AR071920A1 - Compuestos derivados de piridina, proceso para su preparacion, una composicion farmaceutica que lo comprende , metodo para tratar un estado de enfermedad - Google Patents

Compuestos derivados de piridina, proceso para su preparacion, una composicion farmaceutica que lo comprende , metodo para tratar un estado de enfermedad

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Publication number
AR071920A1
AR071920A1 ARP090101896A ARP090101896A AR071920A1 AR 071920 A1 AR071920 A1 AR 071920A1 AR P090101896 A ARP090101896 A AR P090101896A AR P090101896 A ARP090101896 A AR P090101896A AR 071920 A1 AR071920 A1 AR 071920A1
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Argentina
Prior art keywords
alkyl
alkoxy
heterocyclyl
optionally substituted
heteroaryl
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ARP090101896A
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English (en)
Inventor
Glen Andrews
Rhona Jane Cox
Hitesh Jayantilal Sanganee
Premji Meghani
Daniel Jon Warner
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Astrazeneca Ab
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Publication of AR071920A1 publication Critical patent/AR071920A1/es

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Otolaryngology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Un proceso para preparar el compuesto, uso de un compuesto de este tipo en el tratamiento de un estado e enfermedad mediado por PDE4 y un producto farmaceutico. Estos compuestos son utiles en el tratamiento de trastornos inflamatorios e inmunes. Reivindicacion 1: Un compuesto car4cterizado porque es de la formula (1) donde: R1 es NR7C(O)R8, NR7S(O)2R8 o NR9R10; R2 es hidrogeno o alquil C1-6; R3 es hidrogeno, halogeno, alquil C1-4 o alcoxi C1-4; R4 es hidrogeno, halogeno, ciano, hidroxi, alquil C1-4, alcoxi C1-4, CF3, OCF3, alquiltio C1-4, S(O)(alquil C1-4), S(O)2(alquil C1-4), CO2H o CO2(alquil C1-4); R5 es alquil C1-6(sustituido por NR11R12 o heterociclil), alcoxi C1-6 (sustituido por NR11R12 o heterociclil), cicloalquil C3-6 (sustituido por NR11R12 o heterociclil) o heterociclil; a condicion de que si R5 incluye un heterociclil entonces dicho heterociclil comprende uno o m s  tomos de nitrogeno del anillo; y que si dicho heterociclil est  unido directamente a traves de un nitrogeno del anillo: al alquil, alcoxi o cicloalquil de R5, o al anillo de fenil de la formula (1) al cual R5 est  directamente unido, entonces dicho heterociclil tiene al menos dos hetero tomos del anillo, o tiene un sustituyente NR46R47; R6 es hidrogeno, halogeno, ciano, hidroxi, SH, alquil C1-4, alcoxi C1-4, CF3, OCF3, C(O)H, alquiltio C1-6, S(O)(alquil C1-6), S(O)2(alquil C1-6), CO2H, CO2(alquil C1-6), NR13R14, alquil C1-6 (opcionalmente sustituido por halogeno, OH, CO2H, NR15R16, NHC(O)O(alquil C1-6), OS(O)2(alquil C1-6) o heterociclil), alcoxi C1-6 (opcionalmente sustituido por halogeno, OH, CO2H, NR15R16 o heterociclil), cicloalquil C3-6 (opcionalmente sustituido por halogeno, OH. CO2H, NR15R16 o heterociclil) o heterociclil; R7 es hidrogeno o alquil C1-6 (opcionalmente sustituido por NR26R27); R8 es alquil C1-6 (opcionalmente sustituido por hidroxil, alcoxi C1-6, NR21R22, heterociclil {opcionalmente sustituido por oxo, hidroxi, alquil C1-6, CO2(alquil C1-6), aril, heteroaril, aril(alquil C1-4), heterociclil o C(O)(alquil C1-4)fenil}, aril, heteroaril, cicloalquil C3-7, cicloalquil C3-7(alquil C1-4), CO2H, CO2(alquil C1-4), aril(alcoxi C1-4), aril(alquiltio C1-4), S(O)2(alquil C1-6), NHC(O)heteroaril o NHC(O)R23}, alcoxi C1-6, cicloalquil C3-6 {opcionalmente sustituido por hidroxil, NR24R25 o alquil C1-6}, heterociclil {opcionalmente sustituido por oxo, hidroxi, alquil C1-6, amino, aril, heteroaril, aril(alquil C1-4), heteroaril(alquil C1-4), heterociclil o C(O)(alquil C1-4)fenil}, aril(alquil C1-4) {sustituido por amino(alquil C1-4)}, aril o heteroaril; R9 es hidrogeno, alquil C1-6 (opcionalmente sustituido por aril o heteroaril), R10 es hidrogeno, alquil C1-6 (opcionalmente sustituido por hidroxil, alcoxi C1-6, aril, ariloxi, fenil(alcoxi C1-6), heteroaril, cicloalquil C3-10, CO2H, CO2(alquil C1-6), NHC(O)O(alquil C1-6) o NHC(O)R23), alcoxi C1-6, cicloalquil C3-6 (opcionalmente sustituido por hidroxi, alquil C1-6, fenil, fenil(alquil C1-6), heteroaril o heteroaril(alquil C1-6)), heterociclil (opcionalmente sustituido por alquil C1-6, C(O)NH2 o fenil(alquil C1-6)), aril o heteroaril; R21 y R22 son, independientemente, hidrogeno, alquil C1-6 o fenil(alquil C1-4); R23 es alquil C1-6 o fenil; las mitades fenil, aril y heteroaril precedentes de R5, R8, R9, R10, R23, R21 y R22 son, independientemente, opcionalmente sustituidas por: halogeno, ciano, nitro, CF3, hidroxi, S(O)qR26, OC(O)NR27R28, NR29R30, NR31C(O)R32, NR33C(O)NR34R35, S(O)2NR36R37, NR38S(O)2R39, C(O)NR40R41, C(O)R42, CO2R43, NR44CO2R45, OC(O)(alquil C1-6), alquil C1-6, hidroxialquil C1-6, haloalquil C1-6, alcoxi C1-6-alquil C1-6, amino(alquil C1-4), di(alquilamino C1-6)-alquiI C1-6, alcoxi C1-6, haloalcoxi C1-6, hidroxil(C1-6 alcoxi), heterociclil(C1-6 alcoxi), alcoxi C1-6-alcoxi C1-6, amino(alcoxi C1-4), alquilamino C1-4-alcoxi C1-4 (este opcionalmente sustituido por fenil), di(aIquil C1-4)amino-alcoxi C1-4, alquiltio C1-6,alquenil C2-6, alquinil C2-6, cicloalquil C3-10 (este opcionalmente sustituido por alquil C1-4 u oxo), metilenodioxi, difluorometilenodioxi, heterociclil, heterociclil(alquil C1-4), fenil, fenil(alquil C1-4, fenoxi, feniltio, fenil(alcoxi C1-4), heteroaril, heteroaril(alquil C1-4), heteroariloxi o heteroaril(alcoxi C1-4); donde cualquiera de las mitades fenil y heteroaril inmediatamente precedentes son opcionalmente sustituidas con halogeno, hidroxi, nitro, S(O)r(alquil C1-4), S(O)2NH2, S(O)2NH(alquil C1-4), S(O)2N(alquil C1-4)2, ciano, alquil C1-4, alcoxi C1-4, C(O)NH2, C(O)NH(alquil C1-4), C(O)N(alquil C1-4)2, CO2H, CO2(alquilC1-4), NHC(O)(alquil C1-4), NH(O)2(alquil C1-4), C(O)(alquil C1-4), CF3 u OCF3; q y r son, independientemente, 0, 1 o 2; a menos que se declare lo contrario el heterociclil es opcionalmente sustituido por OH, alquil C1-6, cicloalquil C3-7, NR46R47, (alquil C1-6)OH o (alquil C1-6)NR48R49, NR50CO2(alquil C1-6), CO2(alquil C1-6), C(O)(alquil C1-6), C(O)heterociclil, heteroaril, (alquil C1-6)C(O)NR51 R52, (alquil C1-6)C(O)NR53R54, (alquil C1-6)C(O)heterociclil o heterociclil; R26, R27, R28, R29, R30, R31, R32, R33, R34, R35, R36, R37, R38, R39, R40, R41, R42, R43, R44 y R45 son, independientemente, alquil C1-6 {opcionalmente sustituido por halogeno, hidroxi o alcoxi C1-6}, CH2(alquenil C2-6), fenil {este opcionalmente sustituido por halogeno, hidroxi, nitro, NH2, NH(alquil C1-4), N(alquil C1-4)2, S(O)2(alquil C1-4), S(O)2NH2, S(O)2NH(alquil C1-4), S(O)2N(alquil C1-4)2, ciano, alquil C1-4, alcoxi C1-4, C(O)NH2, C(O)NH(alquil C1-4), C(O)N(alquil C1-4)2, CO2H, CO2(alquil C1-4), NHC(O)(alquil C1-4), NH(O)2(alquil C1-4), C(O)(alquil C1-4), CF3 u OCF3} o heteroaril {este opcionalmente sustituido por halogeno, hidroxi, nitro, NH2, NH(alquil C1-4), N(alquil C1-4)2, S(O)2(alquil C1-4), S(O)2NH2, S(O)2NH(alquil C1-4), S(O)2N(alquil C1-4)2, ciano, alquil C1-4, alcoxi C1-4, C(O)NH2, C(O)NH(alquil C1-4), C(O)N(alquil C1-4)2, CO2H, CO2(alquil C1-4), NHC(O)(alquil C1-4), NH(O)2(alquil C1-4), C(O)(alquil C1-4), CF3 u OCF3}; R27, R28, R29, R30, R31, R32, R33, R34, R35, R36, R37, R38, R40, R41, R42, R43, R44 y R45 tambien pueden ser hidrogeno; R12, R14, R15, R25, R47 y R49 son, independientemente, hidrogeno, alquil C1-6 (opcionalmente sustituido por hidroxi, alcoxi C1-6, alquiltio C1-6, cicloalquil C3-7 (opcionalmente sustituido por hidroxi) o NR55R56), cicloalquil C3-7 (opcionalmente sustituido por hidroxi(alquil C1-6)) o heterociclil (opcionalmente sustituido por alquil C1-6); R11, R13, R16, R24, R26, R27, R46, R48, R50, R51, R52, R53, R54, R55 y R56 son, independientemente. hidrogeno o alquil C1-6; o un N-oxido de este; o una sal farmaceuticamente aceptable de este.
ARP090101896A 2008-05-27 2009-05-27 Compuestos derivados de piridina, proceso para su preparacion, una composicion farmaceutica que lo comprende , metodo para tratar un estado de enfermedad AR071920A1 (es)

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EP2433124B1 (en) * 2009-05-19 2017-03-01 Vivia Biotech S.L. Methods for providing personalized medicine tests ex vivo for hematological neoplasms
US9073820B2 (en) 2011-11-04 2015-07-07 Oregon Health & Science University Pharmaceutical compositions comprising napthamides
AU2015315171A1 (en) * 2014-09-10 2017-03-16 Epizyme, Inc. Substituted cyclohexylamine compounds
WO2017089347A1 (en) 2015-11-25 2017-06-01 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas
AU2017223132B2 (en) * 2016-02-23 2019-12-05 Pfizer Inc. 6,7-Dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide compounds
WO2020179859A1 (ja) 2019-03-06 2020-09-10 第一三共株式会社 ピロロピラゾール誘導体
EP3782702A1 (en) * 2019-08-21 2021-02-24 AC BioScience SA Compounds and use thereof for the treatment of infectious diseases and cancer
KR102271305B1 (ko) 2020-05-21 2021-06-30 주식회사 아리바이오 치매 예방 및 치료용 조성물
KR102272907B1 (ko) 2020-11-05 2021-07-05 주식회사 아리바이오 치매 예방 및 치료용 조성물
KR102272910B1 (ko) 2021-01-28 2021-07-06 주식회사 아리바이오 당뇨병을 동반한 치매 예방 및 치료용 조성물
KR20220140960A (ko) 2021-04-12 2022-10-19 주식회사 아리바이오 당뇨병을 동반한 치매 예방 및 치료용 조성물
KR102311224B1 (ko) 2021-04-23 2021-10-13 주식회사 아리바이오 Pde5 억제제와 글루코코르티코이드 수용체 길항제 병용투여를 통한 치매 예방 및 치료용 조성물
KR20220146095A (ko) 2021-04-23 2022-11-01 주식회사 아리바이오 Pde5 억제제와 글루코코르티코이드 수용체 길항제 병용투여를 통한 치매 예방 및 치료용 조성물

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8334494D0 (en) 1983-12-24 1984-02-01 Tanabe Seiyaku Co Carbostyril derivatives
EP0260817B1 (en) 1986-08-21 1991-05-15 Pfizer Inc. Quinazolinediones and pyridopyrimidinediones
GR1001529B (el) 1990-09-07 1994-03-31 Elmuquimica Farm Sl Μέ?οδος για την λήψη νέων 21-εστέρων της 16-17-ακετάλης της πρ να-1,4-διενο-3,20-διόνης.
US5264437A (en) 1992-03-20 1993-11-23 Syntex (U.S.A.) Inc. Optionally substituted pyrido[2,3-d]pyridine-2,4(1H,3H)-diones and pyrido[2,]pyrimidine-2(1H,3H)-ones
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
KR19990082463A (ko) 1996-02-13 1999-11-25 돈 리사 로얄 혈관 내피 성장 인자 억제제로서의 퀴나졸린유도체
DK0885198T3 (da) 1996-03-05 2002-03-25 Astrazeneca Ab 4-Anilinoquinazolinderivater
FR2750862B1 (fr) 1996-07-12 1998-10-16 Dupin Jean Pierre Utilisation d'heterocycles diazotes fusionnes avec un systeme aromatique ou heteroaromatique pour le traitement des maladies thrombo-emboliques
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
GB9714249D0 (en) 1997-07-08 1997-09-10 Angiogene Pharm Ltd Vascular damaging agents
EP0958297A1 (en) 1997-08-06 1999-11-24 Suntory Limited 1-aryl-1,8-naphthylidin-4-one derivative as type iv phosphodiesterase inhibitor
US6022884A (en) * 1997-11-07 2000-02-08 Amgen Inc. Substituted pyridine compounds and methods of use
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
GB9900752D0 (en) 1999-01-15 1999-03-03 Angiogene Pharm Ltd Benzimidazole vascular damaging agents
WO2000045800A2 (en) 1999-02-02 2000-08-10 K.U. Leuven Research & Development Immunosurpressive effects of pteridine derivatives
ES2165768B1 (es) 1999-07-14 2003-04-01 Almirall Prodesfarma Sa Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
CA2406979A1 (en) 2000-05-31 2001-12-06 Astrazeneca Ab Indole derivatives with vascular damaging activity
GB0015876D0 (en) 2000-06-28 2000-08-23 Novartis Ag Organic compounds
RU2003103603A (ru) 2000-07-07 2004-08-20 Энджиоджен Фармасьютикалз Лимитед (Gb) Производные колхинола в качестве ингибиторов ангиогенеза
AU2001266233B2 (en) 2000-07-07 2006-06-29 Angiogene Pharmaceuticals Limited Colchinol derivatives as vascular damaging agents
DE10050995A1 (de) 2000-10-14 2002-04-18 Boehringer Ingelheim Pharma Neue Anticholinergika, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
US7045658B2 (en) 2001-03-22 2006-05-16 Glaxo Group Limited Formailide derivatives as beta2-adrenoreceptor agonists
AU2002253342B2 (en) 2001-04-30 2007-01-04 Glaxo Group Limited Novel anti-inflammatory androstane derivatives
DE60205899T2 (de) 2001-05-24 2006-06-29 Merck Frosst Canada & Co, Kirkland 1-biaryl-1,8-naphthyridin-4-one als phosphodieseterase-inhibitoren
TWI249515B (en) 2001-11-13 2006-02-21 Theravance Inc Aryl aniline beta2 adrenergic receptor agonists
US20030229058A1 (en) 2001-11-13 2003-12-11 Moran Edmund J. Aryl aniline beta2 adrenergic receptor agonists
AU2003201745A1 (en) * 2002-02-11 2003-09-04 Pfizer Limited Nicotinamide derivatives and a tiotropium salt in combination for the treatment of e.g. inflammatory, allergic and respiratory diseases
PL372756A1 (en) * 2002-02-11 2005-08-08 Pfizer Inc. Nicotinamide derivatives useful as pde4 inhibitors
DE10216339A1 (de) 2002-04-13 2003-10-23 Boehringer Ingelheim Pharma Neue Ester hydroxy-substituierter Stickstoffheterocyclen, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
PL376396A1 (en) 2002-10-11 2005-12-27 Pfizer Inc. Indole derivatives as beta-2 agonists
US7056916B2 (en) 2002-11-15 2006-06-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments for the treatment of chronic obstructive pulmonary disease
US6909002B2 (en) * 2002-11-22 2005-06-21 Merck & Co., Inc. Method of preparing inhibitors of phosphodiesterase-4
IS7839A (is) 2002-11-22 2004-05-23 Merck Frosst Canada Ltd. 4-oxó-1-(3-setið fenýl-1,4-díhýdró-1,8-naftýridín-3-karboxamíð fosfódíesterasa-4 hindrar
AU2003286024A1 (en) 2002-11-22 2004-06-18 Daniel Dube Use of phosphodiesterase-4 inhibitors as enhancers of cognition
US20060258668A1 (en) 2003-05-29 2006-11-16 Scolnick Edward M Use of phosphatase inhibitors as adjunct therapy for psychiatric disorders
US7153870B2 (en) * 2003-07-25 2006-12-26 Pfizer Inc. Nicotinamide derivatives useful as PDE4 inhibitors
GB0317516D0 (en) * 2003-07-25 2003-08-27 Pfizer Ltd Nicotinamide derivatives useful as PDE4 inhibitors
GB0317484D0 (en) * 2003-07-25 2003-08-27 Pfizer Ltd Nicotinamide derivatives useful as pde4 inhibitors
GB0317482D0 (en) * 2003-07-25 2003-08-27 Pfizer Ltd Nicotinamide derivatives useful as pde4 inhibitors
US7132435B2 (en) * 2003-07-25 2006-11-07 Pfizer Inc. Compounds
GB0317509D0 (en) * 2003-07-25 2003-08-27 Pfizer Ltd Nicotinamide derivatives useful as PDE4 inhibitors
GB0317471D0 (en) * 2003-07-25 2003-08-27 Pfizer Ltd Novel compounds
WO2005013967A1 (en) * 2003-07-28 2005-02-17 Boehringer Ingelheim International Gmbh Medicaments comprising pde iv inhibitors and a novel anticholinergic and their use for treating respiratory disorders
WO2005013993A1 (en) * 2003-07-29 2005-02-17 Boehringer Ingelheim International Gmbh Medicaments comprising pde iv inhibitors and an anticholinergic for treating respiratory disorders
EP1663979B1 (en) * 2003-09-03 2013-10-09 RaQualia Pharma Inc. Phenyl or pyridyl amide compounds as prostaglandin e2 antagonists
US20090246281A1 (en) 2003-11-03 2009-10-01 Norton Healthcare Ltd. Soft steroid compositions for use in dry powder inhalers
ES2257152B1 (es) 2004-05-31 2007-07-01 Laboratorios Almirall S.A. Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos.
WO2006046916A1 (en) 2004-10-29 2006-05-04 Astrazeneca Ab Novel sulphonamide derivatives as glucocorticoid receptor modulators for the treatment of inflammatory diseases
EP1981885A2 (en) 2005-10-27 2008-10-22 Merck & Co., Inc. A method of preparing a 4-oxo-1-(3-substituted phenyl)-1,4-dihydro-1,8-naphthyridine-3-carboxamide phosphodiesterase-4 inhibitor
WO2007101213A2 (en) 2006-02-28 2007-09-07 Kalypsys, Inc. Novel 2-oxo-1,2,3,4-tetrahydropyrimidines, bicyclic pyrimidine diones and imidazolidine-2,4-diones useful as inducible nitric oxide synthase inhibitors
TW200800997A (en) * 2006-03-22 2008-01-01 Astrazeneca Ab Chemical compounds

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