AR070634A1 - Derivados de carboxamida-heteroarilo,proceso para prepararlos,medicamentos que los contienen y usos de los mismos en el tratamiento de la diabetes,obesidad,neuropatias y/o nefropatias. - Google Patents
Derivados de carboxamida-heteroarilo,proceso para prepararlos,medicamentos que los contienen y usos de los mismos en el tratamiento de la diabetes,obesidad,neuropatias y/o nefropatias.Info
- Publication number
- AR070634A1 AR070634A1 ARP090100678A ARP090100678A AR070634A1 AR 070634 A1 AR070634 A1 AR 070634A1 AR P090100678 A ARP090100678 A AR P090100678A AR P090100678 A ARP090100678 A AR P090100678A AR 070634 A1 AR070634 A1 AR 070634A1
- Authority
- AR
- Argentina
- Prior art keywords
- alk
- het
- conr10r11
- nr10r11
- nr10cor11
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Son activadores de la glucoquinasa y se pueden usar para la prevencion y/o tratamiento de diabetes de tipo 1 y 2, obesidad, neuropatía y/o neuropatía. Reivindicacion 1: Compuestos de la formula 1 en donde D denota el grupo de formulas 2, Y', Y'' denotan, de modo independiente entre sí, O, S(O)n, NR3 o está ausente, E', E'', E''' denotan, de modo independiente, N o CH, en donde uno o varios E', E'', E'''= N, R1, R2, R3 denotan, de modo independiente entre sí, H, A, Hal, Ar, Het, OR10, S(O)nR10, NR10R11, NO2, CN, COOR10, CONR10R11, NR10COR11, NR10CONR10R11, NR10SOnR11, CHO, COR10, SO3H, SOnR10R11, O-Alk-NR10R11, O-Alk-CONR10R11, O-Alk-NR10COR11, O-Alk-Het, O-Alk-Ar, Alk-Ar, Alk-Het, S(O)n-Alk-Het, S(O)-Alk-Ar, Alk-CO-NA2 o Alk-NA2, G', G'', G''', G'''' denotan, de modo independiente entre sí, O, S(O)n , CR4 o NR5 R4 denota, de modo independiente entre sí, H, Hal, A', OR10, S(O)nR10, NR10R11, CN, CONR10R11, NR10COR11, NR10CONR10R11, NR10SOnR11, COR10, SO3H, SOnNR10R11, O-A-NR10R11, O-A-CONR10R11, O-A-NR10COR11, O-A-Het, O-A-Ar, A-Ar, A-Het, S(O)n-A-Het o S(O)n-A-Ar, R5 denota H, A', S(O)nR10, CONR10R11, COR10, SOnNR10R11, Alk-Ar, Alk-Het, S(O)n-Alk-Het, o S(O)n-Alk-Ar, R10, R11 denotan, de modo independiente entre sí, H, A, Ar o Het, A es alquilo ramificado o no ramificado con 1-10 átomos de C, que puede estar mono-, di- o trisustituido con =S , =NR10 (imina) y/u =O, y/o en donde uno, dos o tres grupos CH2 están reemplazados por O, S SO, O2 NH, NAr, NHet, F y o Cl o alquilo cíclico con 3-7 átomos de C, donde 1-7 átomos de H pueden estar reemplazados por F, Cl, OR10, SOnR10 y/o NR10R11, A' es alquilo ramificado o no ramificado con 1-10 átomos de C, que puede estar mono-, di- o trisustituido con, =S, =NR10 (imina) y/u =O, y/o en donde uno, dos o tres grupos CH2 están reemplazados por O, S, SO, SO2, NH, NAr, NHet F y o Cl, Ar denota fenilo, naftilo o bifenilo, cada uno de los cuales no está sustituido o está mono-, di-, tri-, tetra- o pentasustituido con A, Hal, Ar, Het, OR10, S(O)nR10, NR10R11, NO2, CN, COOR10, CONR10R11, NR10COR11, NR10CONR10R11, NR10SOR11, CHO, COR10, SO3H, SONR10R11, O-Alk-NR10R11, O-Alk-CONR10R11, O-Alk-NR10COR11, O-Alk-Het, Alk-Het, S(O)n-Alk-Het, y/o S(O)-Alk-Ar, Het denota, de modo independiente, un heterociclo saturado, insaturado o aromático mono- o bicíclico que tiene 1 a 4 átomos de N, O y/o S, que puede estar mono-, di- o trisustituido con A, Hal, Ar, Het, OR10, S(O)nR10, NR10R11, NO2, CN, COOR10, CONR10R11, NR10COR11, NR10CONR10R11, NR10SOnR11, CHO, COR10, SO3H, SOnNR10R11, O-Alk-NR10R11, O-Alk-CONR10R11, O-Alk-NR10COR11, O-Alk-Het, O-Alk-Ar, Alk-Ar, Alk-Het, S(O)n-Alk-Het, S(O)n-Alk-Ar, =S, =NR10 y/u =O; Hal es F, Cl, Br o I, n es 0, 1 o 2, si E' = E '' = N y E'''= CH, entonces R1-Y' y R2-Y'' no son OH y sus derivados, sales, solvatos y estereoisomeros de utilidad farmacéutica, incluyendo sus mezclas en todas las proporciones.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08003517 | 2008-02-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR070634A1 true AR070634A1 (es) | 2010-04-21 |
Family
ID=40521625
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090100678A AR070634A1 (es) | 2008-02-27 | 2009-02-27 | Derivados de carboxamida-heteroarilo,proceso para prepararlos,medicamentos que los contienen y usos de los mismos en el tratamiento de la diabetes,obesidad,neuropatias y/o nefropatias. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20110009437A1 (es) |
| EP (1) | EP2245025A1 (es) |
| JP (1) | JP2011513253A (es) |
| KR (1) | KR20100117137A (es) |
| AR (1) | AR070634A1 (es) |
| AU (1) | AU2009218805A1 (es) |
| CA (1) | CA2716385A1 (es) |
| EA (1) | EA201001367A1 (es) |
| IL (1) | IL207520A (es) |
| WO (1) | WO2009106209A1 (es) |
| ZA (1) | ZA201006827B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| WO2011122458A1 (ja) * | 2010-03-29 | 2011-10-06 | 第一三共株式会社 | 含窒素芳香環化合物 |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| MX2016005760A (es) * | 2013-11-06 | 2016-07-18 | Squibb Bristol Myers Co | Inhibidores de glucogeno sintasa cinasa 3 (gsk-3). |
| EA201690846A1 (ru) | 2013-11-06 | 2016-08-31 | Бристол-Маерс Сквибб Компани | Замещенные производные пиридина, пригодные в качестве ингибиторов gsk-3 |
| AU2017327539B2 (en) | 2016-09-15 | 2020-12-24 | Boehringer Ingelheim International Gmbh | Heteroaryl carboxamide compounds as inhibitors of RIPK2 |
| CN106334524B (zh) * | 2016-11-08 | 2019-07-05 | 山东大学 | 核-壳结构层状双金属氢氧化物复合粒子制备方法及应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10063868A1 (de) * | 2000-12-21 | 2002-06-27 | Bayer Ag | Dichlorpyridincarbamide |
| WO2003039529A1 (en) * | 2001-11-07 | 2003-05-15 | 4Sc A.G. | Selective antibacterial agents |
| WO2003055477A1 (en) * | 2001-12-21 | 2003-07-10 | 7Tm Pharma A/S | Method for the treatment of mc receptor related disorders with a chelate and/or a chelator |
| AU2003221140B9 (en) * | 2002-03-26 | 2009-07-30 | Banyu Pharmaceutical Co., Ltd. | Novel aminobenzamide derivative |
| CA2515841C (en) * | 2003-02-13 | 2010-06-01 | Banyu Pharmaceutical Co., Ltd. | Novel 2-pyridine carboxamide derivatives |
| CN101712657A (zh) * | 2003-02-26 | 2010-05-26 | 万有制药株式会社 | 杂芳基氨基甲酰基苯衍生物 |
| GB0403155D0 (en) * | 2004-02-12 | 2004-03-17 | Vernalis Res Ltd | Chemical compounds |
| CN1933838A (zh) * | 2004-02-12 | 2007-03-21 | 默克公司 | 作为代谢型谷氨酸受体－5调节剂的联吡啶酰胺 |
| ES2322709T3 (es) * | 2004-02-18 | 2009-06-25 | Astrazeneca Ab | Derivados de benzamida y su uso como agentes activadores de la glucocinasa. |
| WO2005080360A1 (en) * | 2004-02-18 | 2005-09-01 | Astrazeneca Ab | Compounds |
| CN101087601A (zh) * | 2004-08-02 | 2007-12-12 | 根梅迪卡治疗公司 | 用于抑制含铜胺氧化酶的化合物及其应用 |
| GB0423043D0 (en) * | 2004-10-16 | 2004-11-17 | Astrazeneca Ab | Compounds |
| CA2586870A1 (en) * | 2004-11-10 | 2006-05-18 | Synta Pharmaceuticals Corp. | Il-12 modulatory compounds |
| US20100160286A1 (en) * | 2005-08-09 | 2010-06-24 | Astrazeneca Uk Limited Ab | Heteroarylcarbamoylbenzene derivatives for the treatment of diabetes |
-
2009
- 2009-02-03 CA CA2716385A patent/CA2716385A1/en not_active Abandoned
- 2009-02-03 KR KR1020107021449A patent/KR20100117137A/ko not_active Application Discontinuation
- 2009-02-03 EP EP09714218A patent/EP2245025A1/en not_active Withdrawn
- 2009-02-03 US US12/919,627 patent/US20110009437A1/en not_active Abandoned
- 2009-02-03 AU AU2009218805A patent/AU2009218805A1/en not_active Abandoned
- 2009-02-03 JP JP2010547982A patent/JP2011513253A/ja active Pending
- 2009-02-03 WO PCT/EP2009/000705 patent/WO2009106209A1/en active Application Filing
- 2009-02-03 EA EA201001367A patent/EA201001367A1/ru unknown
- 2009-02-27 AR ARP090100678A patent/AR070634A1/es unknown
-
2010
- 2010-08-10 IL IL207520A patent/IL207520A/en active IP Right Grant
- 2010-09-23 ZA ZA2010/06827A patent/ZA201006827B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2716385A1 (en) | 2009-09-03 |
| WO2009106209A1 (en) | 2009-09-03 |
| IL207520A (en) | 2015-08-31 |
| EP2245025A1 (en) | 2010-11-03 |
| AU2009218805A1 (en) | 2009-09-03 |
| JP2011513253A (ja) | 2011-04-28 |
| EA201001367A1 (ru) | 2011-04-29 |
| KR20100117137A (ko) | 2010-11-02 |
| US20110009437A1 (en) | 2011-01-13 |
| IL207520A0 (en) | 2010-12-30 |
| ZA201006827B (en) | 2011-05-25 |
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