembros con 1 o 2 sustituyentes seleccionados independientemente uno de otro del grupo fluor, trifluorometilo y alquilo C1-4, o R17 y R18 conjuntamente con el átomo de nitrogeno al que están unidos, forman un heterociclo de 4 a 7 miembros,. pudiendo estar sustituido el heterociclo de 4 a 7 miembros con 1 o 2 sustituyentes seleccionados independientemente uno de otro del grupo fluor, oxo, hidroxilo, alquilo C1-4 y trifluorometilo, R19 representa hidrogeno o alquilo C1-4, R20 representa alquilo C1-4 o cicloalquilo C3-7, R19 y R20 conjuntamente con los átomos a los que están unidos, forman un heterociclo de 5 a 7 miembros pudiendo estar sustituido el heterociclo de 5 a 7 miembros con 1 o 2 sustituyentes seleccionados independientemente uno de otro del grupo fluor, alquilo C1-4 y trifluorometilo, n representa el numero 0, 1 o 2, R21 representa hidrogeno, alquilo C1-4 o cicloalquilo C3-7, R24 representa hidrogeno, alquilo C1-4 o cicloalquilo C3-7, R25 representa hidrogeno, alquilo C1-4 o cicloalquilo C3-7, o R24 y R25 conjuntamente con el átomo de nitrogeno al que están unidos, forman un heterociclo de 4 a 7 miembros, pudiendo estar sustituido el heterociclo de 4 a 7 miembros con 1 o 2 sustituyentes seleccionados independientemente uno de otro del grupo fluor, oxo, hidroxilo, alquilo C1-4 y trifluorometilo, R26 representa hidrogeno o alquilo C1-4; R27 representa hidrogeno, alquilo C1-4 o cicloalquilo C3-7, R28 representa hidrogeno, alquilo C1-4 o cicloalquilo C3-7, o R26 y R27 conjuntamente con los átomos de nitrogeno a los que están unidos, forman un heterociclo de 5 a 7 miembros, pudiendo estar sustituido el heterociclo de 5 a 7 miembros con 1 o 2 sustituyentes seleccionados independientemente uno de otro del grupo fluor, trifluorometilo y alquilo C1-4, o R27 y R28 conjuntamente con el átomo de nitrogeno al que están unidos, forman un heterociclo de 4 a 7 miembros, pudiendo estar sustituido el heterociclo de 4 a 7 miembros con 1 o 2 sustituyentes seleccionados independientemente uno de otro del grupo fluor, oxo, hidroxilo y alquilo C1-4, R30 representa hidrogeno, alquilo C1-4 o cicloalquilo C3-7, R31 representa alquilo C1-4 o cicloalquilo C3-7, o R30 y R31 conjuntamente con el átomo de nitrogeno al que están unidos, forman un heterociclo de 4 a 7 miembros, pudiendo estar sustituido el heterociclo de 4 a 7 miembros con 1 o 2 sustituyentes seleccionados independientemente uno de otro del grupo fluor, oxo, hidroxilo, alquilo C1-4 y trifluorometilo, R4 representa fenilo, naftilo o un heteroarilo de 5 a 10 miembros, pudiendo estar sustituidos el fenilo, el naftilo y el heteroarilo de 5 a 10 miembros con 1 a 3 sustituyentes seleccionados independientemente unos de otros del grupo halogeno, ciano, nitro, alquilo C1-4, difluorometilo, trifluorometilo, hidroxilo, alcoxi C1-4, difluorometoxi y trifluorometoxi, R5 representa hidrogeno, deuterio, trifluorometilo o alquilo C1-4, R29 representa hidrogeno o alquilo C1-4, y sus sales, solvatos y solvatos de las sales.
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Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006024024A1 (de) * 2006-05-23 2007-11-29 Bayer Healthcare Aktiengesellschaft Substituierte Arylimidazolone und -triazolone sowie ihre Verwendung
DE102008060967A1 (de) 2008-12-06 2010-06-10 Bayer Schering Pharma Aktiengesellschaft Substituierte Phenylsulfonyltriazolone und ihre Verwendung
DE102010001064A1 (de) 2009-03-18 2010-09-23 Bayer Schering Pharma Aktiengesellschaft Substituierte 2-Acetamido-5-Aryl-1,2,4-triazolone und deren Verwendung
DE102009028929A1 (de) * 2009-08-27 2011-07-07 Bayer Schering Pharma Aktiengesellschaft, 13353 Heterocyclisch-substituierte 2-Acetamido-5-Aryl-1,2,4-triazolone und deren Verwendung
ES2635340T3 (es) 2010-02-27 2017-10-03 Bayer Intellectual Property Gmbh Ariltriazolonas ligadas a bis-arilo y su uso
DE102010040187A1 (de) 2010-09-02 2012-03-08 Bayer Schering Pharma Aktiengesellschaft Substituierte N-Phenethyl-triazolonacetamide und ihre Verwendung
DE102010040924A1 (de) 2010-09-16 2012-03-22 Bayer Schering Pharma Aktiengesellschaft Substituierte Phenylacet- und Phenylpropanamide und ihre Verwendung
ES2712886T3 (es) 2014-09-24 2019-05-16 Bayer Pharma AG Derivados de piridobenzazepina y piridobenzazocina que inhiben el factor XIa
US20170313665A1 (en) 2014-11-03 2017-11-02 Bayer Pharma Aktiengesellschaft Hydroxyalkyl-substituted phenyltriazole derivatives and uses thereof
WO2017191114A1 (en) 2016-05-03 2017-11-09 Bayer Aktiengesellschaft Hydroxyalkyl-substituted heteroaryltriazole derivatives and uses thereof
EP3452469A1 (en) 2016-05-03 2019-03-13 Bayer Pharma Aktiengesellschaft Fluoroalkyl-substituted aryltriazole derivatives and uses thereof
EP3452457B1 (en) 2016-05-03 2020-03-18 Bayer Pharma Aktiengesellschaft Oxoalkyl-substituted phenyltriazole derivatives and uses thereof
WO2017191117A1 (en) 2016-05-03 2017-11-09 Bayer Pharma Aktiengesellschaft V1a receptor antagonists for use in the treatment of renal diseases
US9988367B2 (en) 2016-05-03 2018-06-05 Bayer Pharma Aktiengesellschaft Amide-substituted pyridinyltriazole derivatives and uses thereof
WO2017191105A1 (en) 2016-05-03 2017-11-09 Bayer Pharma Aktiengesellschaft Amide-substituted aryltriazole derivatives and uses thereof
AR108265A1 (es) 2016-05-03 2018-08-01 Bayer Pharma AG Derivados de feniltriazol sustituidos con amida y usos de estos
JOP20170103A1 (ar) * 2016-05-03 2017-11-03 Bayer Pharma AG عملية لتحضير مشتقات 1-فنيل-1، 2، 4-تريازول مستبدلة بـ 5-هيدروكسي ألكيل
CA3030204A1 (en) 2016-07-11 2018-01-18 Bayer Pharma Aktiengesellschaft 7-substituted 1-pyridyl-naphthyridine-3-carboxylic acid amides and use thereof
JOP20190045A1 (ar) 2016-09-14 2019-03-14 Bayer Ag مركبات أميد حمض 1- أريل-نفثيريدين-3-كربوكسيليك مستبدلة في الموضع 7 واستخدامها.
EP3296298A1 (de) 2016-09-14 2018-03-21 Bayer Pharma Aktiengesellschaft 7-substituierte 1-aryl-naphthyridin-3-carbonsäureamide und ihre verwendung
JOP20190080A1 (ar) 2016-10-14 2019-04-11 Bayer Pharma AG مركبات مشتقة من 6-(1h-بيرازول-1-يل) بيريميدين-4- أمين مستبدل واستخداماتها
US10927098B2 (en) 2016-10-20 2021-02-23 Bayer Pharma Aktiengesellschaft Hydroxyalkyl-substituted triazole derivatives and uses thereof
EP3700900A1 (en) 2017-10-24 2020-09-02 Bayer Aktiengesellschaft Substituted triazole derivatives and uses thereof
WO2019081302A1 (en) 2017-10-24 2019-05-02 Bayer Pharma Aktiengesellschaft SUBSTITUTED TRIAZOLE DERIVATIVES AND USES THEREOF
WO2019081303A1 (en) 2017-10-24 2019-05-02 Bayer Pharma Aktiengesellschaft SUBSTITUTED TRIAZOLE DERIVATIVES AND USES THEREOF
WO2019081291A1 (en) 2017-10-24 2019-05-02 Bayer Aktiengesellschaft PRODRUGS OF SUBSTITUTED TRIAZOLE DERIVATIVES AND USES THEREOF
MA50440A (fr) 2017-10-24 2020-09-02 Bayer Ag Imidazopyridinamides substituées et leur utilisation
US11298367B2 (en) 2017-10-24 2022-04-12 Bayer Aktiengesellschaft Prodrugs of substituted triazole derivatives and uses thereof
EP3700899A1 (en) 2017-10-24 2020-09-02 Bayer Pharma Aktiengesellschaft Substituted triazole derivatives and uses thereof
CA3079770A1 (en) 2017-10-24 2019-05-02 Bayer Pharma Aktiengesellschaft Amine substituted triazole derivatives and uses thereof
EP3553079A1 (en) 2018-04-12 2019-10-16 Bayer Aktiengesellschaft C-type natriuretic peptide engrafted antibodies
EP3553082A1 (en) 2018-04-12 2019-10-16 Bayer Aktiengesellschaft Brain natriuretic peptide engrafted antibodies
EP3553081A1 (en) 2018-04-12 2019-10-16 Bayer Aktiengesellschaft Atrial natriuretic peptide engrafted antibodies
MA52616A (fr) 2018-05-15 2021-03-24 Bayer Ag Benzamides à substitution 1,3-thiazol-2-yl pour le traitement de maladies associées à la sensibilisation de fibres nerveuses
SG11202010679SA (en) 2018-05-17 2020-11-27 Bayer Ag Substituted dihydropyrazolo pyrazine carboxamide derivatives
WO2020216669A1 (de) 2019-04-23 2020-10-29 Bayer Aktiengesellschaft Phenylsubstituierte imidazopyridinamide und ihre verwendung
WO2021094208A1 (en) 2019-11-12 2021-05-20 Bayer Aktiengesellschaft Substituted imidazo pyrimidine ep3 antagonists
WO2021094210A1 (en) 2019-11-12 2021-05-20 Bayer Aktiengesellschaft Substituted pyrazine carboxamide derivatives as prostaglandin ep3 receptor antagonists
WO2021094209A1 (en) 2019-11-12 2021-05-20 Bayer Aktiengesellschaft Substituted pyrrolo triazine carboxamide derivatives as prostaglandin ep3 receptor antagonists
EP3822268A1 (en) 2019-11-15 2021-05-19 Bayer Aktiengesellschaft Substituted hydantoinamides as adamts7 antagonists
EP3822265A1 (en) 2019-11-15 2021-05-19 Bayer AG Substituted hydantoinamides as adamts7 antagonists
US12569481B2 (en) 2020-06-12 2026-03-10 Vanderbilt University Methods of treatment for gastrointestinal motility disorders
WO2021259852A1 (en) 2020-06-25 2021-12-30 Bayer Aktiengesellschaft Process for preparing 5-(alkoxycarbonyl)-and 5-(carboxamide)-1-aryl-1,2,4-triazole derivatives
EP4011873A1 (en) 2020-12-10 2022-06-15 Bayer Aktiengesellschaft Substituted pyrazolo piperidine carboxylic acids
WO2022122917A1 (en) 2020-12-10 2022-06-16 Bayer Aktiengesellschaft The use of sgc activators for the treatment of ophthalmologic diseases
EP4011874A1 (en) 2020-12-10 2022-06-15 Bayer Aktiengesellschaft Substituted pyrazolo piperidine carboxylic acids
CN116710439B (zh) 2020-12-10 2026-05-26 拜耳公司 取代的吡唑并哌啶羧酸
CA3204595A1 (en) 2020-12-10 2022-06-16 Bayer Aktiengesellschaft Substituted pyrazolyl piperidine carboxylic acids
CN119300815A (zh) 2022-06-09 2025-01-10 拜耳公司 用于治疗女性射血分数保留型心力衰竭的可溶性鸟苷酸环化酶激活剂

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3042466A1 (de) 1980-11-11 1982-06-16 A. Nattermann & Cie GmbH, 5000 Köln N-substituierte (omega) -(2-oxo-4-imidazolin-l-yl)-alkansaeure-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
EP0412594B1 (en) 1989-07-28 1996-01-03 Merck & Co. Inc. Substituted triazolinones, triazolinethiones, and triazolinimines as angiotensin II antagonists
US5468448A (en) * 1989-12-28 1995-11-21 Ciba-Geigy Corporation Peroxide disinfection method and devices therefor
AU640016B2 (en) * 1990-05-30 1993-08-12 Imperial Chemical Industries Plc Hydroquinazoline derivatives
DE4107857A1 (de) * 1991-03-12 1992-09-17 Thomae Gmbh Dr K Cyclische harnstoffderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
EP0586513A1 (en) 1991-05-10 1994-03-16 Merck & Co. Inc. Acidic aralkyl triazole derivatives active as angiotensin ii antagonists
IT1251488B (it) 1991-09-17 1995-05-15 Mini Ricerca Scient Tecnolog Ossa(tia)diazol- e triazol-oni(tioni) ad attivita' acaricida ed insetticida
WO1993017681A1 (en) 1992-03-02 1993-09-16 Abbott Laboratories Angiotensin ii receptor antagonists
SK94393A3 (en) 1992-09-11 1994-08-10 Thomae Gmbh Dr K Cyclic derivatives of urea, process for their production and their pharmaceutical agents with the content of those
US6844005B2 (en) * 2002-02-25 2005-01-18 Trutek Corp Electrostatically charged nasal application product with increased strength
FR2708608B1 (fr) * 1993-07-30 1995-10-27 Sanofi Sa Dérivés de N-sulfonylbenzimidazolone, leur préparation, les compositions pharmaceutiques en contenant.
US5897858A (en) * 1994-02-03 1999-04-27 Schering-Plough Healthcare Products, Inc. Nasal spray compositions exhibiting increased retention in the nasal cavity
US20010020100A1 (en) 1994-06-14 2001-09-06 G.D. Searle & Co. N-substituted-1, 2, 4-triazolone compounds for treatment of cardiovascular disorders
JP3951342B2 (ja) * 1996-07-10 2007-08-01 味の素株式会社 新規アスパルチルジペプチドアミド誘導体及び甘味剤
ES2243016T3 (es) 1997-12-17 2005-11-16 MERCK & CO., INC. Antagonistas de receptores de integrinas.
DE19816882A1 (de) 1998-04-17 1999-10-21 Boehringer Ingelheim Pharma Triazolone mit neuroprotektiver Wirkung
CN1597672A (zh) 1998-07-24 2005-03-23 拜尔公司 取代的苯甲酰基环己二酮类化合物
DE19834044A1 (de) 1998-07-29 2000-02-03 Bayer Ag Neue substituierte Pyrazolderivate
DE19834047A1 (de) 1998-07-29 2000-02-03 Bayer Ag Substituierte Pyrazolderivate
DE19914140A1 (de) 1999-03-27 2000-09-28 Bayer Ag Substituierte Benzoylpyrazole
DE19920791A1 (de) * 1999-05-06 2000-11-09 Bayer Ag Substituierte Benzoylisoxazole
DE19921424A1 (de) * 1999-05-08 2000-11-09 Bayer Ag Substituierte Benzoylketone
DE19929348A1 (de) 1999-06-26 2000-12-28 Bayer Ag Verfahren zur Herstellung von 2-Heterocyclylmethyl-benzoesäurederivaten
US6531142B1 (en) * 1999-08-18 2003-03-11 The Procter & Gamble Company Stable, electrostatically sprayable topical compositions
DE19943636A1 (de) 1999-09-13 2001-03-15 Bayer Ag Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE19943639A1 (de) 1999-09-13 2001-03-15 Bayer Ag Dicarbonsäurederivate mit neuartigen pharmazeutischen Eigenschaften
DE19943634A1 (de) 1999-09-13 2001-04-12 Bayer Ag Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE19943635A1 (de) 1999-09-13 2001-03-15 Bayer Ag Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften
AR027575A1 (es) 2000-03-06 2003-04-02 Bayer Ag Benzoilciclohexenonas substituidas
US7080644B2 (en) 2000-06-28 2006-07-25 Microdose Technologies, Inc. Packaging and delivery of pharmaceuticals and drugs
UA82048C2 (uk) * 2000-11-10 2008-03-11 Эли Лилли Энд Компани Агоністи альфа-рецепторів, активованих проліфератором пероксисом
AR031176A1 (es) 2000-11-22 2003-09-10 Bayer Ag Nuevos derivados de pirazolpiridina sustituidos con piridina
WO2002066447A1 (en) 2001-02-21 2002-08-29 Ono Pharmaceutical Co., Ltd. 4h-1,2,4-triazole-3(2h)-thione deratives as sphingomyelinase inhibitors
DE10110749A1 (de) 2001-03-07 2002-09-12 Bayer Ag Substituierte Aminodicarbonsäurederivate
DE10110750A1 (de) 2001-03-07 2002-09-12 Bayer Ag Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften
CA2442428A1 (en) * 2001-03-28 2002-10-10 Mark D. Wittman Novel tyrosine kinase inhibitors
US20040071757A1 (en) * 2001-11-20 2004-04-15 David Rolf Inhalation antiviral patch
DE10220570A1 (de) 2002-05-08 2003-11-20 Bayer Ag Carbamat-substituierte Pyrazolopyridine
EP1606264B1 (en) * 2003-03-14 2012-05-02 Merck Sharp & Dohme Corp. Monocyclic anilide spirohydantoin cgrp receptor antagonists
KR20060066141A (ko) 2003-06-27 2006-06-15 버글린 코퍼레이션 오브 워싱턴 사과 및 연한 코아를 가지거나 피트를 가진 다른 과일들을작은 응력을 가지고 정확하게 코아제거하고슬라이스절단하기 위한 기계
WO2005097112A2 (en) 2004-03-08 2005-10-20 Wyeth Ion channel modulators
JP2007527909A (ja) 2004-03-08 2007-10-04 ワイス イオンチャンネルモジュレーター
DE102004017627A1 (de) 2004-04-10 2005-10-27 Bayer Healthcare Ag Verwendung von vollen 5-HT1A-Agonisten zur Hemmung der opiat/opioid-induzierten Atemdepression
US20070225333A1 (en) 2004-04-28 2007-09-27 Bryans Justin S 3-Heterocyclyl-4-Phenyl-Triazole Derivatives as Inhibitors of the Vasopressin Via Receptor
US7642275B2 (en) 2004-12-16 2010-01-05 Takeda San Diego, Inc. Histone deacetylase inhibitors
WO2006117657A1 (en) 2005-05-03 2006-11-09 Ranbaxy Laboratories Limited Triazolone derivatives as anti-inflammatory agents
DE102006024024A1 (de) 2006-05-23 2007-11-29 Bayer Healthcare Aktiengesellschaft Substituierte Arylimidazolone und -triazolone sowie ihre Verwendung
US20080095863A1 (en) * 2006-10-24 2008-04-24 Alcon Manufacturing Ltd. 2-pyrrolidone derivatives for preservation of ophthalmic, otic and nasal compositions
DE102010001064A1 (de) 2009-03-18 2010-09-23 Bayer Schering Pharma Aktiengesellschaft Substituierte 2-Acetamido-5-Aryl-1,2,4-triazolone und deren Verwendung
DE102009013642A1 (de) * 2009-03-18 2010-09-23 Bayer Schering Pharma Aktiengesellschaft Substituierte Phenylalaninderivate und deren Verwendung
DE102009028929A1 (de) * 2009-08-27 2011-07-07 Bayer Schering Pharma Aktiengesellschaft, 13353 Heterocyclisch-substituierte 2-Acetamido-5-Aryl-1,2,4-triazolone und deren Verwendung
ES2635340T3 (es) * 2010-02-27 2017-10-03 Bayer Intellectual Property Gmbh Ariltriazolonas ligadas a bis-arilo y su uso

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