EA201001367A1 - Производные карбоксамид-гетероарила для лечения диабета - Google Patents

Производные карбоксамид-гетероарила для лечения диабета

Info

Publication number
EA201001367A1
EA201001367A1 EA201001367A EA201001367A EA201001367A1 EA 201001367 A1 EA201001367 A1 EA 201001367A1 EA 201001367 A EA201001367 A EA 201001367A EA 201001367 A EA201001367 A EA 201001367A EA 201001367 A1 EA201001367 A1 EA 201001367A1
Authority
EA
Eurasian Patent Office
Prior art keywords
diabetes
heteroaril
carboxamide
derivatives
treatment
Prior art date
Application number
EA201001367A
Other languages
English (en)
Inventor
Ларс Торе Бургдорф
Штефан Бендер
Кристоф Заал
Кристине Шарон
Норберт Байер
Original Assignee
Мерк Патент Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мерк Патент Гмбх filed Critical Мерк Патент Гмбх
Publication of EA201001367A1 publication Critical patent/EA201001367A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)

Abstract

Новые гетероциклические соединения формулы Iв которой D представляет собойгде R, R, Е', Е", Е'", Y', Y", G', G", G'" и G'"' имеют значения, указанные в п.1, являются активаторами глюкокиназы и могут использоваться для предотвращения и/или лечения диабета 1 и 2 типа, ожирения, невропатии и/или нефропатии.
EA201001367A 2008-02-27 2009-02-03 Производные карбоксамид-гетероарила для лечения диабета EA201001367A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08003517 2008-02-27
PCT/EP2009/000705 WO2009106209A1 (en) 2008-02-27 2009-02-03 Carboxamide-heteroaryl derivatives for the treatment of diabetes

Publications (1)

Publication Number Publication Date
EA201001367A1 true EA201001367A1 (ru) 2011-04-29

Family

ID=40521625

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201001367A EA201001367A1 (ru) 2008-02-27 2009-02-03 Производные карбоксамид-гетероарила для лечения диабета

Country Status (11)

Country Link
US (1) US20110009437A1 (ru)
EP (1) EP2245025A1 (ru)
JP (1) JP2011513253A (ru)
KR (1) KR20100117137A (ru)
AR (1) AR070634A1 (ru)
AU (1) AU2009218805A1 (ru)
CA (1) CA2716385A1 (ru)
EA (1) EA201001367A1 (ru)
IL (1) IL207520A (ru)
WO (1) WO2009106209A1 (ru)
ZA (1) ZA201006827B (ru)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2011122458A1 (ja) * 2010-03-29 2011-10-06 第一三共株式会社 含窒素芳香環化合物
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (en) 2011-09-27 2015-10-21 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
CA2929502A1 (en) 2013-11-06 2015-05-14 Bristol-Myers Squibb Company Substituted pyridine derivatives useful as gsk-3 inhibitors
CA2929528A1 (en) * 2013-11-06 2015-05-14 Bristol-Myers Squibb Company Gsk-3 inhibitors
WO2018052772A1 (en) 2016-09-15 2018-03-22 Boehringer Ingelheim International Gmbh Heteroaryl carboxamide compounds as inhibitors of ripk2
CN106334524B (zh) * 2016-11-08 2019-07-05 山东大学 核-壳结构层状双金属氢氧化物复合粒子制备方法及应用

Family Cites Families (14)

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DE10063868A1 (de) * 2000-12-21 2002-06-27 Bayer Ag Dichlorpyridincarbamide
WO2003039529A1 (en) * 2001-11-07 2003-05-15 4Sc A.G. Selective antibacterial agents
AU2002367087A1 (en) * 2001-12-21 2003-07-15 7Tm Pharma A/S Method for the treatment of mc receptor related disorders with a chelate and/or a chelator
AU2003221140B9 (en) * 2002-03-26 2009-07-30 Banyu Pharmaceutical Co., Ltd. Novel aminobenzamide derivative
BRPI0407283A (pt) * 2003-02-13 2006-01-31 Banyu Pharma Co Ltd Composto, composição farmacêutica, e, agente ativador de glucoquinase, agentes terapêuticos e/ou agentes preventivos para diabetes melito e obesidade
RU2330030C2 (ru) * 2003-02-26 2008-07-27 Баниу Фармасьютикал Ко., Лтд. Производные гетероарилкарбамоилбензола
WO2005079802A1 (en) * 2004-02-12 2005-09-01 Merck & Co., Inc. Bipyridyl amides as modulators of metabotropic glutamate receptor-5
GB0403155D0 (en) * 2004-02-12 2004-03-17 Vernalis Res Ltd Chemical compounds
ES2322709T3 (es) * 2004-02-18 2009-06-25 Astrazeneca Ab Derivados de benzamida y su uso como agentes activadores de la glucocinasa.
CA2554686A1 (en) * 2004-02-18 2005-09-01 Astrazeneca Ab Compounds
AU2005268781A1 (en) * 2004-08-02 2006-02-09 Genmedica Therapeutics Sl Compounds for inhibiting copper-containing amine oxidases and uses thereof
GB0423043D0 (en) * 2004-10-16 2004-11-17 Astrazeneca Ab Compounds
JP2008519850A (ja) * 2004-11-10 2008-06-12 シンタ ファーマシューティカルズ コーポレーション Ｉｌ−１２調節化合物
WO2007017649A1 (en) * 2005-08-09 2007-02-15 Astrazeneca Ab Heteroarylcarbamoylbenzene derivatives for the treatment of diabetes

Also Published As

Publication number Publication date
KR20100117137A (ko) 2010-11-02
WO2009106209A1 (en) 2009-09-03
IL207520A0 (en) 2010-12-30
EP2245025A1 (en) 2010-11-03
US20110009437A1 (en) 2011-01-13
JP2011513253A (ja) 2011-04-28
AU2009218805A1 (en) 2009-09-03
ZA201006827B (en) 2011-05-25
AR070634A1 (es) 2010-04-21
CA2716385A1 (en) 2009-09-03
IL207520A (en) 2015-08-31

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